Karen Whalen Lippincott Illustrated Reviews Pharmacology 2019

2019·48.1 MB·english

by  Karen Whalen

Lippincott®
Illustrated Reviews:
Pharmacology
South Asian Edition
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Lippincott®
Illustrated Reviews:
Pharmacology
South Asian Edition
Karen Whalen PharmD, BCPS, FAPhA Editors
Clinical Professor Sangeeta Sharma MD (Pharmacology),
Department of Pharmacotherapy and Translational MBA (Health Care Administration)
Research Professor & Head
College of Pharmacy Department of Neuropsychopharmacology
University of Florida Institute of Human Behaviour & Allied Sciences
Gainesville, Florida (IHBAS)
Delhi
Thirumurthy Velpandian PhD
Professor (Pharmacology)
Ocular Pharmacology & Pharmacy Division
Dr. R.P. Centre for Ophthalmic Sciences
All India Institute of Medical Sciences (AIIMS)
New Delhi
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Sr Publisher: Dr. Binny Mathur
Commissioning Editor: Gagandeep Kaur
Development Editor: Dr. Sahil Handa
Production Editor: Tamali Deb
Asstt. Manager Manufacturing: Sumit Johry
Copyright © 2019 by Wolters Kluwer Health (India)
10th Floor, Tower C, Building No. 10, Phase – II, DLF Cyber City
Gurgaon, Haryana - 122002
All rights reserved. This product, consisting of the printed book, is protected by copyright. No part of this book may be reproduced in any
form or by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from
the copyright owner.
The publisher is not responsible (as a matter of product liability, negligence, or otherwise) for any injury resulting from any material
contained herein. This publication contains information relating to pharmacology that should not be construed as specific instructions
for individual patients. Manufacturers’ product information and package inserts should be reviewed for current information, including
contraindications, dosages, and precautions. All products/brands/names/processes cited in this book are the properties of their respective
owners. Reference herein to any specific commercial products, processes, or services by trade name, trademark, manufacturer, or otherwise
is purely for academic purposes and does not constitute or imply endorsement, recommendation, or favoring by the publisher. The views
and opinions of authors expressed herein do not necessarily state or reflect those of the publisher, and shall not be used for advertising or
product endorsement purposes.
Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the
authors, editors, and publishers are not responsible for errors or omissions or for any consequences from application of the information
in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the
publication. Application of this information in a particular situation remains the professional responsibility of the practitioner. Readers are
urged to confirm that the information, especially with regard to drug dose/usage, complies with current legislation and standards of practice.
Please consult full prescribing information before issuing prescription for any product mentioned in the publication.
The publishers have made every effort to trace copyright holders for borrowed material. If they have inadvertently overlooked any, they will be
pleased to make the necessary arrangements at the first opportunity.
South Asian Edition
ISBN: 978-93-88313-20-9
Published by Wolters Kluwer (India) Pvt. Ltd., New Delhi
Compositor: SourceHOV
For product enquiry, please contact– Marketing Department ([email protected]) or log on to our website
www.wolterskluwerindia.co.in.
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Contributing Authors
Katherine Vogel Anderson, PharmD, BCACP Zachary L. Cox, PharmD
Associate Professor Associate Professor
Colleges of Pharmacy and Medicine College of Pharmacy
University of Florida Lipscomb University
Gainesville, Florida Heart Failure Clinical Pharmacist
Vanderbilt University Medical Center
Shawn Anderson, PharmD, BCACP
Nashville, Tennessee
Clinical Pharmacy Specialist—Cardiology
NF/SG Veterans Medical Center Stacey Curtis, PharmD
Adjunct Clinical Assistant Professor Clinical Assistant Professor
College of Pharmacy College of Pharmacy
University of Florida University of Florida
Gainesville, Florida Gainesville, Florida
Angela K. Birnbaum, PhD Eric Dietrich, PharmD, BCPS
Professor Clinical Assistant Professor
Department of Experimental and Clinical College of Pharmacy
Pharmacology University of Florida
College of Pharmacy Gainesville, Florida
University of Minnesota
Lori Dupree, PharmD, BCPS
Minneapolis, Minnesota
Clinical Assistant Professor
Nancy Borja-Hart, PharmD College of Pharmacy
Associate Professor University of Florida
The University of Tennessee Health Science Center Jacksonville, Florida
College of Pharmacy
Eric F. Egelund, PharmD, PhD
Nashville, Tennessee
Clinical Assistant Professor
Lindsey Childs-Kean, PharmD, MPH, BCPS College of Pharmacy
Clinical Assistant Professor University of Florida
College of Pharmacy Jacksonville, Florida
University of Florida
Carinda Feild, PharmD, FCCM
Gainesville, Florida
Clinical Associate Professor
Jonathan C. Cho, PharmD, MBA Department of Pharmacotherapy and Translational
Clinical Assistant Professor Research
The University of Texas at Tyler College of Pharmacy
Tyler, Texas University of Florida
St. Petersburg, Florida
Michelle Chung, PharmD
Clinical Pharmacy Specialist—Cardiology Chris Giordano, MD
NF/SG Veterans Medical Center Associate Professor
Gainesville, Florida Department of Anesthesiology
College of Medicine
Jeannine M. Conway, PharmD
University of Florida
Associate Professor
Gainesville, Florida
College of Pharmacy
University of Minnesota Benjamin Gross, PharmD, MBA
Minneapolis, Minnesota Associate Professor
College of Pharmacy
Kevin Cowart, PharmD, MPH, BCACP
Lipscomb University
Assistant Professor
Nashville, Tennessee
College of Pharmacy
Clinical Pharmacist
University of South Florida
Maury Regional Medical Group
Tampa, Florida
Columbia, Tennessee
v
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vi Contributing Authors
Jennifer Jebrock, PharmD, BCPS Kyle Melin, PharmD, BCPS
Liver and GI Transplant Clinical Pharmacist Assistant Professor
Jackson Memorial Hospital School of Pharmacy
Miami, Florida University of Puerto Rico
San Juan, Puerto Rico
Sandhya Jinesh, BPharm, MS, PharmD, RPh
Chief Pharmacist Shannon Miller, PharmD, BCACP
West Haven Pharmacy Clinical Associate Professor
West Haven, Connecticut College of Pharmacy
University of Florida
Jacqueline Jourjy, PharmD, BCPS
Orlando, Florida
Clinical Assistant Professor
College of Pharmacy W. Cary Mobley, BS Pharmacy, PhD
University of Florida Clinical Associate Professor
Orlando, Florida College of Pharmacy
University of Florida
Adonice Khoury, PharmD, BCPS
Gainesville, Florida
Clinical Assistant Professor
College of Pharmacy Cynthia Moreau, PharmD, BCACP
University of Florida Assistant Professor
UF Health Shands Hospital College of Pharmacy
Clinical Pharmacy Specialist Nova Southeastern University
Gainesville, Florida Fort Lauderdale, Florida
Jamie Kisgen, PharmD Carol Motycka, PharmD, BCACP
Pharmacotherapy Specialist—Infectious Diseases Clinical Associate Professor
Sarasota Memorial Health Care System College of Pharmacy
Sarasota, Florida University of Florida
Jacksonville, Florida
Kenneth P. Klinker, PharmD
Clinical Associate Professor Joseph Pardo, PharmD, BCPS-AQ ID, AAHIVP
College of Pharmacy Infectious Diseases Clinical Specialist
University of Florida North Florida/South Georgia Veterans Health System
Gainesville, Florida Gainesville, Florida
Kourtney LaPlant, PharmD, BCOP Kristyn Pardo, PharmD, BCPS
Clinical Pharmacy Program Manager—Oncology Ambulatory Care Clinical Specialist
Department of Veterans Affairs Department of Pharmacy
Gainesville, Florida North Florida/South Georgia VA Medical Center
Gainesville, Florida
Robin Moorman Li, PharmD, BCACP, CPE
Clinical Associate Professor Charles A. Peloquin, PharmD
College of Pharmacy Professor
University of Florida College of Pharmacy
Jacksonville, Florida University of Florida
Gainesville, Florida
Brandon Lopez, MD
Clinical Assistant Professor Joanna Peris, PhD
Department of Anesthesiology Associate Professor
College of Medicine College of Pharmacy
University of Florida University of Florida
Gainesville, Florida Gainesville, Florida
Paige May, PharmD, BCOP Rajan Radhakrishnan, BPharm, MSc, PhD
Oncology Pharmacy Specialist Professor of Pharmacology
Malcom Randall VA Medical Center College of Medicine
Clinical Assistant Professor Mohammed Bin Rashid University of Medicine and
University of Florida Health Sciences
Gainesville, Florida Dubai, United Arab Emirates
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Contributing Authors vii
Jane Revollo, PharmD, BCPS Joseph Spillane, PharmD, DABAT
Kidney/Pancreas Transplant Clinical Pharmacist Courtesy Associate Professor
Jackson Memorial Hospital Department of Emergency Medicine
Miami, Florida College of Medicine
University of Florida
Jose A. Rey, MS, PharmD, BCPP
Jacksonville, Florida
Professor
Nova Southeastern University
Amy Talana, BS, PharmD
Davie, Florida
Instructor
Clinical Psychopharmacologist
College of Pharmacy
South Florida State Hospital
University of Florida
Pembroke Pines, Florida
Gainesville, Florida
Karen Sando, PharmD, BCACP, BC-ADM
Thirumurthy Velpandian, PhD
Associate Professor
Professor (Pharmacology)
College of Pharmacy
Ocular Pharmacology & Pharmacy Division
Nova Southeastern University
Dr. R.P. Centre for Ophthalmic Sciences
Fort Lauderdale, Florida
All India Institute of Medical
Sangeeta Sharma, MD (Pharmacology), Sciences (AIIMS),
MBA (Health Care Administration) New Delhi
Professor & Head
Department of Neuropsychopharmacology Veena Venugopalan, PharmD
Institute of Human Behaviour & Allied Sciences Clinical Assistant Professor
(IHBAS), Delhi College of Pharmacy
University of Florida
Elizabeth Sherman, PharmD
Gainesville, Florida
Associate Professor
Nova Southeastern University Karen Whalen, PharmD, BCPS, FAPhA
Fort Lauderdale, Florida Clinical Professor
HIV/AIDS Clinical Pharmacy Specialist Assistant Dean for Clinical Education
Division of Infectious Disease Department of Pharmacotherapy and Translational
Memorial Healthcare System Research
Hollywood, Florida College of Pharmacy
University of Florida
Shyamal Sinha
Gainesville, Florida
Assistant Professor
Department of Pharmacology
Emily Jaynes Winograd, PharmD
Grant Govt. Medical College &
Clinical Toxicology/Emergency Medicine Fellow
Sir J.J. Group of Hospitals
Florida/USVI Poison Information
Mumbai, India
Center—Jacksonville
Kaylie Smith, PharmD Jacksonville, Florida
Instructor
Marylee V. Worley, PharmD, BCPS
College of Pharmacy
Assistant Professor
University of Florida
College of Pharmacy
Gainesville, Florida
Nova Southeastern University
Dawn Sollee, PharmD Fort Lauderdale, Florida
Assistant Director
Florida/USVI Poison Information Center—Jacksonville Venkata Yellepeddi, BPharm, PhD
Associate Professor Associate Professor
Department of Emergency Medicine Department of Pediatrics
College of Medicine School of Medicine
University of Florida University of Utah
Jacksonville, Florida Salt Lake City, Utah
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Reviewers
Dr. Shashikant Bhargava
Senior Resident
All India Institute of Medical Sciences (AIIMS),
New Delhi
Nandita Mehta
Third-year UG Student
Vardhman Mahavir Medical College and
Safdarjung Hospital
New Delhi
Illustration and Graphic Design
Michael Cooper
Cooper Graphic
www.cooper247.com
Claire Hess
hess2 Design
Louisville, Kentucky
viii
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Contents
Contributing Authors…v Chapter 14: Opioid Analgesics...281
Reviewers…viii Robin Moorman Li
Illustration and Graphic Design…viii Chapter 15: CNS Stimulants...299
Jose A. Rey
UNIT I: Principles of Drug Therapy
UNIT IV: D rugs Affecting the
Chapter 1: General Pharmacology,
Cardiovascular System
Pharmacotherapeutics,
and Pharmacokinetics...1 Chapter 16: Antihypertensives...309
Venkata Yellepeddi and Benjamin Gross
Sangeeta Sharma
Chapter 17: Diuretics...331
Chapter 2: Pharmacodynamics...57 Zachary L. Cox
Joanna Peris and Sangeeta Sharma
Chapter 18: Drugs for Heart Failure...347
Shawn Anderson
UNIT II: Drugs Affecting the Autonomic Katherine Vogel Anderson
Nervous System Chapter 19: Antiarrhythmics...365
Shawn Anderson and Michelle Chung
Chapter 3: Autonomic Nervous System...103
Chapter 20: Antianginal Drugs...381
Rajan Radhakrishnan
Kristyn Pardo
Chapter 4: Cholinergic Agonists...117
Chapter 21: Anticoagulants...391
Rajan Radhakrishnan
Katherine Vogel Anderson
Chapter 5: Cholinergic Antagonists...133
and Kaylie Smith
Rajan Radhakrishnan and Carinda Feild
Chapter 22: Drugs for Hyperlipidemia...413
Chapter 6: Adrenergic Agonists...147
Karen Sando and Kevin Cowart
Rajan Radhakrishnan
Chapter 7: Adrenergic Antagonists...167
UNIT V: Drugs Affecting the Endocrine System
Rajan Radhakrishnan
and Sandhya Jinesh Chapter 23: Pituitary and Thyroid...427
Shannon Miller and Karen Whalen
UNIT III: Drugs Affecting the Central Chapter 24: Drugs for Diabetes...437
Nervous System Karen Whalen and Cynthia Moreau
Chapter 25: Estrogens and Androgens...457
Chapter 8: D rugs for Neurodegenerative
Karen Whalen
Diseases...181
Chapter 26: Adrenal Hormones...471
Jose A. Rey
Shannon Miller and Karen Whalen
Chapter 9: Anxiolytic/Hypnotic Drugs...197
Chapter 27: Drugs Affecting Bone Metabolism...481
Jose A. Rey
Karen Whalen
Chapter 10: Antidepressants...213
Jose A. Rey
UNIT VI: Chemotherapeutic Drugs
Chapter 11: Antipsychotics...227
Jose A. Rey Chapter 28: P rinciples of Antimicrobial
Chapter 12: Drugs for Epilepsy...239 Therapy...489
Jeannine M. Conway and Angela Jamie Kisgen
K. Birnbaum Chapter 29: Cell Wall Inhibitors...505
Chapter 13: Anesthetics...257 Veena Venugopalan and Kenneth Klinker
Brandon Lopez and Chris Giordano
ix
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