Kaplan USMLE Step 1 Lecture Notes 2006-2007: Pharmacology

355 Pages·2006·10.386 MB·English

by  Lionel Raymon, Craig Davis, Maris Nora, Steven Harris, Anthony Trevor

Step I
Pharmacology
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USMLE·Step 1
Pharmacology Lecture Notes
2006-2007 Edition
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•USMLEisajoint programoftheFederationofState Medical Boardsofthe UnitedStates, Inc.andthe National BoardofMedical Examiners.
©2006 Kaplan, Inc.
Allrights reserved. No part of this book may be reproduced in any form, byphotostat,
microfilm, xerography or any other means, or incorporated into any information retrieval
system, electronic or mechanical, without the written permission of Kaplan, Inc.
Not for resale.
Author
Lionel P.Rayman, Pharm.D., Ph.D.
Department ofPathology
Forensic Toxicology Laboratory
University ofMiami School ofMedicine
Miami, FL
Contributing Authors Director of Medical Curriculum
Sonia Reichert, M.D.
Craig Davis, Ph.D.
Associate Professor
Editorial Director
University ofSouth Carolina School ofMedicine
Kathlyn McGreevy
Department ofPharmacology, Physiology, and Neuroscience
Columbia, SC
Production Manager
Maris Victor Nora, Pharm.D., Ph.D. Michael Wolff
Associate Professor
Production Editor
Rush Medical College
Chicago.Tl. William Ng
Anthony Trevor, Ph.D. Cover Design
ProfessorEmeritus
Joanna Myllo
Department ofCellular and Molecular Pharmacology
University of California CoverArt
San Francisco,CA
Christine Schaar
Steven R.Harris, Ph.D.
Associate Dean for Basic Sciences
Associate ProfessorofPharmacology
Pikeville CollegeSchool ofOsteopathic Medicine
Pikeville, KY
Contributor
Kenneth H. Ibsen, Ph.D.
Director ofAcademic Development
Kaplan Medical
ProfessorEmeritus Biochemistry
University ofCalifornia-Irvine
Irvine, CA
•
Contents
Preface ix
Sedion I: General Principles
Chapter 1:Pharmacokinetics 3
Chapter 2: Pharmacodynamics 21
Chapter 3: Practice Questions 31
Sedion II:Autonomic Pharmacology
Chapter 1:TheAutonomic Nervous System (ANS) 41
Chapter 2: Cholinergic Pharmacology 47
Chapter 3:Adrenergic Pharmacology 57
Chapter 4: Autonomic Drugs: Glaucoma Treatment and
ANSPracticeProblems 65
Chapter 5: Autonomic Drug Listand Practice Questions 73
Sedion III:cardiac and Renal Pharmacology
Chapter 1:Fundamental Concepts 87
Chapter 2: Antiarrhythmic Drugs 93
Chapter 3: Antihypertensive Drugs 97
Chapter 4: Drugs for Heart Failure 103
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Chapter 5: Antianginal Drugs 107
Chapter 6: Diuretics ......................... ..... ................ 111
Chapter 7: Antihyperlipidemics ..................................... 117
Chapter 8: Cardiac and Renal Drug list and PracticeQuestions .......... 121
Sedion IV: eNS Pharmacology
Chapter 1:Sedative-Hypnotic-Anxiolytic Drugs 133
Chapter 2: Alcohols ........................ 139
Chapter 3: Anticonvulsants 141
Chapter 4: Drugs Used inAnesthesia 145
Chapter 5: Opioid Analgesics 151
Chapter 6: Drugs Used in Parkinson Disease and Psychosis 155
Chapter 7:Drugs Used for Depression, Bipolar Disorders,
and Attention DeficitHyperactivity Disorder (ADHD) 161
Chapter 8: Drugs ofAbuse 165
Chapter 9: CNSDrug list and Practice Questions 169
Sedion V.Antimicrobial Agents
Chapter 1:Antibacterial Agents 181
Chapter 2: AntifungalAgents 197
Chapter 3:AntiviralAgents 201
Chapter 4: Antiprotoloal Agents 209
Chapter 5: Antimicrobial Drug list and Practice Questions 213
vi m8CIical
Sedion VI. Drugs for Inflammatory and Related Disorders
Chapter 1:Histamine and Antihistamines 227
Chapter 2: Drugs Usedin Gastrointestinal Dysfunction .•... ;........•.. 229
Chapter 3: Drugs Acting on Serotonergic Systems ................•.... 235
Chapter 4: Eicosanoid Pharmacology ......................•......... 239
Chapter 5: Drugs Usedfor Treatment of Rheumatoid Arthritis 245
Chapter 6: Drugs Usedfor Treatment of Gout............•......••.... 247
Chapter 7: Glucocorticoids ........................•.......•.......• 249
Chapter 8: Drugs Usedfor Treatment of Asthma 251
Chapter 9:list of Drugsfor Inflammatory Disordersand PracticeQuestions... 255
Sedion VII: Drugs Used in Blood Disorders
Chapter 1:Anticoagulants 269
Chapter 2: Thrombolytics ......................•........•........•. 273
Chapter 3: Antiplatelet Drugs .........................•............ 275
Chapter 4: list of DrugsUsedin Blood DisordersandPracticeQuestions ..... 277
Sedion VIII: Endocrine Pharmacology
Chapter 1:Drugs Usedin Diabetes....................••............ 283
Chapter 2: Steroid Hormones ...............................•...... 287
Chapter 3: Antithyroid Agents........................•...•......... 293
Chapter 4: Drugs Relatedto Hypothalamic and Pituitary Hormones 295
Chapter 5: Drugs Usedfor Bone and Mineral Disorders 297
Chapter 6: Endocrine Drug list and PracticeQuestions ...........•..... 299
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Sedion IX: Anticancer Drugs .
Chapter 1:Anticancer Drugs 307
Chapter 2: Anticancer Drug PracticeQuestions 311
Sedion X: Immunopharmacology
Chapter 1:Immunopharmacology 315
Chapter 2: Immunopharmacology PracticeQuestions .................. 317
Sedion XI: Toxicology
Chapter 1:Toxicology 321
Chapter 2: Toxicology PracticeQuestions 327
Index " 329
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Preface
These seven volumes of Lecture Notes represent a yearlong effort on the part of the Kaplan
Medical faculty to update our curriculum to reflect the most-likely-to-be-tested material on
the current USMLE Step 1exam. Please note that these are Lecture Notes, not review books.
The Notes were designed to be accompanied by faculty lectures-live, on video, or on the web.
Reading these Notes without accessing the accompanying lectures is not an effective way to
reviewfor the USMLE.
To maximize the effectiveness of these Notes, annotate them as you listen to lectures. To
facilitate this process, we've created wide, blank margins. While these margins are occasionally
punctuated by faculty high-yield "margin notes," they are, for the most part, leftblank for your
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Many students find that previewing the Notes prior to the lecture is a very effective way to
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Finally,wewant to hear what you think. What doyou likeabout the notes? What do you think
could be improved? Pleaseshare your feedback [email protected].
Thank you forjoining Kaplan Medical, and best ofluck on your Step 1exam!
KaplanMedical
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