JACC Journal of the American College of Cardiology Editor-in-Chief SIMON DACK, MD, New York, NY Associate Edit Senior Assistant Edit ANTHONY N. DEMARIA, MD, Lexington, KY IRA J. GELB, MD, New Rochelle, NY SUZANNE B. KNOEBEL, MD, Indianapolis, IN MARTIN E. GOLDMAN, MD, New York, NY DAN G. MCNAMARA, MD, Houston, TX MELVIN KAHN, MD, New York, NY JOHN A. WALDHAUSEN, MD, Hershey, PA LESLIE A. KUHN, MD, New York, NY Editorial Consul GEORGE S. ABELA, MD, Boston, MA NOBLE O. FOWLER, MD, Cincinnati, OH BARRY M. MASSIE, MD, San Francisco, CA ROBERT J. ADOLPH, MD, Cincinnati, OH ARTHUR C. FOX, MD, New York, NY ERIC L. MICHELSON, MD, Philadelphia, PA JOHN AMBROSE, MD, New York, NY GARY S. FRANCIS, MD, Minneapolis, MN JOEL MORGANROTH, MD, Gladwyne, PA FRED L. ANDERSON, MD, Salt Lake City, UT ROBERT M. FREEDOM, MD, Ontario, Canada HILTRUD S. MUELLER, MD, Bronx, NY WILLIAM F. ARMSTRONG III, MD, Ann Arbor, MI GOTTLIEB C. FRIESINGER II, MD, Nashville, TN NAVIN C. NANDA, MD, Birmingham, AL DONALD S. BAIM, MD, Boston, MA VICTOR F. FROELICHER, MD, Long Beach, CA RICK A. NISHIMURA, MD, Rochester, MN ROBERT A. BAUERNFEIND, MD, Richmond, VA EDWARD D. FROHLICH, MD, New Orleans, LA MILTON PACKER, MD, New York, NY LEWIS C. BECKER, MD, Baltimore, MD VALENTIN FUSTER, MD, New York, NY BERTRAM PITT, MD, Ann Arbor, MI DANIEL S. BERMAN, MD, Los Angeles, CA JULIUS M. GARDIN, MD, Orange, CA GARY D. PLOTNICK, MD, Baltimore, MD EUGENE H. BLACKSTONE, MD, Birmingham, AL EDWARD M. GELTMAN, MD, St. Louis, MO ERIC N. PRYSTOWSKY, MD, Indianapolis, IN ROBERTO BOLLI, MD, Houston, TX BERNARD J. GERSH, MB, ChB, PhD, Rochester, MN CHARLES E. RACKLEY, MD, Washington, DC KENNETH M. BOROW, MD, Chicago, IL WELTON M. GERSONY, MD, New York, NY SHAHBUDIN H. RAHIMTOOLA, MD, Los Angeles, CA NATHANIEL REICHEK, MD, Philadelphia, PA CHARLES A. BOUCHER, MD, Boston, MA RICHARD A. GOLDSTEIN, MD, Houston, TX SAMUEL B. RITTER, MD, New York, NY MARTIAL G. BOURASSA, MD, Quebec, Canada RICHARD J. GOLINKO, MD, New York, NY ALLAN M. ROSS, MD, Washington, DC EUGENE BRAUNWALD, MD, Boston, MA THOMAS P. GRAHAM, Jr., MD, Nashville, TN RICHARD O. RUSSELL, Jr., MD, Birmingham, AL BRUCE H. BRUNDAGE, MD, Torrance, CA ROLF M. GUNNAR, MD, Maywood, IL THOMAS J. RYAN, MD, Boston, MA ANDREW J. BUDA, MD, Ann Arbor, MI WARREN G. GUNTHEROTH, MD, Seattle, WA ROBERT C. SCHLANT, MD, Atlanta, GA ROBERT M. CALIFF, MD, Durham, NC DAVID R. HATHAWAY, MD, Indianapolis, IN MARK H. SCHOENFELD, MD, New Haven, CT RICHARD O. CANNON III, MD, Bethesda, MD CHARLES B. HIGGINS, MD, San Francisco, CA ARTHUR SELZER, MD, San Francisco, CA BLASE CARABELLO, MD, Charleston, SC L. DAVID HILLIS, MD, Dallas, TX DAVID J. SKORTON, MD, lowa City, IA BERNARD R. CHAITMAN, MD, St. Louis, MO DAVID R. HOLMES, Jr., MD, Rochester, MN DAVID H. SPODICK, MD, DSc, Worcester, MA KANU CHATTERJEE, MD, San Francisco, CA LEONARD N. HOROWITZ, MD, Philadelphia, PA LEONARD STEINFELD, MD, New York, NY JAMES H. CHESEBRO, MD, Rochester, MN JAMES C. HUHTA, MD, Philadelphia, PA BORYS SURAWICZ, MD, Indianapolis, IN ROBERT J. CODY, MD, Columbus, OH JEFFREY M. ISNER, MD, Boston, MA ERIC J. TOPOL, MD, Ann Arbor, MI PATRICIA C. COME, MD, Boston, MA MARK E. JOSEPHSON, MD, Philadelphia, PA MARIO S. VERANI, MD, Houston, TX HAROLD DASH, MD, Everett, WA JOEL S. KARLINER, MD, San Francisco, CA DAVID D. WATERS, MD, Quebec, Canada JOHN P. DiMARCO, MD, PhD, Charlottesville, VA SANJIV KAUL, MD, Charlottesville, VA KARL T. WEBER, MD, Columbia, MO JAMES C. DILLON, MD, Indianapolis, IN KENNETH M. KESSLER, MD, Miami, FL MYRON L. WEISFELDT, MD, Baltimore, MD LEONARD S. DREIFUS, MD, Philadelphia, PA THOMAS KILLIP, MD, New York, NY ARTHUR E. WEYMAN, MD, Boston, MA TOBY R. ENGEL, MD, Omaha, NE LLOYD W. KLEIN, MD, Chicago, IL DAVID O. WILLIAMS, MD, Providence, RI MARY ALLEN ENGLE, MD, New York, NY ROBERT A. KLONER, MD, PhD, Los Angeles, CA ANDREW E. EPSTEIN, MD, Birmingham, AL MORRIS N. KOTLER, MD, Philadelphia, PA STEPHEN M. FACTOR, MD, Bronx, NY MARTIN J. LIPTON, MD, Chicago, IL E ti E lit JACK FERLINZ, MD, Southfield, MI FLOYD D. LOOP, MD, Cleveland, OH ROSS D. FLETCHER, MD, Washington, DC BARRY J. MARON, MD, Bethesda, MD RUTH OHMAN, New York, NY © 1991 by THE AMERICAN COLLEGE OF CARDIOLOGY Journal of the American College of Cardiology (ISSN 0735-1097) is issued monthly, except semimonthly in March and November, in two indexed volumes per year by Elsevier Science Publishing Co., Inc., 655 Avenue of the Americas, New York, NY 10010. This journal has been registered with the Copyright Clearance Center, Inc. Consent is given for the copying of articles for personal or internal use, or for the personal or internal use of specific clients. This consent is given on the condition that the copier pay through the center the per copy fee stated in the code on the first page of each article for copying beyond that permitted by the U.S. Copyright Law. If no code appears on an article, the author has not given broad consent to copy, and permission to copy must be obtained directly from the author. This consent does not extend to other kinds of copying, such as for general distribution, resale, advertising and promotional purposes, or for creating new collective works. CONTENTS OF VOLUME 17 JANUARY 1991 VOLUME 17 NUMBER 1 COOPERATIVE STUDIES F. Hiratzka, Linda Thorpe, Mark L. Armstrong, Melvin L. Marcus, Richard E. Kerber Avoiding Interpretive Pitfalls When Assessing Arrhythmia Suppression After Myocardial Infarction: Insights From the 87 Detection of Coronary Blood Flow Associated With Left Main Long-Term Observations of the Placebo-Treated Patients in the Coronary Artery Stenosis by Transesophageal Doppler Color Cardiac Arrhythmia Pilot Study (CAPS) Craig M. Pratt, Al Flow Echocardiography Masakazu Yamagishi, Takanori Hallstrom, Pierre Theroux, Donald Romhilt, James Coromilas, Yasu, Kuniyoshi Ohara, Masakazu Kuro, Kunio Miyatake James Myles, for the CAPS Investigators 94 Percutaneous Coronary Excimer Laser-Assisted Balloon Editorial Comment The Variability of Spontaneous Ventricular Angioplasty: Initial Clinical and Quantitative Angiographic Arrhythmias in the Year After Myocardial Infarction Results in 50 Patients Timothy A. Sanborn, Sabino R. Torre, J. Thomas Bigger, Jr., Joseph L. Fleiss Samin K. Sharma, Ronnie A. Hershman, Marc Cohen, Warren Sherman, John A. Ambrose ll Reasons for the Lack of Benefit of Immediate Angioplasty During Recombinant Tissue Plasminogen Activator Therapy for 100 Percutaneous Angioscopy During Coronary Angioplasty Using a Acute Myocardial Infarction: A Regional Wall Steerable Microangioscope Stephen R. Ramee, Christopher J. Motion Analysis Alfred E. R. Arnold, Patrick W. Serruys, White, Tyrone J. Collins, Juan E. Mesa, Joseph P. Murgo Wolfgang Rutsch, Maarten L. Simoons, David P. De Bono, 106 Evaluation of Preload Reserve During Isometric Exercise Testing Jan G. P. Tijssen, Jacobus Lubsen, Marc Verstraete for the in Patients With Old Myocardial Infarction: Doppler European Cooperative Study Group Echocardiographic Study Kayo Hayashi, Kenji Dote, Yasushi 22 Clinical and Angiographic Determinants of Primary Coronary Sunaga, Tetsuro Sugiura, Toshiji lwasaka, Mitsuo Inada Angioplasty Success Michael P. Savage, Sheldon Goldberg, 112 Noninvasive Assessment of Intrinsic Ventricular Load Dynamics John W. Hirshfeld, Theodore A. Bass, Robert G. MacDonald, in Dilated Cardiomyopathy Karl /saaz, Ares Pasipoularides James R. Margolis, Andrew S. Taussig, George Vetrovec, Hall B. Whitworth, Andrew Zalewski, James A. Hill, Michael 122 Editorial Comment Toward a More Complete Understanding of Cowley, Ralph Jugo, Carl J. Pepine for the M-Heart Left Ventricular Afterload Richard B. Devereux Investigators 125 Methodology of Head-Up Tilt Testing in Patients With Unexplained Syncope Adam P. Fitzpatrick, George CLINICAL STUDIES Theodorakis, Panos Vardas, Richard Sutton 29 Outcome Probabilities and Life History After Surgical Mitral 131 Editorial Comment Tilt Table for the Investigation of Syncope: Commissurotomy: Implications for Balloon Commissurotomy There Is Nothing Simple About Fainting Paul Kligfield Mark S. J. Hickey, Eugene H. Blackstone, John W. Kirklin, Larry S. Dean ELECTROPHYSIOLOGIC STUDIES 43 Spontaneous Alterations in Coronary Blood Flow Velocity Before 133 Immediate Reproducibility of Electrically Induced Sustained and After Coronary Angioplasty in Patients With Severe Angina Monomorphic Ventricular Tachycardia Before and During Eric J. Eichhorn, Paul A. Grayburn, John E. Willard, Antiarrhythmic Therapy Marlon S. Rosenbaum, David J. H. Vernon Anderson, John B. Bedotto, Melissa Carry, Joel K. Wilber, Dianne Finkelstein, Jeremy N. Ruskin, Hasan Garan Kahn, James T. Willerson 139 Editorial Comment Cardiac Excitability, the Electrophysiologic 53 Elevated Plasma Beta-Endorphin Levels in Patients With Matrix and Electrically Induced Ventricular Arrhythmias: Congestive Heart Failure Seinosuke Kawashima, Naoshige Order and Reproducibility in Seeming Electrophysiologic Chaos Fukutake, Katsuhiko Nishian, Susumu Asakuma, Morton F. Arnsdorf Tadaaki Iwasaki 143 Differences in QRS Configuration During Unipolar Pacing From 59 Implications of Echocardiographically Assisted Diagnosis of Adjacent Sites: Implications for the Spatial Resolution of Pace- Pericardial Tamponade in Contemporary Medical Patients: Mapping Alan H. Kadish, Keith Childs, Stephen Schmaltz, Detection Before Hemodynamic Embarrassment Marc J. Fred Morady Levine, Beverly H. Lorell, Daniel J. Diver, Patricia C. Come 152 Lack of Prognostic Value of Syncope in Patients With Wolff- Superiority of Transesophageal Echocardiography in Detecting Parkinson-White Syndrome Angelo Auricchio, Helmut Klein, Cardiac Source of Embolism in Patients With Cerebral Ischemia Hans-Joachim Trappe, Paul Wenzlaff of Uncertain Etiology Anthony C. Pearson, Arthur J. Labovitz, Satyararayan Tatineni, Camilo R. Gomez 159 Editorial Comment Syncope and Sudden Death in the Wolff- Parkinson-White Syndrome Thomas N. James 73 Recognition and Embolic Potential of Intraaortic Atherosclerotic Debris Dean G. Karalis, Krishnaswamy Chandrasekaran, 161 Longitudinal Dissociation of Atrioventricular Accessory Mark F. Victor, John J. Ross, Jr., Gary S. Mintz Pathways Jacob Atié, Pedro Brugada, Josep Brugada, Joep L. R. M. Smeets, Fernando E. §. Cruz, Ayrton Peres, METHODS Mauricio Duque, Hein J. J. Wellens 79 Coronary Arterial Remodeling Studied by High-Frequency PEDIATRIC CARDIOLOGY Epicardial Echocardiography: An Early Compensatory Mechanism in Patients With Obstructive Coronary 167 Tricuspid Valve Disease With Significant Tricuspid Insufficiency Atherosclerosis David D. McPherson, Sara J. Sirna, Loren in the Fetus: Diagnosis and Outcome Lisa K. Hornberger, David J. Sahn, Charles §. Kleinman, Joshua A. Copel, Experimental Pericardial Effusion: Relation of Abnormal Kathryn L. Reed Respiratory Variation in Mitral Flow Velocity to Hemodynamics and Diastolic Right Heart Collapse Mark S. Gonzalez, 174 _ Electrophysiologic Findings After Fontan Repair of Functional Michael A. Basnight, Christopher P. Appleton with the Single Ventricle © Cheryl C. Kiirer, Carol S. Tanner, Victoria technical assistance of Melissa Carucci, Christopher Henry, L. Vetter Marcey Olajos 182 Late Noninvasive Evaluation of Cardiac Performance in Mildly 249 Editorial Comment The Effects of Pericardial Effusion on Symptomatic Older Patients With Ebstein’s Anomaly of Respiratory Variations in Hemodynamics and Ventricular Tricuspid Valve: Role of Radionuclide Imaging Anita Saxena, Function Ralph Shabetai Lance V. Fong, Maria Tristam, Duncan M. Ackery, Barry R. Keeton 251 Effect of Lovastatin on Intimal Hyperplasia After Balloon Angioplasty: A Study in an Atherosclerotic Hypercholesterolemic SEMINAR ON BALLOON AORTIC VALVULOPLASTY—I Rabbit Joel Gellman, Michael D. Ezekowitz, lan J. William W. O'Neill. Guest Editor Sarembock, Michael A. Azrin, Lucien E. Nochomowitz, Emanuel Lerner, Christian C. Haudenschild 187 Introduction William W. O'Neill 260 A Quantitative Index of Regional Blood Flow in Canine 189 In-Hospital Mortality After Balloon Aortic Valvuloplasty: Myocardium Derived Noninvasively With N-13 Ammonia and Frequency and Associated Factors David R. Holmes, Jr., Rick Dynamic Positron Emission Tomography Christoph A. A. Nishimura, Guy S. Reeder Nienaber, Osman Ratib, Sanjiv S. Gambhir, Janine 193 Predictors of Long-Term Survival After Percutaneous Aortic oo % yo ig Huang, Michael E. Phelps, Valvuloplasty: Report of the Mansfield Scientific Balloon Aortic Valvuloplasty Registry William W. O'Neill for the Mansfield 270 Editorial Comment Quantitative Determination of Regional Scientific Aortic Valvuloplasty Registry Investigators Myocardial Blood Flow: Can It Be Accurately Measured Noninvasively? Denny D. Watson, George A. Beller REPORTS ON THERAPY 199 Ventricular Load Optimization by Unloading Therapy in DIAGNOSTIC TECHNIQUES Patients With Heart Failure Tomoki Kameyama, Hidetsugu 272 The Flail Mitral Valve: Echocardiographic Findings by Asanoi, Shinji Ishizaka, Shigetake Sasayama Precordial and Transesophageal Imaging and Doppler Color 208 Cardiovascular and Hormonal Effects of Calcitonin Gene- Flow Mapping Ronald B. Himelman, Fred Kusumoto, Keith Related Peptide in Congestive Heart Failure Inder S. Anand, Oken, Edmond Lee, Michael K. Cahalan, Pravin M. Shah, Jane Gurden, Gurpreet S. Wander, Peter O’Gara, Sian E. Nelson B. Schiller Harding, Roberto Ferrari, A. Cornacchiari, A. Panzali, Purshotam L. Wahi, Philip A. Poole-Wilson CASE REPORTS , 280 Cardiac Tamponade Early After Thrombolysis for Acute BASIC CONCEPTS IN CARDIOLOGY Myocardial Infarction: A Rare but Not Reported Hemorrhagic Complication Jean Renkin, Bernard De Bruyne, Edouard Arnold M. Katz, Guest Editor Benit, Jean-Marc Joris, Marc Carlier, Jacques Col 218 Maturational Changes in Excitation-Contraction Coupling in Mammalian Myocardium Thomas S. Klitzner HISTORICAL MILESTONES 286 Historical Vignette Celebrating the 30th Anniversary of EXPERIMENTAL STUDIES Diagnostic Ambulatory Electrocardiographic Monitoring and 227 _ Influence of Incremental Changes in Heart Rate on Mitral Flow Data Reduction Systems — Eliot Corday Velocity: Assessment in Lightly Sedated, Conscious Dogs Christopher P. Appleton with the technical assistance of SPECIAL SECTIONS Melissa J. Carucci, Christopher P. Henry, Marcey Olajos 293 ACC News President’s Page: Committee Participation—A 237 Editorial Comment The Increasing Complexity of Assessing Blueprint for Success or Failure William L. Winters, Jr. Diastolic Function From Ventricular Filling Dynamics William A. Zoghbi, Roberto Bolli 296 Letter to the Membership Charles Fisch FEBRUARY 1991 VOLUME 17 NUMBER 2 COOPERATIVE STUDIES Myocardial Infarction With Minimal Coronary Atherosclerosis in the Era of Thrombolytic Reperfusion Dean J. Kereiakes, 297 Flecainide Acetate Treatment of Paroxysmal Supraventricular Eric J. Topol, Barry S. George, Richard S. Stack, Charles W. Tachycardia and Paroxysmal Atrial Fibrillation: Dose-Response Abbottsmith, Stephen Ellis, Richard J. Candela, Lynn Studies Edward L. C. Pritchett, Steven D. DaTorre, Marc L. Harrelson, Linda H. Martin, Robert M. Califf and the Platt, Sally E. McCarville, Andrina J. Hougham for the Thrombolysis and Angioplasty in Myocardial Infarction Flecainide Supraventricular Tachycardia Study Group (TAMI) Study Group CLINICAL STUDIES Prolonged and Fractionated Right Atrial Electrograms During Sinus Rhythm in Patients With Paroxysmal Atrial Fibrillation Natural History of Moderate Aortic Stenosis Kelley D. and Sick Sinus Node Syndrome Muneo Tanigawa, Masahiko Kennedy, Rick A. Nishimura, David R. Holmes, Jr., Fukatani, Atsushi Konoe, Shojiro Isomoto, Mitsuo Kadena, Kent R. Bailey Kunitake Hashiba Clinical and Electrophysiologic Determinants, Treatment and Spontaneous Changes in Ventricular Tachycardia Cycle Length Survival of Patients With Sustained Malignant Ventricular Kent J. Volosin, Lou-Anne M. Beauregard, Rosemary Tachyarrhythmias Occurring Late After Myocardial Infarction Fabiszewski, Howard Mattingly, Harvey L. Waxman J. Anthony Gomes, Stephen L. Winters, Arisan Ergin, Joseph Machac, Manuel Estioko, Dimitrious Alexopoulous, Elena Pe CARDIAC PACING Editorial Comment Sustained Ventricular Tachyarrhythmias After Infarction: When Should the Worrying Begin? Automatic Implantable Cardioverter-Defibrillator Implantation Mark H. Schoenfeld Without Thoracotomy Using an Endocardial and Submuscular Patch System Ronald McCowan, James Maloney, Bruce Late Potentials on Signal-Averaged Electrocardiograms and Wilkoff, Tony Simmons, Dirar Khoury, Hugh McAlister, Patency of the Infarct-Related Artery in Survivors of Acute Victor Morant, Lon Castle Myocardial Infarction Pierce J. Vatterott, Stephen C. Hammill, Kent R. Bailey, Christine M. Wiltgen, Bernard J. Gersh REPORTS ON HYPERTENSION Effect of H, Receptor Stimulation on Coronary Artery Diameter Echocardiographic Evaluation of Cardiac Structure and in Patients With Variant Angina: Comparison With Effect of Function in Elderly Subjects With Isolated Systolic Hypertension Acetylcholine Ken Okumura, Hirofumi Yasue, Koshi Anthony C. Pearson, Chalapathirao Gudipati, David Matsuyama, Kozaburo Matsuyama, Yasuhiro Morikami, Nagelhout, James Sear, Jerome D. Cohen, Arthur J. Labovitz Hisao Ogawa, Kenji Obata with the technical assistance of Denise Mrosek, Jan St. Vrain Editorial Comment _Histaminergic Modulation of Coronary Editorial Comment _ Significance of Increased Left Ventricular Vascular Resistance: Are We Missing a Therapeutic Adjunct for Mass in Isolated Systolic Hypertension of the Elderly the Treatment of Myocardial Ischemia? Morton J. Kern Robert A. Phillips Percutaneous Mitral Valvuloplasty in Surgical High Risk Patients Thierry Lefévre, Raoul Bonan, Antonio Serra, MORPHOLOGIC STUDIES Jacques Crépeau, Thor Dyrda, Robert Petitclerc, Yves Leclerc, Restenosis After Percutaneous Transluminal Coronary Olivier Vanderperren, David Waters Angioplasty: Pathologic Observations in 20 Patients Masakiyo Nobuyoshi, Takeshi Kimura, Hiroto Ohishi, Hisanori METHODS Horiuchi, Hideyuki Nosaka, Naoya Hamasaki, Hiroatsu The Variable Extent of Jeopardized Myocardium in Patients Yokoi, Koutaku Kim With Single Vessel Coronary Artery Disease: Quantification by Editorial Comment What Does Pathology Teach Us About Thallium-201 Single Photon Emission Computed Tomography Recurrent Stenosis After Coronary Angioplasty? Jay Hollman John J. Mahmarian, Craig M. Pratt, Terri M. Boyce, Mario §. Verani Differential Histopathology of Primary Atherosclerotic and Restenotic Lesions in Coronary Arteries and Saphenous Vein Editorial Comment Relation Between Functional and Anatomic Bypass Grafts: Analysis of Tissue Obtained From 73 Patients by Descriptors of Coronary Artery Disease Directional Atherectomy Kirk N. Garratt, William D. Abdulmassih S. Iskandrian Edwards, Urs P. Kaufmann, Ronald E. Vlietstra, Primary Angioplasty in Myocardial Infarction: Assessment of David R. Holmes, Jr. Improved Myocardial Perfusion With Technetium-99m Isonitrile Transplant Coronary Artery Disease: Histopathologic Correlations Thomas Behrenbeck, Patricia A. Pellikka, Kenneth C. Huber, With Angiographic Morphology Danna E. Johnson, Edwin L. John F. Bresnahan, Bernard J. Gersh, Raymond J. Gibbons Alderman, John S. Schroeder, Shao-Zhou Gao, Sharon Hunt, Differentiating Cardiomyopathy of Coronary Artery Disease William M. DeCampli, Edward Stinson, Margaret Billingham From Nonischemic Dilated Cardiomyopathy Utilizing Positron Emission Tomography Freny Vaghaiwalla Mody, Richard C. PEDIATRIC CARDIOLOGY Brunken, Lynne Warner Stevenson, Christoph A. Nienaber, Michael E. Phelps, Heinrich R. Schelbert Immunosuppressive Therapy in the Management of Acute Myocarditis in Children: A Clinical Trial Kit Y. Chan, A Randomized Comparison of the Nephrotoxicity of lopamidol Masazumi Iwahara, Lee N. Benson, Gregory J. Wilson, and Diatrizoate in High Risk Patients Undergoing Cardiac Robert M. Freedom Angiography Charles P. Taliercio, Ronald E. Vlietstra, Duane M. Ilstrup, John C. Burnett, Kris K. Menke, Shauna L. Lung Function and Pulmonary Regurgitation Limit Exercise Stensrud, David R. Holmes, Jr. Capacity in Postoperative Tetralogy of Fallot Stuart A. Rowe, Kenneth G. Zahka, Teri A. Manolio, Peter J. Horneffer, ELECTROPHYSIOLOGIC STUDIES Langford Kidd Drug Therapy for Ventricular Tachyarrhythmias: How Many Electropharmacologic Trials Are Appropriate? Katherine M. REPORTS ON THERAPY Kavanagh, D. George Wyse, Henry J. Duff, Anne M. Gillis, A Randomized Placebo-Controlled Trial of Combined Early Robert S. Sheldon, L. Brent Mitchell Intravenous Captopril and Recombinant Tissue-Type Comparison of Pre- and Postoperative Conduction Patterns in Plasminogen Activator Therapy in Acute Myocardial Infarction Patients Surgically Cured of Atrioventricular Node Reentrant Elizabeth G. Nabel, Eric J. Topol, Anita Galeana, Stephen G. Tachycardia Michael A. Ruder, R. Hardwin Mead, Nellis A. Ellis, Eric R. Bates, Steven W. Werns, Joseph A. Walton, Smith, Vincent A. Gaudiani, Roger A. Winkle David W. Muller, Markus Schwaiger, Bertram Pitt 474 Methionine Restores the Venodilative Response to Nitroglycerin EXPERIMENTAL STUDIES After the Development of Tolerance Warren S. Levy, Richard J. Katz, Alan G. Wasserman 509 Atrial Activation Sequence During Atrial Flutter in the Canine Pericarditis Model and Its Effects on the Polarity of the Flutter 480 Effect of Atenolol and Diltiazem on Heart Period Variability in Wave in the Electrocardiogram Ken Okumura, Vance J. Normal Persons James R. Cook, J. Thomas Bigger, Jr., Plumb, Pierre L. Pagé, Albert L. Waldo Robert E. Kleiger, Joseph L. Fleiss, Richard C. Steinman, Linda M. Rolnitzky 519 Comparison of Indium-111 Antimyosin Antibody and Technetium-99m Pyrophosphate Localization in Reperfused and SEMINAR ON BALLOON AORTIC VALVULOPLASTY—II Nonreperfused Myocardial Infarction Kan Takeda, Norman William W. O’Neill, Guest Editor D. LaFrance, Harlan F. Weisman, Henry N. Wagner, Jr., Lewis C. Becker 485 The Mansfield Scientific Aortic Valvuloplasty Registry: Overview —— ‘ of Acute Hemodynamic Results and Procedural Complications 527 Editorial Comment Technetium-99m Pyrophosphate and seen . Indium-111 Antimyosin Antibody Scintigraphy Appear to Be Raymond G. McKay for the Mansfield Scientific Aortic ; Valvuloplasty Registry Investigators Comparable Methods for Infarct Detection James T. Willerson, L. Maximilian Buja REVIEWS 530 Hypertrophy, Fibrosis and Diastolic Dysfunction in Early Canine Experimental Hypertension Pamela S. Douglas, 492 Association Between Primary Pulmonary Hypertension and Barbara Tallant Portal Hypertension: Analysis of Its Pathophysiology and Clinical, Laboratory and Hemodynamic Manifestations Benjamin D. Robalino, Douglas S. Moodie DIAGNOSTIC STUDIES EDITORIAL REVIEWS 537 Transesophageal Echocardiography Is Superior to Transthoracic ‘ : ~* - ,' Echocardiography in the Diagnosis of Sinus Venosus Atrial 499 Mechanisms of Angina Pectoris in Syndrome X_ Aitilio Maseri, Bye “ Filippo Crea, Juan Carlos Kaski, Tom Crake Septal Defect /tzhak Kronzon, Paul A. Tunick, Robin S. Freedberg, Naresh Trehan, Barry P. Rosenzweig, Editorial Comment Syndrome X Revisited Harvey G. Kemp, Jr. Matthew E. Schwinger FEBRUARY 1991 VOLUME 17 NUMBER 2 (SUPPLEMENT A) ABSTRACTS Abstracts of Original Contributions to Be Presented at the 16A Original Contributions: 40th Annual Scientific Session American College of Cardiology 40th Annual Scientific Session March 3-7, 1991 Atlanta, Georgia 392A Acknowledgments Original Contributions: Young Investigators’ Awards 394A Author Index Competition Original Contributions: Computer Application Program 411A Subject Index MARCH 1, 1991 VOLUME 17 NUMBER 3 ACC/AHA TASK FORCE REPORT Erbel, Timothy M. Brown, Nathan Laufer, Jurgen Meyer, 543 Guidelines and Indications for Coronary Artery Bypass Graft William W. O'Neill Surgery John W. Kirklin, Chairman 604 Heart Rate Variability in Patients With Ventricular Arrhythmias: Effect of Antiarrhythmic Drugs Giulio Zuanetti, COOPERATIVE STUDIES Roberto Latini, James M. M. Neilson, Peter J. Schwartz, David J. Ewing and the Antiarrhythmic Drug Evaluation 590 Digoxin-[mmune Fab Therapy in the Management of Digitalis Group (ADEG) Intoxication: Safety and Efficacy Results of an Observational Surveillance Study Anne R. Hickey, Thomas L. Wenger, CLINICAL STUDIES pra’ Fates pry 4p ese ygh e| t g 613 Factors Determining Improvement in Left Ventricular Function Thomas W. Smith After Reperfusion Therapy for Acute Myocardial Infarction: Primacy of Baseline Ejection Fraction Ulrike Marzoll, Neal S. 599 Multicenter Registry of Angioplasty Therapy of Cardiogenic Kleiman, J. Kay Dunn, Mario S. Verani, Steven T. Minor, Shock: Initial and Long-Term Survival Linda Lee, Raimund Robert Roberts, Albert E. Raizner Incidence and Clinical Significance of Transient Creatine Kinase EPIDEMIOLOGIC STUDIES Elevations and the Diagnosis of Non-Q Wave Myocardial Relation of Alcohol Intake to Left Ventricular Mass: The Infarction Associated With Coronary Angioplasty Lloyd W. Framingham Study Teri A. Manolio, Daniel Levy, Robert J. Klein, Barry L. Kramer, Elizabeth Howard, Michael Lesch Garrison, William P. Castelli, William B. Kannel Reactivity of Eccentric and Concentric Coronary Stenoses in Patients With Chronic Stable Angina Juan Carlos Kaski, PEDIATRIC CARDIOLOGY Dimitris Tousoulis, Agha W. Haider, Stavros Gavrielides, Filippo Crea, Attilio Maseri Surgery for Ebstein’s Anomaly: The Clinical and Echocardiographic Evaluation of a New Technique Jan M. Long-Term Follow-Up of Medical Versus Surgical Therapy for Quaegebeur, Narayanswami Sreeram, Alan G. Fraser, Hypertrophic Cardiomyopathy: A Retrospective Study Ad J. J. C. Bogers, Oliver F. W. Stiimper, John Hess, Egbert Christian Seiler, Otto M. Hess, Marietta Schoenbeck, Juraj Bos, George R. Sutherland Turina, Rolf Jenni, Marko Turina, Hans-Peter Krayenbuehl The Role of Chronotropic Impairment During Exercise After the Editorial Comment Surgical Versus Medical Therapy of Mustard Operation Stephen M. Paridon, Richard A. Humes, Hypertrophic Cardiomyopathy: Is the Perspective Changing? William W. Pinsky Robert A. Chahine Obstruction of Mechanical Heart Valve Prostheses: Clinical REPORTS ON THERAPY Aspects and Surgical Management Ehud Deviri, Pinhas Sareli, Thomas Wisenbaugh, Stephanus L. Cronje Effect of Captopril, an Angiotensin-Converting Enzyme Inhibitor, in Patients With Angina Pectoris and Heart Failure Myocardial Magnesium: Relation to Laboratory and Clinical John G. F. Cleland, Esther Henderson, James McLenachan, Variables in Patients Undergoing Cardiac Surgery Richard A. lain N. Findlay, Henry J. Dargie Reinhart, James J. Marx, Jr., Steven K. Broste, Ronald G. Haas Editorial Comment Management of Patients With Heart Failure and Angina: Do Coexistent Diseases Alter the Response to METHODS Cardiovascular Drugs? Milton Packer, Marrick L. Kukin Prediction of the Frequency and Duration of Ambulatory Effect of Maintenance Digoxin Therapy on Aerobic Performance Myocardial Ischemia in Patients With Stable Coronary Artery and Exercise Left Ventricular Function in Mild to Moderate Disease by Determination of the Ischemic Threshold From Heart Failure Due to Coronary Artery Disease: A Randomized, Exercise Testing: Importance of the Exercise Protocol Julio A. Placebo-Controlled, Crossover Trial Jerome L. Fleg, Panza, Arshed A. Quyyumi, Jean G. Diodati, Timothy S. Benjamin Rothfeld, Sheldon H. Gottlieb with the technical Callahan, Stephen E. Epstein assistance of Jeanette Wright Editorial Comment Differences in Electrocardiographic Treatment of Recurrent Ischemia After Thrombolysis and Demonstration of Myocardial Ischemia Robert A. Bruce Successful Reperfusion for Acute Myocardial Infarction: Effect Stress Echocardiography and the Human Factor: The on In-Hospital Mortality and Left Ventricular Function Importance of Being Expert Eugenio Picano, Fabio Lattanzi, Stephen G. Ellis, Darrell Debowey, Eric R. Bates, Andrés Orlandini, Cecilia Marini, Antonio L’ Abbate Eric J. Topol Silent Ischemia After Coronary Angioplasty: Evaluation of REVIEWS Restenosis and Extent of Ischemia in Asymptomatic Patients by Tomographic Thallium-201 Exercise Imaging and Comparison A Paradigm for Restenosis Based on Cell Biology: Clues for the With Symptomatic Patients Harvey S. Hecht, Richard E. Development of New Preventive Therapies James S. Shaw, Henry L. Chin, Colman Ryan, Simon H. Stertzer, Forrester, Michael Fishbein, Richard Helfant, James Fagin Richard K. Myler Percutaneous Support Devices for High Risk or Complicated ELECTROPHYSIOLOGIC STUDIES Coronary Angioplasty A. Michael Lincoff, Jeffrey J. Popma, Stephen G. Ellis, Robert A. Vogel, Eric J. Topol Concealed Entrainment As a Guide for Catheter Ablation of Ventricular Tachycardia in Patients With Prior Myocardial EXPERIMENTAL STUDIES Infarction Fred Morady, Alan Kadish, Shimon Rosenheck, Hugh Calkins, William H. Kou, Michael De Buitleir, Joao Sousa Regional Myocardial Blood Flow and Left Ventricular Diastolic Effects of Standing on the Induction of Paroxysmal Properties in Pacing-Induced Ischemia Shin-ichi Momomura, Supraventricular Tachycardia Takaaki Hashimoto, Masahiko James J. Ferguson, Michael J. Miller, J. Anthony Parker, Fukatani, Mitsuhiro Mori, Kunitake Hashiba William Grossman Pressure-Length Loop Area: Its Components Analyzed During CARDIAC PACING Graded Myocardial Ischemia Amira Safwat, Bruce J. Leone, A Randomized Double-Blind Crossover Comparison of Four Robin M. Norris, Pierre Foéx Rate-Responsive Pacing Modes Neil Sulke, John Chambers, Modification of Atrioventricular Node Transmission Properties Athanase Dritsas, Edgar Sowton by Intraoperative Neodymium-YAG Laser Photocoagulation in The Automatic Implantable Cardioverter-Defibrillator: Effect of Dogs Laszlo Littmann, Robert H. Svenson, Istvan Patch Polarity on Defibrillation Threshold Padraig G. O'Neill, Tomcsanyi, Christoph Hehrlein, John J. Gallagher, Saroja Kwabena A. Boahene, Gerald M. Lawrie, Lynette F. Harvill, Bharati, Maurice Lev, Robert Splinter, George P. Tatsis, Antonio Pacifico Jan R. Tuntelder Concurrent Nitroglycerin Administration Decreases MORPHOLOGIC STUDIES Thrombolytic Potential of Tissue-Type Plasminogen Activator Dissection of the Aorta Associated With Congenital Jawahar L. Mehta, Francesca A. Nicolini, Wilmer W. Malformation of the Aortic Valve Charles §. Roberts, Nichols, Tom G. P. Saldeen with the technical assistance of William C. Roberts Audra C. Wilson, Linda V. Thompson 812 Duchenne’s Cardiomyopathy in a Canine Model: 828 Follow-Up of Patients With Low Output, Low Gradient Electrocardiographic and Echocardiographic Studies Hemodynamics After Percutaneous Balloon Aortic N. Sydney Moise, Beth A. Valentine, Cynthia A. Brown, Valvuloplasty: The Mansfield Scientific Aortic Valvuloplasty Hollis N. Erb, Kathy A. Beck, Barry J. Cooper, Robert F. Registry Rick A. Nishimura, David R. Holmes, Jr., Michelle Gilmour A. Michela 821 Natural Evolution of Cardiac Function, Cardiac Pathology and Antimyosin Scan in a Murine Myocarditis Model Chiharu Kishimoto, Guo-Long Hung, Masatoshi Ishibashi, Ban An Khaw, Gerald M. Kolodny, Walter H. Abelmann, SPECIAL SECTIONS Tsunehiro Yasuda 834 ACC News President’s Page: A Key Map William L. Winters, Jr. SEMINAR ON BALLOON AORTIC VALVULOPLASTY—III William W. O’Neill, Guest Editor 838 New Members of the College MARCH 15, 1991 VOLUME 17 NUMBER 4 COOPERATIVE STUDIES 898 Editorial Comment Aortic Regurgitation: The Need for an Integrated Physiologic Approach Kenneth M. Borow and 843 Perioperative Myocardial Ischemia in Patients Undergoing Richard H. Marcus Noncardiac Surgery—I: Incidence and Severity During the 4 Day Perioperative Period Dennis T. Mangano, Milton 901 Impact of Orifice Geometry on the Shape of Jets: An In Vitro Hollenberg, Ginger Fegert, M. Lou Meyer, Martin J. London, Doppler Color Flow Study James D. Thomas, John P. Julio F. Tubau, William C. Krupski and the Study of O'Shea, Leonardo Rodriguez, Aleksandar D. Popovic, Perioperative Ischemia (SPI) Research Group Tracy Svizerro and Arthur E. Weyman 851 Perioperative Myocardial Ischemia in Patients Undergoing Noncardiac Surgery—II: Incidence and Severity During the Ist SEMINAR ON BALLOON AORTIC VALVULOPLASTY—IV Week After Surgery Dennis T. Mangano, Martin G. Wong, William W. O’ Neill, Guest Editor Martin J. London, Julio F. Tubau, Joseph A. Rapp and the Study of Perioperative Ischemia (SPI) Research Group Patient Age and Results of Balloon Aortic Valvuloplasty: The Mansfield Scientific Registry Experience Guy S. Reeder, Rick A. Nishimura, David R. Holmes, Jr. and the Mansfield CLINICAL STUDIES Scientific Aortic Valvuloplasty Registry Investigators Influence of Right Bundle Branch Block on Short- and Long- Term Survival After Acute Anterior Myocardial Infarction ELECTROPHYSIOLOGIC STUDIES Francois Ricou, Pascal Nicod, Elizabeth Gilpin, Hartmut Henning and John Ross, Jr. 914 Drug Response at Electropharmacologic Study in Patients With Ventricular Tachyarrhythmias: The Importance of Ventricular Editorial Comment Right Bundle Branch Block After Anterior Refractoriness Anne M. Gillis, D. George Wyse, Henry J. Myocardial Infarction Joel S. Karliner Duff and L. Brent Mitchell Thrombosis-Related Markers in Unstable Angina Pectoris Dimitrios Alexopoulos, John A. Ambrose, David Stump, Susan Borrico, Richard Gorlin, Pramod Deshmukh and MORPHOLOGIC STUDIES Edward A. Fisher 921 Morphologic Comparison of Patients With Mitral Valve Prolapse 872 Effect of Abrupt Mitral Regurgitation After Balloon Who Died Suddenly With Patients Who Died From Severe Valvuloplasty on Myocardial Load and Performance Valvular Dysfunction or Other Conditions Allen L. Dollar and Thomas Wisenbaugh, Martin Berk, Rafique Essop, Shirley William C. Roberts Middlemost and Pinhas Sareli METHODS PEDIATRIC CARDIOLOGY 879 Coronary Vasodilation Is Impaired in Both Hypertrophied and 932 Tricuspid Atresia or Severe Stenosis With Partial Common Nonhypertrophied Myocardium of Patients With Hypertrophic Atrioventricular Canal: Anatomic Data, Clinical Profile and Cardiomyopathy: A Study With Nitrogen-13 Ammonia and Surgical Considerations Stella Van Praagh, Venturella Vangi, Positron Emission Tomography Paolo Camici, Giampaolo Jun Hee Sul, Dominique Metras, Ira Parness, Aldo R. Chiriatti, Roberto Lorenzoni, Riccardo C. Bellina, Roberto Castaneda and Richard Van Praagh Gistri, Gessica Italiani, Oberdan Parodi, Piero A. Salvadori, Nicola Nista, Lauro Papi and Antonio L’ Abbate Tricuspid Valve Dysplasia or Displacement in Intrauterine Life Gurleen K. Sharland, Sunder K. Chita and Lindsey D. Allan Mechanisms for Left Ventricular Systolic Dysfunction in Aortic Regurgitation: Importance for Predicting the Functional 950 Aortico-Left Ventricular Tunnel: Long-Term Outcome After Response to Aortic Valve Replacement Mark R. Starling, Surgical Repair Narayanswami Sreeram, Roger Franks, Marvin M. Kirsh, Daniel G. Montgomery and Milton D. Gross Robert Arnold and Kevin Walsh REPORTS ON THERAPY DIAGNOSTIC STUDIES Long-Lasting Depression of the Factor XII-Dependent Value of Ventricular Electrogram Recordings in the Diagnosis of Fibrinolytic System in Patients With Myocardial Infarction Arrhythmias Precipitating Electrical Device Shock Therapy Undergoing Thrombolytic Therapy With Recombinant Tissue- Bruce G. Hook and Francis E. Marchlinski Type Plasminogen Activator: A Randomized Placebo-Controlled Study Steffen Munkvad, Jérgen Jespersen, Jérgen Gram and Cornelis Kluft CASE REPORTS Anti-Ischemic Effects of Atenolol Versus Nifedipine in Patients With Coronary Artery Disease and Ambulatory Silent Ischemia Smooth Muscle Cell Proliferation and Restenosis After Stand Prakash C. Deedwania, Enrique V. Carbajal, John R. Nelson Alone Coronary Excimer Laser Angioplasty Karl R. Karsch, and Howard Hait Karl K. Haase, Manfred Wehrmann, Stefan Hassenstein and Sinus Node-Atrioventricular Node Isolation: Long-Term Results Hartmut Hanke With the ‘Corridor’? Operation for Atrial Fibrillation James W. Leitch, George Klein, Raymond Yee and Editorial Comment Early Limitations of Coronary Excimer Gerard Guiraudon Laser Angioplasty Timothy A. Sanborn Editorial Comment Surgical Therapy for Atrial Fibrillation: A First Step on What May Be a Long Road John P. DiMarco SPECIAL SECTIONS EXPERIMENTAL STUDIES Books Received Acute Biologic Response to Excimer Versus Thermal Laser ACC News President’s Page: RBRVS in Review Angioplasty in Experimental Atherosclerosis Jonathan D. William L. Winters, Jr. Marmur, Timothy A. Sanborn, Hirshel Kahn, Juan Jose Badimon, Lina Badimon and Valentin Fuster Correction APRIL 1991 VOLUME 17 NUMBER 5 ACC POLICY STATEMENT Editorial Comment Valvular Heart Disease: The Technologic Dilemma William S. Frankl Standards for Analysis of Ventricular Late Potentials Using High-Resolution or Signal-Averaged Electrocardiography: A Comparison of the Effects of Streptokinase and Tissue Statement by a Task Force Committee of the European Society Plasminogen Activator on Regional Wall Motion After First of Cardiology, the American Heart Association, and the Myocardial Infarction: Analysis by the Centerline Method With American College of Cardiology Giinter Breithardt, Correction for Area at Risk David B. Cross, Noel G. Chairman, Michael E. Cain, Nabil El-Sherif, Nancy C. Ashton, Robin M. Norris, Harvey D. White Flowers, Vinzenz Hombach, Michiel Janse, Michael B. Noninvasive Detection of Reperfusion in Acute Myocardial Simson, Gerhard Steinbeck Infarction Based on Plasma Activity of Creatine Kinase MB Subforms Peter R. Puleo, M. Benjamin Perryman COOPERATIVE STUDIES Prognostic Value of Thallium-201 Myocardial Perfusion Imaging Selective Versus Routine Predischarge Coronary Arteriography in Patients With Unstable Angina Who Respond to Medical After Therapy With Recombinant Tissue-Type Plasminogen Treatment Kenneth A. Brown Activator, Heparin and Aspirin for Acute Myocardial Infarction Comparison of Epicardial Coronary Artery Tone and Reactivity William J. Rogers, Joseph D. Babb, Donald S. Baim, in Prinzmetal’s Variant Angina and Chronic Stable Angina James H. Chesebro, Joel M. Gore, Robert Roberts, David O. Pectoris Juan Carlos Kaski, Dimitris Tousoulis, Stavros Williams, Margaret Frederick, Eugene R. Passamani, Eugene Gavrielides, Eugene McFadden, Alfredo R. Galassi, Braunwald for the TIMI II Investigators Filippo Crea, Attilio Maseri Selective Prolongation of QRS Late Potentials by Sodium Editorial Comment Interaction Between Coronary Artery Tone Channel Blocking Antiarrhythmic Drugs: Relation to Slowing of and Spasm Hiroto Mashiba, Akira Hoshio, Hiroshi Kotake Ventricular Tachycardia Roger A. Freedman, Jonathan §S. Steinberg for the Electrophysiologic Study Versus Exercise Intolerance in Patients With Heart Failure and Electrocardiographic Monitoring Trial (ESVEM) Investigators Preserved Left Ventricular Systolic Function: Failure of the Frank-Starling Mechanism Dalane W. Kitzman, Michael B. Higginbotham, Frederick R. Cobb, Khalid H. Sheikh, CLINICAL STUDIES Martin J. Sullivan Comparison of Cardiac Catheterization and Doppler Editorial Comment Exercise Intolerance in Heart Failure Echocardiography in the Decision to Operate in Aortic and Michael B. Fowler Mitral Valve Disease James Slater, Aaron J. Gindea, Robin S. Freedberg, Larry A. Chinitz, Paul A. Tunick, Coronary Bypass Graft Fate: Long-Term Angiographic Study Barry P. Rosenzweig, Howard E. Winer, Andrew Goldfarb, Gerald M. FitzGibbon, Alan J. Leach, Henryk P. Kafka, John L. Perez, Ephraim Glassman, Itzhak Kronzon Wilbert J. Keon 1081 Editorial Comment Fate of Venous Grafts: The Past, the 1161 Pathologic Spectrum of Malformations of the Tricuspid Valve in Present and the Future Martial G. Bourassa Prenatal and Neonatal Life Dieter Lang, Renate Oberhoffer, Andrew Cook, Gurleen Sharland, Lindsey Allan, Nuala Fagg, Robert H. Anderson METHODS 1168 The Child With Recurrent Syncope: Autonomic Function Testing and Beta-Adrenergic Hypersensitivity James C. 1085 Quantitative Assessment of Ultrasonic Myocardial Reflectivity in Perry, Arthur Garson, Jr. Hypertrophic Cardiomyopathy Fabio Lattanzi, Paolo Spirito, Eugenio Picano, Alessandro Mazzarisi, Luigi Landini, 1172 Balloon Valvuloplasty for Critical Aortic Stenosis in the Alessandro Distante, Carlo Vecchio, Antonio L’Abbate Newborn: Influence of New Catheter Technology Robert H. Beekman, Albert P. Rocchini, Amy Andes 1091 Editorial Comment Ultrasound Characterization of Myocardial Hypertrophy Julio E. Pérez REPORTS ON THERAPY 1094 Adjacent Solid Boundaries Alter the Size of Regurgitant Jets on Doppler Color Flow Maps Edward G. Cape, Ajit P. 1177 Treatment of Complicated Prosthetic Aortic Valve Endocarditis Yoganathan, Arthur E. Weyman, Robert A. Levine With Annular Abscess Formation by Homograft Aortic Root Replacement James J. Glazier, Jo Verwilghen, Robert M. 1103 Doppler Color Flow ‘‘Proximal Isovelocity Surface Area”’ Donaldson, Donald N. Ross Method for Estimating Volume Flow Rate: Effects of Orifice Shape and Machine Factors Toshinori Utsunomiya, Toshio 1183 Immediate and Short-Term Cardiovascular Effects of Fosinopril, Ogawa, Rajen Doshi, Dharmendra Patel, Maureen Quan, a New Angiotensin-Converting Enzyme Inhibitor, in Patients Walter L. Henry, Julius M. Gardin With Essential Hypertension Shmuel Oren, Franz H. Messerli, Ehud Grossman, Guillermo E. Garavaglia, 1112 Effect of Lesion Characteristics on Outcome of Directional Edward D. Frohlich Coronary Atherectomy Tomoaki Hinohara, Michael H. Rowe, Gregory C. Robertson, Matthew R. Selmon, SEMINAR ON BALLOON AORTIC VALVULOPLASTY—V Lissa Braden, James H. Leggett, James W. Vetter, William W. O'Neill, Guest Editor John B. Simpson 1188 Follow-Up Recatheterization After Balloon Aortic Valvuloplasty 1121 Comparison of Early Versus Late Experience With Percutaneous Thomas M. Bashore, Charles J. Davidson and the Mansfield Mitral Balloon Valvuloplasty ££. Murat Tuzcu, Peter C. Scientific Aortic Valvuloplasty Registry Investigators Block, Igor F. Palacios 1125 Transcardiac Release of Leukotriene C, by Neutrophils in EXPERIMENTAL STUDIES Patients With Coronary Artery Disease Stefano De Servi, Giovanni Ricevuti, Antonino Mazzone, Davide Pasotti, 1197 Angiographic Demonstration of Hyperconstriction Induced by Ezio Bramucci, Luigi Angoli, Giuseppe Specchia Serotonin and Aggregating Platelets in Porcine Coronary Arteries With Regenerated Endothelium Hiroaki Shimokawa, Paul M. Vanhoutte ELECTROPHYSIOLOGIC STUDIES 1203 Regional Diastolic Mechanics of Ischemic and Nonischemic 1129 Recovery of Retrograde Fast Pathway Excitability in the Myocardium in the Pig Heart Toshiyuki Takahashi, Marc J. Atrioventricular Node Reentrant Circuit After Concealed Levine, William Grossman Anterograde Impulse Penetration Claudio D. Schuger, Russell T. Steinman, Michael H. Lehmann 1213 Bleeding Time Prolongation and Bleeding During Infusion of Recombinant Tissue-Type Plasminogen Activator in Dogs: Potentiation by Aspirin and Reversal With Aprotinin Harry D. MORPHOLOGIC STUDIES Garabedian, Herman K. Gold, Robert C. Leinbach, Tracy A. 1138 The Severity of Coronary Atherosclerosis at Sites of Plaque Svizzero, Dianne M. Finkelstein, J. Luis Guerrero, Rupture With Occlusive Thrombosis Jian-Hua Qiao, Désiré Collen Michael C. Fishbein 1223 Onset of Induced Atrial Flutter in the Canine Pericarditis Model Akihiko Shimizu, Akira Nozaki, Yoram Rudy, Albert L. Waldo PEDIATRIC CARDIOLOGY 1235 Editorial Comment Atrial Flutter: Progress, but No Final 1143 Hypoplastic Left Heart Syndrome: Hemodynamic and Answer Hein J. J. Wellens Angiographic Assessment After Initial Reconstructive Surgery and Relevance to Modified Fontan Procedure Anthony C. SPECIAL NOTE Chang, Paul E. Farrell, Jr., Kenneth A. Murdison, Jeanne M. Baffa, Gerald Barber, William I. Norwood, John D. Murphy 1237 Mistaken Guidelines for Thrombolytic Therapy of Acute Myocardial Infarction in the Elderly Sol Sherry, 1150 Editorial Comment Modified Fontan Procedure for Hypoplastic Victor J. Marder Response: Rolf M. Gunnar Left Heart Syndrome After Palliation With the Norwood Operation Francisco J. Puga SPECIAL SECTIONS 1152 Transesophageal Echocardiography in Evaluation and 1239 ACC News President’s Page: Access to Cardiovascular Care: Management After a Fontan Procedure Oliver Stiimper, Defining the Role of the ACC Robert L. Frye George R. Sutherland, Rene Geuskens, Jos R.T.C. Roelandt, Egbert Bos, John Hess 1242 1991-1992 Board of Governors