Journal of Labelled Compounds and Radiopharmaceuticals 1991: Vol 29 Table of Contents

15 Pages·1991·0.5 MB·English

VOLUME CONTENTS
JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS
VOLUME XXIX ISSUE NOS. 1-12
ISSUE No. 1
Synthesis of l-nitro-2-(p-hydroxyphenyl)[2-^H,] ethane . 1
B.A. Halkier, C.E. Olsen and J. Marcussen
Syntheses of '^C-Labelled Monoacidic Metabolites of Dithiopyr. 9
M.E. Mehrsheikh, L.A. Clizbe, H. Singh and W.R. Purdum
Synthesis of Deuterium Labelled Lorazepam. 15
G.J. Kdves
Synthesis of ['^C] A-62514, a Radiolabelled Derivative of Erythromycin A, via
[2-'^C]N,N-Dimethylethylenediamine . 23
B.W. Surber, W.R. Baker and L. Seif
Synthesis of [ '"C ] WIN 54954. 29
G. J. Ellames and E.K. Kunec
Isotopically Labelled Compounds for Hazardous Waste Site Cleanup Investigations:
Part I. Synthesis of [phenyl-U-'*C] labelled 2,4-dinitro-6-jec-butylphenol(dino;seb) and
[phenyl-U-'^C] labelled 4-n-propylphenol. 35
S. Goszczynski and R.L. Crawford
Regiospecific Synthesis of Polychlorinated Dibenzofiirans with Chlorine-37 Excess. 43
Yoon-Seok Chang and M.L Deinzer
Synthesis and Evaluation of [^H]-4-Fluoro-l-[ l-(3-hydroxyphenyl)cyclohexyl]piperidin-
e, a Potential Tool for Autoradiographic Study of the Phencyclidine Receptor. 63
B.R. de Costa and M.V. Mattson
Radioiododestannylation. Convenient Synthesis of a High Affinity Thromboxane
A/Prostaglandin Hj Receptor Antagonist. 75
2
D.E. Mais, P.V. Halushka, M. Naka, T.A. Morinelli, J.E. Oatis and N. Hamanaka
Preparation of a '“I Labelled [ 1,3H] Imidazole: 2-n-butyl-4(5)-'“I-iodo-5(4)-hydroxy-
methylene Imidazole. 81
P.R. Bovy and R.L. Simmons
Synthesis of High Specific Activity Tritiated Dihydropyridines: Nicardipine-^H. 87
H. Pames and G. T. Huang
The Synthesis of l,2-Dioleoyl-jn-[2-’H]Glycero-3-phosphoserine. 95
L. Binaglia, G. Alunni-Bistocchi, M. Orlando, P. Orlando, G. Rosa and R. Trenta
The Synthesis of [4-^H]Oxiracetam — a Novel Nootropic Agent . 103
A.M. Crowe, K.W.M. Lawrie, D. Saunders and U. Pfeiffer
a
VOLUME CONTENTS
JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS
VOLUME XXIX ISSUE NOS. 1-12
ISSUE No. 1
Synthesis of l-nitro-2-(p-hydroxyphenyl)[2-^H,] ethane . 1
B.A. Halkier, C.E. Olsen and J. Marcussen
Syntheses of '^C-Labelled Monoacidic Metabolites of Dithiopyr. 9
M.E. Mehrsheikh, L.A. Clizbe, H. Singh and W.R. Purdum
Synthesis of Deuterium Labelled Lorazepam. 15
G.J. Kdves
Synthesis of ['^C] A-62514, a Radiolabelled Derivative of Erythromycin A, via
[2-'^C]N,N-Dimethylethylenediamine . 23
B.W. Surber, W.R. Baker and L. Seif
Synthesis of [ '"C ] WIN 54954. 29
G. J. Ellames and E.K. Kunec
Isotopically Labelled Compounds for Hazardous Waste Site Cleanup Investigations:
Part I. Synthesis of [phenyl-U-'*C] labelled 2,4-dinitro-6-jec-butylphenol(dino;seb) and
[phenyl-U-'^C] labelled 4-n-propylphenol. 35
S. Goszczynski and R.L. Crawford
Regiospecific Synthesis of Polychlorinated Dibenzofiirans with Chlorine-37 Excess. 43
Yoon-Seok Chang and M.L Deinzer
Synthesis and Evaluation of [^H]-4-Fluoro-l-[ l-(3-hydroxyphenyl)cyclohexyl]piperidin-
e, a Potential Tool for Autoradiographic Study of the Phencyclidine Receptor. 63
B.R. de Costa and M.V. Mattson
Radioiododestannylation. Convenient Synthesis of a High Affinity Thromboxane
A/Prostaglandin Hj Receptor Antagonist. 75
2
D.E. Mais, P.V. Halushka, M. Naka, T.A. Morinelli, J.E. Oatis and N. Hamanaka
Preparation of a '“I Labelled [ 1,3H] Imidazole: 2-n-butyl-4(5)-'“I-iodo-5(4)-hydroxy-
methylene Imidazole. 81
P.R. Bovy and R.L. Simmons
Synthesis of High Specific Activity Tritiated Dihydropyridines: Nicardipine-^H. 87
H. Pames and G. T. Huang
The Synthesis of l,2-Dioleoyl-jn-[2-’H]Glycero-3-phosphoserine. 95
L. Binaglia, G. Alunni-Bistocchi, M. Orlando, P. Orlando, G. Rosa and R. Trenta
The Synthesis of [4-^H]Oxiracetam — a Novel Nootropic Agent . 103
A.M. Crowe, K.W.M. Lawrie, D. Saunders and U. Pfeiffer
a
Volume Contents
NOTES
Synthesis of'*N,'*N-Imidazoleacetic Acid. Ill
G.D. Prell
Synthesis of [Methyl-^H]-labelled Ajmalicine, Yohimbine, Tabersonine and
Catharanthine. 117
S. Auriola, T. Naaranlahti and S.P. Lapinjoki
Forthcoming Events. 123
ISSUE No. 2
Synthesis of Tritiated 1 [2-(diphenylmethoxy)ethyl]-4-[3-(3-azidophenyl)propyl]
piperazine ([^H]-meta azido GBR-12935), a Photoaffinity Ligand for the Dopamine
Reuptake Site. 125
A. Thurkauf, B. De Costa, P. Berger, S. Paul and K.C. Rice
'^C-Labelling of Hematopoietic Immunomodulator (Z-100) Consisting of Polysaccharides
Obtained from Cultivation of Mycobacterium Tuberculosis. 131
H. Sano, H. Nagae, M. Suzuki, E. Tagashira, N. Fukasaku, S. Kimishima, H. Yugi
and S. Baba
Synthesis of Aldose Reductase Inhibitor, 3,4-dihydro-4-oxo-3-[ [5-(trifluoromethyl)-2'*C
Benzothiazoly ] methyl ] -1 -phthalazineacetic Acid. 143
B. L My lari and W.J. Zembrowski
Synthesis of a Tri-tritiated Heterobifunctional Reagent, a Potential Tool in Photoaffinity
Labeling Technology . 149
Ph. Klotz, B. Chatrenet, M. Coppo, B. Rousseau, M. Goeldner and C. Hirth
Synthesis of Novel Tritium labeled Oxamyristic Acids. 157
B. Devadas, S.P. Adams and J.I. Gordon
Synthesis of High Specific Activity (3,4-[^H]Cyclohexyl)-N-[ l-(2-benzo[b]thienyl)
cyclohexyl ] piperidine {[^H]BTCP): a Selective Probe for the Dopamine-Reuptake
Complex. 165
B.R. de Costa
Platinum-Catalyzed Exchange Labelling of Representative Organic Compounds with
Tritium Gas or Tritiated Water. 175
P.G. Williams, C.A. Lukey, M.A. Long and J.L. Garnett
Synthesis of (± )-trans-6- [4,4-bis(4-Fluorophenyl)-3-( 1 -methyl-1H-
tetrazol-5-yl)-l(E),3-[2-“*C]butadienyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one .. 193
G.M. Luke and J.E. Swigor
Synthesis of Optically Pure '^C-Labelled Propionate from Alanine by Asymmetric
Hydrolysis using Porcine Kidney Acylase. 201
K. lida and M. Kajiwara
Synthesis of Carbon-14 Labeled LTD4 Antagonist MK-571. 217
D.C. Dean, D.G. Melillo and R.L. Ellsworth
Hi
Volume Contents
Synthesis of High Specific Activity Tritium-labelled Chloroethylcyclohexylnitrosourea
and its Application to the Study of DNA Modification. 223
E. L. Slew, Y. Habraken and D.B. Ludlum
Synthesis of Tritium Labelled Choline Analogs. 231
S. Rajagopal and M. Diksic
Synthesis of Two '^C-Labelled Catechol-O-methyltransferase Inhibitors. 237
C. Karlsson and E. Honkanen
NOTE
Synthesis of Tritiated Lomoparan® (Org 10172). 241
F. M. Kasper sen, I.H.G. Schlachter and G.W.K van Dedem
ISSUE No. 3
Synthesis of 5-(2,3-Ditritiopropoxy)-3-(l,2,5,6-tetrahydropyrid-4-yl)indole
([^H]CP-96,501): a Selective Ligand for the Serotonin (5-HT|b) Receptor. 249
J. E. Macor, C.A. Burkhart, L.A. Lebel, B.K. Koe, P.M. Chalabi, J.C. Windels and
R.W. Roth
A Convenient Synthesis of '^C-Cotinine from '^C-Nicotine. 259
D.H. Desai, M.V. Djordjevic and S. Amin
Deuterierte Herz-affme Technetium-Isonitril-Komplexe. 265
M. Wenzel
Synthesis of 3,5-Diisopropyl[carboxy-‘^C]Salicylic Acid and its ”Cu Complex. 273
M.V. Chidambaram, C.E. Epperson, S. Williams, R.A. Gray and J.R.J. Sorenson
Specific Tritium Labelling of Sphingosines at the 3-Position. 289
R. Birk, G. Brenner-Weifi, A. Giannis, K. Sandhoff and R.R. Schmidt
Preparation of Biologically Active Radioiodinated Thymopentin. 299
K. Venkat, J. Tischio, J. Crowther, T. Audhya and G. Goldstein
Synthesis of the Enantiomers of 3-Deuterium Labelled Lactic Acid. 305
M. Saniere, H. El Hafa, Y. Le Merrer, J. C. Depezay and F. Rocchiccioli
Synthesis of [8,9,10,ll-'^C4]Leukotriene C4. 313
M.J. Raftery and S.J. Gaskell
Synthesis of l-(3,4-Dimethylphenyl)-l-[ring-U-'^C]phenylethane, and of
1-(3,4-Dimethylphenyl)-l-phenyl [1-'*C] ethane, '^C-Labeled Distillate of Ecoscint-O™, a
Biodegradable Liquid Scintillator . 319
K. Saito and N. Kurihara
Synthesis of Deuterium Labelled Cocaine and Pseudococaine. 327
J.F. Casale, A.H. Lewin, H.T. Raney and D.A. Cooper
tv
Volume Contents
NOTE
Syntheses of '*F-Labeled Reduced Haloperidol and "C-Labeled Reduced 3-N-
Methylspiperone. 337
H.T. Raven, R.F. Dannals, A.A. Wilson, D.F. Wong and H.N. Wagner, Jr.
COMPOUND INDEX VOLUME XXVIII. 345
ANNOUNCEMENTS. 367
Forthcoming Meetings. 372
ISSUE No. 4
The Synthesis of o- and p-['*F]Fluorobenzyl Bromides and their Application to the
Preparation of Labeled Neuroleptics. 373
K. Hatano, T. Ido and R. Iwata
Synthesis of a Carbon-14 Labelled Peptidyl Carbamate Human Leukocyte Elastase
Inhibitor and its Immobilization on a Tritiated Water Soluble Polymer. 381
W.R. Banks, F. Rypacek and G.A. Digenis
Synthesis of High Specific Activity *^Br and '^^I Labeled 5-Halodeoxyurid>aes and other
*°"Br Compounds for the Study of Auger Electron Toxicity. 393
R.C. Mease, S.J. Gatley and A.M. Friedman
Preparation of Deuteriated Succinic Acids. 405
M. Toshiro, H. Tsuzuki, S. Isobe, H. Goto, S. Ogasahara, S. Mataka and
T. Yonemitsu
Synthesis of Triple ('^Cj, '*N), Single ('*C), and Double C^Cj) Labeled Trimetrexate ... 415
J.L. Hicks, J.D. Hanman, R.W. Skeean, C.C. Huang, J.A. Kepler and C-H Liang
Synthesis of Carbon-11 Labelled Calcium Channel Antagonists . 431
M. Holschback, W. Roden and W. Hamkens
Synthesis and Characterization of Optically Pure [^H](-l-)-Azidophenazocine ([^H ](-!-)-
AZPH), a Novel Photoaffmity Label for Sigma Receptors . 443
B. R. de Costa and W.D. Bowen
Stereoselective Synthesis of L-[4-'^C] Carnitine . 455
C. J. Unkefer and D.S. Ehler
Synthesis of Tritium-Labeled (+)Loxistatin (E-64d). 463
Z. Huang, E.B. McGowan and T.C. Detwiler
Synthesis of [2-“‘C]-2'-Deoxycytidine-^N-Cyanoborane. 469
B.S. Burnham, S.D. Wyrick, l.H. Hall, A. Sood and B.F. Spielvogel
Preparation of 4-Phenylbutyric [2,3-^H2]-, [4,4,-^H2]-, [2,3,4,4-^H4]-, and
[2,2,3,3,4,4-^H<i]-Acids by use of Crossed Kolbe Electrolysis as a Key Reaction. 475
M. Toshiro, H. Tsuzuki, H. Goto, S. Ogasahara and S. Mataka
V
Volume Contents
NOTE
An Efficient Synthesis of 2-[cartony/-"C] Acetamido-2-Deoxy-D-Glucopyranose
(N- [ carbonyl- 'C ] Acetyl-D-Glucosamine) . 485
Af. Tada, A. Oikawa, R. Iwata, K. Sato, H. Sugiyama, K. Kubota, K. Ishiwata,
H. Takahashi, A. Wakui, Y. Abe, T. Yamaguchi, T. Fujiwara, T. Sato and T. Ido
Book Reviews. 491
Forthcoming Meetings. 495
ISSUE No. 5
New Synthesis System of (C-ll)Propyl Ketene and its Reactions with Various Alcohols 497
R. Fujii, Y. Itnahori, T. Ido, T. Yagyu, H. Horii, K. Wakita, Y. Moriyama, S. Ueda,
Y.L Yamamoto and H. Nakahashi
Tritium Incorporation in a-Amino Acids by Isotope Exchange Using High-temperature
Solid-state Catalysis. 507
Yu. A. Zolotarev, V.S. Kosic, D.A. Zaitsev, E.M. Dorokhova and N.F. Myasoedov
Syntheses of Tritium and Carbon-14 Labelled N-(3-Dimethylaminopropyl)-N-
(Ethylaminocarbonyl)-6-(2-Propenyl)Ergoline-8/3-Carboxamide (Cabergoline), a Potent
Long-Lasting Prolactin Lowering Agent. 519
S. Mantegani, E. Brambilla, A. Ermoli, E. Fontana, P. Angiuli and G.P. Vicario
The Effect of Iodine Position on Uptake in the Mouse Using an Isomeric Series of
2-Deoxy-2-0-( ['”! ] -Iodobenzyl)Glucoses. 535
T. Lutz, H. Dougan, T. Rihela, M. Hudon, P. Cohen, W.R.E. Jamieson and
D.M. Lyster
New Technique using ['”!] Labeled Rose Bengal for the Quantification in Blood
Samples of Pipecuronium Bromide: A Muscle Relaxant Drug. 547
C. Schopfer, J.-F. Pittet, E. Tassonyi and A. Benakis
Rapid Synthesis of '^C Forskolin by a Route Suitable for "C Labeling. 557
T. Sasaki, /. Ogihara-Umeda, H. Nishigori, S. Ikegami, M. Senda, K. Kitani,
K. Ogawa and T. Nozaki
A Facile and Regiospecific Tritiation of Sphingosine: Synthesis of
(2S,3R,4E)-2-Amino-4-Octadecene-l ,3-diol-l-^H. 567
T. Toyokuni, M. Nisar, B. Dean and S. Hakomori
Radiolabelling by Tritium and ['“I]Iodine of an Angiotensin II Related Peptide. 575
P. Pham, C. Ramombordes, C. Perret, P. Ronco, M. Budisavtjevic, P. Verroust and
J.P. Beaucourt
The Synthesis of the ^H, ’H, and '^C-Isotopomers of 2'-Deoxy-2',2'-difluorocytidine
Hydrochloride, an Anti-tumor Compound. 583
W.J. Wheeler, T.E. Mabry and C.D. Jones
VI
Volume Contents
Synthesis of [ 10,10, lO-^HjJGeranyl Diphosphate. 591
S. Izumi, M. Aihara, Y. Hiraga, T. Hirata and T. Suga
Synthesis of Carbon-11 Labelled (R)-Camitine. 599
M. Holschbach, W. Hamkens, W. Roden and L.E. Feinendegen
NOTES
Preparation of 2-[a-(2-Ethoxyphenoxy)benzyl]-[5-'“C]morpholine Methanesulfonate
([“*C]Reboxetine): a New’Antidepressant Agent . 607
P. Angiulu, E. Fontana and G. P. Vicario
Synthesis and NMR-analysis of Deuterated and Tritiated Cyclooctyl Acetic Acid. 613
F.M. Kaspersen, I.H.G. Schlachter, C.W. Funke, G.N. Wagenaars and
J.-R. Mellema
Announcement. 617
Forthcoming Meetings. 618
ISSUE No. 6
Synthesis of '“‘C or ^H-Labelled Indometacin Famesil (E-0710). 619
S. Abe, I. Yamatsu, C. Yamato, S. Kobayashi and M. Mishima
The Synthesis of the Carbonyl-'^C Analog of Zatosetron Maleate, a potent. Long-acting,
Orally Effective S-HT, Receptor Antagonist. 625
D.D. O’Bannon and W.J. Wheeler
The Synthesis of (5R)- and (5S)-[5-^H]-L-Omithine. 633
R.J. Parry, S.Ju and B.J. Baker
Synthesis of Carbon-14 Labelled, Ci5-2-Amino-l,9-Dihydro-9-[4-Hydroxymethyl)-2-
Cyclopenten-l-yl]-6H-Purine-6-one; [8-“*C]Carbovir: a Promising Anti-AIDS Drug ... 645
Af.fi. Gopinathan and J.A. Kepler
A Short Synthesis and its Application to the Preparation of Radiolabelled Leukotriene
Inhibitor Sch 37224 . 651
T. Duelfer and D. Gala
Synthesis of ['^COJEllagic Acid. 657
W. Zeng, Y.-H. Hear, T.H. Kinstle and G.D. Stoner
Syntheses of Poly-deuterated 9(0)-Methano-A‘*’“*-Prostaglandin I, Methyl Esters. 667
T. Tanaka, K. Bannai, A. Hazato, K. Manabe and S. Kurozumi
Asymmetric synthesis of (2S)-and (2R)-4-(3-t-butylamino-2-hydroxypropoxy)-
benzimidazol-2-["C]-one ((S)-and (R)-["C]-CGP 12177) from optically active
precursors. 681
A. Hammadi and C. Crouzel
vii
Volume Contents
Preparation of Valeric Acids, Pentenoic Acids and 7-Valerolactones Labelled with
Deuterium. 691
M. Toshiro, H. Tsuzuki, S. Mataka and T. Yonemitsu
Synthesis of ^H-, ’H- and '^C-Labelled CP-45,634 (Sorbinil). 703
H.R. Howard, M. Evans and R. Sarges
Synthesis of Racemic, R- and S-[ l-"C]-|8-Hydroxybutyric Acid. 709
J.-O. Thorell, S. Stone-Elander, W.A. Kdnig, C. Halldin and L. Widen
Synthesis of (Z)-3-[4-(Acetyloxy)-5-ethyl-3-methoxy-l-naphthalenyl]-2-methyl-2-
propenoic-2-'"C Acid ('"C-E5090). 719
Af. Tanaka, H. Sakurai and T. Yoshimura
NOTES
Preparation of 4,4'-Diaminodiphenylmethane-(^H4) for use as Internal Standard in the
Quantification of 4,4'-Diaminodiphenylmethane . 725
Af. Natangelo, R. Bagnati, R. Fanelli, Af. Gavinelli, C. Ulbricht and E. Benfenati
Preparation of Bromine-77 Labelled Monoclonal Anti-hPLAP Antibody using
Chloramine-T . 729
F. Lambert, G. Siegers and P. Goethals
Book Review . 739
Forthcoming Events. 741
ISSUE No. 7
EDITORIAL ANNOUNCEMENT. 743
PAPERS
Preparation of ['”!]- and ['^’IJepidepride: a Dopamine D-2 Receptor Antagonist
Radioligand. 745
J.A. Clanton, T. de Paulis, D.E. Schmidt, M S. Ansari, R.G. Manning,
R.M. Baldwin and R.M. Kessler
Catalytic Reduction in the Synthesis of Tritiated (6R) and (6S)
5,10-Dideaza-5,6,7,8-tetrahydrofolate. 753
A.D. Cross, H. Morimoto, P.G. Williams and G.P. Beardsley
Radiosynthesis of [''C]-N-Methylacyclovir. 765
A.A. Wilson, P.S. Conti, R.F. Dannals, H.T. Ravert and H.N. Wagner, Jr.
Synthesis of [‘*C]-Labelled Eicosa-5,8,ll-triynoic acid and Conversion to Anti¬
inflammatory Amides. 769
W.R. Pilgrim, P. Nedoncelle, B. Shroot, J. Maignan and S. Restle
An Improved Synthesis of ['*N] Labelled Acetamide and Acetonitrile. Ill
D.R. Morgan and H.C. Dom
via
Volume Contents
Stereoselective Synthesis of Stable Isotope-Labeled L-a-Amino Acids: Biosynthesis of
'H-, "C-, and '*N-Labeled L-Serines. 781
J. Manners, R. Gibson, K. Velarde, J. Hammer, M. Alvarez, J. Griego and
C.J. Unkefer
Synthesis of the Muscle Relaxant ['*C]L-637,510 . 791
S.P. O’Connor, R.L. Ellsworth and G. Gatto
Synthesis of [©-‘'‘CH,] Sinapic Acid. 797
P. Barthes, H. Duran and L. Gorrichon
Synthesis of [20,21-'^C2]-progesterone . 805
G.M. Caballero and E.G. Gros
Syntheses de Methylpyridines Deuterides. 813
M.-F. Lautie and N. Leygue
Synthesis of Deuterium Labelled Geosmin and Methylisobomeol. 823
W. Korth, J. Ellis and K. Bowmer
Novel Selective Catalytic Reduction with Tritium: Synthesis of the GABA^ Receptor,
Radioligand l-(4-Ethynylphenyl)-4-[2,3-^H2]propyl-2,6,7-trioxabicyclo[2.2.2]octane ... 829
C.J. Palmer and J.E. Casida
Synthesis of Carbon-14 Labelled CD 271 (6-[3-(l-Adamantyl)-4-Methoxyphenyl]-
2-Naphthoic Acid): a Potential New Agent for Dermatology. 841
W.R. Pilgrim, P. Nedoncelle, J-P. Frideling and B. Shroot
NOTES
An Improved Synthesis of Labelled Fatty Acid Carboxamides. N-Phenyl [9,10(n)-^H]
oleamide and ^-[ring-G-'^Cejphenyloleamide as Standards for Spanish Toxic Oil
Syndrome Studies. 847
J. Casas and A. Messeguer
Synthesis of Tritium Labelled 5,6-Dihydro-7-(lH-imidazol-l-yl)-naphthalene-2-
carboxylic Acid (FCE 22178): a New Thromboxane Synthetase Inhibitor. 853
E. Fontana, G.P. Vicario, A. Pillan and P. Cozzi
Book Reviews. 859
Announcement. 863
Forthcoming Events. 865
ISSUE No. 8
Synthesis of [1,1 '-'^Cj ] -L-cystine. 867
K. Uchida and M. Kainosho
Determination of the Stereochemistry of Tritium Label in Sulbactam Obtained by
Isotope Exchange of Penicillanic Acid (R)-Sulphoxide Benzyl Ester. 875
C.L. Gibson, J.R. Jones, A.P. Sharratt and R.H. Uss
ix
Volume Contents
Regio- and Stereo-controlled Synthesis of [24,30-'‘'C]-labeled-2,3-epoxysqualene. 883
Xiao-yi Xiao and G.D. Prestwick
Synthesis of Tritium Labeled MK-886, a Leukotriene Biosynthesis Inhibitor;
Employment of Epibromohydrin as a Masked Electrophilic Acetone Synthon. 891
S. J. Schmidt, K.T. Games, J.R. Heys, S.W. Landvatter and J.L. Adams
Synthesis of [Cb-CHj-'^C] and [Cb-CHj-^Hj] mitomycin C. 903
H. Arai and M. Kasai
Synthesis of R-(+)- and S-(—)-8-hydroxy-2-(N,N-dipropylamino)-[2-^H]tetralin. HCl
(8-OH-DPAT) a 5HT,a Receptor Agonist . 909
M. J. Ackland, LG. Dring, J.R. Jones and N. Gilon
An Expedient Synthesis of High Specific Activity Tritium Labelled
4-Fluoro-l-[ l-(2-thienyl)]cyclohexylpiperidine ([^HJFTCP), a Ligand for Further
Characterization of the Phencyclidine/NMDA Receptor Complex. 919
N. A. Grayson, B.R. de Costa, J.T.M. Linders and K.C. Rice
Synthase du Chlorure de 2-(Dimethylaminophenyl)-3,6-dimethyl Benzo
[2-‘^C]-thiazolium ou Thioflavine T . 927
M. Vemy, C. Nicolas and A. Veyre
Syntheses of ^H- and ^H-Labeled (17/?)-17,20-Dimethyl-7-thiaprostaglandin E, Methyl
Ester. 933
T. Tanaka, K. Bannai, K. Manabe and S. Kurozumi
Preparation of the a-[D]Galvinoxyl Radical. 945
C. Tsiao, C. Wild, J. Gu and H.C. Dom
NOTES
A Concise Synthesis of [Cflrbo/iy/-"C] Melatonin and N-[Carbony/-"C] Acetylserotonin 949
M. Tada, A. Oikawa, R. Iwata, K. Sato, H. Sugiyama, H. Takahashi, A. Wakui,
H. Fukuda, K. Kubota, Y. Abe, T. Yamaguchi, T. Fujiwara, T. Sato and T. Ido
Preparation of ['^CjlDMSO. 957
R. Beerli and H.-J. Borschberg
Synthesis of Radioiodo- [ 4-(2-iodo-4-fluoro-Benzoyl)piperidin-1 -YL ] -2' -acetonaphthone . 963
J. Mertens and M. Thomas
COMPOUND INDEX VOLUME XXX. 969
IIS NEWS. 979
Announcement. 981
Forthcoming Meetings. 982
X