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ISSN 0815-9319 Journal of Gastroenterology and Hepatology Volume 18 2003 EDITORS-IN-CHIEF H ISHII RKTANDON Blackwell Publishing Journal of Gastroenterology and Hepatology editors-in-chii:e Indian I3dition CH Cho, Hong Kong V .Mahachai, Bangkok H Ishii, Tokyo RK Tandon, Xezv Delhi GJ Cleghorn, Brisbatie T .Miwa, Isehara RK Tandon, Xezv Delhi ST Fan, Hong Kong Y Nakanuma, Kanazazva FOUNDING EDITORS KM Fock, Singapore lOL Ng, Hong Kong EDITORS SK Lam, Hottg Kotig R Fujita, Yokohania .M Nishioka, Kagazva Gastroenterology and Endoscopy K Okuda, Chiba K Fujiwara, Saitaina S Okada, Tokyo RK Tandon, Xezv Delhi LW Powell, Brisbatie E Gane, Auckland iM Omata, Tokyo BCY Wong, Hottg Kotig Dje Shearman, Adelaide E Gowans, Brisbane De-Kai Qiu, Shanghai (Ct)ordinating Editor) N Hayashi, Osaka H Qureshi, Karachi A Terano, Tochigi EDITORS EMERITUS ] Ho, Hong Kong S.M Shrestha, Kathmandu ND Yeomans, Melbourne W Doe, Birtnittghatn PI Hu, Guangzhou J Sollano, Philippines GF Farrell, Sydney .M Imawari, Tochigi K Sugano, Tokyo Hepatology KL Goh, Kuala Lumpur Ji-Dong Jia, Beijing .A Terano, Tokyo CM Chu, Taipei SK l.am, Hong Kong G Kajiyama, Hiroshima TTsuji, Okayama H Ishii, Tokyo YF Liaw, Taipei S Kakuma, Aiehi Ji-Aao Wang, Shanghai SD Ixc, Taipei N Sato, Tokyo JY Kang, London ,A Watanabe, Toyama G McCaughan, Sydney S Kawano, Osaka S Watanabe, Akita (Coordinating Editor) INTER.NATIONAL .M Khan, Bangladesh SJ Williams, Sydney Dl.Yang, Wuhati ADVISORY PANEL CY Kim, Seoul J Wong, Hong Kong .M Asaka, Sapporo K Kiyosawa, Xagano S-D Xiao, Shanghai Education and Imaging H Asakura, Xiigata K Kobayashi, Kanazazva J-A’ Xu, Shanghai IC Roberts-Thomson, Adelaide T Bamba, Shiga R Kochhar, Chandigarh T A’amakawa, Kazvasaki (Coordinating Editor) DK Bhasin, Chandigarh ■M Kojiro, Kurunie A’ Aamashiro, 'Rtkyo YK Chawla, Chatidigarh CL Lai, Hong Kong .M A’ano, Xagasaki Chinese Edition DS Chen, Taipei D Lebrec, Clichy SK Lam, Hong Kong ,MF Chen, Taipei N Leung, Hong Kong B-E Wang, Beijing T Chiba, Kyoto YA’ Li, Guangzhou Editorial OfHce Administrator Production Editor R Stewart (email: roisin.stewartai blackwellpublishingasia.com) M Slawson (email: marion.slawson u blackwellpublishingasia.com) This journal is also published online at www.blackwell-synergy.com .Adopted as the official publication of the Asian Pacific Association for the Study of the Liver and the Asian Pacific Association of Gastroenterology and an affiliated publication of the Association for the Study of the Liver, Bangladesh, Gastroenterological Society of .Australia, the Hong Kong Society of Gastroenterology and the Thailand Gastroenterology .Association. 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BIOBASE Curretit Ateareness in Biological Sciences, EMBASE Exeerpta Mediea, Index Medieus .MEDLIXE, InfoMed, Inplianna WIeekly, Cover pictures: (left) Typical gross feature of type 11 herpes simplex Medical Doeuinentation Service, Reactions Weekly, Research Alert, ,Seienee esophagitis (p. 1410). (right) Alcoholic hepatitis: cardinal features of Citation Index, SeiSeareli and World Digestology Xettvork. steatosis, fibrosis, inflammation, and hepatocellular injury (p. 1336). .Manuscript Submission: For information and to submit manuscripts visit http: jgh.manuscriptcentral.com ISSN 0815-9319 (Print) ISSN 1440-174b (Online) For submission instructions, subscription and all other information visit www.blackwellpublishing.com/jgh JCH.JHB.OJ Contents Volume 18 Number 1 January 2003 Editorial 1 Parathyroid hormone-related peptide: A jack of all trades that masters gastric responses to stress LA Blackshaw See article in volume 17, issue 12, pages 1260-6 Review 4 Oval cell-mediated liver regeneration: Role of cytokines and growth factors KN Lowes, EJ Croager, JK Olynyk, LJ Abraham and GOT Yeoh Helicobacter pylori and the gut 13 Low Helicobacter pylori eradication rates with 4- and 7-day regimens in an Iranian population R Malekzadeh, S Moral. M-H Derakhshan. F Siavoshi, A Yazdanbod, J Mikaeli, R Sotoudemanesh, M Sotoudeh. M-J Farahvash. S Nasseri-Moghaddam, A Pourshams. S Dolatshahi, B Abedi, M Babaei, S Arshi and A Majidpour 18 Relationship between non-steroidal anti-inflammatory drug use and Helicobacter pylori infection in bleeding or uncomplicated peptic ulcers: A case-control study A Okan, E Tankurt, BU Aslan. H Akpinar, I Simsek and 0 Gonen 26 Evaluation of two stool antigen tests tor the detection of Helicobacter pylori infection in the Chinese population BCY Wong. HHX Xia. HKL Cheung. FH Ng. SY Wong. KC Chow, SK Lin, Y Yin, WM Wong, MF Yuen and SK Lam Genetic Mutation in Tumors 32 Impaired expression of proteasome subunits and human leukocyte antigens class I in human colon cancer cells T Miyagi, T Tatsumi, T Takehara. T Kanto. N Kuzushita, Y Sugimoto. M Jinushi, A Kasahara. Y Sasaki, M Hori and N Hayashi Gastric Function Abnormalities 41 Infrared spectrometry based '^C-octanoic acid breath test in measuring human solid gastric emptying C-P Chen. C-Y Chen. C-L Lu, F-Y Chang. S-D Lee. L-S Chu. R-S Liu and H-C Wu AT Sialyl Lewis X analog attenuates gastric microcirculatory disturbance and gastric mucosal erosion induced by thermal injury in rats H Ishikawa. M Yoshida. G Wakabayashi, M Nakamura. M Shimazu and M Kitajima Intestinal and Colonic Diseases 53 Examination of small bowel enzymes in chronic diarrhea M Simadibrala. RJA Wanders. G Jan, GNJ Tytgat. LA Lesmana. Daldiyono and I Arlawan 57 Gastrointestinal dysmotility in patients with acute pancreatitis X Wang, I Gong. K Wu. B Wang and Y Yuang Hepatitis and Hepatocellular Carcinoma 63 Relationship between human leukocyte antigen-DRBI and autoimmune hepatitis type I in Chinese patients D-K Qiu and X Ma 68 Prediction of relapse after interferon therapy in hepatitis C virus-infected patients by the use of triple assay MK El-Awady. MM Abdel Rahman. SM Ismail. KS Amr, M Omran and SA Mohamed 74 In vitro binding of hepatitis C virus to CD81-positive and -negative human cell lines M Sasaki. K Yamauchi. T Nakanishi, Y Kamogawa and N Hayashi 80 Hepatocellular carcinoma in a hepatitis B ‘x’ transgenic mouse model: A sequential pathological evaluation R Lakhtakia. 1/ Kumar. H Reddi. M MaIhur, S Dattagupta and SK Panda Dynamic Imaging of the Liver 92 Contrast media-enhanced power Doppler sonography for evaluation of hemangiomas and malignant tumors in the liver A Karabacakoglu. S Karakose, AS Cil and A Kaya 99 Preoperative assessment of hepatic function: Utility of a new convenient two-compartment model analysis using galactosyl human serum albumin scintigraphy K Kinoshila. M Ukikusa. K Iwalsako, A Arimoto, N Fujisawa, T Ozaki. H Tanaka. S Seo, M Naitoh. A Nomura. T Inomoto. T Kilai. K Ino. H Higashiyama. T Hanafusa and Y Nakajima Images of Interest 107 Gastrointestinal: Abdominal distension in irritable bowel syndrome 105 Hepatobiliary and pancreatic: Primary rabdomyosarcoma of the liver Case Report 108 A case of pseudotumorous pancreatitis that presented unique pancreatoscopic findings with the peroral electronic pancreatoscope T Kodama. M Abe. H Sato. Y Imamura, T Koshitani. K Kato. H Uehira. Y Yamane. Y Horii, M Yamagishi and H Yamagishi 112 Letters to the Editor 118 Corrigendum 119 Notices IV Contents Volume 18 Number 2 February 2003 Editorial 121 Hepatocellular carcinoma in sustained responders of interferon-treated chronic hepatitis C T Okanoue and Y Itoh See article in volume 17, issue 11, pages 1229-35 Okuda Lecture 124 Non-alcoholic steatohepatitis: What is it, and why is it important in the Asia-Pacific region? GC Farrell Smoking and Ulcerative Colitis 139 Is smoking an indirect risk factor for the development of ulcerative colitis? An age- and sex-matched case-control study N Abraham, W Selby, R Lazarus and M Solomon Gene Mutation and Gastrointestinal Tumors 147 c-kit Gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors K Kinoshita, K Isozaki, S HIrota, T Nishida, H Chen. M Nakahara, Y Nagasawa, A OhashI, Y Shinomura, Y Kitamura and Y Matsuzawa Treatment of Hepatorenal Syndrome 152 Beneficial effects of terlipressin in hepatorenal syndrome: A prospective, randomized placebo-controlled clinical trial PSolankI, A Chawla, R Garg. R Gupta. M Jain and SK Sarin Treating Gallstones in the Elderly 157 Impaired gallbladder mucosal function in aged gallstone patients suppresses gallstone recurrence after successful extracorporeal shockwave lithotripsy S Tazuma, T Nishioka, H Ochl, H Hyogo, Y Sunami, K Nakai, K Tsuboi, Y Asamoto. M Sakomoto, Y Numata. K Kanno, A Yamaguchi, T Kobuke, D Komichi, Y Nonaka and K Chayama Gastric Lymphoma 162 Long-term follow up of gastric low-grade mucosa-associated lymphoid tissue lymphoma by endosonography emphasizing the application of a miniature ultrasound probe H-Z Yeh, G-H Chen. W-D Chang, S-K Poon, S-S Yang, H-C Lien, C-S Chang and G Chou Gastric Acid Suppression and Helicobacter pylori Infection 168 Influence of lansoprazole, famotidine, roxatidine and rebamipide administration on the urea breath test tor the diagnosis of Helicobacter pylori infection K Adachi, H Fujishiro, T Mihara, Y Komazawa and Y Kinoshita Reflux Esophagitis in Japan 172 Clinical characteristics of Japanese reflux esophagitis patients as determined by Los Angeles classification M Inamori, J-l Togawa, H Nagase, Y Abe. T Umezawa. A Nakajima, T Salto. N Ueno. K Tanaka. H Sekihara. H Kaifu, H Tsuboi. H Kayama, S Tominaga and H Nagura Lafutidine and Hepatic Blood Flow 177 Lafutidine increases hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats M Yoneda. M Kurosawa, H Watanobe and A Terano Differentiating Cirrhosis from Extrahepatic Portal Venous Obstruction 185 Clinical and laboratory differentiation of cirrhosis and extrahepatic portal venous obstruction in children L Peter, SK Dadhich and SK Yachha AnW-Helicobacter pylorntealmenX in India 190 Mi-Helicobacter pylori in India: Differences in eradication efficiency associated with particular alleles of vacuolating cytotoxin (vacA) gene S Chaudhuri, A Chowdhury S Datta, AK Mukhopadhyay S Chattopadhya, DR Saha. G Dhali. A Sanira. GB Nair, S Bhattacharya and DE Berg Cisapride and Gastroesophageal Reflux 196 Meta-analysis of randomized controlled trials on the benefits and risks of using cisapride for the treatment of gastroesophageal reflux in children JR Dalby-Payne. AM Morris and JC Craig Aquaporin and Colonic Cells 203 Enhancement of aquaporin-3 by vasoactive intestinal polypeptide in a human colonic epithelial cell line A Itoh, T Tsujikawa, Y Fujiyama and T Bamba Ethanol-induced Liver Injury 211 Low-dose ethanol attenuates gut ischemia/reperfusion-induced liver injury in rats via nitric oxide production Y Horie, Y Yamagishi. S Kato, M Kajihara. H Kimura and H Ishii Therapeutic Vaccine against Hepatitis B Infection 218 Failure of therapeutic vaccination using hepatitis B surface antigen vaccine in the immunotolerant phase of children with chronic hepatitis B infection B Dikici, M Bosnak, H Ucmak. A Dagli, A Fee and K Haspolat Images of Interest 225 Gastrointestinal: Iatrogenic gastrointestinal bleeding 223 Hepatobiliary and pancreatic: An old man with jaundice and abdominal pain 226 Hepatobiliary and pancreatic: Commentary Contents V Case Report 227 Simultaneous occurrence of adenoma, focal nodular hyperplasia, and hemangioma of the liver: Are they derived from a common origin? / Di Carlo. GS Urrico, 1/ Ursino, D Russello, S Puleo and F Latter! 231 Letter to the Editor 233 Notices Volume 18 Number 3 March 2003 Editorial Comment 235 Expanding horizons for the Journal: The role of the Journal of Gastroenterology and Hepatology Foundation GC Farrell Editorial 237 Dual effect of lafutidine on the gut and liver H Kaneko See article in volume 18, issue 2, pages 177-184 Special Report 239 Asian-Pacific consensus statement on the management of chronic hepatitis B: An update Y-F Llaw, N Leung, R Guan, GKK Lau and I Merican Review 246 Hepatitis flares and hepatitis B e antigen seroconversion: Implication in anti-hepatitis B virus therapy Y-F Llaw Chronic Hepatitis 253 Clinical use of hyaluronic acid as a predictor of fibrosis change in hepatitis C K Patel. A Lajole, S Heaton. S Planko, CA Behling, D Bylund, PJ Pockros, LM Blatt, A Conrad and JG McHutchlson 258 Incidence of Sjogren’s syndrome in Japanese patients with hepatitis C virus infection Y Nagao, S Hanada, S Shlshldo, T Ide. R Kumashiro, T Ueno and M Sata Hepatocellular Carcinoma 267 Longer survival in female than male with hepatocellular carcinoma Kl Dohmen, H Shigematsu. Kl Irle and H IshIbashI 273 Assessment of cancer cell differentiation in small hepatocellular carcinoma by computed tomography and magnetic resonance imaging S Amano, M Ebara. T Yajtma. H Fukuda. M Yoshlkawa. N Sugiura. K Kato, F Kondo, T Matsumoto and H Salsho 280 Wnt signaling in hepatocellular carcinoma: Analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes J Cut, X Zhou. Y Liu, I Tang and M Romelh 288 Evaluation of the albumin-y-glutamyltransferase isoenzyme as a diagnostic marker of hepatocellular carcinoma-complicating liver cirrhosis M Pomplll, G Addolorato, G Pignataro, C Rossi, C Zuppi, M Coving A Grieco, G Gasbarrini and G Ludovico Rapaccini 296 Effects of insulin-like growth factors -IR and -HR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells J-M Yang. 14^-S Chen, Z-P Liu, Y-H Luo and W-W Liu Portal Hypertension: Imaging and Endoscopy 302 Colonic mucosa in patients with portal hypertension V Misra, SP Misra. M Dwivedi, PA Singh and VKumar 309 Role of para-esophageal collateral veins in patients with portal hypertension based on the results of endoscopic ultrasonography and liver scintigraphy analysis A Irisawa, K Obara, MS Bhutan!, A Salto, H Shlshldo, G Shibukawa, T Takagi, G Yamamoto. 0 Seino, F Shlshldo, R Kasukawa, and Y Sato GERD and Barrett’s Esophagus 315 Lower esophagus in dyspeptic Iranian patients: A prospective study S Nasseri-Moghaddam, R Malekzadeh. M Sotoudeh. M Tavangar, K Azimi, A-A Sohrabpour, P Mostadjabi, H Fathi and M Minapoor Community Gastroenterology 322 Cost of community gastroenteritis ME Hellard, Ml Sinclair, AH Harris, M Kirk and CK Eairley Inflammatory Bowel Diseases 329 Increasing incidence of Crohn’s disease in Victorian children N Phavichitr, DJS Cameron and AG Catto-Smith Biliary Tract Diseases 333 Microbiology of choledochal bile in patients with choledocholithiasis admitted to a tertiary hospital C Flores. I Maguilnik, E Hadlich and LZ Goldani 337 Cholangiocarcinoma in liver cirrhosis C-K Hui, M-F Yuen, W-K Tso, I Oi-Lin Ng. A On-On Chan and C-L Lai Images of Interest 343 Gastrointestinal: Gastric metastases 344 Hepatobiliary and pancreatic: Diabetic woman with chronic liver disease unrelated to a virus or alcohol 350 Hepatobiliary and pancreatic: Commentary VI Contents Case Report 345 Skip lymph node metastases from a small hepatocellular carcinoma with difficulty in preoperative diagnosis K Uehara. H Hasegawa. S Ogiso, E Sakamoto. S Ohira. T Igami and Toshiharu Mori 351 Letters to the Editor 356 Notices Volume 18 Number 4 April 2003 Editorial 357 Is there a common cause ot adenoma, focal nodular hyperplasia, and hemangioma ot the liver? F Kondo See article in issue 2, pages 227-30 Review 359 Can a non-invasive strategy for managing young dyspeptics be safely implemented in Asia? S Mahadeva and K-L Goh Acute Pancreatitis 363 Immune function in patients with acute pancreatitis S Uehara. K Gothoh, H Handa. H Tomita and Y Tomita Chronic Hepatitis 371 How reversible is hepatic functional impairment in autoimmune hepatitis? SA Coverdale, J Field and GC Farrell 376 Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and ALIG3 JK Leach. L Qiao. Y Fang. SLY Han. D Gilfor. PB Fisher. S Grant. PB Hylemon. D Peterson and P Dent 386 Steatosis in chronic hepatitis C: Association with increased messenger RNA expression of collagen I, tumor necrosis factor-a and cytochrome P450 2E1 PA Gochee. JR Jonsson, AD Clouston, N Pandeya. DM Purdie and EE Powell 393 Transforming growth factor beta in hepatitis C virus infection: In vivo and in vitro findings S Ray SL Broor Y Vaishnav. C Sarkar. R Girish, L Dar, P Seth and S Broor 404 Hepatitis C virus genotypes and hepatic fibrosis regulate 24-h decline of serum hepatitis C virus RNA during interferon therapy in patients with chronic hepatitis C Y Karino. J Toyota. M Sugawara. K Miyazaki. Y Kuwata. K Yamazaki, T Sato. T Ohmura and T Matsushima 411 Efficacy of interferon-a treatment in Japanese children with chronic hepatitis C E Nakashima. T Fujisawa. A Kimura. M Kage, Y Yamato. K Maeda. M Kumagai, K Ushijima, Y Yamashita and T Matsuishi Cirrhosis and Hepatocellular Carcinoma 415 Sarcomatous hepatocellular carcinoma: A special reference to ordinary hepatocellular carcinoma H Nishi. K-l Taguchi. Y Asayama. S-l Aishima. K Sugimachi. H Nawata and M Tsuneyoshi 424 Comparison of Doppler ultrasonography and the hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis YJ Choi, SK Baik. DH Park. MY Kim. HS Kim. DK Lee. SO Kwon. YJ Kim and JW Park 430 Loss of heterozygosity ot chromosome 8p and lip in the dysplastic nodule and hepatocellular carcinoma YS Kahng. YS Lee. BKKim. H/S Park. JY Lee and CS Kang 437 In vivo inefficiency of pentoxifylline and interferon-alpha on hepatic fibrosis in biliary-obstructed rats: Assessment by tissue collagen content and prolidase activity 0 Targin. K Avgar, L Demirturk, M Gultepe. BK Oklar. OC Ozdogan. 0 Targin. H Baloglu andAK Gurbuz 445 Inducibility ot microsomal liver function may differentiate cirrhotic patients with maintained compared with severely compromised liver reserve C Herold. M Ganslmayer M Ocker. S Zopl. B Gaiter EG Hahn and D Schuppan 450 Randomized controlled trial to compare the dose of adjuvant chemotherapy after curative resection of hepatocellular carcinoma PC-H Kwok. TW Lam. PW-Y Lam. KW Tang, SC-H Chan. JS-THwang. MT Cheung. DL-C Tang. TK-M Chung. NH Chia. WK Wong. MK Chan. HYLo and WM Lam Images of Interest 457 Gastrointestinal: Synchronous and metachronous colorectal cancers 458 Hepatobiliary and pancreatic: Right-upper-quadrant pain 461 Hepatobiliary and pancreatic: Commentary Case Report 459 Chronic hepatitis C associated with monoclonal gammopathy ot undetermined significance K Hamazaki, M Baba, H Hasegawa, M Kai, M Araki, N Watanabe, Y Tuneya. M Kumazawa and Y Adachi 462 Letters to the Editor 473 Notices Contents vii Volume 18 Numbers May 2003 Editorial 475 Mutations of c-kit at exons 17/13 are rare but clinically relevant in human subjects S Tsuji and N Sato See article in volume 18, issue 2, pages 147-151 Review 479 Intestinal barrier; An intertace between health and disease A Farhadi. A Banan, J Fields and Ai Keshavarzian Helicobacter pylori 498 Is apoptosis in antral mucosa correlated with serum nitrite concentration in Japanese Helicobacter pylori-\n\ec\ed patients? A Tati, K Kodama. Y Kitadai. M Ohta, K Sumii and G Kajiyama 505 Enhanced somatostatin secretion into the gastric juice with recovery ot basal acid output after Helicobacter pylori eradication in gastric ulcers T Hayakawa. H Kaneko, T Konagaya. K Shinozaki, A Kasahara, Y Funaki, S Mori, T Yokoi, Y Hirooka. K KusugamI and S Kakumu 512 Has education about Helicobacter pylori intention been eftective? Worldwide survey ot primary care physicians J Huang. S Kum Lam. P Malfertheiner and RH Hunt 521 Endoscopic hemostasis; Safe treatment tor peptic ulcer patients aged 80 years or older? Y Yamaguchi, T Yamalo. N Katsumi, K Morozumi, T Abe. H Ishida and S Takahashi Acid Peptic Disease and Complications 526 Barrett's esophagus; Macroscopic markers and the prediction of dysplasia and adenocarcinoma LC Hillman. L Chiragakis. AC Clarke. SP Kaushik and GL Kaye 534 Deregulation of E-cadherin-catenin complex in precancerous lesions ot gastric adenocarcinoma A Chan. B Wong. H Ian. S Loke. W Chan. W Hui. Y Yuen. I Ng. L Hou. W Wong. M Yuen. J Moon-Ching Luk and S Lam Intestinal Infections and Functions 540 Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time UC Ghoshal. U Ghoshal. A Ayyagari. P Banjan, N Krishnani. A Misra. R Aggarwal. S Naik and SR Naik 548 Inhibition of ileal bile acid absorption by colestimide A Takeuchi. N Sano and H Takikawa 554 Rapid absorption ot luminal polyamines in a rat small intestine ex vivo model K Uda. T Tsujikawa. Y Fujiyama and T Bamba 560 Enhanced intestinal inflammation induced by dextran sulfate sodium in tumor necrosis factor-alpha deficient mice Y Naito. T Takagi. 0 Handa. T Ishikawa. S Nakagawa. T Yamaguchi. N Yoshida. M Minami. M Kita. J Imanishi and T Yoshikawa Inflammatory Bowel Diseases 570 Altered expression of epimorphin in ulcerative colitis T Shirasaka. M lizuka. M Yukawa. Y Hirai. Y Horie. H Itou. S Kon-no. TFukushima and S Watanabe 578 Evidence for the critical role of interleukin-12 but not interferon-y in the pathogenesis of experimental colitis in mice K Tozawa. H Hanai. K Sugimoto. S Baba. H Suglmura. T Aoshi, M Uchijima. T Nagata and Y Koide Non-alcoholic Liver Diseases 588 Non-alcoholic fatty liver syndrome; A hepatic consequence ot common metabolic diseases F Angelico. M Del Ben. R Conti. S Francioso. K Feole. D Maccioni. T Maria Antonini and C Alessandri 595 Long-term results of multiple minocycline hydrochloride injections for the treatment of symptomatic solitary hepatic cyst H Yoshida. M Onda. T Tajiri, Y Arima. Y Mamada. N Taniai and K Akimaru Images of Interest 601 Gastrointestinal; Hereditary hemorrhagic telangiectasia 599 Hepatobiliary and pancreatic; Hyperplastic nodules in cirrhosis Case Report 602 Diarrhea associated with lansoprazole S Mukherjee 604 Letters to the Editor 608 Corrigendum 609 Notices Volume 18 Number 6 June 2003 In Memoriam 611 Kunlo Okuda 21 May 1921-2 February 2003 Editorial 613 Resistance to glucocorticosteroid therapy in inflammatory bowel disease THJ Florin See article in volume 17, issue 10, pages 1070-7 viii Contents Review 616 Thermal ablative therapy for malignant liver tumors: A critical appraisal KK-C Ng. C-M Lam. RT-P Poon. VAi, W-K Tso and S-T Fan Chronic Liver Diseases 630 Effects of interferon alpha therapy on the catalytic domains of the polymerase gene and basal core promoter, precore and core regions of hepatitis B virus RYM Chen. S Bowden. PV Desmond, J Dean and SA Locamini 638 Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases A Sanjo, J Satoi, A Ohnishi, J Maruno, M Fukata and N Suzuki 645 Decreased ratio of CD4/CD8 lymphocytes might be predictive tor successful interferon alpha and lamivudine combined therapy in childhood chronic hepatitis B infection: A preliminary study F Genel, F Unal, F Ozgenc, G Aksu. S Aydogdu. N Kutukculer and RV Yagci 651 Autonomic nervous dysfunction in patients with liver cirrhosis using '^^l-metaiodobenzylguanidine myocardial scintigraphy and spectrum analysis of heart-rate variability A Iga, M Nomura. Y Sawada, S Ito and Y Nakaya 660 Scirrhous changes in dysplastic nodules do not indicate high-grade status HJ An, P lllei, T Diflo, D John, G Morgan, L Teperman and N Theise Liver Cell Cancer 666 Tumor progression in hepatocellular carcinoma: Relationship with tumor stroma and parenchymal disease DSR Lockwood. TM Yeadon, AD Clouston. DG Crawford, J Fawcett. SA Callaghan and DC Gotley 673 Gross appearance of hepatocellular carcinoma reflects E-cadherin expression and risk of early recurrence after surgical treatment J Inayoshi, T Ichida. S Sugitanl, Y Tsuboi, T Genda, N Flonnma and H Asakura Acid Peptic Disease 678 Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without LLelicobacter pylori infection Y Komazawa. K Adachi, T Mihara, M Ono, A Kawamura, H Fujishiro and Y Kinoshita 683 Loss of heferozygosity on chromosome 17p predicts neoplastic progression in Barrett’s esophagus K Dolan, Al Morris, JR Gosney, JK Field and R Sutton Colorectal Malignancy 690 Differential, stage-dependent expression of Hsp70, HspllO and Bcl-2 in colorectal cancer TS Hwang. HS Han. HK Choi, YJ Lee, Y-J kirn, M-Y Han and Y-M Park 701 Flat colonic adenomas in Malaysia: Fact or fancy? S Rajendra, K Kutty and N Karim Experimental Studies 705 Alterations in the DNA binding activity of transcriptional factors activator protein-1, Spl. and hepatocyte nuclear tactor-1 in rat jejunum during starvation and refeeding T lhara, T Tsujikawa, Y Fujiyama and T Bamba 712 Novel human and mouse genes encoding a shank-interacfing profein and its upregulation in gastric fundus of IN/Yf mouse Y Daigo, I Takayama, SM Ward, KM Sanders and MA Fujino 719 Nufrifional benefifs of enferal alanyl-glufamine supplementation on rat small intestinal damage induced by cyclophosphamide J Satoh, T Tsujikawa, Y Fujiyama and T Bamba Testing for Helicobacter pylori 726 Delta ’^C-urea breath test value is a useful indicator for Helicobacter pylori eradication in patients with functional dyspepsia Y-W Chang, S-K Min. K-J Kim. Y-S Han. J-H Lee. S-H Dong. H-J Kim. B-H Kim. J-l Lee and R Chang 732 Evaluation of Helicobacter pylori stool antigen test before and after eradication therapy A Tanaka. K Watanabe, K Tokunaga. S Hoshiya, K Imase, H Sugano. M Shingaki, A Kai, T Itoh, H Ishida and S’I Takahashi Images of Interest 741 Gastrointestinal: Cap polyposis 739 Hepatobiliary and pancreatic: A boy with anorexia and an abnormal gallbladder 742 Hepatobiliary and pancreatic: Commentary Case Report 743 Primary small cell carcinoma of the stomach S Kusayanagi. K Konishi. N Miyasaka, K Sasaki. T Kurahashi, K Kaneko, Y Akita. N Yoshikawa, M Kusano. T Yamochi. M Kushima and K Mitamura 748 Letters to the Editor 752 Notices Volume 18 Number 7 July 2003 Editorial 753 TRAILing gastrointestinal pathogenesis S Tsuji See article in volume 18, issue 7, pages 763-770 Contents IX Review 756 Emerging role of calprotectin in gastroenterology A Poullis. R Foster, MA Mendall and MK Fagerhol Helicobacter pylori \n\ec\\on: Its effects and treatment 763 Flow cytometric measurement ot tumor necrosis factor-related apoptosis-inducing ligand and its receptors in gastric epithelium and infiltrating mucosal lymphocytes in Flelicobacter pylori-assodated gastritis S Koyama 771 Pulse-wave velocity and cardiovascular risk factors in subjects with Helicobacter pylori infection K Adachi, N Arima, T Takashima, Y Miyaoka, M Yuki, M Ono, Y Komazawa. A Kawamura, H Fujishiro, S Ishihara and Y Kinoshita 778 Effect ot different doses of furazolidone with amoxicillin and omeprazole on eradication ot Helicobacter pylori H Salmanroghani. S Massarral. M Shirkhoda and I Butorabi 783 Rabeprazole in a one-week eradication therapy ot Helicobacter pylori: Comparison ot different dosages F Di Mario. N Dal Bo. G Aragona, AM Moussa, V lori, GM Cavestro. A Pilotto. G Leandro, M Franceschi. M Bugge and A Frame 787 Rabeprazole treatment attenuated Helicobacter py/o/'/-associated gastric mucosal lesion formation in Mongolian gerbils H Suzuki. M Miyazawa. S Nagahashi, M Sato, M Bessho, H Nagata, S Mima and H Ishii Functional Gastrointestinal Disorders 796 Validation ot Rome II criteria for functional gastrointestinal disorders by factor analysis ot symptoms in Asian patient sample AC Kwan, TN Bao. S Chakkaphak. F Chang, MY Ke, NM Law, S Leelakusoivong, JY Luo, C Manan, HJ Park, W Piyaniran, A Qureshi, T Long. GM Xu, L Xu and H Yuen Experimental Gastroenterology 803 Alteration ot aquaporin mRNA expression after small bowel resection in the rat residual ileum and colon T Tsujikawa, A Hob, T Fukunaga, J Satoh, T Yasuoka and Y Fujiyama 809 Simple method ot preparation ot rat colonocyte apical membranes using polyethylene glycol precipitation R Prabhu and KA Balasubramanian 815 Effects ot lipopolysaccharide on the biliary excretion ot bile acids and organic anions in rats M Hojo, N Sano and H Takikawa Hepatitis A Vaccination 822 Seroepidemiology of hepatitis A virus infection among school children in Delhi and north Indian patients with chronic liver disease: Implications tor HAV vaccination SK Acharya, Y Batra, B Bhatkal, B Ojha, K Kaur S Hazari. A Saraya and SK Panda Endoscopic Ultrasound 828 Preclinical study of endoscopic ultrasonography with electronic radial scanning echoendoscope K Niwa, Y Hirooka, A Itoh, S Hashimolo, T Hirai, K Takeda and H Goto 836 Pretransplant hepatitis C virus infection and its effect on the post-transplant course ot living renal allograft recipients B Einollahi, B Hajarizadeh. S Bakhtiari, M Lesanpezeshki, MR Khatami, MH Nourbala. V Pourfarziani and SM Alavian 841 Australian women's experiences ot living with hepatitis C virus: Results from a cross-sectional survey SM Gifford, ML OBrien. G Bammer C Banwell and M Stoove Drugs and the Liver 851 Clinical usefulness of edaravone tor acute liver injury S Tada, N Nakamoto, K Kameyama, S Tsunematsu, N Kumagai, H Saifo and H Ishii 858 Ethanol administration generates oxidative stress in the pancreas and liver, but tails to induce heat-shock proteins in rats Z Rakonczay Jr I Boros. K Jarmay, P Hegyi, J Lonovics and T Takacs 868 Utilization ot hepatoprotectants within the National Health Insurance in Taiwan T Chen, L Chou and S Hwang Images of Interest 875 Gastrointestinal: Bleeding colonic diverticulum 873 Hepatobiliary and pancreatic: Arterioportal fistula causing portal hypertension Case Report 876 Expression ot gastric mucin in the stomachs ot two patients with Menetrier's Disease: An immunohistochemical study AS Mall, K Taylor, R Barnard. DM Dent and D Kahn 880 Letters to the Editor 885 Notices Volume 18 Numbers August 2003 Editorial 887 What is tropical sprue? MM Walker Review 891 Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection NC Teoh and GC Farrell X Contents Upper Gastrointestinal Bleeding 903 Simplified acute physiology score: A valid role in the assessment of patients with medically refractory upper gastrointestinal bleeding? DP Hurlstone. DS Sanders, MJ Carter B Goodman-Jones, J Batten. AG Johnson and AJ Lobo 910 Pleuropulmonary complications of esophageal variceal sclerotherapy with absolute alcohol PK Sethy, R Kochhar D Behera. DK Bhasin, K Raja and K Singh Acute Pancreatitis in Children 915 Acute pancreatitis associated with biliary disease in children BH Choi, YJ Urn. CH Yoon, EA-R Kim. YS Park and KM Kim Liver-cirrhosis-related Issues 922 Peripheral neuropathy in liver cirrhosis PS Kharbanda, S Prabhakar. YK Chawla, CP Das and P Syal 927 Recent increase in antibiotic-resistant microorganisms in patients with spontaneous bacterial peritonitis adversely affects the clinical outcome in Korea YH Park. HC Lee. HG Song. S Jung. SH Ryu. JW Shin, Y-H Chung, YS Lee and DJ Suh 934 Balloon-occluded retrograde transvenous obliteration improves liver function in patients with cirrhosis and portal hypertension Y Miyamoto, K Oho. M Kumamoto. A Toyonaga and M Sata Perinatal Transmission of Hepatitis B 943 Combined passive and active immunoprophylaxis for preventing perinatal transmission of the hepatitis B virus carrier state in Shizuoka, Japan during 1980-1994 H Noto, T Terao, S Ryou, Y Hirose, T Yoshida. H Ookubo, H Mito and H Yoshizawa lor the Special Committee for Preventing Hepatitis B in Shizuoka Gallbladder Cancer 950 Clinicopathological features and management of gallbladder cancer in Pakistan: A prospective study of 233 cases lA Malik 954 Gallbladder cancer in northern Jordan KE Bani-Hani, RJ Yaghan. II Matalka and NJ Shatnawi Ulcerative Colitis 960 Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice T Ishikura. T Kanai. K Uraushihara. R liyama. S Makita, T Totsuka. M Yamazaki, T Sawada. T Nakamura. T Miyata, T Kitahora. T Hibi, T Hoshino and M Watanabe Rectal Lymph Node Adhesion Molecules 970 Expression of adhesion molecules in the rectum-associated lymph nodules of pre- and postnatal specific pathogen-free rats S Ichikawa and A Yamashita Helicobacter py/or/-related Issues 980 Lactoterrin sequestration and its contribution to iron-deficiency anemia in Helicobacter pylori-'m\ec\ed gastric mucosa YH Choe. YJ Oh, NG Lee. I Moto, Y Adachi. N Toyoda and EC Gabazza 986 Lactobacillus gasseri 0LL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection A Ushiyama. K Tanaka. Y Aiba, T Shiba, A Takagi, T Mine and Y Koga Images of Interest 993 Gastrointestinal: Mesenteric cyst 994 Hepatobiliary and pancreatic: Inflammatory pseudotumor ot the liver Case Report 995 Case ot mucinous adenocarcinoma with porcelain gallbladder Y-E Joo, H-S Kim. S-K Choi, J-S Rew. H-J Kim, H-K Kang. S-WJuhng and S-JKim 999 Letters to the Editor 1006 Notices Volume 18 Number 9 September 2003 Editorial 1007 Irritable bowel syndrome: A global view R Eass See article in volume 17, issue 11, pages 1180-6 Review 1010 Of blood and guts: Association between Helicobacter pylori and the gastric microcirculation N Kalia and KD Bardhan Helicobacter pylori and the gut 1018 Genotypes of Helicobacter pylori in children with upper abdominal pain M Singh, KN Prasad, SK Yachha and N Krishnani 1024 Effect ot Helicobacter pylori infection and low-dose aspirin use on iron stores in the elderly A Kaffes, J Cullen, H Mitchell and PH Katelarls