Table Of Content

Contents Volume 11 Number 1 January 1996 i Editorial Comment Liver and Biliary 1 Dose-dependent effects of a nitric oxide biosynthesis inhibitor on hyperdynamic circulation in two models of portal hypertension in conscious rats C Pilette, P Kirstetter, P Sogni, S Cailmail, R Moreau and D Lebrec 7 Plasma cytokine levels and monocyte activation in patients with obstructive jaundice MCA Puntis and WG Jiang 14 A comparison of Doppler flowmetry with conventional assessment of acute changes in hepatic blood flow PR Gibson, RN Gibson, JD Donlan, PA Jones, JC Colman and FJ Dudley 21 Biliary strictures after liver transplantation: Clinical picture, correlates and outcomes RB Feller, RC Waugh, WS Selby, PM Dolan, AGR Shell and GW McCaughan 26 Characterization of an animal model of hepatic metastasis D Kuruppu, C Christophi, JF Bertram and PE O'Brien 33 Influence of clinicopathological variables on CYP protein expression in human liver J George, K Byth and GC Farrell 40 Echo-Doppler measurements of portal vein and superior mesenteric artery blood flow in humans: Inter-and intra-observer short-term reproducibility T Iwao, A Toyonaga, H Shigemori, K Oho, M Sumino, M Sato and K Tanikawa Alimentary Tract and Pancreas 47 Changes in the localization of colorectal cancer: Implications for clinical practice? RJLF Loffeld, ABMM Putten and A Balk 51 Treatment of gastric fundal varices by balloon-occluded retrograde transvenous obliteration H Kanagawa, S Mima, H Kouyama, K Gotoh, T Uchida and K Okuda 59 Prevalence of gastric ulcer in cirrhotic patients and its relationship to portal hypertension L-S Chen, H-C Lin, S-J Hwang, F-Y Lee, M-C Hou and S-D Lee 65 The effect of minimum luminal nutrition on bacterial translocation and atrophy of the jejunum during parenteral nutrition RD McCauley, KA Heel, KJ Christiansen and JC Hall 71 Patterns of methane production in a Burmese (Myanmar) population TD Bolin, JR Genge, VM Duncombe, Soe-Aung and Myo-Khin 77 Clinicopathological study of colorectal mucinous carcinoma in Taiwan: A multivariate analysis C-S Wu, S-Y Tung, P-C Chen and Y-C Kuo 82 Some factors associated with mortality in perforated peptic ulcer: A case-control study JH McIntosh, K Berman, FM Holliday, K Byth, R Chapman and DW Piper 88 Sulindac and indomethacin inhibit formation of aberrant crypt foci in the colons of dimethyl hydrazine treated rats D Charalambous, C Farmer and PE O'Brien Editorial 93 Risk factors, Helicobacter pylori and a role for laparoscopic treatment of perforated peptic ulcer? FJ Branicki Case Reports 97 Pancreatic calculi superimposed upon slow growing pancreatic cancer A Noda, K Takeuchi, E Ibuki, H Murayama, T Kobayashi and T Nonogaki 102 Notices Volume 11 Number 2 February 1996 Alimentary Tract and Pancreas 103 Bowel preparation for colonoscopy: A randomized prospective trial comparing sodium phosphate and polyethylene glycol in a predominantly elderly population A Thomson, P Naidoo and B Crotty 108 Gastric metaplasia of regenerating duodenal mucosa and deformity of duodenal bulb: A correlative study S Pan, G-S Lien, C-H Liao and S-H Chen 113 A comparative study of the influence of differing barley brans on DMH-induced intestinal tumours in male Sprague-Dawley rats GH McIntosh, RK le Leu, PJ Royle and GP Young 120 Duodenal mucosal histology and histochemistry in active, treated and healed duodenal ulcer: Correlation with duodenal prostaglandin E^ production S Pugh, AP Jayaraj and KD Bardhan 125 Vagal hyperactivity in stress induced gastric ulceration in rats CH Cho, BS Qiu and 1C Bruce 129 Effects of transforming growth factors on the wound repair of cultured rabbit gastric mucosal cells 0 Kobayashi, S Watanabe, M Hirose and N Sato Liver and Biliary 137 Herbal medicine ‘Sho-saiko-to’ induces tumour necrosis factor-a and granulocyte colony-stimulating factor in vitro in peripheral blood mononuclear cells of patients with hepatocellular carcinoma M Yamashiki, A Nishimura, M Nomoto, H Suzuki and Y Kosaka Contents 143 Severe clinical rebound upon \withdrawal of corticosteroid before interferon therapy; Incidence and risk factors IS Sheen, Y-F Liaw, S-M Lin and C-M Chu 148 Endoscopic management of postoperative bile leak VA Saraswat, G Choudhuri, BC Sharma, DK Agarwal, R Gupta, SS Baijal, SS Sikora, R Saxena and VK Kapoor 152 Role Of endotoxaemia in hyperdynamic circulation in rats with extrahepatic or intrahepatic portal hypertension F-Y Lee, SS Wang, MC-M Yang, Y-T Tsai, S-L Wu, R-H Lu, C-Y Chan and S-D Lee 159 Long-term administration of natural interferon-a in patients with chronic hepatitis C: Relationship to serum RNA concentration, HCV-RNA genotypes, histological changes and hepatitis C virus T Kumada, S Nakano, I Takeda, K Sugiyama, T Osada, S Kiriyama, H Toyoda, T Sasa, M Shibata, T Morishima, I Nakano, Y Fukuda, Y Kosaka, Y Tameda and M Nakashima 166 Relationship between hepatocellular carcinoma and subtypes of hepatitis C virus: A nationwide analysis A Takada, M Tsutsumi, S-C Zhang, T Okanoue, T Matsushima, S Fujiyama and M Komatsu 170 Endemicity and clinical picture of liver disease due to obstruction of the hepatic portion of the inferior vena cava in Nepal SM Shrestha, K Okuda, T Uchida, KG Maharjan, S Shrestha, BL Joshi, S Larsson and Y Vaidya Editorial 180 Acute pancreatitis associated with hypercalcaemia in adult T-cell leukaemia-lymphoma M Senba and Ml Senba Review Article 183 Does Crohn’s disease need differentiation from tuberculosis? VJayanthi, RJ Robinson, S Malathi, B Rani, R Balambal, S Chari, K Taghuram, N Madanagopalan and JF Mayberry 187 Chronic liver disease; Do alcohol and hepatitis C virus interact? WGE Cooksley Case Reports 193 Acute pancreatitis induced by hypercalcaemia associated with adult T-cell leukaemia: A case report Y Ono, T Kimura, I Nakano, M Furukawa, T Ito, S Sakamoto, K Konomi and H Nawata 196 Hepatic angiomyelolipoma and tuberous sclerosis W Yeo, ASY Leong, SC Ward, PK Hui and PJ Johnson 199 Book Review 200 Notices Volume 11 Numbers March 1996 Liver and Biliary 201 Distribution of the different subtypes of hepatitis C virus in Japan and the effects of interferon: A nationwide survey A Takada, M Tsutsumi, T Okanoue, T Matsushima, M Komatsu and S Fujiyama 208 Sequential changes in serum levels of individual bile acids in patients with chronic cholestatic liver disease SA Azer, SA Coverdale, K Byth, GC Farrell and NH Stacey 216 Vasopressin plus oxygen vs vasopressin alone in cirrhotic patients with portal-hypertensive gastropathy: Effects on gastric mucosal haemodynamics and oxygenation T Iwao, A Toyonaga, H Shigemori, K Oho, M Sumino, M Sato and K Tanikawa 223 Monoclonai antibodies to rabbit hepatocyte myosin that cross-react with human liver myosin T Ueno, S Watanabe, M Hirose, R Nozawa, S Yasuura, H Egawa, N Sato and El Kominami 230 Role of pentobarbitone anaesthesia and sympathetic tone in the haemodynamic effects of isosorbide dinitrate in rats with cirrhosis P Kirstetter, C Pilette, R Moreau, S Cailmail, V Safka, T Soupison and D Lebrec 236 Hepatic HCV-RNA as a predictor of outcome after interferon therapy in patients with chronic hepatitis C M Kondo, K Tanaka, M Ikeda, S Arata, S Saito, T Sakaguchi, M Morimoto, T Fujii, K Mitsui, H Okazaki, M Hoshino and H Sekihara 241 Analysis of HLA alleles in Japanese patients with cirrhosis due to chronic hepatitis C Y Higashi, N Kamikawaji, H Suko and M Ando Alimentary Tract and Pancreas 247 Sonographically-guided extracorporeal shockwave lithotripsy for pancreatic stones in patients with chronic pancreatitis F Schreiber, GCH Gurakuqi, H Pristautz, M Trauner and W SchnedI 252 Estimation of usefulness of /V-butyl-2-cyanoacrylate-lipiodol mixture in transcatheter arterial embolization for urgent control of life- threatening massive bleeding from gastric or duodenal ulcer H Toyoda, S Nakano, T Kumada, I Takeda, K Sugiyama, T Osada and S Kiriyama 259 Adaptation of the gastric epithelium to injury is maintained in vitro and is associated with increased TGFa expression K Doljanin, MV Skeijo, NO Yeomans and AS Giraud 264 Correlation between transmucosal potential difference and morphological damage during aspirin injury of gastric mucosa in rats GA Cook, SL Elliott, MV Skeijo, AS Giraud and NO Yeomans 270 Clinical and histological features of gastric antral vascular ectasia: Successful treatment with endoscopic laser therapy lOL Ng, KCLaiandMNg Contents V 275 Mental retardation and colorectal disease; Colonoscopic mass screening to determine whether the risk of adenomatous polyposis syndrome is increased in the mentally retarded Y Uno 279 Role of endothelin-1 in repeated electrical stimulation-induced microcirculatory disturbance and mucosal damage in rat stomach D Fukumura, I Kurose, S Miura, H Serizawa, E Sekizuka, H Nagata, H Ishii and M Tsuchiya 286 Polymerase chain reaction diagnosis of Helicobacter pylori in gastroduodenal diseases: Comparison with culture and histopathological examinations S-Y Lin, Y-S Jeng, C-K Wang, F-TKo, K-Y Lin, C-S Wang, J-D Liu, P-H Chen and J-G Chang 290 Metronidazole resistance: A predictor of failure of Helicobacter pylori eradication by triple therapy PD Midolo, JR Lambert and J Turnidge Review Article 293 The transjugular intrahepatic portosystemic stent-shunt: A review of the literature and our own experiences M Rossle, K Haag and HE Blum Case Reports 299 Pedunculated extraluminal leiomyoma of the sigmoid colon SS David and JJ Samuel 301 Portal-systemic shunting in a patient with normal portal vein pressures and histological evidence of idiopathic portal hypertension T Sugimura, Y Tsuji, H Ibayashi, H Sakai and H Nawata 305 Control of colonic variceal haemorrhage with a somatostatin analogue BJ Chakravarty and JW Riley Volume 11 Number 4 April 1996 Alimentary Tract and Pancreas 307 Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis D Charalambous and PE O’Brien 311 Measurement of faecal a,-antitrypsin: Methodologies and clinical application SR Choudhary, PR Gibson, MC Deacon and GP Young 319 DNA flow-cytometric analysis in colorectal cancer: A comparison of metastasizing and non-metastasizing tumours J-L Yang, PJ Crowe, KT Ow, JM Ham, RL Crouch and PJ Russell 325 Regeneration of nerve fibres across a colonic anastomosis in the guinea-pig SJH Brookes, TCF Lam, DZ Lubowski, M Costa and DW King 335 Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats / Tsukimi, C Nozue and S Okabe Liver and Biliary 341 Cold activation of complement in sera from patients with persistent hepatitis C virus infection on interferon therapy TAikawa, I Kimura, M Kojima, C Ueno, K Miyamoto, T Tango and N Tanaka 347 Increased urinary endothelin excretion in patients with liver cirrhosis M Kitano, J Uemasu and H Kawasaki 353 Response to interferon in chronic hepatitis C due to mixed genotype infection N Horiike, T Masumoto, K Michitaka, K Kurose, SMFAkbar and M Onji 358 Microheterogeneity of serum transferrin in the diagnosis of hepatocellular carcinoma Y Suzuki, Y Aoyagi, S Mori, T Suda, A Naitoh, 0 Isokawa, M Yanagi, H Igarashi and HAsakura 366 Improvement of peripheral blood lymphocyte subsets in primary biliary cirrhosis after ursodeoxycholic acid therapy T Ikeda, C Sato, 0 Noguchi, FKobayashi, S Tozuka, S Sakamoto and FMarumo 373 UDP glucuronosyltransferase in the cirrhotic rat liver HS Debinski, PI MacKenzie, CS Lee, ML Mashford, JA Danks, TR Tephly, M Green and PV Desmond 380 Gastric mucosal energy metabolism and intracellular mucin content changes in patients with liver cirrhosis S Kawano, H Tanimura, S Tsuji, Y Takei, K Nagano, T Kashiwagi, H Fusamoto and T Kamada 385 Increase of sulfated ursodeoxycholic acid in the serum and urine of patients with chronic liver disease after ursodeoxycholic acid therapy K Nakamura, M Yoneda, A Kimura, K Tamori, S Yokohama, Y Sato, T Kato, T Hasegawa, H Saito, MAoshima, M Fujita and I Makino 391 Effect of verapamil on renal haemodynamics in a portal hypertensive rat model C-S Lay, MC-M Yang, S-L Wu, Y-T Tsai, K-L Wu and S Chien Review Article 396 Current concepts of hepatic uptake, intracellular transport and biliary secretion of bile acids: Physiological basis and pathophysiological changes in cholestatic liver dysfunction SA Azer and NH Stacey Case Reports 408 Classical Kaposi’s: A rare cause of gastrointestinal haemorrhage SM Chapman, SJ Bell, S Chen and W Cosolo 411 Idiopathic adulthood ductopaenia / Nakano, Y Fukuda, Y Koyama, F Urano, M Yamada, Y Katano, A Marui, K Imada, T Hayakawa, M Ito, Y Yamashita, M Imoto and Y Nakanuma 416 Notices VI Contents Volume 11 Numbers May 1996 Clinical Hepatology Complications ot cirrhosis 417 Metabolic bone disease of liver cirrhosis: Is it parallel to the clinical severity of cirrhosis? C-C Chen, S-S Wang, F-S Jeng and S-D Lee 422 Hyperglucagonaemia in cirrhotic patients and its relationship to the severity of cirrhosis and haemodynamic values H-C Lin, MC-M Yang, M-C Hou, F-Y Lee, Y-T Huang, L-F Lin, S-M Li, S-J Hwang, S-S Wang, Y-T Tsai and S-D Lee Cholestatic disorders 429 Primary sclerosing cholangitis: An experience from India R Kochhar, MK Goenka, K Das, B Nagi, DK Bhasin, YK Chawla, K Vaiphei, K Singh and JB Dilawari 434 Case report: Paucity of interlobular bile ducts in Chinese children H-H Chiu, M-H Chang, C-L Chen, H-Y Hsu and Y-H Ni 439 Case report: A patient with primary biliary cirrhosis and autoimmune haemolytic anaemia EM Yoshida, SH Nantel, DA Owen, PF Galbraith, Bl Dalai, HS Ballon, SYL Kwan, JP Wade and SR Erb Experimental Hepatology Focus on fibrosis 443 Serum markers for fibrosis and plasma transforming growth factor-8, in patients with hepatocellular carcinoma in comparison with patients with liver cirrhosis Y Murawaki, Y Ikuta, Y Nishimura, M Koda and H Kawasaki 451 Differential effects between tauroursodeoxycholic and taurochenodeoxycholic acids in hepatic fibrosis: An assessment by primary cultured Ito and Kupffer cells from the rat liver K Sugata, S Kamimura and H Shijo 459 Clinical significance of serum hyaluronan in patients with chronic viral liver disease Y Murawaki, Y Ikuta, M Koda, Y Nishimura and H Kawasaki Advances in liver regeneration 466 Review: Regulation of liver regeneration by pro-inflammatory cytokines AM Diehl and R Rai 471 Treatment with a novel lipid A analogue, FS-112, and partial hepatectomy causes submassive liver necrosis and impaired liver regeneration in mice T Maeda, H Ohnishi, T Hayashi, Y Ishiki, H Morikawi and Y Muto Pathophysiology of Oesophageal Disorders 478 Distribution of peptide-containing nerve fibres in achalasia of the oesophagus DA Wattchow and M Costa 486 Detection of duodenal fluid in the oesophagus with a sodium ion selective electrode Dl Watson, A Smythe, YF Mangnall and AG Johnson Pancreatic Disorders 491 Risk factors for pancreatic cancer in Orientals C-T Lee, F-Y Chang and S-D Lee 496 Serum procarboxypeptidase B, amylase and lipase in chronic renal failure C-C Chen, S-S Wang, T-W Chen, T-S Jap, S-J Chen, F-S Jeng and S-D Lee Luminal Devices 500 The Cathlocator: A novel non-radiological method for the localization of enteral tubes AJK Williams, R Fraser, DP Chorley and J Dent 506 An assembled electrogastrographic device to examine the meal effect on gastric slow wave F-Y Chang, C-T Lee, S-D Lee, H-C Jang, D-S Tsai and S-E Fu Third Dceanic Symposium on Paediatric Liver Transplantation SI Paediatric liver transplantation: A10 year experience in Taiwan C-L Chen, Y-S Chen, Y-C Chiang, Y-F Cheng, T-L Huang, and H-L Eng S4 Chronic liver disease in children on long-term parenteral nutrition S Misra, ME Ament, JH Vargas, C Skoff, L Reyen and F Herzog S7 Pre- and postoperative nutritional care in liver transplantation in children RW Shepherd Volume 11 Number 6 June 1996 Disorders of the Stomach and Duodenum 511 Relationship between age and clinical characteristics of patients with gastric cancer S-S Lo, C-W Wu, M-C Hsieh, H-S Kuo, W-Y Lui and F-K P'eng 515 Chronic upper abdominal pain due to duodenal ulcer and other structural and functional causes: Its localization and nocturnal occurrence JY Kang, KY Ho, KG Yeoh and R Guan 520 Do non-steroidal anti-inflammatory drugs cause duodenal ulcer? Evaluation of basal acid output and ulcer complications MJ Collen, JD Abdulian and YK Chen Enteric Infections and Infestations 524 A distinctive aphthous ileitis tentatively linked to Ancylostoma caninum J Croese, S Fairley, A Loukas, J Hack and P Stronach 532 Case report Gastrointestinal tuberculosis simulating Crohn’s disease SP Kaushik, ML Bassett, BPC Lin and EL Bokey Contents vii Clinical Hepatology Liver tumours 535 Detection of hepatocellular carcinoma after interferon therapy for chronic hepatitis C: Clinical study of 26 cases N Sugiura, Y Sakai, M Ebara, H Fukuda, M Yoshikawa, H Saisho, M Ohio and F Kondo 540 Hepatocyte volume as an indicator of hepatic functional reserve in cirrhotic patients with liver tumours Y Matsui, W Tu, H Kitade, A Nakagawa, T Kamiya, A-H Kwon, S Uetsuji and Y Kamiyama 546 Case report; Multiple cancers: Hepatocellular carcinoma and adenocarcinomas of the common bile duct and the gall-bladder in a woman with primary biliary cirrhosis J Imada, H Hoshino, D Nishimura, K Morita, N Yoshida, N Katada, H Sana, K Kato and N Mori 551 Case report; Fibrolamellar hepatocellular carcinoma in a Japanese woman; A case report and review of Japanese cases hi Hoshino, N Katada, D Nishimura, J imada, K Morita, N Yoshida, H Sano, K Okamoto and K Kato 556 Case REPORt Hepatic adenoma with bone marrow metaplasia in a patient with glycogen storage disease type la S Moriura, M Kuroda, A Kimura, Y iwatsuka, S ikeda, T Sakai and A Usui Hepatitis B 560 Prognostic factor analysis for fulminant and subfulminant hepatic failure in an area endemic for hepatitis B T-i Huo, J-C Wu. W-Y Sheng, C-Y Chan, S-J Hwang, T-Z Chen and S-D Lee 566 Point mutation in a precore region of hepatitis B virus: Sequential changes from ‘wild' to ‘mutant’ T Ehata, 0 Yokosuka, F imazeki and M Omata Experimental Hepatology Bile secretion 575 Review: New insights into the mechanisms of hepatic transport and bile secretion S Eriinger 580 Pravastatin transport across the hepatocyte canalicular membrane requires both ATP and a transmembrane pH gradient / Adachi, Y Okuyama, H Miya, H Matsusita, M Kitano, T Kamisado and T Yamamoto Hepatic blood flow 586 Longitudinal study of intrahepatic portal flow: A novel approach using Doppler technique Z-Y Lin, W-Y Chang, L-Y Wang, J-H Wang, S-C Chen, W-L Chuang, M-Y Hsieh and J-F Tsai 594 Halothane-induced liver injury in guinea-pigs: Importance of cytochrome P450 enzyme activity and hepatic blood flow GC Farrell, L Frost, M Tapner, J Field, M Weltman and J Mahoney 602 Notices Volume 11 Number? July 1996 Clinical Hepatology Primary biliary cirrhosis 605 Review: Treatment of primary cirrhosis J Heathcote 610 Autoantibodies to M2 mitochondrial autoantigens in normal human sera by immunofluorescence and novel assays K Omagari, MJ Rowley, S Whittingham, JA Jois, SL Byron and IR Mackay Encephalopathy 617 Case report: Liver function abnormalities in a severe case of hyperreactio luteinalis H Senturk, S Erding, M Tasyurekli, A Mert, MArvas and C Sen 621 Case report: Recurrent hyperammonaemic encephalopathy due to citrullinaemia in a 52 year old man WC Chow, HS Ng, IK Tan and TY Thum 626 Case report: Portal-systemic encephalopathy due to a congenital extrahepatic portosystemic shunt M Kiriyama, S Takashima, H Sahara, Y Kurosaka, M Matsushita, T Akiyama, F Tomita, H Saito, T Kosaka, I Kita, Y Kojima and S Takegawa Portal haemodynamics 630 Complications of percutaneous transhepatic catheterization of the portal venous system in patients with portal hypertension M Ohta, M Hashizume, H Kawanaka, K Akazawa, K Ueno, M Tomikawa, FKishihara, K Tanoue and K Sugimachi 635 Plasma interleukin-8 levels in patients with post-hepatitic cirrhosis; Relationship to severity of liver disease, portal hypertension and hyperdynamic circulation C-P Li, F-Y Lee, Y-T Tsai, H-C Lin, R-H Lu, M-C Hou, T-F Wang, L-S Chen, S-S Wang and S-D Lee Hepatitis C 641 Phylogenetic tree-based epidemiological analysis of hepatitis C virus transmission in a region of Japan with a high prevalence of infection T Hara, Y Setoguchi, S Kajihara, K Yamamoto, T Sakai, T Inoue, K Ohba and M Mizokami 646 Serum hyaluronic acid reflects the effect of interferon treatment on hepatic fibrosis in patients with chronic hepatitis C M Yamada, Y Fukuda, Y Koyama, I Nakano, F Urano, Y Katano and T Hayakawa viii Contents Experimental Hepatology Liver injury 652 Premedication with cyclosporine and perindopril modifies the ischaemia-reperfusion injury during liver resection in rats KJ Hardy, S Tancheroen and A Shulkes 658 Potentiation of carbon tetrachloride-induced liver damage by dibutylyl-3',5'-cyclic AMP in unstarved rats K Irita, H Okabe, M Yamakawa, J-l Yoshitake and S Takahashi Helicobacter pylori 662 Review: Diagnosis of Helicobacter pylori infection T Azuma, T Kato, M Hirai, S Ito and Y Kohli 670 Long-term follow-up of gastric histology after Helicobacter pylori eradicaWon GM Forbes, JR Warren, ME Glaser, DJE Cullen, BJ Marshall and BJ Collins 674 High acid secretion may protect the gastric mucosa from injury caused by ammonia produced by Helicobacter pylori in duodenal ulcer patients T Shibata, I Imoto, Y Taguchi, S Takaji, N Ikemura, K Nakao, M Koshiyama and T Shima Colonic mucosa 681 Microvascular disturbances in the colonic mucosa in antibiotic-associated haemorrhagic colitis: Involvement of platelet aggregation / Yonei, Y Yoshizaki, N Tsukada, Y Inagaki, K Miyamoto, 0 Suzuki, Y Kiryu, T Hibi, M Oda and H Ishii 686 Epithelial cell proliferation during colonic chemical carcinogenesis in the rat H Okada, M Mizuno, N Ikeda, J Tomoda and T Tsuji 692 Case report; Hippocratic digital and Crohn’s disease K Makiyama, K Ishida, WZea-lriarte, M Itsuno, M Yamakawa and N Mori Volume 11 Numbers August 1996 Hepatitis C 697 Lymphocyte proliferative responses ro recombinant hepatitis C virus antigens in patients with chronic hepatitis C H Mori, K Yabu, K Yoshizawa, E Tanaka and K Kiyosawa 705 Real-time monitoring of HCV-RNA by single tube assay kit and potential importance for predicting virological sustained response in patients with chronic hepatitis C Y Shiratori, N Kato, S Tamatsukuri, H Yoshida, T Kawabe, R Nakata, K Okano and M Omata 712 Relationship between the intrahepatic expression of interferon-a/p receptor mRNA and the histological progress of hepatitis C virus-associated chronic liver diseases N Ishimura, R Fukuda and S Fukumoto 718 Efficacy and side effects of intermittent recombinant interferon-a2a in chronic aggressive hepatitis C: With or without initial daily administration H Itoh, H Nakata, Y Yokoya, S Nakashima, T Yamanishi, T Hara, J Kawai, H Miyamoto, K Higashi and S Nishioka 724 Case report: Primary splenic non-Hodgkin’s B cell lymphoma in a patient with chronic hepatitis C. T Fukutomi, M Fukushima, Y Tanabe, K Hiroshige, H Itasaka, T Matsumata, N Kasai, K Yoshida, J Suzumiya, M Kikuchi, Y Yufu, H Sakai, J Nishimura and H Nawata Complications of Cirrhosis 728 Frequency and factors influencing portal hypertensive gastropathy and duodenopathy in cirrhotic portal hypertension R Gupta, VA Saraswat, M Kumar, SR Naik and R Pandey 734 Case report: Delayed resolution of severe pulmonary hypertension after isolated liver transplantation in a patient with cirrhosis MT Levy, P Torzillo, M Bookallil, AGR Sheil and GW McCaughan Lipoproteins 738 Comparison of haptoglobin and apolipoprotein A-l on biliary lipid particles involved in cholesterol crystallization G Yamashita, R Secknus, A Chernosky KA Krivacic and RT Holzbach 746 Reduction of intestinal apo A-IV mRNA levels in the cirrhotic rat M Seishima, T Usui, S Naganawa, M Nishimura, H Moriwaki, Y Muto and A Noma Tumours of Liver and Pancreas 752 Proliferative activity in intrahepatic metastasis of hepatocellular carcinoma T Maeda, E Adachi, K Kajiyama, K Takenaka, K Sugimachi and M Tsuneyoshi 758 A clinicopathological study on combined hepatocellular and cholangiocarcinoma J Taguchi, 0 Nakashima, M Tanaka, T Hisaka, T Takazawa and M Kojiro 765 Case report: Gastrointestinal bleeding from a hepatocellular carcinoma invading the transverse colon M Hashimoto, G Watanabe, M Matsuda, T Yamamoto, K Tsutsumi and M Tsurumaru 768 Case report: Mucin-producing cystic neoplasm of the pancreas with onset in childhood S Koyanagi, T Miyahara, Y Migita, M Goto, T Ito, H Yamaguchi, I Nakano, S Takano, Y Hara, T Fukuyama, K Konomi, J Haratake and H Nawata 771 Case report: Intrahepatic cholangiocarcinoma with rhabdoid transformation M Honda, M Enjoji, H Sakai, I Yamamoto, M Tsuneyoshi and H Nawata Oesophageal Disorders 775 Abnormal gastro-oesophageal reflux in Chinese with atypical chest pain GKK Lau, WM Hui, CP Lau, WHC Hu, KC Lai and SK Lam Contents IX Endoscopic Procedures and Complications 780 Effects of endoscopic variceal sclerotherapy on azygos vein blood flow and systemic haemodynamics M Yokoyama, H Shijo, K Ota, K Kubara, H Kokawa, T Kim, N Akiyoshi, H Tokomitsu and M Okumura 786 Case report; Lymphangioma of the oesophagus endoscopically resected T Suwa, S Ozawa, N Ando, H Shinozaki, K Tsujitsuka, H Miki, H Makuuchi and M Kitajima 789 Case report; Pneumomediastinum and pneumothorax complicating colonoscopy WCE Tam, I Pollard and RD Johnson 793 Notices Volume 11 Number 9 September 1996 Physiology 797 Lubrication of visceral moverment and gastric motility by peritoneal surfactant BA Hills 804 Cyclic AMP-dependent anion secretion in human small and large intestine IM Brzuszczak, J Zhao, C Bell, D Stiel, I Fielding, J Percy, R Smith and EV O’Loughlin 811 Reversal of altered intestinal mucosal immunity in rats fed elemental diet by supplementation of oleic acid H Serizawa, S Miura, H Imaeda, S Tanaka, H Kimura, Y Tsuzuki H Jing-Yang, K Toda, Y Hamada, M Tshuchiya and H Ishii Helicobacter pylori 819 Cytotoxin and urease activities of Helicobacter pylori isolates from Japanese patients with atrophic gastritis or duodenal ulcer H Murakita, M Hirai, S Ito, T Azuma, T Kato, Y Kohli and M Kuriyama 825 Risk factors of peptic ulcer disease; Different impact of Helicobacter pylori in Dutch and Japanese populations? RJ Schlemper, SDJ Van der Wert, JP Vandenbroucke, I Biemond and CBHW Lamers Therapeutic endoscopy 832 Endoscopic laser therapy for watermelon stomach MJ Bourke, RL Hope, P Boyd, PE Gillespie, M Ward, AE Cowen and SJ Wiiliams 835 Complications and outcome of percutaneous endoscopic gastrostomy in different patient groups MA Chowdhury and R Batey Biliary masses 840 Differential diagnosis of gall-bladder masses using colour Doppler ultrasonography Y Hirooka, Y Naitoh, H Goto, T Furukawa, A Ito and T Hayakawa 847 Case report. Giant choledochal cyst AJA Holland and PA Childs Pathogenesis of ascites 850 Reduced liver function is the trigger for renal sodium retention following portal vein ligation in the rat S Murakami, T Ohno, JF Bernardo, CA Pfeifer, T Li, Y Zhang, RK Dubey, RA Branch and R Sabra 857 Renal and haemodynamic responses to a novel kappa opioid receptor agonist, niravoline (RU 51,599), in rats with cirrhosis R Moreau, S Cailmail, G Hamon and D Lebrec Bile and bile acids 864 Method for quantitative assessment of transformation of non-micellar cholesterol carriers in model bile systems Y Yamashita, S Tazuma and G Kajiyama 870 Bile acids produce a generalized reduction of the catalytic activity of cytochromes P450 and other hepatic microsomal enzymes in vitro: Relevance to drug metabolism in experimental cholestasis J Chen and GC Farrell Special article: Career paths in medical research 878 A tribute to June Halliday LW Powell 879 Career paths for medical research; The proceedings of a Festschrift for Professor June Halliday (Part 1) GC Farrell and LW Powell 880 The basic scientist in a clinical department MJ Eadie 882 A commentary on; Career. aths for basic scientists in medical research GA Ramm 885 Women in medical research; Headaches and hurdles P Hart 887 Myths and realities in clinical research M Ward 891 Career paths for clinical scientists GC Farrell 895 Notices Volume 11 Number 10 October 1996 Omeprazole and Complicated Gastro-oesophageal Reflux Disease 897 Editorial; Towards an increased efficacy of acid inhibition in the treatment of erosive oesophagitis R Lambert 900 Omeprazole in the treatment of patients with complicated gastro-oesophageal reflux disease D Jasperson, H Schwacha, W Schorr, M Brennenstuhl, CH Hammar X Contents Gastrointestinal Haemorrhage 903 Gastrointestinal bleeding in children SK Yachha, A Khanduri, BC Sharma, M Kumar 908 Case report: Gastrointestinal haemorrhage from jejunal diverticulosis, probably induced by low dose aspirin SP Kaushik, JM D’Rozario, G Chong, ML Bassett Peptic Ulcer; Pathogenesis Healing and Anti-ulcer Drugs 911 Hepatic and cerebrospinal fluid accumulation of aluminium and bismuth in volunteers taking short-course anti-ulcer therapy E Gane, MM Sutton, J Pybus, I Hamilton 916 A method of evaluating drug efficacy by statistical analysis of healing speed of peptic ulcer K Kimura, K Ido, T Suzuki, Y Taniguchi, Y Yoshida, S Kawano and S Tsuji 922 Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat E Gydmber, P Vattay, S Szabo and KD Rainsford 928 Study of the repairing process of gastric ulcer using multivariate analysis of bFGF-positive cells, haemodynamics, PAS-positive mucus amount and glandular index in the gastric mucosa T Terasaki, K Shimada, H Wakabayashi, M Tanaka and A Watanabe Endoscopy 938 Preventing endoscopic retrograde pancreatography related sepsis: A randomized controlled trial comparing two antibiotic regimens BC Smith, JR Alqamish, KJR Watson, G Shaw, JH Andrew, PV Desmond Aetiopathogenesis of Hepatocellular Carcinoma 942 Editorial: Different clinicopathological features of hepatitis B- and C-related hepatocellular carcinoma Y Shiratori 944 Relationship between sustained elevation of serum alanine aminotransferase and progression from cirrhosis to hepatocellular carcinoma: Comparison in patients with hepatitis B virus- and hepatitis C virus-associated cirrhosis A Sato, Y Kato, K Nakata, K Nakao, M Daikoku, Nobuko Ishii, T Matsumoto, K Iseki, H Mazume, S Nagataki 949 Evaluation of hepatitis B and C viral markers: Clinical significance in Asian and Caucasian patients with hepatocellular carcinoma in the United States of America S-J Hwang, MJ Tong, PPC Lai, ES Ko, RL Co, D Chien, G Kuo 955 Case report: Development of hepatocellular carcinoma in a patient with chronic hepatitis C infection after a complete and sustained response to interferon-a N Hirashima, M Mizokami, E Orito, T Koide, I Itazu, K Kumada, K Sakakibara, H Kano, JYN Lau 959 Case report: Multiple systemic lymph node metastases from a small hepatocellular carcinoma H Toyoda, Y Fukuda, Y Koyama, D Nishimura, H Hoshino, N Katada, K Kato, T Hayakawa Portal Haemodynamics and Hepatic Blood Flow 963 Pathophysiological changes caused by occlusion of blood flow into the liver during hepatectomy in dogs with obstructive jaundice: Effects of intestinal congestion K Takahashi, Y Ogura, Y Kawarada 971 Experimental extrahepatic obstruction of portal vein: Documentation of histopathological alterations in liver and extrahepatic tissues NAgnihotri, SR Bhusnurmath, KL Narasimhan, JB Dilwari, S Majumdar, U Kaur 978 Increase in hepatic tissue blood flow by teprenone T Kurihara, Y Kitamura, Y Adachi, M Obuchi, K Abe, M Akimoto, H Hashimoto, H Ishiguro, A Niimi, A Maeda, M Shigemoto, K Yamashita, I Yokoyama 985 Haemodynamic effects of combined treatment with molsidomine and propranolol on portal hypertension in conscious and unrestrained cirrhotic rats N Hori, T Okanoue, Y Sawa, T Mori, K Kashima 993 Notices Volume 11 Number 11 November 1996 Smoking and Portal Blood Flow 995 Editorial: Cigarette smoking, abdominal blood flow and abdominal diseases L Bolondi and F Piscaglia 997 Doppler ultrasound evaluation of acute effects of cigarette smoking on portal blood flow in man GL Rapaccini, M Pompili, M-A Marzano, A Grattagliano, A Cedrone, A Aliotta, FPignatoaro, E Caturelli, C Cellebrino and G Gasbarrini Hepatitis C 1001 Hepatitis C transmission between spouses T Koda, M Yonaha, A Hayashi and K Ishikawa 1006 Effects of combination therapy with interferon and ofloxacin on chronic type C hepatitis: A pilot study M Tsutsumi, A Takada, S Takase and M Sawada 1012 Case Report Agranulocytosis induced by interferon-a therapy for chronic hepatitis C Y Higashi, K Sakai, S Tada, S Miyase, T Nakamura, T Kamio and 0 Haraguchi Primary Biliary Cirrhosis 1016 Aminoterminal propeptide of type III procollagen and hyaluronan in patients with primary biliary cirrhosis: Markers of fibrosis in primary biliary cirrhosis T Remmel, H Remmel and V Salupere 1021 Case Report: Acanthosis nigricans in association with primary biliary cirrhosis: Resolution after liver transplantation TH Pham, S Kaushik, BPC Lin and DB Jones Contents XI Iron Metabolism and Liver Disease: Special Article 1024 Iron metabolism and liver disease; The proceedings of a Festschrift for Professor June Halliday (Part 2) LW Powell and GC Farrell 1025 Contributions of the Brisbane Liver Group to knowledge of iron metabolism TH Bothwell 1027 Cellular iron processing EH Morgan 1030 Control of iron absorption GJ Anderson 1033 Serum ferritin: Does it differ from tissue ferritin? MC Under, KJ Schaffer, M Hazegh-Azam, CYJ Zhou, TN Tran and GM Nagel 1037 Iron in an Australian population: Too little or too much? BA Leggett 1039 Alcohol and iron: One glass of red or more? LM Fletcher 1041 Current status in identifying the haemochromatosis gene EC Jazwinska 1043 Determinants of disease expression in Australian haemochromatosis patients DHG Crawford Molecular Hepatology 1046 Review: Molecular pathogenesis of hepatic acute porphyrias B Grandchamp, H Puy, J Lamorll, JC Deybach and Y Nordmann 1053 Construction of retroviral vectors to induce strong hepatoma cell-specific expression of cytokine genes G Cao, S Kuriyama, P Du, T Sakamoto, W Yang, K Masui and Z Qi Medical History 1062 Morgagni: His book, vision and views on hepatic coma TSN Chen and PSY Chen Hepatic Transport Processes 1065 ATP modulates sulfobromophthalein uptake in rat liver plasma membrane vesicles AM Torres 1072 Effect of the microtubular inhibitor vinblastine on ferritin clearance and release in the rat GA Ramm, LW Powell and JW Halliday Gastric Cancer: Clinical and Laboratory Studies 1079 Studies on the hypomethylation of c-myc, c-Ha-ras oncogenes and histopathological changes in human gastric carcinoma J-YFang, S-S Zhu, S-D Xiao, S-J Jiang, Y Shi, X-Y Chen, X-M Zhou and L-F Qian 1083 Clinicopathological significance of intestinal and diffuse types of gastric carcinoma in Taiwan Chinese C-W Wu, S-H Tsay, M-C Hsieh, S-S Lo, W-Y Lui and F-K P'eng Gastric Uicer Healing: Experimental Aspects 1089 Keratinocyte growth factor is an endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture M Takahashi, S Ota, S Nishimura, K Ogura, S Maeda, N Toda, E Hamada, A Terano and M Omata 1097 Helicobacter pylori infection delays the healing of acetic acid-induced gastric ulcer in Japanese monkeys R Kodama, T Fujioka, R Shuto, T Kubota and M Nasu 1103 Notices Volume 11 Number 12 December 1996 Oesophageal Varices 1105 Editorial: Sclerotherapy resistant oesophageal varices: What are their clinical significance in prophylactic sclerotherapy? M Hashizume and K Sugimachi 1110 Distinctive portal venographic pattern in patients with sclerotherapy resistant oesophageal varices A Toyonaga, T Iwao, M Sumino, K Takagi, K Oho, H Shigemori and K Tanikawa 1115 Circadian occurrence of variceal bleeding in patients with liver cirrhosis S Siringo, L Bolondi, S Soccorsa, RC Hermida, L Gramantieri, S Gaiani, FPiscaglia, C Carbone, B Misitano and R Corinaldesi Advances in Hepatology 1121 New approaches to the Budd-Chiari syndrome AEA Mahmoud and E Elias 1124 Iron overload and liver fibrosis MJP Arthur Hepatic Proteins in Regenerating Liver 1130 UDP-Glucuronosyltransferase in the regenerating rat liver A-M Pelliner, SA Smid, SI Strasser, CS Lee, ML Mashford and PV Desmond 1137 Synthesis of secretory protein in regenerating liver of rat after partial hepatectomy M Iwai, M Kashiwadani, Y Harada, K Tada, Y Ishii, Y Kitagawa, T Nakashima, T Okanoue, K Kashima and Y Ibata Liver and Bone 1143 Bone changes and mineral metabolism disorders in rats with experimental liver cirrhosis A Nakano, T Kanda and H Abe Ursodeoxycholic Acid 1155 Efficacy of ursodeoxycholic acid in combination with interferon-a in treating chronic hepatitis C K Tanaka, M Kondo, T Sakaguchi, S Salto, S Arata, M Ikeda, T Kitamura, M Morimoto and H Sekihara 1161 Case report Anti-proteinase 3 antibody activity in a patient with primary sclerosing cholangitis: clinical remission following ursodeoxycholic acid therapy SS Wong and JWM Lawton xii Contents Gastric Secretion 1164 Changes in gastic HCOj'secretory response to /V°-nitro-L-arginine methyl ester in rats following repeated administration K Takeuchi, K Takehara, S Kato, YAsada and T Yasuhiro 1171 Twice daily nizatidine or ranitidine is superior to once daily dosing in elevating 24 h intragastric pH in patients with duodenal ulcer disease A Thompson, V Mahachai, RJ Bailey, P Kirdeikis, L Zuk, B Marriage, I Simpson and FJamali Sedation for Endoscopy 1177 Pharmocokinetics of midazolam in Vietnamese subjects KR Balson, DJ Morgan, BH Richmond, ME McAlindon, SL Elliott and NO Yeomans 1181 Notices 1183 Referees 1186 Author Index 1190 Subject Index