Table Of Content

Volume 51 ¢ Number 1 ¢ January 1993 PROSPECTS SYMPOSIUM Introduction: Protein Phosphorylation and Signal Transduction in Bacteria I Naka anced Stender tn hac pase as NRE aalasc ocoons NINA A RE GATE lata Maelo A. CLASSICAL ATP-DEPENDENT KINASES ATP-Dependent Protein Kinases in Bacteria Alain J. Cozzone The Isocitrate Dehydrogenase Phosphorylation Cycle: Regulation and Enzymology David C. LaPorte The Role of Phosphorylation of HPr, a Phosphocarrier Protein of the Phosphotransferase System, in the Regulation of Carbon Metabolism in Gram-Positive Bacteria Jonathan Reizer, Antonio H. Romano, and Josef Deutscher Catabolite Repression in the Gram-Positive Bacteria: Generation of Negative Regulators of Transcription George C. Stewart Eukaryotic-Like Protein Serine/ Threonine Kinases in Myxococcus xanthus, a Developmental Bacterium Exhibiting Social Behavior Jose Munoz-Dorado, Sumiko Inouye, and Masayori Inouye B. SENSOR KINASE-RESPONSE REGULATORS The Regulation of Nitrogen Utilization in Enteric Bacteria Boris Magasanik Response Regulation in Bacterial Chemotaxis Gudrun S. Lukat and Jeffry B. Stock Gene Regulation by Phosphate in Enteric Bacteria B.L. Wanner The Phosphorelay Signal Transduction Pathway in the Initiation of Bacillus subtilis Sporulation James A. Hoch C. THE BACTERIAL PHOSPHOTRANSFERASE SYSTEMS Regulatory Interactions Involving the Proteins of the Phosphotransferase System in Enteric Bacteria Milton H. Saier, Jr Signal Transduction in Chemotaxis Mediated by the Bacterial Phosphotransferase System Friedrich Titgemeyer Three-Dimensional Structures of the Central Regulatory Proteins of the Bacterial Phosphotransferase System, HPr and Enzyme IIA9!¢ Y. Chen, W.J. Fairbrother, and P.E. Wright Transcriptional Regulation of the bg/ Operon of Escherichia coli Involves Phosphotransferase System-Mediated Phosphorylation of a Transcriptional Antiterminator Orna Amster-Choder and Andrew Wright : ARTICLES Okadaic Acid as an Inducer of the 78-kDa Glucose-Regulated Protein in 9L Rat Brain Tumor Cells Ming-Chin Hou, Chi-Hsiu Shen, Wen-Chuan Lee, and Yiu-Kay Lai Volume 51 ¢ Number 1 ¢ January 1993 PROSPECTS SYMPOSIUM Introduction: Protein Phosphorylation and Signal Transduction in Bacteria I Naka anced Stender tn hac pase as NRE aalasc ocoons NINA A RE GATE lata Maelo A. CLASSICAL ATP-DEPENDENT KINASES ATP-Dependent Protein Kinases in Bacteria Alain J. Cozzone The Isocitrate Dehydrogenase Phosphorylation Cycle: Regulation and Enzymology David C. LaPorte The Role of Phosphorylation of HPr, a Phosphocarrier Protein of the Phosphotransferase System, in the Regulation of Carbon Metabolism in Gram-Positive Bacteria Jonathan Reizer, Antonio H. Romano, and Josef Deutscher Catabolite Repression in the Gram-Positive Bacteria: Generation of Negative Regulators of Transcription George C. Stewart Eukaryotic-Like Protein Serine/ Threonine Kinases in Myxococcus xanthus, a Developmental Bacterium Exhibiting Social Behavior Jose Munoz-Dorado, Sumiko Inouye, and Masayori Inouye B. SENSOR KINASE-RESPONSE REGULATORS The Regulation of Nitrogen Utilization in Enteric Bacteria Boris Magasanik Response Regulation in Bacterial Chemotaxis Gudrun S. Lukat and Jeffry B. Stock Gene Regulation by Phosphate in Enteric Bacteria B.L. Wanner The Phosphorelay Signal Transduction Pathway in the Initiation of Bacillus subtilis Sporulation James A. Hoch C. THE BACTERIAL PHOSPHOTRANSFERASE SYSTEMS Regulatory Interactions Involving the Proteins of the Phosphotransferase System in Enteric Bacteria Milton H. Saier, Jr Signal Transduction in Chemotaxis Mediated by the Bacterial Phosphotransferase System Friedrich Titgemeyer Three-Dimensional Structures of the Central Regulatory Proteins of the Bacterial Phosphotransferase System, HPr and Enzyme IIA9!¢ Y. Chen, W.J. Fairbrother, and P.E. Wright Transcriptional Regulation of the bg/ Operon of Escherichia coli Involves Phosphotransferase System-Mediated Phosphorylation of a Transcriptional Antiterminator Orna Amster-Choder and Andrew Wright : ARTICLES Okadaic Acid as an Inducer of the 78-kDa Glucose-Regulated Protein in 9L Rat Brain Tumor Cells Ming-Chin Hou, Chi-Hsiu Shen, Wen-Chuan Lee, and Yiu-Kay Lai Low Fluences of Ultraviolet Irradiation Stimulate HeLa Cell Surface Aminopeptidase and Candidate “TGFaase” Activity S.B. Brown, D. Krause, and K.A.O. Ellem Acidic Fibroblast Growth Factor Gene 5’ Non-Coding Exon and Flanking Region From Hamster DDT1 Cells: Identification of the Promoter Region and Transcriptional Regulation by Testosterone and aFGF Protein Jeffrey A. Hall, Marie A. Harris, Richard Intres, and Stephen E. Harris Volume 51 ¢ Number 2 « February 1993 IN MEMORIAM Dedication: William Leo McGuire Bert W. O’Malley VIEWPOINT Multiple Mechanisms for Regulation of Steroid Hormone Action Kerry L. Burnstein and John A. Cidlowski PROSPECTS Estrogen Receptor Mutations in Breast Cancer S.A.W. Fuqua, G.C. Chamness, and W.L. McGuire On the Mechanism of DNA Binding by Nuclear Hormone Receptors: A Structural and Functional Perspective Leonard P. Freedman and Ben F. Luisi Mechanisms of Transcriptional Activation by Steroid Hormone Receptors Aria Baniahmad and Ming-Jer Tsai ARTICLES Characteristics of DNA Replication in Isolated Nuclei Initiated by an Aprotinin-Binding Protein Frederick D. Coffman, Kerin L. Fresa, Meera Hameed, and Stanley Cohen 4-Quinolones Cause a Selective Loss of Mitochondrial DNA From Mouse L1210 Leukemia Cells Jeffrey W. Lawrence, Sandra Darkin-Rattray, Fan Xie, Allen H. Neims, and Thomas C. Rowe Expression of Histone and Alkaline Phosphatase Genes in UMR 106-01 Rat Osteoblast-Like Cells Exposed to the Hoechst Dye H33342 M.H. Zheng, S. Wysocki, J.M. Papadimitriou, and D. Wood Effect of Retinyl Acetate on the Assembly of the Fibronectin Extracellular Matrix and the Processing of the Fibronectin Receptor 6 Subunit of Confluent C3H/10T1/2 Mouse Embryo Fibroblasts Satoshi S. Suzuki and Lawrence H. Piette Selection of Malonate-Resistant Stromal Cell-Derived Osteoprogenitor Cells In Vitro Benjamin Y. Klein, Irena Gal, and David Segal Temporally Different Poly(Adenosine Diphosphate-Ribosylation) Signals Are Required for DNA Replication and Cell Division in Early Embryos of Sea Urchins Maria Imschenetzky, Martin Montecino, and Marcia Puchi Identification of a Role of the Vitronectin Receptor and Protein Kinase C in the Induction of Endothelial Cell Vascular Formation Cynthia M. Davis, Susan C. Danehower, Antonio Laurenza, and J. Leslie Molony Detection and Characterization of Low Abundance Cellular Proteins That Specifically Increase Upon Loss of the Metastatic Phenotype Sheila M. Nielsen-Preiss and James P. Quigley Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies Affecting Signal Transduction Hans-Albert Reins, Gerhard Steinhilber, Brigitte Freiberg, and F. Alfred Anderer Volume 51 « Number 3 ¢ March 1993 VIEWPOINT Advances in Cellular Construction Glenn F. Spaulding, J. Milburn Jessup, and Thomas J. Goodwin PROSPECTS Utilization of Microgravity Bioreactors for Differentiation of Mammalian Skeletal Tissue Brenda J. Klement and Brian S. Spooner Cultivation of Cell-Polymer Cartilage Implants in Bioreactors L.E. Freed, G. Vunjak-Novakovic, and R. Langer Use of Microgravity Bioreactors for Development of an In Vitro Rat Salivary Gland Cell Culture Model Marian L. Lewis, Debra M. Moriarity, and P. Samuel Campbell Studies of Chondrogenesis in Rotating Systems P. Jackie Duke, Elizabeth L. Daane, and Dina Montufar-Solis Three-Dimensional Growth and Differentiation of Ovarian Tumor Cell Line in High Aspect Rotating-Wall Vessel: Morphologic and Embryologic Considerations Jeanne L. Becker, Tacey L. Prewett, Glenn F. Spaulding, and Thomas J. Goodwin Prospects for Use of Microgravity-Based Bioreactors to Study Three-Dimensional Host-Tumor Interactions in Human Neoplasia J.M. Jessup, T.J. Goodwin, and G. Spaulding Reduced Shear Stress: A Major Component in the Ability of Mammalian Tissues to Form Three-Dimensional Assemblies in Simulated Microgravity T.J. Goodwin, T.L. Prewett, David A. Wolf, and G.F. Spaulding ARTICLES pH Sensitivity of Epidermal Growth Factor Receptor Complexes Marissa Nunez, Kevin H. Mayo, Cindy Starbuck, and Douglas Lauffenburger A Point Mutation in the 5’ Splice Region of Intron 7 Causes a Deletion of Exon 7 in Adenosine Deaminase mRNA Hiroshi Kawamoto, Kazuhiko Ito, Saburo Kashii, Sumie Monden, Masahiro Fujita, Mihoko Norioka, Yoshiki Sasai, and Minoru Okuma Binding of Tissue-Type Plasminogen Activator to Human Melanoma Cells Jozef Bizik, Ross W. Stephens, Marta Grofova, and Antti Vaheri DNA Repair and Repair Fidelity in Metastatic Variants of the B16 Murine Melanoma B.A. Usmani, J. Lunec, and G.V. Sherbet Binding and Subcellular Distribution of Cyclosporine in Human Fibroblasts David A. Tipton and Mustafa Kh. Dabbous Drosophila Acidic Ribosomal Protein rpA2: Sequence and Characterization Pamela F. Olson, Tuula Salo, Katherine Garrison, and John H. Fessler High Mannose Type N-Linked Oligosaccharides on Endothelial Cells May Influence 62 Integrin Mediated Neutrophil Adherence In Vitro P. Sriramarao, Elaine Berger, J. David Chambers, Karl-E. Arfors, and Kurt R. Gehisen Enhanced Phosphorylation of a 65 kDa Protein Is Associated With Rapid Induction of Stress Proteins in 9L Rat Brain Tumor Cells Yiu-Kay Lai, Chi-Hsiu Shen, Ting-Jen Cheng, Ming-Ching Hou, and Wen-Chuan Lee Volume 51 ¢ Number 4 « April 1993 PROSPECTS Effects of Electromagnetic Field Exposure on Gene Transcription Jerry L. Phillips Beneficial Effects of Electromagnetic Fields C. Andrew L. Bassett Static and Extremely Low Frequency Electromagnetic Field Exposure: Reported Effects on the Circadian Production of Melatonin Russel J. Reiter Prospects on Clinical Applications of Electrical Stimulation for Nerve Regeneration Betty F. Sisken, Janet Walker, and Michael Orgel Biological Effects of Electromagnetic Fields W. Ross Adey Environmental Magnetic Fields: Influences on Early Embryogenesis lvan L. Cameron, W. Elaine Hardman, Wendell D. Winters, Selma Zimmerman, and Arthur M. Zimmerman Electroporation: A General Phenomenon for Manipulating Cells and Tissues James C. Weaver Electromagnetic Fields and Celis Reba Goodman, Yuri Chizmadzhev, and Ann Shirley-Henderson ARTICLES The Possible Involvement of Protein Phosphatase 1 in Thrombin-Induced Ca?* Influx of Human Platelets Kouhei Murata, Masato Sakon, Jun-ichi Kambayashi, Masao Yukawa, Yoshiko Yano, Kazumasa Fujitani, Tomio Kawasaki, Eiichi Shiba, and Takesada Mori Derivatives of 4-Amino-3,6-Disulfonato-1 ,8-Naphthalimide Inhibit Reverse Transcriptase and Suppress Human and Feline Immunodeficiency Virus Expression in Cultured Cells Darryl Rideout, Raymond Schinazi, C. David Pauza, Kathleen Lovelace, Lin-Chang Chiang, Theodora Calogeropoulou, Michael McCarthy, and John H. Elder Fatty Acyl-CoA Binding Activity of the Nuclear Thyroid Hormone Receptor Qiulin Li, Naoki Yamamoto, Seiji Morisawa, and Akira Inoue Homotypic Leukocyte Aggregation Triggered by a Monoclonal Antibody Specific for a Novel Epitope Expressed by the Integrin 81 Subunit: Conversion of Nonresponsive Cells by Transfecting Human Integrin a4 Subunit CDNA John L. Bednarczyk, James N. Wygant, Margit C. Szabo, Laura Molinari-Storey, Mark Renz, Sherman Fong, and Bradley W. Mcintyre Differential Expression of the Chromosomal High Mobility Group Proteins 14 and 17 During the Onset of Differentiation in Mammalian Osteoblasts and Promyelocytic Leukemia Cells Abdul Rauf Shakoori, Thomas A. Owen, Victoria Shalhoub, Janet L. Stein, Michael Bustin, Gary S. Stein, and Jane B. Lian Isolation and Characterization of Deteriosomes From Rat Liver Kening Yao, Xiumei Wu, John E. Thompson, and John C. Carlson Author Index to Volume 51 Subject Index to Volume 51