Table Of Content

Volume 48 ¢ Number 1 « January 1992 VIEWPOINT Insulin Secretion and Action and Diabetes Mellitus Ira D. Goldfine and Paul Pilch PROSPECTS Desensitization of the Insulin-Secreting Beta Cell Gerold M. Grodsky and Janice L. Bolaffi Substrates and Signalling Complexes: The Tortured Path to Insulin Action Richard A. Roth, Bei Zhang, Janice E. Chin, and Kristina Kovacina The Insulin-Binding Domain of Insulin Receptor Is Encoded by Exon 2 and Exon 3 Cecil C. Yip Insulin Receptor Signaling Through Non-Tyrosine Kinase Pathways: Evidence From Anti-Receptor Antibodies and Insulin Receptor Mutants Chin K. Sung Protein-Tyrosine Phosphatases and the Regulation of Insulin Action Barry J. Goldstein Insulin/IGF-1 Hybrid Receptors: Implications for the Dominant-Negative Phenotype in Syndromes of Insulin Resistance Anne L. Frattali, Judith L. Treadway, and Jeffrey E. Pessin Acute and Chronic Signals Controlling Glucose Transport in Skeletal Muscle Amira Klip and André Marette ARTICLES Expression and Release of Phosphatidylinositol Anchored Cell Surface Molecules by a Cell Line Derived From Sensory Neurons M. Théveniau, P. Durbec, G. Gennarini, J.N. Wood, and G. Rougon The Endocytic Hyaluronan Receptor in Rat Liver Sinusoidal Endothelial Cells Is Ca*?-Independent and Distinct From a Ca*?-Dependent Hyaluronan Binding Activity Judith Yannariello-Brown, Carl T. McGary, and Paul H. Weigel A Monoclonal Antibody to the T-Cell Receptor Increases IGF-I Receptor Content In Normal T-Lymphocytes: Comparison With Phytohemagglutinin Klaus K.P. Hartmann, Thomas G. Baier, Vincenzo Papa, Michael Kronenwett, Eric J. Brown, Ira D. Goldfine, and Stephen M. Rosenthal Acetyl-CoA Carboxylase in Reuber Hepatoma Cells: Variation in Enzyme Activity, insu: : Regulation, and Cellular Lipid Content Antonella Bianchi, Joseph L. Evans, Ann-Charlotte Nordlund, Thomas D. Watts, and Lee A. Witters mRNA Association With the Cytoskeletal Framework Likely Represents a Physiological Binding Event Diane Biegel and Joel S. Pachter Cellular Distribution of Gastric Chief Cell Protein Kinase C Activity: Differential Effects of Diacylglycerol, Phorbol Esters, Carbachol, and Cholecystokinin Robert D. Raffaniello and Jean-Pierre Raufman Volume 48 ¢ Number 2 ¢ February 1992 PROSPECTS Tissue-Specific Regulation of Glucokinase Gene Expression Mark A. Magnuson Alterations in Glucose Transporter Expression and Function in Diabetes: Mechanisms for Insulin Resistance Barbara B. Kahn identification of a Core Motif That ls Recognized by Three Members of the HMG Class of Transcriptional Regulators: IRE-ABP, SRY, and TCF-1a M. Alexander-Bridges, Louis Ercolani, X.F. Kong, and Nargis Nasrin Insulin/IGF-1| Receptor Hybrids: A Mechanism for Increasing Receptor Diversity Cary P. Moxham and Steven Jacobs ARTICLES Heterotrimeric Configuration Is Essential to the Adhesive Function of Laminin J.C. Lissitzky, P. Cantau, and P.M. Martin Modulation of Collagen and Fibronectin Synthesis in Fibroblasts by Normal and Malignant Cells A. Noel, C. Munaut, A. Boulvain, C.M. Calberg-Bacq, C.A. Lambert, B. Nusgens, C.M. Lapiere, and J.M. Foidart Butanol-Extractable and Detergent-Solubilized Cell Surface Components From Murine Large Cell Lymphoma Cells Associated With Adhesion to Organ Microvessel Endothelial Cells Robert J. Tressler and Garth L. Nicolson Comparison Between Avian and Human Prolyl 4-Hydroxylases: Studies on the Holomeric Enzymes and Their Constituent Subunits Norberto A. Guzman, William Q. Ascari, Kenneth R. Cutroneo, and Robert J. Desnick Characterization of the Human Myeloid Cell Nuclear Differentiation Antigen: Relationship to Interferon-inducible Proteins G.R. Burrus, J.A. Briggs, and R.C. Briggs Rate Transition and Regulatory Coupling in Endocytosis of Interferon-a and Tumor Necrosis Factor-a in Human Epithelial Tumor Cells Zeljko Bajzer and Stanimir Vuk-Paviovié Cloning and Sequence Determination of Bovine Insulin-Like Growth Factor Binding Protein-2 (IGFBP-2): Comparison of Its Structural and Functional Properties With IGFBP-1 Maureen J. Bourner, Walker H. Busby, Jr., Ned R. Siegel, Gwen G. Krivi, Robert H. McCusker, and David R. Clemmons Volume 48 ¢ Number 3 ¢ March 1992 PROSPECTS Defective Insulin Secretion in NIDDM: Integral Part of a Multiplier Hypothesis R. Paul Robertson The Role of lon Channels in Insulin Secretion A.E. Boyd Ill ARTICLES Rapid Induction of Competence Formation Is PDGF-Isoform Specific Steven R. Coats, J.E. Olson, and W.J. Pledger Expression of the Chicken Hepatic Glycoprotein Receptor in Xenopus Oocytes: Conservation of Ligand and Receptor Targeting Signals Doris A. Wall and Raisa Holguin Protein Kinase C Activation Amplifies Prostaglandin F,,-Induced Prostaglandin E, Synthesis in Osteoblast-Like Cells Haruhiko Tokuda, Yutaka Oiso, and Osamu Kozawa Receptor Binding of Asialoerythropoietin Yi Jie Dong, Charles Kung, and Eugene Goldwasser Expression of Heat Shock Genes During Differentiation of Mammalian Osteoblasts and Promyelocytic Leukemia Cells Abdul Rauf Shakoori, Annette M. Oberdorf, Thomas A. Owen, Lee A. Weber, Eileen Hickey, Janet L. Stein, Jane B. Lian, and Gary S. Stein Protein Kinase C Involved in Zymosan-induced Release of Arachidonic Acid and Superoxide but Not in Calcium lonophore-Elicited Arachidonic Acid Release or Formation of Prostaglandin E, From Added Arachidonate Justus Duyster, Agnes Schulze-Specking, Edith Fitzke, and Peter Dieter Superoxide Radical Formation and Associated Biochemical Alterations in the Plasma Membrane of Brain, Heart, and Liver During the Lifetime of the Rat Masaaki Sawada, Ulrike Sester, and John C. Carlson TGF-B, Inhibits DNA Synthesis and Phosphorylation of the Retinoblastoma Gene Product in a Rat Liver Epithelial Cell Line Robert H. Whitson, Jr., and Keiichi Itakura Biochemical and Morphological Differentiation of the Human Colonic Epithelial Cell Line SW620 in the Presence of Dimethylsulfoxide M. Bishr Omary, Louise de Grandpre, Michael McCaffrey, and Martin F. Kagnoff Monoclonal Antibody to the Human Insulin Receptor, but Not Insulin, Stimulates S6 Kinase via Human Insulin Receptors Mutated at Three Major Tyrosine Autophosphorylation Sites Chin K. Sung Announcement Volume 48 ¢ Number 4 « April 1992 PROSPECT Pima Indians as a Model to Study the Genetics of NIDDM Clifton Bogardus and Stephen Lillioja ARTICLES Apoptosis and DNA Fragmentation Precede TNF-Induced Cytolysis in U937 Cells Susan C. Wright, Poornima Kumar, Albert W. Tam, Naiping Shen, Madhu Varma, and James W. Larrick The Inhibition of ATP-Dependent Shape Change of Human Erythrocyte Ghosts Correlates With an Inhibition of Mg2+-ATPase Activity by Fluoride and Aluminofluoride Complexes Michael B. Morris, Gregory Monteith, and Basil D. Roufogalis Ligand-Induced Formation of the Leukotriene B, Receptor-G Protein Complex of Human Polymorphonuclear Leukocytes Jeffrey W. Sherman, Michelle A. Mendelson, John M. Boggs, Catherine H. Koo, and Edward J. Goetzl The Effect of Age on the Response of the Detrusor to Intracellular Mechanical Stimulus: DNA Replication and the Cell Actin Matrix Omer M.A. Karim, Narihito Seki, Kenneth J. Pienta, and Jacek L. Mostwin Flow Cytometric Analysis of Porcine Preadipocytes J.T. Wright Dihydropyridine Calcium Antagonist Modulates Cholesterol Metabolism and Eicosanoid Biosynthesis in Vascular Celis Andrew C. Nicholson, Orli R. Etingin, Kenneth B. Pomerantz, Barbara D. Summers, Karen Friday, Andrew A. Wolff, and David P. Hajjar Reversible Inhibition of Osteoclastic Activity by Bone-Bound Gallium (Ill) Harry C. Blair, Steven L. Teitelbaum, Hong-Lin Tan, and Paul H. Schlesinger Development of a Sensitive Peptidase Assay: In Search of Cell Associated Proteases Responsible for the Cleavage of preproTGF, S.B. Brown, D. Krause, E. Townsend, and K.A.O. Ellem 1a,25-Dihydroxyvitamin D, Modulation in Lipid Metabolism in Established Bone Marrow-Derived Stromal Cells, MC3T3-G2/PA6 Manabu Shionome, Toshimasa Shinki, Naoyuki Takahashi, Kohji Hasegawa, and Tatsuo Suda Announcement