Journal of Cell Biology 2003: Vol 162 Table of Contents

17 Pages·2003·0.8 MB·English

Volume 162 | No. 1
July 7, 2003
- News - - Research Articles -
in This Issue Reports
• Histones help clones forget their pasts 10 The Caenorhabditis elegans pi 20 15
• A fusion inhibitor on endosomes catenin homologue, JAC-1, modulates
cadherin-catenin function during
• Controlling flagellar strokes
epidermal morphogenesis
• Splicing fibronectin's functions
J. IVttitt, F..A. C^ox, l.D. Bnudboiit. A. l icit,
• Hierarchical condensation
and |. Hardin
\.\\ . Ddvc
On the Cover Articles
Research Roundup The characteristic width Engineered chromosome regions 21
of DNA inserts (green)
• Fibronectin for branching packed into chromo¬ with altered sequence composition
• Spare the MbI, spoil the rod? somes (red) indicates demonstrate hierarchical large-scale
that chromatin packs in
folding within metaphase chromosomes
• Remodeling the nucleus a hierarchical rather
• Glutamate in unusual places than radial loop man¬ Y.(i. Sirukov, Y. W’ang, and A.S. Belmont
ner. See page 23.
• Dying cells say come-hither
Changes in histone acetylation during 17
1 i-Br.issiiir mouse oocyte meiosis
|.-M. Kim, H. Liu, M. l a/aki, M. Nagata,
and L. Aoki
A subunit of the dynein regulatory 47
complex in Chlamydomonas is a
homologue of a growth arrest-specific
gene product
C'l. Rupp and M.L. Porter
Bax and Bak can localize to 59
the endoplasmic reticulum
to initiate apoptosis
Vi'.-X. /.ong, CL Li, Cl. 1 lar/iva,ssiliou, I. Lindsten,
C).-CL Yu, J. Yuan, and CLB. Thompson
Function of the p97-Ufd1-Npl4 71
complex in retrotranslocation from
the ER to the cytosol: dual recognition
of nonubiquitinated polypeptide
segments and polyubiquitin chains
Y. Ye, H.H. Meyer, and T—'Y. Rapoport
Articles with related stories in
the In This Issue section have
page numbers in red.
Reduced chondrocyte proliferation 139
and chondrodysplasia in mice
Lack of GTP-hound Rhol p lacking the integrin-linked
in secretory vesicles of kinase in chondrocytes
S.u chiimmvces cercvisiae
1 . 1 i.rp'.ii.i, |. I’liid liiiinnu'. \. Ar.il'i.ui.
s. I .ikid.i, (... s. !)i.-diKir.
,md R. \iII.Hill
Dual ree,ulation of neuronal
morphogenesis by a (Vcatenin-cortactin The neuronal specific 6- Regulated splicing of the fihronectin
complex and Rho catenin mediates a bal¬ EDA exon is essential for proper skin
ance between process wound healing and normal lifespan
elongation (v\hen Sre
family kinase activity is .1.1 . \.k. ( ii.Hi, n. ( .
reduced) and branchins; \. l.ii^iiKiu, I .
(when Rho is inhibited). ,liul I .1 - I),II ill.-
ARF(> stimulates clathrin/AP-2 ^ ^ ^ See paj^e 99.
recruitment to synaptic membranes
bv activating pbospbatidylinositol
phosphate kinase type I7
ER
Mrs regulates early endosome • . •
fusion by inhibiting formation . er
of an endosomal SNARE complex
Bax (j>old particles) and
Bak localize not only to
mitochondria but also
to the ER where they
can intiate a parallel
pathway of capsase ac¬
tivation and apoptosis.
See pai>e .>9.
-v
^
i-
/
\
!
i.
f. <•
ir^—^
f
/ :
i P
■,j
<9
) vv<t,
[
■ ■, ' : ■ f
I •
Reduced chondrocyte proliferation 139
Articles (cont.)
and chondrodysplasia in mice
Lack of GTP-bound Rhol p lacking the integrin-linked
in secretory vesicles of kinase in chondrocytes
Saccharomyces cerevisiae
I,. I crp.stra, ). Prud'homme, A. Arabian,
\1. Ahc, 11. Qadota, A. 1 lirara, and Y. Dhya S. I'akc'da, tl. Karsenty, ,S. ["tedhar,
and R. St-Arn.uid
Dual regulation of neuronal
morphogenesis by a ft-catenin-cortactin The neuronal specific 8- Regulated splicing of the fibronectin
complex and Rho catenin mediates a bal¬ EDA exon is essential for proper skin
ance between process wound healing and normal lifespan
M. (ail/ iVlartincv, 1. (\liiishi, M. Majcwski. elongation (when Sre
and K.S. Kusik family kinase activity is A.Ik Mnro, A.K. Cdiaulian, S. (lajovic,
reduced) and branching A. laconcig, b. Porro, (i. Stania,
(when Rho is inhibited), and IM-,. liarallc
ARF6 stimulates clathrln/AP-2 n 3 See page 99.
recruitment to synaptic membranes
by activating phosphatidylinositol
phosphate kinase type ly
M. Kraiiss. M. Kiiuita, M.R. Wcnk,
I’. Uc Claiitilli, K. l akci, and V. I lanckc
'ER
Mrs regulates early endosome 125
fusion by inhibiting formation
of an endosomal SNARE complex
Bax (gold particles) and
W. Smi, Yan. I .A. Vida, and A.j. Bean Bak localize not only to
mitochondria but also
to the ER where they
can intiate a parallel
pathway of capsase ac¬
tivation and apoptosis.
See page 59.
- News - - Research Articles -
,ln This Issue Articles
• Polyamines in inflammation Ibb Epstein-Barr virus LMPl blocks 175
• Desulfation on the cell surface pi 6"^'‘^‘*-RB pathway by promoting
• A building block of two organelles nuclear export of E2F4/5
• Neural cells turn and run N. Oht.ini. 1’. Brennan, S. (iauhai/, 1.. Sanij,
• Kicking out antiviral proteins I’. I Icrt/og, 1'.. W'oivctang, |. C ihvsclacl,
M. Rowe, and I- Kara
N. l.cHrasscur
Research Roundup A novel role for dpi 15 in the 185
On the Cover
organization of tER sites in Drosophila
• A loss, or two gains? 168 The Epstein-Barr virus
protein LMP1 averts V. KonJylisand (... Ralioiiille
• Nervous picket fences
cellular defense pro¬
• Sticky transmission grams by relocating key
Identification of synaptotagmin 199
• Activation by reduction transcription factors, in¬
cluding Ets2 (red), to effectors via acute inhibition of
• Doing the CDC20 shuffle the cytoplasm (bottom secretion from cracked PCI 2 cells
cell). See page 173.
W.A. WlIIs l iickcr, I dwardson. |. Bal.
H.-|. Kim. r.l'.j. ,\lartin, ,ind l .Iv ( liapman
Editorial
Proposed legislation supports 171 Vacuole membrane fusion: 211
an untested publishing model V„ functions after trans-SNARE
\1,|. WM pairing and is coupled to tbe
Ca^ -releasing channel
M.J. Bayer, t , Reese, S. Biihler, C . I’eters,
and A. .\la\er
Activity of Rho-family CTPases 223
during cell division as visualized
with FRET-based probes
H. 'loslii/aki, . t)liB,i, K. Knrokawa.
R.l. lioh, ! . Nakamura, \. Moehi/nki.
K. Nag.istiima, and M. Matsuda
Rbo activation patterns after spinal 233
cord injury and the role of activated
Rho in apoptosis in the central
nervous system
(M. Duhreiiil, \\ innin,
and 1,. .MeKerraelier
Articles with related stories in
the In This Issue section have
page numbers in rial.
The cytoplasmic domain of the 317
Articles (cont.j
Plasmodium falciparum ligand
Alternating metabolic pathways in 245 EBA-175 is essential for invasion
NGF-deprived sympathetic neurons but not protein trafficking
affect caspase-independent death
I .-W. (iilhcrgcr, ).K. I hompson, .M.B. lUcd,
1..K. C^hang, R.F.. Schmidt, and K.M. Johnson. Jr. R.T. (iood, and A.1-. (iowman
Polyamines play a critical role in the 257 Critical roles for the COOH-terminal 329
control of the innate immune response NITY and RGT sequences of the
in the mouse central nervous system integrin (Bj cytoplasmic domain in
inside-out and outside-in signaling
n. Soiilct and S. Rivcst
X.d. Xi, R.|. Bodnar, /,. l.i, .S.C,.-I'. 1 am.
Dual function of Slit2 in repulsion 269 and X. Du
and enhanced migration of trunk,
hut not vagal, neural crest cells QSulfl remodels the 6-0 sulfation .341
states of cell surface heparan
l)c Bcllard, Y. Rao, and M. Bronncr-F'-ascr
sulfate proteoglycans to promote
Activation of RhoA
(green) near a spinal Wnt signaling
PAKl phosphorylation of MEK1 281
cord injury site depends
regulates fihronectin-stimulated on the p75 neurotro- X. Ai. A.-r. Do, O. 1 o/ynska,
.\1. Kuschc-t lullhcrg, L’, I indahl,
MAPK activation phin receptor and leads
to cell death. See page and (!.P. Pmcrson, Jr.
J.K. Slack-Davis. S.T. l-.hlen, M. Zcccvic, 233.
.S..A. Bocrncr, A. 1 arc.satalsi. H.B. Diaz,
Additions and corrections 353
M.S. .Marshall, .M.l. Wchcr, ). 1 . Parsons,
and Ciatling
Homer 2 tunes G protein-coupled 293
receptors stimulus intensity
by regulating RGS proteins
and PLC(B GAP activities
D.M. .Shin, .M, Dehoff, X. l.uo, S.H. Kang,
J. 1 u, S.K. Navak, Ross, P.P. Worlcv,
and S. Muallcm
Regulation of phospholipase
D1 subcellular cycling through
coordination of multiple membrane Loss of the V-ATPase
association motifs subunit Vphip disrupts
vacuole fusion, leading
Cl, Du, Y..M. .Altshullcr, N. VYtaie, P. Huang, to clusters of fragment¬
S. C'.hasscroi-C'iolaz, A.J. Morris, M.-P. Bader, ed vacuoles. See page
and Prohman 211.
11
The lournal of ^ |
Biolog^ Volume 162 [ No. 3
August 4, 2003
- News - - Research Articles -
In This Issue
When myosin heads go walking Direct observation of microtubule
Schwann cells don caps, touch nodes dynamics at kinetochores in Xenopus
Neural progenitors play favorites extract spindles: implications for
A simple way to get cleavage
spindle mechanics
Watching kinetochores sweat
A. Dove P. .Maddox, A. Straight, P. (atughlin,
r.J. Mitchison, and F.D. Salmon
Research Roundup
Microtubules are the only structural
• Cilia take charge in L-R asymmetry On the Cover
constituent of the spindle apparatus
• Network architecture determines stability
Dividing neuronal stem
• Exocytosis—one vesicle at a time required for induction of cell cleavage
cells initiate apoptosis
• The elusive cell cycle-transcription link in one daughter cell ( i.B. .Al.sop and I). Zhang
• Loss of Rb launches cell cycle through asymmetric
distribution of PAR-4
(red) and ceramide. The
surviving cell (green) Importin |3 contains a COOH-terminal
differentiates into a
nucleoporin binding region important
Lipid rafts make for slippery platforms neural progenitor cell.
See page 469. for nuclear transport
J. Bednenko, Cl. Cingolani, and I. Clcr.icc
- Reviews - The ER v-SNAREs are required for
CPI-anchored protein sorting from
Comments other secretory proteins upon exit
from the ER
After Hrs with HIV
P. .Morsomme, C. Prcscianotto-lkcschong,
A. Ainara and D.R. I ittinan
and H. Ric/man
Vps27 recruits ESCRT machinery to
endosomes during MVB sorting
n.J. Rat/mann, Cl.J. Stchin, .\l. Bahst,
and S.D. Enir
HIV Gag mimics theTsgl01-recruiting
activity of the human Hrs protein
C). Pornillos, l).S. Higginson, K.M. Str.iy,
R.l). l ishcr, J.H. Ciarru.s, .M. Payne. CI.-P. He,
H.K. W ang, S.Ci. .Morham, and W’.l. Simdquist
Articles with related stories in
the In This Issue section have
page numbers in red; articles
with Comments or Mini-Reviews
have page numbers in blue.
Local ERM activation and dynamic
Articles (cont.)
growth cones at Schwann cell tips
Hrs regulates multivesicular body implicated in efficient formation of
formation via ESCRT recruitment nodes of Ranvier
to endosomes
CM,. Clatto, H.J. Walker, and S. Lambert
K.Ci. Baehe, A. Brech, A. Mehliim,
and H. Stenmark
Dynamic changes in the osteoclast
cytoskeleton in response to growth
Infectious HIV-1 assembles in late
factors and cell attachment are
endosomes in primary macrophages
controlled by P3 integrin
A. Belcben-Matthews, B. Kramer, and
Infectious HIV-1 particles IC. Faccio, I^.V. Nnvack, A. Zallone, F.l’. Re
M. Marsh
assemble in macro¬ and S.I.. I eitelbaum
phage endosomes. See
Regulation of the expression and page 443.
Identification of a putative pathway
processing of caspase-12
for the muscle homing of stem cells in
M. Kalai, M. l.amkanfi, (L Denecker, a muscular dystrophy model
•M. Boogmans, S. l.ippens, A. Meeus,
Y. l orrente, ti. C'amirand, F. I’isati,
W. Deelereq, and I’. Vandenabeele
M. Belicchi, B. Rossi, F. C'olombo,
M. Fd Fahime, N.j. (kiron, .A.C'. Issekiit/,
Regulation of cell death in mitotic (1. C'onstantin, J.l*. Fremblay, and N. Bresolin
neural progenitor cells by asymmetric
distribution of prostate apoptosis Additions and corrections
response 4 (PAR-4) and simultaneous
elevation of endogenous ceramide
F.. Bicbcrich, S. MacKinnon, |. .Silva, S. Nogglc
and B.Ci. Ciondic
A mutant heterodimeric myosin with
Hrs (blue) initiates the
one inactive head generates maximal formation of multi¬
displacement vesicular bodies by
recruiting the ESCRT
N.M. Kad, A.S. Rovner, I’.M. Fagnant, machinery (red) to
I’.B. Joel, Cl.CL Kennedy, j.B. I’atlak, endosomes (green). See
1).M. W'arsbavv, and K.M. Frc'bus page 435.
- News - - Research Articles -
In This Issue Reports
• Prions prefer caveosomes Regulation of insulin-like growth 535
• Stop and go LI CAM factor-dependent myoblast
differentiation by Foxo forkhead
• Synapse too exclusive for CD148
transcription factors
• G-proteins for spindle geometry
M.I.. Hrib.il. |. Nakac. 1. Kitamura.
• BubRI checks In with CENP-E
J. R. Shutter, and D. Accili
N. LcBrasscur
Impaired membrane resealing 543
Research Roundup On the Cover
and autoimmune myositis in
• Pulling backwards 532 lacking CENP-E di¬ synaptotagmin Vll-deficient mice
vide despite the pres¬
• Reprogrammed by a frog ence of a few polar- S. Cdiakraharti, K.S. Kohayashi, R.A. Flavell,
• Surviving heat through destruction attached chromosomes C.B. .Marks, K. .Miyake, D.R. l.iston,
that attract the check¬
K. r. Howler. H.S. (ioreliek, and N.V(’. .Andrews
• My mother, the wave point protein Buhl
(green). See page 551.
• The checkpoint of death Articles
W'.A. Wells Centromere-associated protein-E is 551
essential for the mammalian mitotic
checkpoint to prevent aneuploidy
due to single chromosome loss
B..A..\. Weaver, Z.Q. Bond.iy, H.R. Rutkey,
Ci.J.lM . Kops, A.n. Silk, and D.W. Cleveland
Visualization of chromatin domains 565
created by the gypsy insulator
of Drosophila
K. Byrd and \'.C1. (atrees
Dual recognition of the ribosome and 575
the signal recognition particle by tbe
SRP receptor during protein targeting
to the endoplasmic reticulum
H.C. Mandon, V. Jiang, and R. Gilmore
Articles with related stories in
the In This Issue section have
page numbers in red.
The tyrosine phosphatase GDI 48 673
Articles (cont.)
is excluded from the immunologic
Gene expression during ER stress- 587 synapse and down-regulates
induced apoptosis in neurons: prolonged T cell signaling
induction of the BH3-only protein
I. 1 in and A. Weiss
Bbc3/PUMA and activation of the
mitochondrial apoptosis pathway
Unique targeting of cytosolic 683
CI'.. CRhciimttecnrtd/e, n1,) .a Kndci gJc.Hl, .AM. .R Ia’mreih, n gMeincien VlaIcI kianrge ismynpaapirteod- phospholipase A2 to plasma
in membrane resealing, membranes mediated by the
leading to fibrosis NADPH oxidase in phagocytes
Spatial and temporal changes in Bax 599 (shown) and autoimmune
subcellular localization during anoikis disorders. See page 543. Z. Shmcl/.cr, N. Ihiddad, K. Admon, 1. Pcssach,
r.I,. l.eto, Z. F.itan-Ma/an, M. Hcrshfinkcl.
A.J. Valentijn, A.l). Metcalfe, J. Kott, and R. Few
('.H. Streiili, and A.R. Cilmore
Phosphatidylinositol phosphate 693
FOXO transcription factors directly 5-kinase ip recruits AP-2 to the plasma
activate him gene expression membrane and regulates rates
and promote apoptosis of constitutive endocytosis
in sympathetic neurons
I). Padrdn, Y.j. Wang, M. Yamamoto, H. Yin,
J. (]ille\, I’.j. C'ofter, and J. 1 lam and M.C. Roth
Distinct roles of Gai and Gpi3F 623 Trafficking of prion proteins 703
subunits of the heterotrimeric through a caveolae-mediated
G protein complex in the mediation endosomal pathway
of Drosophila neuroblast
P.F Peters, A. Mironov, jr., 1). Peret/.,
asymmetric divisions 1,. van Doti.selaar, IF Feclerc, Si lirpel,
S.J. DeArmond, l^.R. Burttin,
h'. Yu, Y. C.ai, R. Kaiishik, X. Yang,
R.A. Williamson. M. \’ey, and S.B. Prusiner
and W. Cilia
Ankyrin binding mediates LI CAM 719
The GAP activity of Msb3p and Msb4p
interactions with static components
for the Rab GTPase Sec4p
of the cytoskeleton and inhibits
is required for efficient exocytosis
retrograde movement of LI CAM
and actin organization
on the cell surface
X. -I). Cao, S. Albert, S.H. 1 cheperegine, C.C.
Burd, 1). CalKvitz, and H. Bi 0.1). tiil, 1. Sakurai, A.F.. Bradley, M.Y. Fink,
■M.R. C'assella, F.Y. Kuo, and D.P. Felsenteld
ARF6 regulates a plasma membrane 647 The gypsy nuclear insu¬
pool of phosphatidylinositol- lator tethers DNA (red Spatial restriction of a4 integrin 731
and green) to the nucle¬ phosphorylation regulates
(4,.'5)bisphosphate required ar matrix, thus creating
lamellipodial stability and
for regulated exocytosis chromatin loops. See
page 565. a4pi-dependent cell migration
Y. Aikawa and r.F.J. Martin
1..F.. (loldtuiger, ). 1 Ian, W.B. Kiosses,
A.K. Flowe, and ,\F11. (linsherg
EphBI recruits c-Src and p52*'’‘^ 661
to activate MAPK/ERK
and promote chemotaxis
C. V'indis, D.B. Cerretti, I'.O. naniel.
and U. Huvnh-Do