Journal of Cell Biology 2003: Vol 160 Table of Contents

15 Pages·2003·0.78 MB·English

Volume 160 | No. 1
January 6, 2003
- News - - Research Articles -
In This Issue Reports
• Rafts and the evil amyloids Phosphoinositide 3-kinase activates
• Caspases chew on electron transport Rac by entering in a complex
with Eps8, Abil, and Sos-1
• The complex life of a GEF
• FRET-ing over scaffolds M. Innocenti, E. Frittoli, 1. Ponzanelli,
J.R. Ealck, Sa.M. Brachmann,
• RNA travels with ZBP1
P.P. Di Fiore, and CE Scita
N. LcBrasseiir
Articles
Research Roundup On the Cover Human centromere chromatin
• Tubes go apical Interaction of a scaffold protein hMisI 2, essential for equal
protein AKAP79 and a
segregation, is independent
• The importance of catastrophe calcineurin subunit can
be detected by fluores¬ of CENP-A loading pathway
• Cohesin resolves to let go
cence resonance energy
C'l. Cioshima, 1. Kiyomitsii, K. Yoda,
• Oscillating wildly transfer (FRET), with
highest FRET intensity in and M. Yanagida
• A trigger for myelination red. See page 101.
W.A. Wells A transgene carrying an A2G missense
mutation in the SMN gene modulates
phenotypic severity in mice with
- Reviews -
severe (type I) spinal muscular atrophy
U.R. Monani, M. 1. Pasrore, E.O. Ciavrilina,
Mini-Reviews
S. Jablonka, T.T. Lc, C. Andreassi,
Direct cadherin-activated 11 J.M. Di('oca), C. Lorson, E.J. Androphy,
M. Sendtner, \E Podcll, and A.H.M. Burghes
cell signaling: a view from
the plasma membrane
Characterization of the signal that
A.S. Yap and E.M. Kovacs
directs BcI-Xl, but not Bcl-2, to the
mitochondrial outer membrane
1. Kautmann, S. Schlipt, ). San/., K. Neubert,
R. Stein, and C. Bonier
Caspase-mediated loss
of mitochondrial function
and generation of reactive
oxygen species during apoptosis
|.-E. Ricci, R.A. tiottlieb. and D.R. Green
Articles with related stories in
the In This Issue section have
page numbers in red.
Dynamic changes in the mobility 125
Articles (cont.)
of LAT in aggregated lipid rafts
Two ZBPl KH domains facilitate upon T cell activation
^•actin mRNA localization,
N. I animura. \1. Nagafiiku, V. Minaki.
granule formation, Y. Umeda, F. H.iyashi, J. Sakakura,
and cytoskeletal attachment A. Karo, D.R. l.iddicoar, M. C')gata,
1. Flamaoka, and A. Kosugi
K.I.. Farina, S. Hiirtclmaier, K. Musunuru,
R. Darnell, and R.FF Singer
Muscle weakness (left)
is evident in a mouse PTPa regulates integrin-stimulated 137
Roles of GP7 in membrane recruitment model for spinal muscu¬ FAK autophosphorylation and
lar atrophy. See page
and activation of pIlOyplOI 41. cytoskeletal rearrangement
phosphoinositide 3-kinase 7 in ceil spreading and migration
C. Brock, M. Sehaeter, H.P. Reuseh, 1.. Zeng, X. Si. W.-P. Yu, H.T. l.c, K.P. Ng,
C. O.upalla, M. Miehalke, K. Spicher, R. M.H. Feng, K. Ryan, D.Z.-M. VC'ang,
ti. Schulrz, and B. NiirnBerg S. Ponniah, and CI.J. Pallcn
Imaging kinase-AKAP79-phosphatase 101
scaffold complexes at the plasma
membrane in living cells
using FRET microscopy
S. F. Oliveria, L.I.. (iomez, and M.L. Dell'Acqua
Immobilization during
Amyloidogenic processing of the signaling events of LAT
Alzheimer ^-amyloid precursor (green), an adaptor pro¬
protein depends on lipid rafts tein in T cell receptor
signaling, may help to
R. Fi,hehah, I*. Keller, C. Haass, C], 1 hide, sustain signaling in lipid
and K. Simons rafts. See page 125.
/
11
The lournal of ^ |
Biolow
Volume 160 ] No. 2
January 20, 2003
- News - - Research Articles -
In This Issue
• Tumor cells get primitive Traffic-independent function
• Venus dye trap catches executioners of the Sarlp/COPII machinery
in proteasomal sorting of the
• Taking close-ups of a rafting trip
cystic fibrosis transmembrane
• Rejection and killing, without MPR
conductance regulator
• An interaction that gets things started
L. Fu and F.. SztuI
Direct visualization of Ras
On the Cover
proteins in spatially distinct
- Reviews - Both control fibrosarco¬
cell surface microdomains
ma cells (green) and
cells treated with a
Comments I.A. Prior, C. Miinckc. R.CF Parton,
cocktail of protease in¬
and j.F. Hancock
hibitors (red) can move
Endocytosing the death sentence
through extracellular
(i.M. Ciriffiths matrix (light brown). Tenascin-C signaling through
The inhibitor-treated
induction of 14-3-3 tau
cells resort to an ame¬
boid form of movement. 1). Martin. M. Brovvn-Liicdi,
See page 267.
and R. Chiqiift-Fhrismann
HA95 and LAP2P mediate a novel
chromatin-nuclear envelope
interaction implicated in initiation
of DNA replication
S. Martins, S. F'ikvar, K. Furukawa, and P. Collas
Mitofusins Mfni and Mfn2 coordinate^
regulate mitochondrial fusion and are
essential for embryonic development
H. Cdien, S.A. Dctmcr, A.J. Ewald, E.F. Ciriffin,
S.F^. Fra.scr, and D.C. Chan
The coiled-coil membrane protein
golgin-84 is a novel rab effector
required for Golgi ribbon formation
A. [)iao, H. Rahman, H.J.C. Pappin, J. Eucocq,
and M. Luvvc
Articles with related stories in
the In This Issue section have
page numbers in red; articles
with Comments have page
numbers in blue.
I vm
RhoA is required for cortical 255
Articles (cont.) r.
retraction and rigidity during mitotic
EpsinR: an API/clathrin interacting 213 ceil rounding
protein involved in vesicle trafficking
A.S. Maddox and K. Burridge
I.c;. Mills, C.J.K. Pracfckc, Y. Vallis, B.J. Peter,
L.E. Olesen, J.L. Gallop, P. Jonathan G. Butler,
Compensation mechanism in tumor cell •267
P.R. Evans, and H.T. McMahon
migration: mesenchymal-amoeboid
transition after blocking
A clathrin/dynamin- and mannose-6' 223
of pericellular proteolysis
phosphate receptor-independent
pathway for granzyme B-induced K. WoK, 1. Mazo, H. i.eung, K. Engelkc,
U.H. von Andrian, E.l. Derv’ugina,
cell death
A.Y. Strongin, E.-B. Brdckcr, and P. Fricdl
j.A. I rapani, V.R. Sutton, K.Y.T. Thia,
Y.Q. Ei, C.J. Froelich, I).A. Jans, M.S. Sandrin, Red and green mito¬
and K.A. Browne chondria fuse in wild-
type cells (top) but not
in cells derived from
Spatio-temporal activation of caspase 235 mice deficient for the
revealed by indicator that is mitofusins Mfni or
Mfn2 (bottom). See
insensitive to environmental effects
page 189.
K. 1 akemoto, 1. Nagai, A. Miyawaki,
and M. Miura
Binding of an ankyrin-1 isoform to 245
obscurin suggests a molecular link
between the sarcoplasmic reticulum
and myofibrils in striated muscles Two ankyrin isoforms
P. Bagnato, V. Barone, E. Giacomello, (red) bind obscurin
(green), thus localizing
D. Rossi, and V. Sorrentino
a large protein complex
that may link the sarco¬
plasmic reticulum and
myofibrils. See page
245.
11
I I
The|ournalof
Volume 160 | No. 3
Biology^
February 3, 2003
- News - - Research Articles -
In This Issue
• Two motors, one transmission Dynactin is required for bidirectional
• A model of missegregation organelle transport
• Multimembrane fusion
• Urge to merge erects filopodia S.W. Deacon, A.S. Serpinskaya, P.S. Vaughan,
• Anthrax toxin takes charge M.I.. Fanarraga, 1. V'ernos, K.T. Vaughan,
and V.l. Geltand
AAV. Dove
Research Roundup The intramitochondrial dynamin-related
GTPase, Mgml p, is a component
• Is Botryllus a natural killer? On the Cover
of a protein complex that mediates
• Bacterial aging
• Replicating dominos Filopodia form when mitochondrial fusion
actin filaments are gath¬
• Hearts grow with the flow ered together (blue) and E.D. Wong, J.A. Wagner, S.V'. Scott,
• Poised to migrate protected by a set of V. (^kregkik, F.J. Holewin.ske,
W.A. Wells molecules (gold) that A. Cassidy-Stone, and J. Nunnari
includes VASP. See page
409.
Binding site for pi 20/8-catenin
- Reviews -
is not required for Drosophila
E-cadherin function in vivo
Comments
A. Pacquelet, L. Lin, and P. Rorth
List at the microtubule plus end
and its role in dynein-mediated
Anthrax toxin triggers endocytosis of
nuclear migration
its receptor via a lipid raft-mediated
X. Xiang clathrin-dependent process
l.. Abrami, S. l.iii, P. Cosson, S.H. l.eppla,
Dynactin polices two-way and F.C. van der Coot
organelle traffic
K.R. Dell
The budding yeast Ipil/Aurora
protein kinase regulates mitotic
Anthrax toxin rafts into cells
spindle disassembly
1. Kur/.chalia
S. Buvelot, S.Y. I'atsutani, D. V'ermaak,
and S. Biggins
Rael is an essential mitotic
checkpoint regulator that
cooperates with Bub3 to prevent
chromosome missegregation
Articles with related stories in ).R. Babu, K.B. jeganathan, D.j. Baker, X. Wu,
the In This Issue section have N. Kang-Decker, and J.M. van Deursen
page numbers in red; articles
with Comments have page
numbers in blue.
Mechanism of filopodia initiation by 409
Articles (cont.)
reorganization of a dendritic network
The role of the lissencephaly protein 355
T'.iM. Svitkina, F.A. Bulanova. O.Y. Chaga,
Pad during nuclear migration
' D.M. V'ignjcvic, S.-i. Kojima, J.M. Vasiliov,
in budding yeast and Ci.Ci. Bori.sy
'X'.-L. l.ec, J.R. Obtrle, and J.A. Cooper
The ZO-1-associated Y-box factor 423
Hierarchy of protein assembly at the 365 ZONAB regulates epithelial cell
vertex ring domain for yeast vacuole proliferation and cell density
Cells lacking the Aurora
docking and fusion kinase IpMp are defec¬ M.S. Baida, M.I). (kirrctt, and K. Matter
tive for mitotic spindle
L. Wang, A.j. Merz, K.M. Collins,
disassembly. See page
and W. Wickner 329. Drosophila p120catenin plays 433
a supporting role in cell adhesion
Rac and Cdc42 play distinct roles 375 but is not an essential adherens
in regulating PI(3,4,5)P3 and polarity junction component
during neutrophil chemotaxis
S.H. Mvster, R. C'avallo, C. I. Anderson,
S. Sriniv.asan, I-. Wang, S. Clavas, A. Ott, D.T. Fox. and M. Beifer
F. Fiofmann, K. Aktories, I). Kalman,
and H.R. Bourne Additions and corrections 451
A biomimetic motility assay provides 387
insight into the mechanism
of actin-based motility
S. Wiesner, FI. Helter, D. Didrs-, G. Dueouret, The single Drosophila
F. Latuma, M.-F. Carlier, and D. I’antaloni pi 20 catenin (green) lo¬
calizes to cell junctions
but is not an essential
EPLIN regulates actin dynamics by 399 component of these
cross-linking and stabilizing filaments junctions when wild-
type cadherins and 3-
R.S. Maul, Y. .Song, K.J. Amann, S.(]. Cierbin, catenin are present. See
1.1). Bollard, and D.I). Chang pages 433 and 313.
Volume 160 I No. 4
February 17, 2003
- News - - Research Articles -
In This Issue Reports
• Sticky cells in a prickly system 462 The FGF receptor uses the 481
• TRAP builds a better translocon endocannabinoid signaling system to
couple to an axonal growth response
• This is your neuron on cannabinoids
• Cajal compartments E.-J. Williams, E.S. 'OC'alsh, and P. Doherty
• Four channels, but only one program
Cyclic AMP induces integrin-mediated 487
A.W. Dove cell adhesion through Epac
and Rapi upon stimulation
Research Roundup On the Cover
of the P -adrenergic receptor
Proteins enter chloro- 2
• Hox signals death for neuronal 464 plasts through a four- S. Rangarajan, J.M. F.nserink, H.B. Kuiperij,
precursors channeled translocon. J. de Rooij, L.S. Price, E. Schwede, and J.I.. Bos
• Rec'd and repaired See page 541.
’Articles
• Promoting passage in plasmodesmata
• Keeping wing cells in line Steady-state dynamics of Cajal body 495
components in the Xenopus
• A minus-end motor sees the plus side
germinal vesicle
N. l.cBrassciir
K.E. Handwerger, C'. Murphy, and J.C. tlall
Meeting Report
Targeting of U4/U6 small nuclear 505
Stories of Cells: The American Society 466
RNP assembly factor SART3/p110
for Cell Biology San Francisco, CA
to Cajal bodies
December 14-18, 2002
D. Stanek, 1 S.D. Rader, M. Klingaut,
W.A. Wells and N. LeBrasseur and K.M. Neugebauer
- Reviews - The molecular function of Asel p: 517
evidence for a MAP-dependent
Mini-Reviews midzone-specific spindle matrix
S.C. Schuyler, J.Y. I.in, and D. Pellman
Is all of the endoplasmic reticulum 475
created equal? The effects of the
Substrate-specific function of the 529
heterogeneous distribution
translocon-associated protein
of endoplasmic reticulum
complex during translocation
Ca^*-handling proteins
across the ER membrane
S. Papp, E'. D/.iak, M. Michalak, and M. Opas
R.D. Eons, B.A. Bogert, and R.S. Elegde
Articles with related stories in
the In This Issue section have
page numbers in red.
Amassin, an olfactomedin protein, 597
Articles (cont.)
mediates the massive intercellular
Characterization of the translocon 541 adhesion of sea urchin coelomocytes
of the outer envelope of chloroplasts
B.J. Hillicrand V.D. Vacqiiicr
E. Schiciff, ). Soil, M. Kiichlcr, W. Kiihlbrandt,
and R. Harrcr
Elevated glucose inhibits VEGF-A- 605
mediated endocardial cushion
The inner membrane protein Mdm33 553
formation: modulation by PECAM-1
controls mitochondrial morphology
and MMP-2
in yeast
J.M. Enciso, D. Clratzingcr, T.D. C'amcni.scb,
M. Mcsscrschmitt, S. Jakobs, F. Vogel, S. Fritz, S. Canosa. FI. Pinter, and J.A. Madri
K.S. Dimmer, W. Neupert, and B. Westermann A constitutively activat¬
ed integrin (green), mu¬
tated in a human tumor, Retraction 617
Regulation of the formation 565 can suppress kerati-
of osteoclastic actin rings nocyte differentiation.
See page 589.
by proline-rich tyrosine kinase 2
interacting with gelsolin
Q. Wang, Y. Xie, Q.-S. Dii, X.-j. Wii, X. Feng,
1.. Mei, j.M. VlcDonald, and W.-C. Xiong
Compartmentalized megakaryocyte 577
death generates functional platelets
committed to caspase-independent death
M.C.H. C:iarke, I. Savill, D.B. Jones, B.S. Noble,
and S.B. Brown Mitochondria with an
intact membrane poten-
___ tial (red) are directed
A tumor-associated ^1 integrin
into forming platelets
mutation that abrogates epithelial (arrow). Exclusion of
differentiation control caspase 9 from these
platelets protects them
R.D. Evans, V.(!. Perkins, A. Henry, from immediate cell
P.E. Stephens, M.K. Robinson, and F.M. Watt death. See page 577.
Volume 160 | No. 5
March 3, 2003
- News - - Research Articles -
In This Issue Reports
• The other side of kinetochore fibers 624 A mechanism of coupling RCC1 635
• Phosphorylation cycles on vesicles mobility to RanGTP production
on the chromatin in vivo
• PDE5 says NO to cGMP
H.Y. Li, D. Wirtz, and Y. Zheng
• A protease inhibitor unsticks cells
• Ran sticks a GEF to chromatin Articles
N.L. LcBrassciir A role of topoisomerase II 645
in linking DNA replication
Research Roundup On the Cover
to chromosome condensation
• Heterochromatin gets dynamic 626 Kinetochores (red) that
face away from the cen¬ O. Cuvier and T. Hirano
• Life on a bed of needles tromere can associate
with microtubule bun¬
• Polarity feeds back dles (green, arrow). The Meiotic cohesin REC8 marks the axial 657
• Linking spindle to furrow minus ends of these elements of rat synaptonemal
bundles are incorporat¬
• Exocytosis in action ed into the mitotic spin¬ complexes before cohesins
dle as kinetochore SMC1 (3 and SMC3
W.A. Wells
fibers by the loop-and-
M. Eijpe, H. Offenberg, R. Jessberger,
capture method de¬
E. Revcnkova, and C. Heyting
scribed on page 671.
- Reviews -
Minus-end capture of preformed 671
Mini-Reviews kinetochore fibers contributes
to spindle morphogenesis
Fluorescence resonance energy
transfer (FRET) microscopy imaging A. Khodjakov, I,. Copenagle, M.B. Gordon,
of live cell protein localizations D.A. Compton, and T'.M. Kapoor
R.B. Sekar and A. Periasaniy
Chromosome order in HeLa cells 685
changes during mitosis and early G1,
but is stably maintained during
subsequent inter phase stages
J. Walter, L. Schermellch, iVl. Cremer,
S. Tashiro, and T. Cremer
AP-1 binding to sorting signals and 699
release from clathrin-coated vesicles is
regulated by phosphorylation
P. Ghosh and S. Korn)eld
Articles with related stories in
the In This Issue section have
page numbers in red.
Integrin mediates outside-in 769
Articles (cont.)
regulation of platelet spreading
Regulation of cytochrome c oxidase 709 on collagen through activation
activity by c-Src in osteoclasts of Src kinases and PLCy2
r. Miyazaki, 1,. NeH, S. 1 anaka. W.C. Horne, Inoue, K. Suzuki-1noue, W.F. Dean,
and R. Baron |. Frampton, and S.F. Watson
Direct activation of PDE5 by cGMP: 719 Plasminogen activator inhibitor-1 781
long-term effects within detaches cells from extracellular
NO/cGMP signaling matrices by inactivating integrins
B. Mullcrshaiisen, A. Friebe, R. Feil, R.-IF C/zekay, K. Aertgeerts, S.A. Curriden,
W.I. riiompson, F. Hofmann, and I). Koesling and D.J. Foskutoff
Identification of a tight junction- 729
associated guanine nucleotide exchange
factor that activates Rho and regulates
paracellular permeability
ti. Benais-Font, A. I’unn, Florcs-Maldon.>do,
J. Fxkcrt, Ci.Rapo.so, F.P. Fleming,
M. (xreijido, M.S. Baida, and K. Matter
Tyrosine-phosphorylated and 741
nonphosphorvlated isoforms The cohesin Rec8 ap¬
of a-dystrobrevin: roles in skeletal pears on chromosomes
early in meiosis (red,
muscle and its neuromuscular top), before other co-
and myotendinous junctions hesins (green, bottom),
and persists until
R.M. Cirady, M. Akaaboime, A.L. Ciohen, anaphase I, suggesting
M..M. .Maimone, | AV. l.iehtman, and J.R. Sanes that Rec8 establishes
axial elements and en¬
sures sister chromatid
Differential regulation of cell motility 753
cohesion throughout
and invasion by FAK meiosis. See page 657.
n.A. Hsia, S.K. Mitra, C.R. Hauck,
D.N. Srreblow, J.A. Nelsttn, I). Hie,
S. Huang, F^ l.i, (i.R. Nemerow,
J. Feng, K.S.R. Spencer, D.A. Cberesh,
and n.D. Sclilaepter