Journal of Cell Biology 2002: Vol 159 Table of Contents

15 Pages·2002·0.72 MB·English

Editor-In-Chief
Ira Mellman
Editors
Lewis Cantley Louis F. Reichardt
Don W. Cleveland Randy Schekman
Elaine Fuchs Kenneth M. Yamada
Alan Hall
News Editors
Nicole LeBrasseur William A. Wells
Review Editors
Karen Dell Louis F. Reichardt
Editorial Board
Angelika Amon Scott Emr Gerard Karsenty Tom A. Rapoport
Kathryn Anderson Werner Franke Hynda Kleinman Anne Ridley
Ben Barres Larry Gerace Douglas Koshland Howard Riezman
Hugo Bellen Larry Goldstein Teymuras Kurzchalia Daniel B. Rifkin
Andrew Belmont Barry Gumbiner Arthur D. Lander David Ron
Vann Bennett Ulrich Hartl Jeanne Lawrence Mark Rose
Juan Bonifacino Rebecca Heald Leslie Leinwand Joshua Sanes
Tony Bretscher Nobutaka Hirokawa Richard Lewis Richard Scheller
Marianne Bronner-Fraser Arthur Horwich Laura Machesky Trina Schroer
EricJ. Brown Alan Rick Horwitz Joan Massague Martin Schwartz
Joan Brugge M. Andrew Hoyt Jacopo Meldolesi Jean Schwarzbauer
Kevin P. Campbell Tony Hunter Tom Misteli Shoichiro Tsukita
Caroline Damsky Ed Hurt Timothy J. Mitchison David L. Vaux
Pietro De Camilli Tony Hyman Randall T. Moon Graham Warren
Elisabetta Dejana Kenneth Jacobson David Morgan Colin Watts
Ray Deshaies Keith Joiner Leslie Parise Judith White
David Drubin Rudy Juliano Mark Peifer Junying Yuan
William Earnshaw Eric Karsenti Daphne Preuss Marino Zerial
Managing Editor
Michael T. Rossner
Tel.: [phone] | Fax: [phone]
E-mail: [email protected]
Volume 159, 2002
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Copyright © 2002 by The Rockefeller University Press
Volume 159 | No. 1
October 14, 2002
- News - - Research Articles -
In This Issue Reports
• Calcium increases the appetite The yeast DHHC cysteine-rich
• Big proteins Ran into import difficulties domain protein Akri p
• Neutrophils choose the right direction
is a paimitoyl transferase
• A GAP in COPI vesicle formation is filled
• Everyone needs a home A.F. Roth, Y. Feng, L. Chen, and N.G. Davis
N. LeBrasseur
Nogo-A expressed in Schwann cells
Research Roundup
impairs axonal regeneration after
• Old and unattracted 14 On the Cover peripheral nerve injury
• Electrical healing Calcium (green) prompts C. Pot, M. Simonen, O. Weinmann,
• MS as a disease of immaturity release of integrins L. Schnell, F. Christ, S. Stoeclde, P. Berger,
• The real role of reelin (white) in neutrophils. T. Riilicke, U. Surer, and M.E. Schwab
• Adenovirus takes the back door The integrins can then
congregate around the
W.A. Wells
phagocytic cup engulfing MAL2, a novel raft protein of the MAL
a b.a cterium. See page family, is an essential component
181
- Reviews - of the machinery for transcytosis
in hepatoma HepG2 cells
Mini-Reviews M.C. de Marco, F. Marn'n-Belmonte,
L. Kremer, J.P. Albar, 1. Correas, J.P. Vaerman,
Cajal bodies and coilin—moving 17 M. Marazuela, J.A. Byrne, and M.A. Alonso
towards function
Articles
S.C. Ogg and A.I. Lamond
Both midzone and astral microtubules
are involved in the delivery
of cytokinesis signals: insights
from the mobility of aurora B
M. Murata-Hori and Y.-l. Wang
Influence of cargo size on Ran
and energy requirements
for nuclear protein import
S.K. Lyman, T. Guan, J. Bednenko,
H. Wodrich, and L. Gerace
ARFGAP1 promotes the formation
of COPI vesicles, suggesting function
as a component of the coat
J.-S. Yang, S.Y. Lee, M. Gao, S. Bourgoin,
P.A. Randazzo, R.T. Premont, and V.W. Hsu
Articles with related stories in
the In This Issue section have
page numbers in red.
TGFp induces GDNF responsiveness 157
Articles (cont.)
in neurons by recruitment of GFRal
Calcium-regulated exocytosis to the plasma membrane
of dense-core vesicles requires the
H. Peterziel, K. Unsicker, and K. Kriegistein
activation of ADP-ribosylation factor
(ARF)6 by ARF nucleotide binding site
DAP-kinase induces apoptosis by 169
opener at the plasma membrane
suppressing integrin activity and
N. Vitale, S. Chasserot-Golaz, Y. Bailly, disrupting matrix survival signals
N. Morinaga, M.A. Frohman, and M.-F. Bader
W.-J. Wang, J.-C. Kuo, C.-C. Yao,
and R.-H. Chen
An intracellular signaling hierarchy
determines direction of migration
Cytosolic free Ca^^ changes and 181
in opposing chemotactic gradients
calpain activation are required for
B. Heit, S. Tavener, E. Raharjo, and P. Kubes P integrin-accelerated phagocytosis
by human neutrophils
Gabl and SHP-2 promote Ras/MAPK 103 A combination of bone
S. Dewitt and M.B. Fiallett
regulation of epidermal growth morphogenetic protein
(BMP) and retinoic acid
and differentiation
signaling can cause
T. Cai, K. Nishida, T. Hirano, and P.A. Khavari transdifferentiation of
preadipogenic cells (top)
into bone cells (bottom).
The LIM-only protein FHL2 interacts 113 See page 135.
with P-catenin and promotes
differentiation of mouse myoblasts
B. Martin, R. Schneider, S. Janetzky,
Z. Waibler, P. Pandur, M. Kiihl, J. Behrens,
K. von der Mark, A. Starzinski-Powirz,
and V. Wixler
Myogenic specification of side
population cells in skeletal muscle
A. Asakura, P. Seale, A. Girgis-Gabardo,
and M.A. Riidnicki
Bone morphogenetic protein and
retinoic acid signaling cooperate
to induce osteoblast differentiation
of preadipocytes
J. Skillington, L. Choy, and R. Derv’nck
Side population (SP)
.. ._ cells from muscle can
Insulin receptor substrate-2 maintains
' form hematopoietic col¬
predominance of anabolic function onies in vitro (top) but
over catabolic function of osteoblasts form muscle cells when
cocultured with other
T. Akune, N. Ogata, K. Hoshi, N. Kubota, muscle cells (bottom) or
Y. Terauchi, K. Tobe, H. Takagi, Y. Azuma, injected into a muscle.
T. Kadowaki, K. Nakamura, and H. Kawaguchi See page 123.
11
TThe^ Jo.u rnal of ^ |
Biolow
Volume 159 1 No. 2
October 28, 2002
- News - - Research Articles -
In This Issue
• A motor for neurofilaments Unfolded cholera toxin is transferred
• Initiate then elongate to the ER membrane and released
• Building the pore from protein disulfide isomerase
upon oxidation by Erol
• Chromosomal cliques
• Gazing into the gap B. Tsai and T.A. Rapoport
Tuberous sclerosis complex
Research Roundup tumor suppressor-mediated
On the Cover
S6 kinase inhibition by
• Choose a side DUP/Cdtl (red) oper¬
• Little PIP, little PIP, let me in ates close to ORC2 (yel¬ phosphatidylinositide-3-OH
low) during DNA kinase is mTOR independent
• Branching out requires VEGF (purple) replication ini¬
• An amidation a day keeps apoptosis away tiation at a fly chorion A. Jaeschke, J. Hankamp, M. Saitoh,
amplification region. At W. Roworth, T. Nobukuni, A. Hodges,
• Arrested cells are Mad as Hec a later, distinct stage of J. Sampson, G. Thomas, and R. Lamb
elongation DUP/Cdtl
N. LeBrasseur
continues to be active.
See page 225.
Visualization of replication initiation
- Reviews -
and elongation in Drosophila
J.M. Claycomb, D.M. MacAlpine, J.G. Evans,
Comments
S.P. Bell, and T.L. Orr-Weaver
The face of TSR revealed:
an extracellular signaling Chromosomes are predominantly
domain is exposed located randomly with respect to
each other in interphase human cells
R.L. Silverstein
M. N. Cornforth, K.M. Greulich-Bode,
B.D. Loucas, J. Arsuaga, M. Vazquez,
R.K. Sachs, M. Bruckner, M. Molls,
P. Hahnfeldt, L. Hlatky, and D.J. Brenner
Distinct cell cycle-dependent roles for
dynactin and dynein at centrosomes
N. J. Quintyne and T.A. Schroer
Assembly of centrosomal proteins
and microtubule organization depends
on PCM-1
Articles with related stories in A. Dammermann and A. Merdes
the In This Issue section have
page numbers in red; articles
with Comments have page
numbers in blue.
Articles (cont.) The L-type voltage-dependent 337
Ca^^ channel EGL-19 controls
Karyopherins in nuclear pore body wall muscle function
biogenesis: a role for Kap121p in Caenorhabditis elegans
in the assembly of Nup53p into
M. Jospin, V. Jacquemond, M.-C. Mariol,
nuclear pore complexes L. Segalat, and B. Allard
C. P. Lusk, T. Makhnevych, M. Marelli,
J.D. Aitchison, and R.W. Wozniak Identification of amino acid 349
residues lining the pore
Myosin Va binding to neurofilaments 279 Dominant-negative of a gap junction channel
PCM-1 (green) inhibits
is essential for correct myosin Va
microtubule (red) an¬ M. Skerrett, J. Aronowitz, J.H. Shin, G. Cymes,
distribution and transport choring but not nucle- E. Kasperek, F.L. Cao, and B.J. Nicholson
and neurofilament density ation at the centrosome.
See page 255.
M.V. Rao, L.J. Engle, P.S. Mohan, A. Yuan, Distinct claudins and associated PDZ 361
D. Qiu, A. Cataldo, L. Hassinger, S. Jacobsen, proteins form different autotypic tight
V.M-Y. Lee, A. Andreadis, J.-P. julien,
junctions in myelinating Schwann cells
P.C. Bridgman, and R.A. Nixon
S. Poliak, S. Matlis, C. Ullmer, S.S. Scherer,
and E. Peles
Ca^^-controlled competitive 291
diacylglycerol binding of protein
Crystal structure of the TSP-1 type 1 373
kinase C isoenzymes in living cells
repeats: a novel layered fold and its
J. C. Lenz, H.P. Reusch, N. Albrecht,
biological implication
G. Schultz, and M. Schaefer
K. Tan, M. Duquette, J.-h. Liu, Y. Dong,
R. Zhang, A. Joachimiak, J. Lawler,
Recapitulation of embryonic 303
and J.-h. Wang
neuroendocrine differentiation
in adult human pancreatic duct
cells expressing neurogenin 3
Y. Heremans, M. Van De Casteele, P. in’t Veld,
G. Gradwohl, P. Serup, O. Madsen, D. Pipeleers,
and H. Heimberg
Down-regulation of Delta 313
by proteolytic processing
K. Mishra-Gorur, M.D. Rand,
B. Perez-Villamil, and S. Artavanis-Tsakonas
Delta cleavage may be
important to down-
Central role of a7 nicotinic receptor 325 regulate Notch signaling,
in differentiation of the stratified as the Delta cleavage
product D1EC has little
squamous epithelium effect on eye develop¬
ment (top) compared to
j. Arredondo, V.T. Nguyen, A.l. Chernyavsky,
that of full-length Delta
D. Bercovich, A. Orr-Urtreger, W. Kummer,
(bottom). See page 313.
K. Lips, D.E. Vetter, and S.A. Grando
11
The Journal of ^ j
Biology Volume 159 | No. 3
November 11, 2002
- News - Research Articles -
In This issue
• cGMP steers axons home Gag proteins of the two Drosophila
• ECM communicates with MMP telomeric retrotransposons are
• Tension seals axons fate targeted to chromosome ends
• E-Cadherin in a stabilizing relationship
• Ribosomes pile up S. Rashkova, S.E. Karam, R. Kellum,
and M.-L. Pardue
N. LeBrasseur
Research Roundup Accumulation of endoplasmic
membranes and novel membrane-
• Flicking the chromosome-attachment On the Cover
switch bound ribosome-signal recognition
The f. coli SRP receptor
• Repressing differentiation particle receptor complexes
FtsY brings ribosomes to
• Switch to survival the membrane, even in in Escherichia coli
• An unlikely culprit in prion diseases the absence of the SRP.
A.A. Herskovits, E. Shimoni, A. Minsky,
• Transcriptional segregation Membrane-bound FtsY-
and E. Bibi
ribosome complexes ac¬
W.A. Wells
cumulate when down¬
stream components,
such as SecE (shown) or
- Reviews - SRP elements, are de¬ Signal recognition particle RNA
pleted. See page 403. localization within the nucleolus
Comments differs from the classical sites
of ribosome synthesis
Unchain my heart, baby let me go—
J.C. Politz, L.B. Lewandowski, and T. Pederson
the entry and intracellular transport
of HIV
Mutant DMPff 3-UTR
B. Sodeik
transcripts disrupt C2C12
myogenic differentiation
by compromising MyoD
J.D. Amack, S.R. Reagan, and M.S. Mahadevan
Rootletin, a novel coiled-coil protein,
is a structural component
of the ciliary rootlet
J. Yang, X. Liu, G. Yue, M. Adamian,
O. Bulgakov, and T. Li
Visualization of the intracellular
behavior of HIV in living cells
D. McDonald, M.A. Vodicka, G. Lucero,
Articles with related stories in
T.M. Svitkina, G.G. Borisy, M. Emerman,
the In This Issue section have
page numbers in red; articles and T.J. Hope
with Comments have page
numbers in blue.
Mechanical tension can specify axonal
Articles (cont.)
fate in hippocampal neurons
EGF controls the in vivo
P. I.amoureux, G. Ruthel, R.E. Buxbaum,
developmental potential of a and S.R. Heidemann
mammary epithelial cell line
possessing progenitor properties
ECM regulates MT1-MMP localization
M.-A. Deugnier, M.M. Faraldo, B. Janji, with pi or avp3 integrins at distinct
P. Rousselle, J.P. Thiery, and M.A. Glukhova HIV (green) uses dynein cell compartments modulating its
and microtubules of in¬ internalization and activity on human
A novel role for pi 20 catenin fected cells to migrate endothelial cells
to the nucleus. Without
in E-cadherin function
dynein (bottom cell), B.G. Galvez, S. Man'as-Roman, M. Yanez-M6,
R.C. Ireton, M.A. Davis, J. van Hengel, migration to the perinu¬ F. Sanchez-Madrid, and A.G. Arroyo
clear region is blocked.
D.J. Mariner, K.Barnes, M.A. Thoreson,
See page 441.
P.Z. Anastasiadis, L. Matrisian, L.M. Bundy,
L. Sealy, B. Gilbert, F. van Roy,
and A.B. Reynolds
Hsc70 is required for endocytosis
and clathrin function in Drosophila
H.C. Chang, S.L. Newmyer, M.J. Hull,
M. Ebersold, S.L. Schmid, and 1. Mellman
cGMP-mediated signaling via cGKIa is
required for the guidance and
connectivity of sensory axons
H. Schmidt, M. Werner, P.A. Heppenstall,
M. Henning, M.I. More, S. Kiihbandner,
G.R. Lewin, F. Hofmann, R. Feil,
and F.G. Rathjen
Fly telomeres consist of
HeT-A and TART ret-
rotransposons. The
HeT-A Gag protein as¬
sociates with fly telo¬
meres (top), but the
TART Gag does not
(bottom), unless the
HeT-A Gag is also
present. See page 397.
11
TThe^ Jo.u rnal of ^ |
IV-A^UL
Biolog^ Volume 159 No. 4
\
November 25, 2002
- News - Research Articles -
■M In This Issue
• Suicide attempt linked to breakdown The Xenopus Xmusi 01 protein is
• CLIPS to the rescue required for the recruitment of Cdc45
to origins of DNA replication
• ER takes a faster track
• Selecting synapse start sites R. A. Van Hatten, A.V. Tutter, A.H. Holway,
A.M. Khederian, J.C. Walter, and W.M. Michael
• A chaperone in motoneuron disease
A.W. Dove hNuf2 inhibition blocks stable
kinetochore-microtubule attachment
Research Roundup On the Cover
and induces mitotic cell death
• Viva the worm Synaptic machinery is in HeLa cells
delivered in TGN or¬
• Polyamino acids take amyloid form ganelles (green), which J.G. DeLuca, B. Moree, J.M. Hickey,
• Poking a hole in mitochondria are linked via spectrin J.V. Kilmartin, and E.D. Salmon
to clusters of NCAM
• Putting a cap on reinitiation (red). These clusters
translocate along neu- K-loop insertion restores microtubule
• Dendritic cells can be self sustaining
rites and are trapped at depolymerizing activity of a
sites of initial neurite-
N. LeBrasseur to-neurite contact. See "neckless" MCAK mutant
page 649.
Y. Ovechkina, M. Wagenbach, and L. Wordeman
Missense mutation in the tubulin-
specific chaperone E {Tbce) gene in
the mouse mutant progressive motor
neuronopathy, a model of human
motoneuron disease
H. Bommel, G. Xie, W. Rossoll, S. Wiese,
S. Jablonka, T. Boehm, and M. Sendtner
Activation of myosin V-based motility
and F-actin-dependent network
formation of endoplasmic reticulum
during mitosis
T. Wollert, D.G. Weiss, H.-H. Gerdes,
and S.A. Kuznetsov
REFI/Aly and the additional exon
junction complex proteins are
dispensable for nuclear mRNA export
Articles with related stories in D. Ciatfield and E. Iz^urralde
the In This Issue section have
page numbers in red.
Clustering of neuronal potassium 663
Articles (cont.)
channels is independent of their
Cytoplasmic linker proteins promote 589 interaction with PSD-95
microtubule rescue in vivo
M.N. Rasband, E.W. Park, D. Zhen,
Y.A. Komarova, A.S. Akhmanova, S.-i. Kojima, M.I. Arbuckle, S. Poliak, E. Peles,
N. Galjart, and G.G. Borisy S.G.N. Grant, and J.S. Trimmer
Iqgl p links spatial and secretion 601 Localized suppression of RhoA activity 673
landmarks to polarity and cytokinesis by Tyr31 /118-phosphorylated paxillin
in cell adhesion and migration
M.A. Osman, J.B. Konopka, and R.A. Cerione
A. Tsubouchi, J. Sakakura, R. Yagi, Y. Mazaki,
Recombinant expression of the 613 The tension exerted by a E. Schaefer, H. Yano, and FI. Sabe
laser trap on a fibronec-
voltage-dependent anion channel
tion-coated bead causes
enhances the transfer of Ca^^ the accumulation of Uroplakin lllb, a urothelial 685
microdomains to mitochondria GFP-vinculin (pseudo¬ differentiation marker, dimerizes
colored) around the with uroplakin lb as an early step
E. Rapizzi, P. Pinton, G. Szabadkai, bead. See page 695.
M.R. Wieckowski, G. Vandecasteele, G. Baird, of urothelial plaque assembly
R.A. Tuft, K.E. Fogarty, and R. Rizzuto F. -M. Deng, F.-X. Liang, L. Tu, K.A. Rcsing,
P. Fiu, M. Supino, C.-C.A. Hu, G. Zhou,
Membrane proximal lysosomes 625 M. Ding, G. Kreibich, and T.-T. Sun
are the major vesicles responsible
for calcium-dependent exocytosis The relationship between force 695
in nonsecretory cells and focal complex development
J.K. jaiswal, N.W. Andrews, and S.M. Simon C.G. Galbraith, K.M. Yamada,
and M.P. Sheet?.
A caspase cleavage fragment of pi 15 637
Additions and corrections 707
induces fragmentation of the Golgi
apparatus and apoptosis
R. Chiu, L. Novikov, S. Mukherjee,
and D. Shields
Neural cell adhesion molecule ^4^ VDAC allows the fast
diffusion of calcium
promotes accumulation
from ER release sites to
of TGN organelles at sites the inner mitochondrial
of neuron-to-neuron contacts membrane at regions
where mitochondria
V. Sytnyk, I. Leshchyns’ka, M. Deiling, (blue) overlap with ER
G. Dityateva, A. Dityatev, and M. Schachner (red). See page 613.