Journal of Cell Biology 2002: Vol 157 Table of Contents

15 Pages·2002·0.72 MB·English

V'olume 157 [ No. 1
April 1, 2002
- News - - Research Articles -
in this Issue Articles
• Clash of the titin 10 Bloom's syndrome protein is 19
• Seeing through the cilium required for correct relocalization
of RAD50/MRE11/NBS1 complex
• Peroxide perturbations
after replication fork arrest
• pl15 SNAREs a vesicle
A. Franchittoand P. Pichierri
• Topo II on the move
N. l.cBrasscur
Dynamics of human DNA 31
Research Roundup On the Cover topoisomerases I la and 11^
in living cells
. ~ A homologue of the al-
• Sticky polarity
gal intraflagellar trans¬ M.('). Christensen, M.K. Ijrsen.
• A BAFfling actin function port (IFT) protein IFT57 H.U. Barthelmes, R. Hock, C.L. Andersen,
(blue) is found at both
• An ES cell caution ends of the cilium (red) E. Kjeldsen, B.R. Knudsen, O. Westergaard.
F. Boege, and C. Mielkc
• Make junction, will travel that connects inner and
outer segments of verte¬
• A chemokine tug-of-war brate photoreceptors. Sequential tethering of Golgins 45
Defects in IFT proteins
W.A. VC'clls lead to a loss of photo¬ and catalysis of SNAREpin assembly
receptor structure. See by the vesicle-tethering protein pi 15
Features page 103.
J. Shorter, M.B. Beard, J. Seemann,
• Is transdifferentiation in trouble? 15 A.B. Dirac-Svejstrup, and C. NX'arren
'X'.A. Wells
Analysis of oxysterol binding 63
protein homologue Kesi p function
in regulation of Seel 4p-dependent
protein transport from the yeast
Golgi complex
X. l.i, M.P. Rivas, M. Fang, J. Marchena,
B. Mehrotra, A. C'haudhars-, L. Feng.
C'l.D. Presnvich, and V.A. Bankaitis
A cycle of Vam7p release from and 79
Ptdins 3-P-dependent rebinding
to the yeast vacuole is required
for homotypic vacuole fusion
C. B(K‘ddingh.ius, A.J. Mcr/., R. Ijage,
and C. Ungermann
Articles with related stories in
the In This Issue section have
page numbers in red.
Articles (cont.) Muscle-specific expression of 137
insulin-like growth factor I counters
Mammalian class E vps proteins 91 muscle decline in mdx mice
recognize ubiquitin and act
E.R. Barton, L. Morris, A. Musaro,
in the removal of endosomal N. Rosenthal, and H.L. Sweeney
protein-ubiquitin conjugates
N. Bishop, A. Horman, and P. Woodman Sre-mediated coupling of focal 149
adhesion kinase to integrin av^S
The intraflagellar transport 103 in vascular endothelial growth
protein, IFT88, is essential for An evolutionarily con¬ factor signaling
vertebrate photoreceptor served, multiprotein B.P. Eliceiri, X.S. Puente, J.D. Hood,
complex that partici¬
assembly and maintenance pates in protein target¬ LT.G. Stupack, D.D. Sehlaepter, X.Z. Huang,
C'l.J. Pa/.our, S.A. Baker, J.A. Deane, D.Ci. Cole, ing and cell polarity D. Sheppard, and D.A. Cheresh
B.L. Dickert, J.I.. Rosenbaum, (i.B. Witman, includes Palst/Stardust
(red) and Pals1-associ¬
and J.C. Besharse The Maguk protein, Palsl, functions 161
ated tight junction pro¬
tein (PAT))/Discs Lost as an adapter, linking mammalian
The anti-apoptotic activity of XIAP 115 (green). The complex is homologues of Crumbs and Discs Lost
found at tight junctions
is retained upon mutation
(blue). See page 161. M.H. Roh, O. Makarova, C.-J. l.iu, K.Y. Shin,
of both the caspase 3- and S. I,ee, S. ljurinee, M. Goyal, R. VC'iggins,
caspase 9-interacting sites and B. Margolis
J. Silke, C.J. Hawkins, P.G. Ekert, J. Chew,
C.L. Day, M. Pakusch, A.M. Verhagen, PECAM-1 (CD31) regulates a 173
and D.I.. V^aux hydrogen peroxide-activated
nonselective cation channel
Muscle-specific RING finger-1 in endothelial cells
interacts with titin to regulate
G. Ji, C;.D. O'Brien, M. Feldman,
sarcomeric M-line and thick filament Y. Manevich, P. Eim, ). Sun, S.M. Albelda,
structure and may have nuclear and M.l. Kotlikofi
functions via its interaction
with glucocorticoid modulatory
element binding protein-1 Overexpression of insu-
lin-like growth factor I
A.S. McElhinny, K. Kakinuma, H. Sorimachi, preserves muscle homo¬
S. Labcit, and C.C. Gregorio geneity and promotes
muscle hypertrophy in
mdx mice, a model for
Duchenne muscular
dystrophy. See page
137.
Volume 157 | No. 2
April 15,2002
- News - - Research Articles -
In this Issue Reports '
• Utrophin gets a new look A twin arginine signal peptide 205
• Consequences of a traffic jam and the pH gradient trigger
reversible assembly of the
• Knowing when to let go
thylakoid ApH/Tat translocase
• Adapting to the pit
H. Mori and K. C'linc
• For healthy eyes and bones: got Lrp?
A.>X'. Dove An inactive pool of GSK-3 at the 211
leading edge of growth cones is
Research Roundup On the Cover
implicated in Semaphorin 3A signaling
• Traffic jam suppresses immunity 1 Qfi LrpS,
a homologue of the B.j. Eickholt, F.S. Vi’alsh, and P. Oohert)'
• Proteases commit microbicide Drosophila arrow gene
that encodes a Wnt co¬ Articles
• Learning by palmitoylation
receptor, have a low
• Pressured into making a kidney bone mass phenotype The aurora kinase AIR-2 functions in 219
• From migration to circulation othuast flreaacdtus retos . sSpeoen tapnaeg¬e the release of chromosome cohesion
303. in Caenorhabditis elegans meiosis
N. LcBra.sscur
K. Rogers, J.l). Bishop, |.A. VC addle,
J.M. Schum.jcher, R. l.in
- Reviews -
Telomeres act autonomously 231
Mini-Reviews in maize to organize the meiotic
bouquet from a semipolarized
Simple centromere, complex 199
chromosome orientation
kinetochore: linking spindle
microtubules and centromeric P.M. (Arlton and VC’.Z. t!!ande
DNA in budding yeast
I.M. C'hce.scman, D.ti. Drubin, and Ci. Barnes
The utrophin actin-binding domain 242
binds F-actin in two different modes:
implications for the spectrin
superfamily of proteins
V.F,. Cialkin, A. Orlova, M.S. X'anLtHK'k, 1
I.N. Rybakova, J.M. Erv.asti, and K.H. Hgelman
Articles with related stories in
the In This Issue section have
page numbers in red.
C6/a 7-independent decrease in 303
Articles (cont.)
osteoblast proliferation, osteopenia,
Translocation of PKC0 in T cells is and persistent embryonic eye
mediated by a nonconventional, vascularization in mice deficient in
PI3-K- and Vav-dependent pathway, Lrp5, a Wnt coreceptor
A translocation com¬
but does not absolutely require plex in plant thylakoids M. Kato, M.S. Patel, R. Levasseur, 1. Lobov,
phospholipase C that uses a pH gradient B.H.-J. Chang, D.A. Cdass 11, Efartmann,
is dependent on a signal
M. V'illalba, K. Bi, J. Hu, Y. Altman, peptide for complex as¬ 1.. Li, T.-H. Hwang, C.F. Brayton, R.A. Lang,
P. Bushvvay, E. Rcits, J. Nec‘f)cs, G. Baier, sembly. See page 205. (]. Karscnty, and L. Chan
R.'I'. Abraham, and A. Altman
Slal p serves as the targeting 315
Coordinate interactions of Csk, Src, 265 signal recognition factor for
and Syk kinases with allb33 initiate NPFX„,2)-mediated endocytosis
integrin signaling to the cytoskeleton J.P. Floward. J.L. Hutton, J.XL Olson,
A. Obergtell, K. Eto, A. Mocsai, C. Buensuceso, and Ci.S. Payne
S.L. Moores, J.S. Brugge, C.A. Lowell,
and S.J. Shattil Overexpression of the myelin 327
proteolipid protein leads to
Specific SHP-2 partitioning in raft accumulation of cholesterol
domains triggers integrin-mediated and proteolipid protein in
signaling via Rho activation endosomes/lysosomes: implications
R. A. Lacalle, E. Mira, C. Cidmez-Moutdn, for Pelizaeus-Merzbacher disease
S. Jimenez-Baranda, C. Martmez-A.,
and S. Manes Inactive glycogen syn¬ XL Simons, FL-Xl. Kramer, P. Xlacchi,
thase kinase-3 (GSK-3; S. Rathke-Hartlieb, J. Frotter, K.-A. Nave,
green) colocalizes with and J.B. Schulz
The GTP binding proteins Gem and 291 actin fibers (red) at the
leading edge of neu¬
Rad are negative regulators of the
ronal cells, but its activ¬
Rho-Rho kinase pathway ity is required for
transduction of the
Y. Ward, S.-F. Yap, V. Ravichandran,
growth cone collapse
F. Matsumura, M. Ito, B. Spinelli, and K. Kelly
signal from Semaphorin
3A. See page 211.
Volume 157 j No. 3
April 29, 2002
- News - ~ Research Articles -
In this issue Articles
• The Golgi's central COG 344 Human Speedy: a novel cell cycle 357
• Bring in the SNAREs regulator that enhances proliferation
through activation of Cdk2
• Wnt defeats death
L.A. Porrer, R.'X’. Dellinger, ).A. Tynan,
• Cdc14p turns MEN on and off
H.A. Barnes, M. Kong, J.-l.. l.enormand,
• Death by autophagy and D.J. Donoghue
W.A. Vi clls
Regulation of the Bfal p-Bub2p 367
Research Roundup On the Cover
complex at spindle pole bodies by the
• Blood cells expand their numbers 346 These three-dimension¬ cell cycle phosphatase Cdcl 4p
al anaglyph images of
• Ras on the inside the conserved oligomer¬ Ci. Pereira. C. Manson, J. Cirindlay,
• Suicidal yeast ic Golgi (COG) complex and E.. Schiebel
(top four rows) are best
• A new member joins the yeast viewed with the stereo
filament party glasses available on the Dislocation and degradation from the 381
inside front cover of this ER are regulated by cytosolic stress
• Exchange is necessary for migration issue of the journal. See
N. l.cRrasscur page 405. J.K. VanSlyke and I..S. Musil
ARF-CAP-mediated interaction 395
- Reviews -
between the ER-Golgi v-SNAREs
and the COPI coat
Mini-Reviews
U. Rein, U. Andag, R. Duden, H.D. Schmitt,
The glutamine commute: 349 and A. Spang
take the N line and transfer to the A
Characterization of a mammalian 405
H.A. Chaudlir)-, R.J. Reimer, and R.H. E^dwards
Golgi-localized protein complex,
COG, that is required for normal
Golgi morphology and function
D. Ungar. T. Oka, E.E. Brittle, E. V'asile,
V'.V’. Lupashin, J.E. Chatterton, J.E. Heuser,
M. Kricger, and M.G. Waters
Mutant ubiquitin found in 417
neurodegenerative disorders is a
ubiquitin fusion degradation substrate
that blocks proteasomal degradation
K. l.indsten, F.M.S. de Vrij, L.Ci.G.C. Verhoef,
D.E. Fischer, F.W. van l.eeuwen, E.M. Hoi,
M.G. Masucci, and N.P. Dantuma
Articles with related stories in
the In This Issue section have
page numbers in red.
Articles (cont.) The integrin avp8 mediates 493
epithelial homeostasis through
Wnt signaling promotes oncogenic MTI-MMP-dependent activation
transformation by inhibiting ofTGF-pl
c-Myc-induced apoptosis
D. Mu, S. Cambicr, E. Fjcllbirkcland,
Z. You, D. Saims, S. C'hen, Z. Zhang, J.L. Baron, J.S. Munger, H. K.iwakatsu,
D.C. Guttridgc, K.-l. Guan, O.A. MacDougald, Heat shock (right) or D. Sheppard, V'.C], Broaddus, and S.E. Nishimura
A.M.C. Brown. CZ Evan, |. Kitajewski, other cytosolic stresses
and C-.-Y. Wang can reduce the disloca¬
tion of proteins from the Interactions of thrombospondins with 509
ER seen during ER- a4pi integrin and CD47 differentially
Intrinsic and extrinsic pathway 441 associated degradation
modulate T cell behavior
signaling during neuronal apoptosis: (ERAD). See page 381.
Z. Ei, M.J. C'alzada, J.M. Sipes, J.A. Cashel,
lessons from the analysis
1E('. Krutzsch, D.S. Annis, D.E. Mosher,
of mutant mice and D.D. Roberts
G.V. Putcha, C.A. Harris, K.E. Moulder,
R.M. Easton, C.B. Ehompson, Cosignaling of NCAM via lipid rafts 521
and E.M. Johnson, Jr.
and the FGF receptor is required
for neuritogenesis
DAP kinase and DRP-1 mediate 455
P. Nietbammer, M. Delling, V. Sytnvk,
membrane blebbing and the formation
A. l')ityatev, K. Fukami, and M. Scbachner
of autophagic vesicles during
programmed cell death
Additions and corrections 533
B. Inbal, ,S. Bialik, I. Sabanay, G. .Shani,
and A. Kimchi
Dynamics of ligand-induced,
Rad-dependent anchoring of
cadherins to the actin cytoskeleton
The behavior of a bead
M. Eambcrt, H. Choquet. and R.-M. Mcgc
coated with an N-cad-
herin ligand (asterisk)
Defective Rac-mediated proliferation 431 suggests that cadherin
anchoring to the actin
and survival after targeted mutation cytoskeleton is an adhe¬
of the Pi integrin cytodomain sion-triggered, Racl-
regulated process en¬
E. Hirsch. L. Barberis, M. Brancaccio, abling the transduction
O. Azzolino, I"). Xu, J.M. Kyriakis, of mechanical forces
L. Silengo, F.(). CJiancotti, G. Taronc, across the cell mem¬
R. Fassicr, and F. Altruda brane. See page 469.
-I
Volume 157 | No. 4
May 13, 2002
- News - - Research Articles -
In this issue Reports
• Turn-ons for axons The p75 receptor transduces 565
• Nuclear proteins get around the signal from myelin-associated
• Transcription in tight spaces glycoprotein to Rho
• A muscular job for spectrin
• Arresting development I. Yamashita. H. Higuchi, and .\1. Tohyama
A.Vi. Dove
Identification of myogenic-endothelial 571
Research Roundup
progenitor cells in the interstitial
• Playing FtsZ before sporulation On the Cover spaces of skeletal muscle
• Getting a GRIP on kinesin movement The NHPX protein tran¬ 1. l amaki, A. Akatsuka, K. Ando,
• Sorting it out, without clathrin sits through nuclear Y. Nakamura, H. Matsuzawa, T. Hotta,
• Connexin the dots speckles (blue) before R.R Roy, and \'.R. Edgerton
• Widening the target for cancer accumulating in Cajal
treatment bodies (red) and nucleoli Articles
N. LcBra,sscur (green). See page 615.
Spatial organization of active and 579
Meeting Report inactive genes and noncoding DNA
within chromosome territories
Stop That Cell: American Association 548
N.L. Mahy, P.F.. Perr)-, S. Gilchrist,
for Cancer Research San Francisco, CA
R.A. Baldtxk, and Bickmorc
April 6-10, 2002
W'.A.WcIls
The kinetically dominant assembly 591
pathway for centrosomal asters
- Reviews - in Caenorhabditis elegans
is y-tubulin dependent
Mini-Reviews E. Hannak, K. Gcgcma, M. Kirkham,
P. Gonezy, B. Habcrmann, and A.A. Hyman
Searching for the middle ground: 551
mechanisms of chromosome
Meiotic spindle stability depends 603
alignment during mitosis
on MAPK-interacting and spindle-
r.M. Kapoor and D.A. Crompton stabilizing protein (MISS), a new
MARK substrate
Secretory traffic in the eukaryotic 557
C. Lcfcbvrc, M.E, Eerret, A. Djianc,
parasite Toxoplasma gondih P. R.tssinicr, B. .\laro, and M.-H. V’crlhac
less is more
K.A. Joiner and H.S. Rck)s In vivo analysis of NHPX reveals 615
a novel nucleolar localization pathway
involving a transient accumulation
in splicing speckles
Articles with related stories in A.K.E. Leung and A.l. Ijmond
the In This Issue section have
page numbers in red.
Myogenic cell proliferation and 693
Articles (cont.)
generation of a reversible tumorigenic
The Sec34/Sec35p complex, a Ypti p phenotype are triggered by
effector required for retrograde preirradiation of the recipient site
intra-Golgi trafficking, interacts
J.E. Morgan, J.Ci. Ciross, C.N. Pagcl,
with Golgi SNAREs and COPI |.R. Beauchamp, A. l-'assati, A.J. Thrasher.
vesicle coat proteins J.P. Di Santo, l.B. Fisher, X. Shiwen,
D.J. Abraham, and F.A. Partridge
E.S. Suvorova, R. Dudcn, and V.V. l.upashin
Inducible dimerization of FGFR1: 703
Slyl protein bound to Golgi
development of a mouse model to
syntaxin SedSp allows assembly Signaling via syndecan-
and contributes to specificity 4 (red) modifies the re¬ analyze progressive transformation
sponse to fibroblast of tbe mammary gland
of SNARE fusion complexes
growth factor 2. See
R. Peng and D. C'lallwitz page 715. B.F. Welm, K.W. Freeman, M. Chen,
A. Contreras, D.M. Spencer, and J.M. Rosen
The NH2-terminal peptide 657
Fibroblast growth factor-specific 715
of a-smooth muscle actin
modulation of cellular response
inhibits force generation by the
by syndecan-4
myofibroblast in vitro and in vivo
A. Horowitz, F'. Fkachenko, and M. Simons
B. Hill/., C. Cahbiani, and C. Chaponnier
Additions and corrections 727
a spectrin is essential 665
for morphogenesis and
body wall muscle formation
in Caenorhabditis elegans
K.R. Norman and D.C. Moerman
Pineber, a pinocytic chaperone 679
for nerve growth factor/TrkA
signaling endosomes
In an inducible model for
Y. Shao, W. Akmentin, J.J. Foledo-Aral, mammary tumorigene-
J. Rosenbaum, CJ. Valdez, J.B. C!abot, sis, normal mammary
B.S. Hilbush, and S. Halegoua glands (top) show in¬
creased lateral budding
of the ductal epithelium
(bottom) after induction
of a receptor for fibro¬
blast growth factor. Sus¬
tained activation induces
hyperplasia and invasive
lesions. See page 703.
- News - Research Articles -
In this Issue Reports
• ROCK and Rho will never Dia 734 Ribosomal genes in focus: new 743
• Bundle loss makes turning possible transcripts label the dense fibrillar
• Blocking caspase-independent death components and form clusters
• Dynein takes its vimentin
indicative of "Christmas trees" in situ
• ROCK-steady centriole migration
N. l.cBrasscur K. Kobirna. |. M.ilinskv, A. I’liss, M. Masata,
J. V'ecerova, M. Fialov.i, J. Bidnar, and 1. Raska
Research Roundup
. Articles
• How to make a helix On the Cover
MAST/Orbit has a role in 749
• Cadherins jump into the pool
Actin bundles (green)
• A flipping permease provide a scaffold for microtubule-kinetochore
• Attack of the microvesicles the survival of protrud¬ attachment and is essential
• The transcription-export link ing microtubules (red), for chromosome alignment and
W.A. Wills and those microtubules maintenance of spindle bipolarity
determine the direction
of migration for a grow¬ H. Maiato. P. Sampaio, C.l,. Lcmos. J. Findlay.
- Reviews - ing axon. See page 839. M. C^irmcna, W.C. Earnshaw, and C.E. Siinkil
^ Comments The trefoil factor 1 participates in 761
gastrointestinal cell differentiation
Building an efficient factory: 739 by delaying G1-S phase transition
where is pre-rRNA synthesized and reducing apoptosis
in the nucleolus?
Bossinmcycr-Pourii, R. Kannan, S. Rihicras,
S. Huang C. Vi’cndling, 1. Stoll. L. Thim, C. 'I’omasitto.
and M.-C. Rio
Cyclosporin A inhibits caspase- 771
independent death of NGF-deprived
sympathetic neurons: a potential
role for mitochondrial
permeability transition
1 .K. C'hang and E.M. Johnson, jr.
Roles of fission yeast teal p in the 783
localization of polarity factors and in
organizing the microtubular
cytoskeleton
R. Bchrins and P. Nurse
Articles with related stories in
the In This Issue section have
page numbers in rcKl; articles
with Comments have page
numbers in blue.
Identification of a novel population
Articles (cont.)
of muscle stem cells in mice: potential
A requirement for cytoplasmic dynein 7 t' for muscle regeneration
and dynactin in intermediate filament
Z. Qu-Petersen, B. Dcasy, R. Jankowski.
network assembly and organization M. Ikczawa, J. C'ummins, R. Prucbnic.
B. I. Hclfand, A. Mikami, R.B. Vallce, J. Mytingcr, B. Cao, C. Cates, A. Wernig,
and R.D. C'loldman m and J. Huard
The Rho-associated protein kinase Tealp (yellow) moves Activated K-Ras and H-Ras display
pi 60ROCK is required for on the tip of growing different interactions with saturable
microtubules (green) to
centrosome positioning reach the ends of fission nonraft sites at the surface of live ceils
V. Chcvrier, M. Picl, N. C'ollomb, Y. Saoudi, yeast cells, where it lo¬ H. Niv, O. Cutman, Y. Kloog, and Y.l. Hcnis
calizes polarity factors
R. Frank, M. Baintrand, S. Narumiya, and helps to organize
M. Borncns, and D. Job microtubules. See page Dual functions of a4pi integrin in
783. epicardiai development: initial
ROCK and mDial antagonize migration and long-term attachment
in Rho-dependent Rac activation
|.K. Scngbusch, W. He, K.A. Pinco,
in Swiss 3T3 fibroblasts and J.’F. Yang
F. 1 suji, F. Ishizaki, M. Okamoto, Hitjashida,
K. Kimura, F. Furuvashiki, Y. Arakawa, Laminin-1 redistributes postsynaptic
R.B. Birgc, T. Nakanioto. H. Flirai,
proteins and requires rapsyn, tyrosine
and ,S. Narumiya
phosphorylation, and Sre and Fyn to
stably cluster acetylcholine receptors
LIM kinase and Diaphanous cooperate
to regulate serum response factor and P.A. Marangi, S. I. W'ieland, and C.. Fuhrer
actin dynamics
C). Cicnestc, J.W. Copeland, and R. Freisman
Focal loss of actin bundles causes
The microtubule-associ¬
microtubule redistribution and growth ated protein MAST/Or-
cone turning bit is required for
functional kinetochore
F.-Q. Zhou, C..\1. Waterman-Storer, attachment. See page
and C^.S. C^ohan 749.