Journal of Cell Biology 2001: Vol 154 Table of Contents

15 Pages·2001·0.77 MB·English

Editor-in-Chief
Ira Mellman
Editors
Lewis Cantley Louis F. Reichardt
Don W. Cleveland Randy Schekman
Elaine Fuchs Kenneth M. Yamada
News Editor
William A. Wells
Review Editors
Karen Dell Louis F. Reichardt
Editorial Board
Angelica Amon Werner Eranke Hynda Kleinman Anne Ridley
Kathryn Anderson Larry Gerace Douglas Koshland Howard Riezman
Ben Barres Larry Goldstein Arthur D. Lander Daniel B. Rifkin
Hugo Bellen Barry Gumbiner Jeanne Lawrence David Ron
Andrew Belmont Alan Hall Leslie Leinwand Mark Rose
Vann Bennett Ulrich Hartl Richard Lewis Joshua Sanes
Juan Bonifacino Rebecca Heald Laura Machesky Richard Scheller
Fony Bretscher Nobutaka Hirokawa Joan Massague Trina Schroer
Marianne Bronner-Fraser Arthur Horwich Jacopo Meldolesi Martin Schwartz
Erie]. Brown Alan Rick Horwitz Timothy ]. Mitchison Jean Schwarzbauer
Kevin P. Campbell M. Andrew Hoyt Randall T. Moon Shoichiro Tsukita
Caroline Damsky Tony Hunter David Morgan David L. Vaux
Pietro De Camilli FLd Hurt Bjorn Olsen Graham Warren
Elisabetta ITejana Pony Hyman Leslie Parise Colin Watts
Ray Deshaies Keith Joiner Mark Peifer Judith White
David Drubin Rudy Juliano Daphne Preuss Junying Yuan
William Earnshaw Eric Karsenti xMartin Raff .Marino Zerial
Scott Emr Gerard Karsenw Tom Rapoport
Managing Editor
Michael T. Rossner
Tel.: [phone] | Fax: [phone]
E-mail: [email protected]
Volume 154, 2001 Editorial Assistants
Jackie Holloway | Helen Lee | Sati Motieram j Heather \'lach
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News - - Research Articles -
Editorial Reports
Ceil biology's journal gets a new look 9 ZNF265—a novel spliceosomal
1. Mcliman protein able to induce alternative
splicing
In this Issue
I).J. .Adams, 1.. van dcr Weyden, .A. Mayeda,
• Long live the pore 10 S. .Stamm, B.J. Morris, and J.F.J. Rasko
• RhoA brings up the rear
• Transcription in tight quarters Articles
• Cataracts and NrCAM
Large-scale chromatin decondensation 33
• How Toxoplasma hooks up On the Cover
• Clumping lysosomes and recondensation regulated by
Monocytes inhibited for
transcription from a natural promoter
A.W. Dove RhoA can still crawl for¬
wards, but they fail to W.C'i. .Miiller, D. XA'alker, G.I.. H,igcr. and
Research Roundup pick up their back ends. J. G. .McNally
The trailing tails are
• Translation in the nucleus 12 packed with integrin ad¬
• Algal Rb sets size limits hesions. See page 147. Normal telomere length and 49
• Containing the bullet Cover design based chromosomal end capping in
• Taking tea with actin and microtubules on a concept by Leslie poly(ADP-ribose) polymerase-deficient
• Microtubules concentrate Thomas, Heidelberg,
Germany. mice and primary cells despite
W'.A. Wells increased chromosomal instability
Meeting Report K. Samper, F..A. Goytisolo,
|. Menissier-de Murcia, F. Cionz.ilez-Suarez,
Death and Destruction: The Cold 14 I.C!. Cigudosa, ti. de .Murcia, and .M..A. Blasco
Spring Harbor Meeting on Proteolysis
and Biological Control. May 2-6, 2001 A role for nuclear lamins in nuclear 61
W.A. Wells envelope assembly
R.l. l.opez-Soler. R.F). .Moir, F.P. Spann,
- Reviews - R. Stick, and R.!"). Cioldman
Nuclear pore complexes form 71
Comments’'
immobile networks and have a very
Nuclear pore complexes: dynamics in 17 low turnover in live mammalian cells
unexpected places
.N. l^aiglc, J. Bcaudouin. 1.. Hartnell, tj. Imrch,
S.K. l.yman and 1.. Gerace FI. Hallhcrg, 1. I.ippincott-Schwartz, and
|. Fllcnbcrg
Fishing out proteins that bind to titin 21
Activity of the APC*'*"’’ form of the 85
J.W. Sanger and J,.M. Sanger
anaphase-promoting complex persists
until S phase and prevents the
Articles with related stories in
the In This Issue section have premature expression of Cdc20p
page numbers in red; articles
J.N. Fluang, 1. Park. F. Fllingson,
with Comments have page
numbers in blue. I..F. I ittlcpagc. and H. Pcilman
Vav2 is required for cell spreading
Articles (cont.)
P,A, Marignani and CEE, CEirpenter
The Toxoplasma gondii protein ROP2
mediates host organelle association
Targeted ablation of NrCAM or
with the parasitophorous vacuole
ankyrin-B results in disorganized lens
membrane
fibers leading to cataract formation
A.l’. Sinai and K.A. Joiner
M.l, More, E,-P, Kirsch, and E,(E Rathjen
Human VamSp promotes lysosome
The colocalization of novel role for FGF and extracellular
clustering and fusion in vivo connexin 43 (green)
signal-regulated kinase in gap
with pi 20 catenin (red)
S. C'aplan. L.M. Hartnell, R.C. Aguilar, has implications for mo¬ junction-mediated intercellular
N, N'aslavskv, and 1,S, Bonilacino tility in cardiac neural communication in the lens
crest cells. See page 61.
A.-C.N. Ee and E.S. .Mu.sil
Obscurin, a giant sarcomeric Rho
guanine nucleotide exchange factor
Modulation of mouse neural crest cell
protein involved in sarcomere
motility by N-cadherin and connexin
assembly
43 gap junctions
P, d oling, E, Ehler, and .\1. Gautel
X. Xu, \N .E,E Ei, C,'>’, Eluang, R, Mever,
r, Cdicn, V, Euo, .\EP, T homas, Ct,E, Radicc,
Myosin II dynamics and cortical flow andCEW, Eo
during contractile ring formation in
Dictyostelium cells
Multiple cadherin extracellular
repeats mediate homophilic binding
and adhesion
RhoA is required for monocyte tail
,S. C'happuis-lTamcnt, E, W’ong, E.D, Hicks
retraction during transendothelial CE.NE Kav, and B,M. C'lumhiner
migration
R,A, W’orthylake, S. l.emoine, Watson,
and K, Burridge
The LD4 motif of paxillin regulates
cell spreading and motility through an Normal nuclear enve¬
lope assembly (top) is
interaction with paxillin kinase linker
disrupted by interfering
(PKL) with lamins (bottom).
See page 217.
K,A, 'X'est, FE /hang, M,(E Brown,
S,N, Nikolopoulo.s, .NEC, Riedy, A.E, Horwitz,
and CEE, 1 timer
11
The journal of ^ |
Bioiog^ Volume 154 1 No. 2
July 23, 2001
News - - Research Articles -
In this issue
Of coilin and Cajal bodies Regulation of limb patterning by
A dystroglycan ligand in the brain extracellular microfibrils
Matrix patterning of digits
Bringing channels into the node E. Artcaga-Solis. B. tlayraud, S.Y. Lee, L. Shum,
Tenascin turns on the EGFR L. Sakai, and F, Ramirez
K. jcgalian
Research Roundup The replication timing program
of the Chinese hamster ^-globin
Fail-safe replication On the Cover
Tensegrity lives locus is established coincident
Christmas in )uly Lack of a matrix compo¬ with its repositioning near peripheral
nent (fibrillin 2) leads to
Keeping the lid on destruction a limb-patterning defect heterochromatin in early G1 phase
1 .M. Powicdgc in mice (bottom). Tbe
F, 1.1, J, ('hen, ,\1. l/iimi, .\1.C. Butler,
syndactyly in tbe mutant
S.M. Keezer, and Gilbert
mice is primarily due to
- Reviews - a defect in mesenchyme
differentiation ratber Residual Cajal bodies in coilin
than a reduction in
knockout mice fail to recruit Sm
Comments apoptosis of interdigital
tissue. See page 275. snRNPs and SMN, the spinal
Mystery solved: discovery of a novel muscular atrophy gene product
integrin ligand in the developing kidney
K.E. Fucker, .\1.1. Berciano, E.V. Jacobs,
D. F. LePage, K.B. Shpargei, J.j. Rossire,
E. K,E, Chan, M, Eatarga, R,.\. Conlon,
Mini-Reviews and A,G. ,\latera
Mitosis, microtubules, and the matrix
Targeting of an abundant cytosolic
J.M. Scholey, ti.C], Rogers, and D.J. Sharp
form of the protein import receptor
atTocl59 to the outer chloroplast
Hsp90: a specialized but essential
membrane
protein-folding tool
A. Hiltbrunner, J, Bauer, P.-A. \’idi, S, Intanger,
J.C. \’oung, 1. Moarefi, and F.U. Idartl P, W'eibei, \E Hoh\v\,and E, Kessler
Golgi clusters and vesicles mediate
mitotic inheritance independently
of the endoplasmic reticulum
F^, jokitalo, N. ('abrera-Poch, G. VCarren, and
l').’F, Shima
Articles with related stories in
the In This Issue section have
page numbers in red; articles
with Comments have page
numbers in blue.
mua-3, a gene required 415
Articles (cont.)
for mechanical tissue integrity
Adenovirus E4orf4 protein induces in Caenorhabditis elegans, encodes
PP2A-dependent growth arrest a novel transmembrane protein
in Saccharomyces cerevisiae and of epithelial attachment complexes
interacts with the anaphase-promoting
M. Bcrcher, J. M'ahl, B.E. V'ogcl, C. l.u.
complex/cyclosome E.M. Hcdgccock, D.EE Hall, and J.I). PlcncEisch
D. Kornitzer, R. Shart, and T. Klcinbcrgcr
Sodium channel and P3 subunits 427
Novel p62dok family members, dok-4 associate with neurofascin through
MU P-4 (red) is required
and dok-5, are substrates of the c-Ret for mechanical coupling their extracellular immunoglobulin¬
receptor tyrosine kinase and mediate of tissues in the worm. like domain
See page 403.
neuronal differentiation C.E. Ratclille, R.EE Wcstcnhrock, R. Curtis,
J. Grimm, M. Sachs, S. Britsch, S. Di Cesarc, and W.A. Ciattcrall
r. Schwarz-Romond, K. Alitalo, and W. Birchmeier
A stoichiometric complex of neurexins 435
Regulation of presynaptic 355 and dystroglycan in brain
phosphatidylinositol 4,5-biphosphate S. Sugita, E. Saito, J. Pang, J. Satz,
by neuronal activity K. Camphell. and 1 .C. Siidhot
K.D. Micheva. R.W. Holz, and S.J. Smith
Identification and characterization 447
Vitamin D3 promotes the 369 of a novel extracellular matrix protein
differentiation of colon carcinoma cells nephronectin that is associated with
by the induction of E-cadherin and integrin aSpi in the embryonic kidney
the inhibition of ^-catenin signaling R. Brandcnhcrgcr, A. Schmidt. J. Linton,
I). Wang, C. Backus, S. I^cnda, U. Miillcr,
H.G. Palmer, J..\t. Gonzalez-Sancho, J. Espada,
and I..E. Reichardt
M.T. Bcrciano, I. Puig. J. Baulida, M. Quintanilla,
A. Cano, A.G. de Elerreros, M. Eatarga,
and A. .Munoz Epidermal growth factor (EGF)-like 459
repeats of human tenascin-C as
Vaccinia virus utilizes microtubules ligands for EGF receptor
for movement to tbe cell surface Vitamin promotes co¬
C.S. Swindle, K. 1. I ran, l .D. Johnson,
lon carcinoma cell dif¬
M. Hollinshead, G. Rodger, H. Van Eijl, ferentiation by inducing P. Banerjee, A.M. Mayes, 1.. Griffith, and A. M'ells
.M. l.aw, R. Elollinshead, D.J.’l. Vaux, the expression of E-cad¬
and G.L. Smith herin (red) and thus the Additions and corrections 469
translocation and colo¬
calization of |3-catenin
MU P-4 is a novel transmembrane 403 (green). See page 369.
protein with functions in epithelial cell
adhesion in Caenorhabditis elegans
L. Eiong, 1. Elhl, J. Ward, C. Eranzini-.Armstrong,
K.K. Ryhicka, B.K. Gatewood, E).I. Baillie,
and E..A. Bucher
In this Issue Reports
• Putting cell polarity on the map 478 Activated platelets mediate 485
• How to survive a macrophage attack inflammatory signaling by regulated
• Deleting keratins to find one interleukin I3 synthesis
• ARNO gets things moving S. Lindcmann, N.D. 1 ollcy, D.A. Dixon,
• The hidden power of platelets T .M. MclnrvTf, S.M. Prescott,
Ci.A. Zimmerman, and A.S. We\ ric
A.W'. Dove
Junctional adhesion molecule (JAM) 491
On the Cover
Research Roundup binds to PAR-3: a possible mechanism
A protein interaction for the recruitment of PAR-3 to tight
• Sudden bacterial death syndrome 430 map for cell polarity in
junctions
yeast reveals new con¬
• A nurse for bicoid
nections between cellu¬ M. Itoh, H. Sasaki, M. Fiiruse, H. (^/aki,
• Formin a link to microtubules lar processes, and new
r. Kita, and S. I'sukita
• Transcription gets a licence candidate yeast polarity
factors such as Ypr171w
• Touching cells transform (localization pictured in
overlay). See page 549. Articles
W'.A. Wells
RNA-mediated interaction of 499
Cajal bodies and U2 snRNA genes
Meeting Report
M.R. Frey and A.Ci. Matera
Biotechnology on Parade: BIO 2001 482
San Diego, CA June 24-27, 2001
Barentsz is essential for the posterior 511
W.A. Wells localization of oskar mRNA and
colocalizes with it to the posterior pole
F.J.M. van Eedcn, l..\l. Palacios, M. Petronezki.
M.J.D. Weston, and D. St Johnston
Head-to-tail oligomerization of 525
calsequestrin: a novel mechanism
for heterogeneous distribution of
endoplasmic reticulum luminal
proteins
C'l. Clatti, S. Tritari, N. Mesaeli. Parker,
\l. Michalak, and j. Meldolesi
Articles with related stories in
the In This Issue section have
page numbers in red.
Myosin light chain kinase binding
Articles (cont.)
to a unique site on F-actin revealed
Clathrin-dependent and -independent by three-dimensional image
internalization of plasma membrane reconstruction
sphingolipids initiates two Golgi
V. Match, G. Zhi, E. Smith, J. I . Stull,
targeting pathways R. (Yaig, and W. Echman
V'. Puri. R. 'OC'atanabc, R.l). Singh,
M. Dominguez, J.C^ Brown, C.L. Wheatley, Discovery of a novel murine keratin 6
D.L. Marks, ami R.E. Pagano
(K6) isoform explains the absence of
hair and nail defects in mice deficient
A protein interaction map for ceil
for K6a and K6b
polarity development Barentsz colocalizes
with oskar mRNA (see S. .M. 'X'ojcik, M.A. l.ongley, and D.R. Roop
B.L. Drees, B. Sundin, E. Brazeau, above) and is necessary
|.P. Caviston, G.-C. Chen, W. Ciuo, for oskar mRNA's polar
Role of phosphatidylinositol 3-kinase
K. G. Kozminski. MAX'. I.au, I.J. Moskow, localization. See page
A. long, 1..R. Schenkman, A. McKenzie 111, 511. and Rab5 effectors in phagosomal
P. Brennwald. M. Longtinc, E. Bi, C. C'han, biogenesis and mycobacterial
P. Novick, C. Boone, J.R. Pringle, E.N. Davis, phagosome maturation arrest
S. Fields, and D.G. Drubin
R. A. Fratti, j.M. Backer, j. Grticnbcrg,
S. Corvera, and \'. Derctic
Expression of a-catenin in a-catenin-
deficient cells increases resistance to
High resolution mapping of mast cell
sphingosine-induced apoptosis
membranes reveals primary and
S. .Marsubara and M. Ozawa secondary domains of FceRI and LAT
B.S. Wilson, J.R. Plcillcr, Z. Stirviladzc,
Neuronal survival induced by E.A. Gaudet, and J.M. CMivcr
neurotrophins requires calmodulin
J. Egea, C. Espinet, R.M. Soler, X. Dolcet, Coordinated expression of matrix Gla
V.J. Yuste, M. Encinas, M. Iglesias, protein is required during endochondral
N. Rocamora, and J.X. Cornelia
ossification for chondrocyte survival
B. Newman, L.l. Gigout, E. Sudre, .Vl.Fl. Grant,
Activation of ARF6 by ARNO
and G.A. Wallis
stimulates epithelial cell migration Sphingomyelin uptake
through downstream activation of occurs via two path¬
ways, one of which can
both Rad and phospholipase D be perturbed by high
cholesterol. See page
L. C. Sanr\' and J.E. Casanova
Volume 154 | No. 4
August 20, 2001
- News - - Research Articles -
in this Issue^ Reports
• Cross-linking can be good 674 Centromere identity in Drosophila is 683
• CENP-E falls off not determined in vivo by replication
• Zones and rings in wound healing timing
• Making virus in the axon B. Sullivan and tl. Karpcn
• Compartmentalized insulin signaling
W'.A. Wells The BPAGl locus: alternative splicing 691
produces multiple isoforms with
Research Roundup
distinct cytoskeletal linker domains,
On the Cover
• Garbage in, garbage out 676 When Duox is prevent¬ including predominant isoforms in
• Running interference ed from crosslinking the neurons and muscles
tyrosines of cuticular
• Cell cycling with Rac C. L. l.vung, M. Zheng, S.-\!. Prater,
collagen, the layers of
and R.K.H. l.iem
• The (formerly) missing link the worm cuticle detach
from each other. See
• Shedding light on protein folding
page 881. Regulation of cytokine-independent 699
1. Powiedgc
survival kinase (CISK) by the Phox
homology domain and
- Reviews - phosphoinositides
J, Xu, 1), Liu, G, Gill, and Z, Songyang
Mini-Reviews
Articles
Abpi p and cortactin, new "hand¬ 679
Elevating the level of Cdc34/Ubc3 707
holds" for actin
ubiquitin-conjugating enzyme in
l.M. Ola/.iibal and I..M. Macheskv
mitosis inhibits association of CENP-E
with kinetochores and blocks
metaphase alignment of chromosomes
l.,M, Topper, H. Bastians, J,V. Ruderman,
and CL). Gorbskv
Thylakoid ApH-dependent precursor 719
proteins bind to a cpTatC-Hcfl 06
complex before Tha4-dependent
transport
R. Cdine and H. .Mori
Articles with related stories in
the In This Issue section have
page numbers in red.
v-Src phosphorylation of connexin 43 815
Articles (cont.)
on Tyr247 and Tyr265 disrupts gap
The discrepancy between presenilin 731 junctional communication
subcellular localization and
k. kin. B.J. 'X'arn-C.ramer, W'.l'.. Kurata.
y-secretase processing of amyloid and A.F. I.aii
precursor protein
1’. Capers, M. Ik'iitahir, K. Oacssaens, Lipid raft microdomain 829
I. Orlans, H. X’andersrichclc, P. .Sahig, compartmentalization oftCIO is
B. Dc Strooper, and W. Annacrt
required for insulin signaling and
GLUT4 translocation
A conserved a-herpesvirus protein 741 Centromeric chromatin
(on a minichromosome R. r. W arson. S. .Shigematsu. ' -H. Chiang,
necessary for axonal localization of
indicated by the arrow) S. Mora. M, Kan/aki, l.('i. Ma ara. A.R. Saltiel.
viral membrane proteins is functional despite and |.F. Pessin
replicating neither early
M.j. l omishima and I..\V. Hnquist
(red) or late (green) in S
phase. See page 683. LAD-1, the Caenorhabditis elegans 841
Disruption of cytoskeletal integrity 753 LI CAM homologue, partit ipates in
impairs Gj-mediated signaling due to embryonic and gonadal
displacement of Gj proteins morphogenesis and is a substrate for
fibroblast growth factor rt ceptor
W. Bloch, . I an, J. Han, ,S. Xuc,
T. ,Schdnchcrg, C. Ji, Z.J. l.u, M, W’althcr, pathway-dependent phosphotyrosine-
R, l assIcT, J. Hc'schfler, K. Addicks, based signaling
and B.K. Flcischmann
1 . Cdtcn, B. Oni;. and \'. Bcnn tt
Simple epithelium keratins 8 and 18 763
The AP2 binding site of synaptotagmin 857
provide resistance to Fas-mediated
1 is not an internalization signal but a
apoptosis. The protection occurs
regulator of endocytosis
through a receptor-targeting
modulation N. laroussc and R.B. Kcllv
S. Cilbcrt, A. l.orangcr, N. Daigle,
and Marceau CRYP-2/cPTPRO Is a neurite 867
inhibitory repulsive guidance cue for
retinal neurons in vitro
Comparisons of CapG and gelsolin-
null macrophages: demonstration of a I- Stcpanck. Q.k. .Sun. j. W'ang. C.. Wang,
unique role for CapG in receptor- and j.l . Bixb\
mediated ruffling, phagocytosis, and
vesicle rocketing Tyrosine cross-linking of extracellular 879
matrix is catalyzed by Duox, a
W'itke, W. l.i, D.|, Kwiatkovvski,
and I'..S. Southwick multidomain oxidase/peroxidase with
homology to the phagocyte oxidase
An amyloid precursor subunit gp91pbox
Contraction and polymerization protein (APP) derivative
cooperate to assemble and close (green) that is retained \\ .A. Fklcns, 1.. Sliarling. C'l. (dicng. R. Shapira.
actomyosin rings around Xenopus in the ER colocalizes J..M. Kinkadc. F. l.cc. H.A. kdens X. Fang.
with presenilin 1 (PS1; Sullards. l^.B. Flahert}-. (I.M. Bcnian.
oocyte wounds red) but shows little or and j.n. l.ambcrh
C.A. Mandate) and \X’,M. Bement no processing. This is
further evidence that
PS1 may not be suffi- Additions and Corrections 893
Impaired skin wound healing in 799 cient for APP process¬
ing. See page 731.
peroxisome proliferator-activated
receptor (PPAR)a and PPAR(3 mutant
mice
I, . Michalik, B. Desvergne, N.S. I'an,
S. Basu-Mi)dak, B. Eschcr, J, Rieusset,
J. M. Peters, C. Kaya, F,|. Conzalez,
J. Zakany, I). Metzger. P, Chambon,
I). Duboule, and W. Wahli