Journal of Applied Toxicology 2004 Volume 24 JJATDK 24(1-6) 1-532 (2004) ISSN 0260-437X ty WILEY Publishers Since 1807 Chichester - New York - Weinheim - Brisbane - Singapore - Toronto Journal of Applied Toxicology (J Appl Toxicol) AN INTERNATIONAL JOURNAL EDITOR-IN-CHIEF EUROPEAN EDITOR Harry Salem Philip W. Harvey Edgewood Chemical & Biological Center Covance Laboratories UK Ltd., Toxicology AMSSB-RRT, Building E3330/143 Otley Road Aberdeen Proving Ground Harrogate MD 21010-5424 North Yorkshire USA HG3 IPY UK Tel: +1 410 436 3034 Fax: +1 410 436 3930 Tel: +44 (1423) 84842] E-mail: [email protected] Fax: +44 (1423) 569595 E-mail: [email protected] ASSISTANT EDITOR FOUNDING EDITOR Teresa Rudd Michael Greenwood EDITORIAL ADVISORY BOARD J. Ashby D. Lison Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, UK Catholic University of Louvain, Belgium P. Baldrick E. A. Lock Covance Laboratories Ltd., Harrogate, UK Medical University of South Carolina, Charleston, SC, USA B. Ballantyne H. Maibach Union Carbide Corporation, Danbury, CT, USA University of California Medical School, San Francis S. I. Baskin M. McFarlane US Army Medical Research Institute of Chemical Defense, MD, USA GlaxoSmithKline, Ware, UK J. R. Beall J. J. McGrath US Department of Energy, Washington, DC, USA Department of Physiology, Texas Tech University, Lubbock, TX, USA D. Benford N. A. Monteiro-Riviere Food Standards Agency, London, UK North Carolina State University, Raleigh, NC, USA J. F. Borzelleca P. J. Nicholls Medical College of Virginia, Richmond, VA, USA Welsh School of Pharmacy, Cardiff, UK W. J. Brock T. Norseth Unilever Research-US, Edgewater, NJ, USA Institute of Occupational Health, Oslo, Norwa N. Chernoff R. A. Parent US Environmental Protection Agency, NC, USA Consultox Ltd, Damariscotta, ME, USA J. Descotes G. Reddy Lyon Poison Centre, Lyon, France US Army Center for Health Promotion and Preventive Medicine S. W. Ernst Aberdeen, MD, USA AstraZeneca R&D, Mélndal, Sweden S.C. Sahu D. J. Everett USFDA Division of Toxicological Research, Laurel, MD, USA Covance Laboratories Ltd., Harrogate, UK H. Satoh V. Eybl Tohoku University Graduate School of Medicine, Sendai, Japan Charles University Faculty of Medicine, Pilsen, Czech Republic K. Savolainen S. C. Gad National Public Health Institute, Kuopio, Finland Gad Consulting Services, Cary, NC, USA V. M. Seabaugh P. Goldfarb Falls Church, VA, USA University of Surrey, Guildford, UK S. Green D. E. Sharp Howard University, Washington, DC, USA Purdue Pharma L.P., Ardsley, NY, USA S. Halbach A. G. Smith GSF Research Centre, Neuherberg, Germany MRC Toxicology Unit, University of Leicester, UK G. Healing R. Snyder AstraZeneca, Alderley Park, Macclesfield, UK EOHSI Busch Campus, Piscataway, NJ, USA R. Kapp, Jr H. Soreq BioTox, Richmond, VA, USA The Hebrew University of Jerusalem, Israel A. C. Katz R. G. Tardiff TOXCEL, Haymarket, VA, USA The Sapphire Group Inc., Bethesda, MD, USA S. A. Katz R. Valentine Rutgers University, Camden, NJ, USA E. 1. du Pont de Nemours & Co., Newark, DE, USA F. Koschier E. K. Weisburger Pfizer Inc., Morris Plains, NJ, USA Rockville, MD, USA K. Kostial C. Winder Institute for Medical Research & Occupational Health, Zagreb, Croatia University of New South Wales, Sydney, Australia K. Krishnan C. Winek University of Montreal, Canada Duquesne University, Pittsburgh, PA, USA JOURNAL OF APPLIED TOXICOLOGY J. Appl. Toxicol, 24, iti—vi (2004) Contents of Volume 24 NUMBER | JANUARY/FEBRUARY 2004 Editorial Significance of the Detection of Esters of p-Hydroxybenzoic Acid (Parabens) in Human Breast Tumours P. W. HARVEY AND D. J. EVERETT Research Articles Concentrations of Parabens in Human Breast Tumours P. D. DARBRE, A. ALJARRAH, W. R. MILLER, N. G. COLDHAM, M. J. SAUER AND G. S. POPI Microarray Profile Analysis of Toxic Cocaine-induced Alterations in the Expression of Mouse Brain Gene Sequences: a Possible ‘Protective’ Effect of Buprenorphine I. HAYASE, Y. YAMAMOTO, K. YAMAMOTO, E. MUSO AND K. SHIOTA Protective Effect of a-Lipoic Acid against Chloroquine-induced Hepatotoxicity in Rats L. PARI AND P. MURUGAVEL Role of Caffeic Acid Phenethyl Ester, an Active Component of Propolis, against Cisplatin-induced Nephrotoxicity in Rats S. OZEN, O. AKYOL, M. IRAZ, S. SOGUT, F. OZUGURLU, H. OZYURT, E.O DACI AND Z. YILDIRIM Examination of Changes in Connective Tissue Macromolecular Components of Large White Pig Skin Following Application of Lewisite Vapour C. D. LINDSAY, J. L. HAMBROOK, R. F. R. BROWN, J. C. PLATT, R.K NIGHT AND P. RICI Protective Effects of Caffeic Acid Phenethyl Ester on Doxorubicin-induced Cardiotoxicity in Rats E. FADILLIOGLU, E. OZTAS, H. ERDOGAN, M. YAGMURCA, S. SOGUT, M. UCAR AND M. K. IRMAK Adrenal Toxicity in Dogs and Cats as a Contributing Cause of Hormonal and Immune Destabilization A. J. PLECHNER Low-level Exposure of Guinea Pigs and Marmosets to Sarin Vapour in Air: Lowest-observable-adverse-effect Level (LOAEL) for Miosis H. P. M. VAN HELDEN. H. C. TRAP, W. C. KUIJPERS, J. P.O OSTDIJK, H. P. BENSCHOP AND J. P. LANGENBERG Mouse Strain Differences in Eosinophilic Airway Inflammation Caused by Intratracheal Instillation of Mite Allergen and Diesel Exhaust Particles I. ICHINOSE, H. TAKANO, K. SADAKANE, R. YANAGISAWA, T. YOSHIKAWA, M. SAGAI AND T. SHIBAMOTO Assessment of the Skin Sensitization Potency of Eugenol and its Dimers Using a Non-radioisotopic Modification of the Local Lymph Node Assay M. T. S. NODA, S. YAMAZAKI, H. KAKISHIMA, K. YAMASAKI AND I. KIMBER NUMBER 2 MARCH/APRIL 2004 Review Article Mutagenicity of Textile Dye Products K. SCHNEIDER, C. HAFNER AND I. JAGER Research Articles L-Arginine Ameliorates Oxidative Stress in Alloxan-induced Experimental Diabetes Mellitus M. A. EL-MISSIRY, A. I.O THMAN AND M. A. AMER Glioma Cell Antioxidant Capacity Relative to Reactive Oxygen Species Produced by Dopamine E. A. MAZZIO AND K. F. A. SOLIMAN Amelioration of Sulfur Mustard Skin Injury Following a Topical Treatment with a Mixture of a Steroid and a NSAID S. DACHIR, E. FISHBEINE, Y. MESHULAM, R. SAHAR, S. CHAPMAN, A. AMIR AND T. KADAR Cytogenetic Risk Assessment of Etoposide from Mouse Bone Marrow R. C.C HOUDHURY, A. K. PALO AND P. SAHU Succimer Treatment and Calcium Supplementation Reduce Tissue Lead in Suckling Rats V. M. VARNAI, M. PIASEK, M. BLANUSA, M. MATEK SARIC, D. JURESA AND K. KOSTIAI Effect of Milk on Intestinal Fluid Accumulation and Renal Injury Following Mercuric Chloride Ingestion in Rats Y. KAMIJO, I. HAYASHI, K.Y OSHIMURA AND K. SOMA In Vivo Exposure of Dreissena polymorpha Mussels to the Quinones Menadione and Lawsone: Menadione is More Toxic to Mussels than Lawsone A. M. OSMAN, S. ROTTEVEEL, P. J. DEN BESTEN AND P. C. M. VAN NOORT CONTENTS OF VOLUME 24 In Vitro Protection of Plasma Cholinesterases by Metoclopramide from Inhibition by Mipafox G. PETROIANU, F. KUHN, K. ARAFAT, K. ZULEGER AND A. A. MISSLER Pulmonary Toxicity of Wollastonite Jn Vivo and In Vitro E. TATRAI, Z. KOVACIKOVA, M. BROZIK AND E. SIX The Development of Acute Inhalation Reference Exposure Levels (RELs) to Protect the Public from Predictable Excursions of Airborne Toxicants J. F.C OLLINS, G. V. ALEXEFF, D. C. LEWIS, D. E. DODGE, M. A. MARTY, T. R. PARKER, J. D. BUDROE, R. H. F. LAM M. J. LIPSETT, J. R. FOWLES AND R. DAS NUMBER 3 MAY/JUNE 2004 Review Endocrine Disrupters and Human Health: Could Oestrogenic Chemicals in Body Care Cosmetics Adversely Affect Breast Cancer Incidence in Women? A Review of Evidence and Call for Further Research P. W. HARVEY AND P. D. DARBRE Research Articles Determination of the Rat Tissue Partitioning of Endotoxin in vitro for Physiologically-based Pharmacokinetic (PBPK) Modeling I. A. ROSS, P. P. SAPIENZA, D. E. HANES, W. JOHNSON AND C. S. KIM Inhibition of Topoisomerase II in 32D.3(G) Cells by Hydroquinone is Associated with Cell Death J. FUNG, M. J. HOFFMANN, D. D. KIM AND R. SNYDER Reactions of Nifurtimox with Critical Sulfhydryl-containing Biomolecules: their Potential Toxicological Relevance E. G.D IAZ, M. M. DE MECCA AND J. A. CASTRO Ultrastructural Changes Induced in HeLa Cells after Phototoxic Treatment with Harmine J. M. PEREZ MARTIN, V. LABRADOR, P. FERNANDEZ FREIRE, M. L. MOLERO AND M. J. HAZEN Bioactivation, Toxicokinetics and Acute Effects of Chloroform in Fisher 344 and Osborne Mendel Male Rats S. GEMMA, E. TESTAI, P. CHIECO AND L. VITTOZZI Effects of Ochratoxin A on Oxidative Damage in Rat Kidney: Protective Role of Melatonin N. OZCELIK, M. SOYOZ AND I. KILINC QT Prolongation in Anaesthetized Guinea-pigs: an Experimental Approach for Preliminary Screening of Torsadogenicity of Drugs and Drug Candidates L. TESTAI, V. CALDERONE, A. SALVADORI, M. C. BRESCHI, P. NIERI AND E. MARTINOTTI Evaluation of Lipid Peroxidation in Red Blood Cells by Monitoring the Uptake of Sucrose and Phenol Red A. H. SAWAS AND S. N. PENTYALA Pulmonary Irritant Potency of Polyisocyanate Aerosols in Rats: Comparative Assessment of Irritant-threshold Concentrations by Bronchoalveolar Lavage J. PAULUHN Influence of Iron (5Fe,O, or *4Fe,0,) in the Upregulation of Cytochrome P4501A1 by Benzo|Q)|pyrene in the Respiratory Tract of Sprague-Dawley Rats G. GARCON, P. GOSSET, B. MAUNIT, F. ZERIMECH, C. CREUSY, J.-F. MULLER AND P. SHIRALI NUMBER 4 JULY/AUGUST 2004 Research Articles In vivo Metoclopramide Protection of Cholinesterase from Paraoxon Inhibition: Direct Comparison with Pralidoxime in Subchronic Low-dose Exposure M. Y. HASAN, S. M. NURULAIN, K. ARAFAT, O. P. NASEER AND G. A. PETROIANU Safety Evaluation of aN ew Allergy Vaccine Containing the Adjuvant Monophosphoryl! Lipid A (MPL®) for the Treatment of Grass Pollen Allergy P. BALDRICK, D. RICHARDSON, A. W. WHEELER AND S. R. WORONIECKI Cisplatin-induced Acute Renal Failure is Ameliorated by Erdosteine in a Dose-dependent Manner H. OZYURT, Z. YILDIRIM, M. KOTUK, H. R. YILMAZ, M. YAGMURCA. M. IRAZ. S. SOGUT AND S. GERGERLIOGL Sidestream Tobacco Smoke as the Main Predictor of Exposure to Polycyclic Aromatic Hydrocarbons (PAH) M. LODOVICI, V. AKPAN, C. EVANGELISTI AND P. DOLARA Gas Chromatographic Determination of Cocaine and its Metabolites in Blood and Urine from Cocaine Users in Northwestern Spain P. FERNANDEZ, L. BUJAN, A. M. BERMEJO AND M. J. TABERNERO CONTENTS OF VOLUME 24 Effects of Rosmarinic Acid against Aflatoxin B, and Ochratoxin-A-induced Cell Damage in a Human Hepatoma Cell Line (Hep G2) C. RENZULLI, F. GALVANO, L. PIERDOMENICO, E. SPERONI AND M. C. GUERRA Letters to the Editor Parabens in Human Breast Tumours Editorial Discussion of Concentrations of Parabens in Human Breast Tumours P. W. HARVEY Book Reviews NUMBER 5 SEPTEMBER/OCTOBER 2004 Special Issue: Developing Advanced Toxicology Technologies for Biomonitoring in National Security Applications Guest Editors: Joseph J. Pancrazio, Robert S. Marks and Philip N. McFadden CONTENTS Preface R. S. MARKS Editorial: Developing Advanced Toxicology Technologies for Biomonitoring in National Security Applications 4. S. RUDOLPH AND J. R. COUGHLIN Eliatox-Oregon Biomonitoring Workshop: Summary and Observations J. J. PANCRAZIO, P. N. MCFADDEN, S. BELKIN AND R. S. MARKS Research Articles Sensitivity Evaluation of the Daphtoxkit and Thamnotoxkit Microbiotests on Blind Samples A. TOROKNE ELIATox-Oregon Workshop: Blind Study Evaluation of Vitotox Test with Genotoxic and Cytotoxic Sample Library J. MERILAINEN AND J. LAMPINEN Detection of Bioavailable Heavy Metals in ELILATox-Oregon Samples Using Whole-cell Luminescent Bacterial Sensors in Suspension or Immobilized onto Fiber-Optics Tips K. HAKKILA, T. GREEN, P. LESKINEN, A. IVASK, R. S. MARKS AND M. VIRTA Water Toxicity Detection by a Panel of Stress Responsive Luminescent Bacteria R. PEDAHZUR, B. POLYAK, R. S. MARKS AND S. BELKIN Toxicity Detection from EILATox-Oregon Workshop Samples by Using Kinetic Photobacteria Measurement, the Flash Method K. HAKKILA, J. LAPPALAINEN AND M. VIRTA Blind and Naive Classification of Toxicity by Fish Chromatophores L. MOJOVIC, K. P. DIERKSEN, R. H. UPSON, B. A. CALDWELL, J. R. LAWRENCE, J. E. TREMPY AND P. N. MCFADDEN Responses of Fish Chromatophore-based Cytosensor to a Broad Range of Biological Agents K. P. DIERKSEN, L. MOJOVIC, B. A. CALDWELL, R. R. PRESTON, R. H. UPSON, J. R. LAWRENCE, P. N. MCFADDEN AND J. E. TREMPY Detection and Classification Threat Agents via High-Content Assays of Mammalian Cells S. B. TENCZA AND M. A. SIPE Cultured Neuronal Networks as Environmental Biosensors T. J. O'SHAUGHNESSY, S. A. GRAY AND J. J. PANCRAZIO Response Characteristics of an Aquatic Biomonitor Used for Rapid Toxicity Detection W. H. VAN DER SCHALIE, T. R. SHEDD, M. W. WIDDER AND L. M. BRENNAN Monitoring Genotoxicity During the Photocatalytic Degradation of p-Nitriphenol M. SHANI SEKLER, Y. LEVI, B. POLYAK, A. NOVOA, P. S. M.D UNLOP, J. A. BYRNE AND R. S. MARKS Use of a Complex Approach for Assessment of Metamizole Sodium and Acetylsalicylic Acid Toxicity, Genotoxicity and Cytotoxicity V. ARKHIPCHUK, V. V.GONCHARUK, V. P. CHERNYKH, L. N. MALOSHTAN AND I. S. GRITSENKO NUMBER 6 NOVEMBER/DECEMBER 2004 Research Articles Evaluation of the Local Irritation Potential of Hypertonic Saline—Dextran (HSD) in Mice and Rabbits M. A. DUBICK, C. E. WADE AND THE HSD DEVELOPMENT GROUP CONTENTS OF VOLUME 24 Components of Diesel Exhaust Particles Differentially Affect Lung Expression of Cyclooxygenase-2 Related to Bacterial Endotoxin K.-I. INOUE, H. TAKANO, R. YANAGISAWA, T. I. ICHINOSE, K. SADAKANE, S. YOSHINO, K. YAMAKI, K. UCHIYAMA AND T. YOSHIKAWA Acetylcholine and Choline Effects on Erythrocyte Nitrite and Nitrate Levels F. A. CARVALHO, R. MESQUITA, J. MARTINS-SILVA AND C. SALDANHA Enzyme Reactivator Treatment in Organophosphate Exposure: Clinical Relevance of Thiocholinesteratic Activity of Pralidoxime G. A. PETROIANU, A. MISSLER, K. ZULEGER, C. THYES, V. EWALD AND W. H. MALECK Strain- and Sex-related Differences of Carbonyl Reductase Activities in Kidney Microsomes and Cytosol of Rats Y. IMAMURA AND H. I. SHIMADA Comparative Sensitivity of Xenopus tropicalis and Xenopus laevis as Test Species for the FETAX Model D. J. FORT, R. L. ROGERS, J. H. THOMAS, B. O. BUZZARD, A. M. NOLL AND C. D. SPAULDING Inhalation Toxicity in Mice Exposed to Sarin (GB) for 20-720 minutes R. W. BIDE AND D. J. RISK Prevention of Fumonisin-induced Maternal and Developmental Toxicity in Rats by Certain Plant Extracts M. A. ABDEL-WAHHAB, A. M. HASSAN, H. A. AMER AND K. M. NAGUIB Low Levels of Sarin Affect the EEG in Marmoset Monkeys: a Pilot Study H. P.M. VAN HELDEN, R. A. P. VANWERSCH, W. C. KULJPERS, H. C. TRAP, I. H. C.P HILIPPENS AND H. P. BENSCHOP Heterogeneity of CD80 Gene Transcription by Human Keratinocytes to Allergens and Irritants: Relevance to Allergic Contact Dermatitis in Vivo P. WAKEM, F. RAMIREZ, D. ZLOTNICK AND A. A. GASPARI Delayed Haematological Complications of Mustard Gas M. GHANEI Pyridoxine (Vitamin B6) Neurotoxicity: Enhancement by Protein-deficient Diet S. LEVINE AND A. SALTZMAN Protection and Inflammatory Markers Following Exposure of Guinea Pigs to Sarin Vapour: Comparative Efficacy of Three Oximes A. LEVY, S. CHAPMAN, G. COHEN, L. RAVEH, I. RABINOVITZ, E. MANISTERSKY, Y. KAPON, N. ALLON AND | GILAT Protective Role of Melatonin in Ochratoxin A Toxicity in Rat Heart and Lung H. OKUTAN, G. AYDIN AND N. OZCELIK Study of Caffeine in Urine and Saliva of Horses Subjected to Urinary Acidification \. B. CARREGARO, M. I. MATAQUEIRO, O. A. B. SOARES AND A. QUEIROZ-NETO Liver Microsomal Biotransformation of Nitro—Aryl Drugs: a Mechanism for Potential Oxidative Stress Induction M. E. LETELIER, P. IZQUIERDO, L. GODOY, A. M. LEPE AND M. FAUNDEZ Book Review P. W. HARVEY Author index for Volume 24 Keyword index for Volume 24 Volume Contents