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Journal of Applied Toxicology 1991 Volume 11 JJATDK 11(1-6) 1-458 (1991) ISSN 0260-437X y/ WILEY Publishers Since 1807 Chichester -N ew York - Brisbane - Toronto - Singapore Journal of Applied Toxicology (J. appl. toxicol.) AN INTERNATIONAL FORUM DEVOTED TO RESEARCH AND METHODS EMPHASIZING DIRECT CLINICAL, INDUSTRIAL AND ENVIRONMENTAL APPLICATIONS EDITOR-IN-CHIEF TECHNICAL EDITOR Harry Salem David Clegg Chemical Research, Development and Engineering Center, Toxicological Evaluation Division US Army, SMCCR-RST, Aberdeen Proving Ground, Health and Welfare Canada, Tunney’s MD 21010-5423, USA Pasture, Ottawa KIA OL2, Canada EUROPEAN EDITOR FOUNDING EDITOR Laszlo Magos Michael R. Greenwood Medical Research Council, Toxicology Unit Xerox Corporation — W843 Woodmansterne Road, Carshalton, Surrey SM5 4EF, UK Webster, NY 14580, USA NORTH AMERICAN EDITOR Richard A. Parent President Consultox Ltd, PO Box 14082, Baton Rouge, LA 70898, USA EDITORIAL ADVISORY BOARD B. Ballantyne K. Kostial Union Carbide Corporation, Charleston, WV, USA Institute of Medical Research and Occupational Health, Zagreb, Yugoslavia S. I. Baskin US Army Medical Research Institute of Chemical Defence, MD, USA R. Lauwerys J. R. Beall University of Louvain, Brussels, Belgium US Department of Energy, Washington, DC, USA E. A. Lock J. F. Borzelleca ICI, Macclesfield, Cheshire, UK Medical College of Virginia, Richmond, VA, USA R. W. Naismith I. Bremner Biofor Inc., Waverly, PA, USA The Rowett Research Institute, Aberdeen, UK T. Norseth T. P. Cameron Occupational Health Institute, Oslo, Norway National Cancer Institute, Bethesda, MD, USA D. Scott N. Chernoff Christie Hospital & Holt Radium Institute, Manchester, UK Biology Division, United States Environmental Protection Agency, V. M. Seabaugh Research Triangle Park, NC, USA US Environmental Protection Administration, Washington, DC, USA T. Connors R. Snyder MRC Laboratories, Surrey, UK Department of Pharmacology & Toxicology, Rutgers College of Phar- H. H. Cornish macy, Piscataway, NJ, USA University of Michigan, Ann Arbor, MI, USA T. Suzuki S. C. Gad Department of Human Ecology, Tokyo University Faculty of G. D. Searle & Co., Skokie, IL, USA Medicine, Japan S. D. Gangolli C. J. Terhaar F The British Industrial Biological Research Association, Surrey, UK Pennwalt Pharmaceutics, Rochester, NY, USA P. Grasso J. B. Terrill Group Occupational Centre, BP, Sunbury-on-Thames, UK National Institute on Drug Abuse, Rockville, MD, USA S. Green A. M. Tometsko US Food and Drug Administration, Washington, DC, USA Litron Laboratories Ltd, Rochester, NY, USA S. Halbach H. Vainio Society for Radiation and Environmental Research, Neuherberg, International Agency for Research on Cancer, Lyon, France West Germany R. Valentine E. D. Helton E. I. du Pont de Nemours & Co., Newark, DE, USA Sigma Tau Pharmaceuticals, 1370 Piccard Dr., Rockville, MD, USA R. K. Wolff S. A. Katz Eli Lilly & Company, Greenfield, IN, USA Rutgers University, Camden, NJ, USA S. Zakhari F. Koschier National Institute for Alcohol and Alcohol Abuse, Rockville, MD, ARCO, 515 S. Flower St., A-P 1263, Los Angeles, CA, USA USA Copyright © 1991 by John Wiley & Sons, Ltd COPYING OF ARTICLES The code and the copyright notice appearing at the bottom of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal or internal use, or for the personal or internal use of specific clients, on the condition that the copier pay for copying beyond that permitted by Sections 107 or 108 of the U.S. Copyright Law. The per-copy fee for each article appears after the dollar sign, and is to be paid through the Copyright Clearance Center Inc. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Such permission requests, or other inquiries, should be addressed to the publisher. JOURNAL OF APPLIED TOXICOLOGY, VOL. 11, iii (1991) Contents of Volume 11 NUMBER 1 FEBRUARY 1991 Evaluation of the Onset and Duration of Response to Cold Air Inhalation Challenge in Cynomolgus Monkeys (Macaca fascicularis) R. E. BIAGINI, J. C. CLARK, W. J. MOORMAN AND E. A. KNECHT Antidotal Effects of Dimercaptosuccinic Acid G.-S. DING AND Y.-Y. LIANG Biochemical Assessment of Cardiac Function and Damage in Animal Species. A Review of the Current Approach of the Academic, Governmental and Industrial Institutions Represented by the Animal Clinical Chemistry Association G. O. EVANS Changes in Urinary Proximal Tubule Parameters in Neonatal Rats Exposed to Cadmium Chloride During Pregnancy A. M. SAILLENFAIT, J. P. PAYAN, M. T. BRONDEAU, D. ZISSU AND J. DE CEAURRIZ Effect of Calcium Channel Blocking Agents on the Reductive Metabolism of Halothane M. KAWAHARA, S. AKITA, K. FUJII AND M. MORIO Evidence for Behavioral Teratogenicity in Humans B. K. NELSON Evaluation of the Embryolethality of Butyl Benzyl Phthalate by Conventional and Pair-feeding Studies in Rats M. EMA, T. ITAMI AND H. KAWASAKI In Situ Assessment of the Rat Heart During Chronic Carbon Monoxide Exposure using Nuclear Magnetic Resonance Imaging G. A. BAMBACH, D. G. PENNEY AND W. G. NEGENDANK Effects of Short-Term Oral Dosing of Polychiorotrifiuoroethylene (PolyCTFE) on the Rhesus Monkey C. E. JONES, M. B. BALLINGER, D. R. MATTIE, N. J. DELRASO, C. SECKEL AND A. VINEGAR Neurotoxic Esterase Activity in Brain, Spinal Cord and Platelets of Certain Birds and Mammals K. HUSAIN, M. A. MIRZA AND M. A. MATIN Evaluation of Potential Chemoprotectants Against Microcystin-LR Hepatotoxicity in Mice S. J. HERMANSKY, S. J. STOHS, Z. M. ELDEEN, V. F. ROCHE AND K. A. MEREISH NOTE Reflections on the Environmental Factors that can Modify the Action of Pyrrolizidine Alkaloids R. SCHOENTAL Book Reviews CONTENTS OF VOLUME 11 NUMBER 2 APRIL 1991 A Comparison Between the Isovolume and the End-inflation Occlusion Methods for Measurement of Lung Mechanics in Rats W. V. CARDOSO, P. H. N. SALDIVA, P. M. P. CRIADO, R. S. SAKAE, G. M. BOHM AND W. A. ZIN Haemolytic Activity and Nephrotoxicity of 2-~Hydroxy-1,4-naphthoquinone in Rats R. MUNDAY, B. L. SMITH AND E. A. FOWKE Gene Mutation Assay of Acrolein in the CHO/HGPRT Test System R. A. PARENT, H. E. CARAVELLO AND J. W. HARBELL Cyanide-induced Alteration of the Adenylate Energy Pool in a Rat Neurosecretory Cell Line E. U. MADUH, J. L.B OROWITZ AND G. E. ISOM A Comparison of the Effects of Inorganic and Alkyllead Compounds on Human Erythrocytic 6- Aminolevulinic Acid Dehydratase (ALAD) Activity in vitro C. B. BURNS AND I. R. GODWIN Interactions between Verapamil and Metoprolol in the Developing Chick Embryo Heart T. NISHIKAWA, T. KASAJIMA AND T. KANAITI Globin Adducts of Benzo[a]pyrene: Markers of Inhalation Exposure as Measured in F344/N Rats W. E. BECHTOLD, J. D. SUN, R. K. WOLFF, W. C. GRIFFITH, J. W. KILMER AND J. A. BOND Cardiotonic Drugs Inhibit Purified Mammalian Acetylcholinesterase D. W. HANKE, M. E. NELSON AND S. I. BASKIN Urinary Cyclophosphamide Excretion in Rats after Intratracheal, Dermal, Oral and Intravenous Administration of Cyclophosphamide P. J. M. SESSINK, P. H. H. VAN DEN BROEK AND R. P. BOS Anamnestic Responses to Contact Allergens: Application in the Murine Local Lymph Node Assay I. KIMBER AND C. WEISENBERGER Methylthiazolidine—4—carboxylate for Treatment of Acute T-2 Toxin Exposure R. F. FRICKE AND J. JORGE Nephrotoxicity of Paracetamol in the Rat—Mechanistic and Therapeutic Aspects W. MOLLER-HARTMANN AND C.-P. SIEGERS A CCI,/CHCI, Interaction Study in Isolated Hepatocytes: Non-induced and Phenobarbital-pretreated Cells T. M. O'HARA, M. A. SHEPPARD, E. C. CLARKE, J. F.B ORZELLECA, C. GENNINGS AND L. W. CONDIE, JR Book Reviews NUMBER 3 JUNE 1991 Inhalation Toxicity of Methyl Isocyanate: Biochemical and Cytolocial Profile of Bronchoalveolar Lavage Fluid in Rats G. S. D. GUPTA, J. L. KAW, S. H. N. NAQVI, R. DIXIT AND P. K. RAY Assessment of Cadmium-induced Osteopenia by Measurement of Serum Bone Gla Protein, Para- thyroid Hormone, and 1a@,25-dihydroxyvitamin D T. KIDO, R. HONDA, I. TSURITANI, M. ISHIZAKI, Y. YAMADA, K. NOGAWA, H. NAKAGAWA AND Y. DOHI CONTENTS OF VOLUME 11 Chinese Hamster Ovary Cell Assays for Mutation and Chromosome Damage: Data from Non- carcinogens Y. OSHIRO, C. E. PIPER, P. S. BALWIERZ AND S. G. SOELTER Cardiopathic Effect of 1,2,3-Trichloropropane after Subacute and Subchronic Exposure in Rats B. A. MERRICK, M. ROBINSON AND L. W. CONDIE Trichloroethylene Interactions with Muscle Cells F. KOSSLER Effectiveness of Some Chelating Agents on Distribution and Excretion of Vanadium in Rats after Prolonged Oral Administration M. GOMEZ, J. L. DOMINGO, J. M. LLOBET AND J. CORBELLA Site of Action of Grayanotoxins in Mad Honey in Rats F. ONAT, B. C. YEGEN. R. LAWRENCE, A. OKTAY AND S. OKTAY Biochemical Toxicology of Argemone Oil. I. Effect on Hepatic Cytochrome P-450 ar.. Xenobiotic Metabolizing Enzymes K. K. UPRETI, M. DAS AND S. K. KHANNA Early Decreases in Pulmonary, Hepatic and Renal Glutathione Levels in Response to Cadmium Instillation into Rat Trachea H. IGUCHI, M. IKEDA AND S. KOJO Kelthane Residues in Tissues of the Tropical Penaeid Prawn, Metapenaeus monoceros (Fabricius), under Sublethal Chronic Exposure—a Monitoring Study P. SURENDRANATH AND K. V. RAMANA RAO Comparative Studies of the Covalent Binding of ['4C]-2-Chioro-4-acetotoluidide by Liver and Kidney Slices of the Starling S. N. GIRI AND D. M. SIEGEL Short Communication The Production of Hepatic Cirrhosis in Rats K. E. TOMASZEWSKI, G. C. HARRIES AND P. JEFFREY Book Review Announcements NUMBER 4 AUGUST 1991 Announcement Poisoning by Gyromitra esculenta—A Review D. MICHELOT AND B. TOTH Metabolic Aspects of the Toxicology of Mixtures of Parathion, Toxaphene and/or 2,4-D in Mice A. K. CHATURVEDI, D. J. KUNTZ AND N. G. S. RAO Altered Developmental Toxicity Caused by Three Carrier Solvents J. R. RAYBURN, D. J. DOYOUNG, J. A. BANTLE, D. J. FORT AND R. McNEW Possible Involvement of 1,2-Diacetylbenzene in Diethylbenzene-Induced Neuropathy in Rats G. GAGNAIRE, A. ENSMINGER, B. MARIGNAC AND J. DE CEAURRIZ vi CONTENTS OF VOLUME 11 Organophosphate Poisoning in Urban Zimbabwe O. J. KASILO, T. HOBANE AND C. F. B. NHACHI Influence of Age and Time of Administration of Dithiocarbamate Analogues on Cadmium Retention in Rats B. KARGACIN, K. KOSTIAL, R. AREZINA, P. K. SINGH, M. M. JONES AND M. CIKRT Ni,S, Uptake by Lung Cells and its Interaction with Plasma Membranes P. SHIRALI, A. M. DECAESTECKER, T. MAREZ, H. F. HILDEBRAND, C. BAILLY AND R. MARTINEZ Interaction of Ethanol and Xylene in their Effects on Erythrocytes and Other Haematological Parameters in the Rat T. WRONSKA-NOFER, J. ROSIN AND G. BARTOSZ Effects of Soman on Calcium Uptake in Microsomes and Mitochondria from Rabbit Aorta C.-Y. HU, C.-H. HSU AND C. P. ROBINSON Four-week Inhalation Exposures of Rats to Aerosols of Three Lubricant Base Oils W. DALBEY, T. OSIMITZ, C. KOMMINENI, T. ROY, M. FEUSTON AND J. YANG Biochemical Assessment of the Genotoxicity of the Jn Vitro Interaction Between Chlordecone and Carbon Tetrachloride in Rat Hepatocytes F. I. IKEGWUONU AND H. M. MEHENDALE Book Reviews NUMBER 5 OCTOBER 199} Announcement Dithiocarbamate Analog N-(4-Methoxybenzyl)-N-dithiocarboxy-D-glucamine Reduces the Retention of Ingested Cadmium in Rats B. KARGACIN, K. KOSTIAL, R. AREZINA, P. K. SINGH, M. M. JONES AND M. CIKRT Ultrastructural Localization of Silver in Rat Testis and Organ Distribution of Radioactive Silver in the Rat E. ERNST, J. RUNGBY AND E. BAATRUP Carcinogenic Effects of Bis(2,3-dibromopropy!)-phosphate in Wistar Rats K. TAKADA, K. NAITO, K. KOBAYASHI, M. TOBE, Y. KUROKAWA AND M. FUKUOKA Complexing of Toxic Hydrolysable Tannins of Yeliow-wood (Terminalia oblongata) and Harendong (Clidemia hirta) with Reactive Substances: an Approach to Preventing Toxicity T. B. MURDIATI, C. S. MCSWEENEY AND J. B. LOWRY Serum Histamine and the Elicitation of Murine Contact Sensitivity I. KIMBER, M. CUMBERBATCH AND J. W. COLEMAN Inhalation Toxicity of Furfural Vapours: an Assessment of Biochemical Response in Rat Lungs G. D. GUPTA, A. MISRA AND D. K. AGARWAL Copper-induced Non-selective Permeability Changes in Intracellularly Perfused Snail Neurons T. KISS, J. GYORI, O. N. OSIPENKO AND S. B. MAGINYAN Cadmium Accumulation in the Lung, Liver and Kidney of Mice and Rats Chronically Exposed to Cigarette Smoke C. G. GAIROLA AND G. J. WAGNER CONTENTS OF VOLUME 11 Application of Alkaline Unwinding to Analysis of Strand Breaks Induced by Bleomycin in Hamster Lung DNA in vivo R. A. HUFF AND D. R. BEVAN Toxicity of 1,4-Bis(aminocyclohexy!)methane G. L. KENNEDY JR Toxicology Updates: Acetaldehyde R. VON BURG AND T. STOUT Metaldehyde R. VON BURG AND T. STOUT Paraldehyde R. VON BURG AND T. STOUT Note: Inhibition of Acetylcholinesterase Activity by Organic Isocyanates: a Possible Mechanism H. SAVOLAINEN Short Communication: A Chronic Study with Lead Acetate in Female Rats A. VYSKOCIL, Z. FIALA, V. LACINOVA AND E. ETTLEROVA Book Reviews NUMBER 6 DECEMBER 1991 Announcements In vitro Effects of Organophosphorus Compounds on Calmodulin Activity I. PALA, P. J. S. VIG, D. DESAIAH AND A. SRINIVASAN Immunotoxicity of Tri-n-butyltin Oxide (TBTO) and Tri-n-butyltin Chloride (TBTC) in the Rat G. BRESSA, R. H. HINTON, S. C. PRICE, M. ISBIR, R. S. AHMED AND P. GRASSO Triorganotin Inhibition of Rat Cardiac Adenosine Triphosphatases and Catecholamine Binding J. A. CAMERON, P. R. S. KODAVANTI, S. N. PENTYALA AND D. DESAIAH Effects of Some Organophosphorus Compounds on the Binding of a Radioligand (8-Cyclopentyl 1,3-[°H]dipropylxanthine) to Adenosine Receptors in Ovine Cardiac Membranes W.-M. LAU, M. SZILAGYI AND S. E. FREEMAN Joint Toxic Action of Binary Mixtures of Osteolathyrogens at Malformation-inducing Concentrations for Xenopus Embryos D. A. DAWSON AND T. S. WILKE Validation of a Non-invasive Technique to Assess Immediate or Delayed Onset of Airway Hyper- sensitivity in Guinea-pigs J. PAULUHN AND A. EBEN Difference in Liver and Serum Malathion Carboxylesterase and Glucose-6-phosphatase in Detecting Carbon Tetrachloride-induced Liver Damage in Rats M. T. BRONDEAU, C. COULAIS AND J. DE CEAURRIZ Vili CONTENTS OF VOLUME 11 Biliary Excretion of Hexachioro-1,3-butadiene and its Relevance to Tissue Uptake and Renal Excretion in Male Rats J. P. PAYAN, J. P. FABRY, D. BEYDON AND J. DE CEAURRIZ Depression of Iron Uptake into Erythrocytes in Mice by Treatment with the Combined Benzene Metabolites p-Benzoquinone, Muconaldehyde and Hydroquinone R. L. GUY, P. HU, G. WITZ, B. D. GOLDSTEIN AND R. SNYDER Toxicology Update: Hydrazine R. VON BURG AND T. STOUT Short Communications: Fast Thir-layer Chromatography Systems for Fumonisin Isolation and Identification Th. ACKERMANN Mycotoxins, Prophyrias and the Decline of the Etruscans R. SCHOENTAL Book Reviews Ke