Table Of Content

CONTENTS Volume 88 • 2002 Reviews Number 1 January 2002 — Current Perspective — Nitric Oxide and Depolarization Induce Hydroxyl Radical Generation Toshio Obata Number 2 February 2002 — Current Perspective — Fundamental Role of Heme Oxygenase in the Protection Against Ischemic Reiko Akagi, Toru Takahashi and Shigeru Sassa Acute Renal Failure — Current Perspective — Neuronal Nicotinic Receptor and Psychiatric Disorders: Functional Hiroaki Araki, Katsuya Suemaru and Yutaka Gomita and Behavioral Effects of Nicotine Number 3 March 2002 Cerebrovascular Inflammation Following Subarachnoid Hemorrhage Richard Sercombe, Yves R. Tran Dinh 227 and Philippe Gomis Number 4 April 2002 Molecular Diversity of Structure and Function of the Voltage-Gated Na* Nobukuni Ogata and Yoshiaki Ohishi 365 Channels — New Drug and Recent Technique — Pharmacological, Pharmacokinetic and Clinical Properties of Olopatadine Kenji Ohmori, Ken-ichi Hayashi, Toshihiko Kaise, 379 Hydrochloride, a New Antiallergic Drug Etsuo Ohshima, Satoshi Kobayashi, Takashi Yamazaki and Akimichi Mukouyama Forum Minireviews Number 1 January 2002 Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function: Preface Hiromu Kawasaki and Hiromichi Tsuru Role of Perivascular Sympathetic Nerves and Regional Differences Hiromichi Tsuru, Noriaki Tanimitsu and Tomohisa Hirai 9 in the Features of Sympathetic Innervation of the Vascular System Sympathetic Cholinergic Vasodilation of Skeletal Muscle Small Arteries Kanji Matsukawa, Mikiyasu Shirai, Jun Murata, 14 Hirotsugu Tsuchimochi, Hidehiko Komine, Ishio Ninomiya and Kiyoshi Shimizu Purinergic Modulation of Vascular Sympathetic Neurotransmission Kazumasa Shinozuka, Hideya Mizuno, 19 Kazuki Nakamura and Masaru Kunitomo Sympathetic Modulation of Nitrergic Neurogenic Vasodilation in Cerebral Tony J.F. Lee 26 Arteries Neurogenic Cerebral Vasodilation Mediated by Nitric Oxide Tomio Okamura, Kazuhide Ayajiki, Hideyuki Fujioka, 32 Kazuya Shinozaki and Noboru Toda Regulation of Vascular Function by Perivascular Calcitonin Gene-Related Hiromu Kawasaki 39 Peptide-Containing Nerves Contents Full Papers Number 1 January 2002 Protective Effect of Thiaton, an Antispasmodic Drug, Against Indomethacin- Tomonori Kunikata, Tohru Miyazawa, Kenji Kanatsu, 45 Induced Intestinal Damage in Rats Shinichi Kato and Koji Takeuchi Effects of Vitamin K2 (Menatetrenone) on Calcium Balance in Ovariectomized Masatoshi Kobayashi, Kuniko Hara 55 Rats and Yasuhiro Akiyama Lung Tissue Distribution After Intravenous Administration of Grepafloxacin: Hiroshi Yamamoto, Tomonobu Koizumi, Masao Hirota, 63 Comparative Study With Levofloxacin Toshimichi Kaneki, Hitoshi Ogasawara, Yoshitaka Yamazaki, Keisaku Fujimoto and Keishi Kubo Human Organic Anion Transporters Mediate the Transport of Tetracycline Eilappan Babu, Michio Takeda, Shinichi Narikawa, 69 Yasuna Kobayashi, Toshinori Yamamoto, Seok Ho Cha, Takashi Sekine, Dhanapal Sakthisekaran and Hitoshi Endou Effect of Protease-Activated Receptor-2 Deficiency on Allergic Dermatitis Junichi Kawagoe, Toshiaki Takizawa, Jiro Matsumoto, 77 in the Mouse Ear Masaki Tamiya, Stephen E. Meek, Andrew J.H. Smith, Gary D. Hunter, Robin Plevin, Naohiro Saito, Toru Kanke, Mikio Fujii and Yasushi Wada Genomic Structure of the Rat and Mouse Histamine MMethyltransferase Gene Nobue Kitanaka, Junichi Kitanaka, Tetsuya Oue, 85 Yoshihiko Tada, Tatsuya Tanaka and Motohiko Takemura Inhibitory Effects of Pre-ischemic and Post-ischemic Treatment With Bing-Mei Zhu, Shigeki Miyamoto, Kazunori Kamiya, 93 FR 168888, a Na^/tH^ Exchange Inhibitor, on Reperfusion-Induced Ventricular Sadayoshi Komori and Keitaro Hashimoto Arrhythmias in Anesthetized Rat Long-Term Treatment With Perindopril Ameliorates Dobutamine-Induced Tsuyoshi Morishita, Masato Tsutsui, 100 Myocardial Ischemia in Patients With Coronary Artery Disease Hiroaki Shimokawa, Hiromi Tasaki, Osamu Suda, Kengo Kobayashi, Masataka Horiuchi, Haruhito Okuda, Yuki Tsuda, Nobuyuki Yanagihara and Yasuhide Nakashima Characterization of ^-Adrenoceptor Subtype in Bladder Smooth Muscle Hiroo Takeda, Yoshinobu Yamazaki, Masuo Akahane, 108 in Cynomolgus Monkey Satoshi Akahane, Hiroshi Miyata, Yasuhiko Igawa and Osamu Nishizawa Modification of 5-Hydroxytryptophan-Evoked 5-Hydroxytryptamine Shu-ichi Kojima, Masashi Ikeda, Asako Shibukawa 114 Formation of Guinea Pig Colonic Mucosa by Reactive Oxygen Species and Yuichiro Kamikawa Number 2 February 2002 Suppression of Endotoxin-Induced Renal Tumor Necrosis Factor-a Ryo Niimi, Akio Nakamura and Yukishige Yanagawa 139 and Interleukin-6 mRNA by Renin-Angiotensin System Inhibitors Existence of Functional aiA- and aio- but No aiB-Adrenoceptor Subtypes Shigetoshi Chiba and Miyoko Tsukada 146 in Rat Common Carotid Arteries Involvement of Calmodulin Inhibition in Analgesia Induced With Low Doses Saeid Golbidi, Hiroshi Moriuchi, Tetsumi Irie, 151 of Intrathecal Trifluoperazine Taghi Ghafghazi and Valiollahe Hajhashemi Novel Mutations in C-terminal Channel Region of the Ryanodine Receptor Hideto Oyamada, Keiko Oguchi, Naoto Saitoh, 1 59 in Malignant Hyperthermia Patients Toshiko Yamazawa, Kenzo Hirose, Yoko Kawana, Kazunao Wakatsuki, Katsuji Oguchi, Megumi Tagami, Kazuo Hanaoka, Makoto Endo and Masamitsu lino Augmented Natriuretic Peptide-Induced Guanylyl Cyclase Activity Hyun Kook, JongUn Lee, Soo Wan Kim, 167 and Vasodilation in Experimental Hyperglycemic Rats Sang Woo Kim and Yung Hong Baik Novel Monoamine Oxidase Inhibitors, 3-(2-Aminoethoxy)-1,2- Kenji Yoshimi, Masao Kozuka, Jyunichi Sakai, 174 benzisoxazole Derivatives, and Their Differential Reversibility Tomoko lizawa, Yuki Shimizu, Isao Kaneko, Kouichi Kojima and Nobuyoshi Iwata Beneficial Effects of Angiotensin-Converting Enzyme Inhibition Kenichi Okumura, Denan Jin, Shinji Takai 183 in Adriamycin-Induced Cardiomyopathy in Hamsters and Mizuo Miyazaki Contents iii Endothelium-Dependent Relaxation of Rat Mesenteric Arterial Rings Maria Lourdes Duarte Weinberg, 189 by a Phoneutria nigriventeryQnom Fraction Marta Nascimento Cordeiro, Maria Elena De Lima, Leida Calegirio Oliveira and Carlos Ribeiro Diniz Involvement of Proteasome in Endothelin-1 Production in Cultured Mamoru Ohkita, Masanori Takaoka, 197 Vascular Endothelial Cells Yutaka Kobayashi, Eriko Itoh, Hiroko Uemachi and Yasuo Matsumura Effects of T-82, a New Quinoline Derivateve, on Cholinesterase Activity Kazuo Isomae, Masago Ishikawa, Megumi Ohta, 206 and Extracellular Acetylcholine Concentration in Rat Brain Yoichiro Ogawa, Hiroshi Hasegawa, Tadayuki Kohda and Junzo Kamei Number 3 March 2002 Pharmacokinetics of Paeoniflorin After Oral Administration of Shao-yao Lih-Chi Chen, Mei-Huei Chou, Ming-Fang Lin 250 Gan-chao Tang 'm Mice and Ling-Ling Yang Role of Rho-Associated Protein Kinase and Histamine in Lysophosphatidic Terumasa Hashimoto, Yuuki Nakano, 256 Acid-Induced Airway Hyperresponsiveness in Guinea Pigs Miyuki Yamashita, Yang-ll Fang, Hisayuki Ohata and Kazutaka Momose Necessity of Enzymatic Activity of Alkaline Phosphatase for Mineralization Yuki Sugawara, Kuniaki Suzuki, Mino Koshikawa, 262 of Osteoblastic Cells Masaki Ando and Junichiro lida Effects of Various Reactive Oxygen Species on the Guinea Pig Trachea Stefan MatySs, Vladimir Pucovsky and Viktor Bauer 270 and Its Epithelium A Peroxisome Proliferator-Activated Receptor y Agonist Influenced Daily Yuki Yoshida, Mineko Ichikawa, Minoru Ohta, 279 Profile of Energy Expenditure in Genetically Obese Diabetic Rats Setsuko Kanai, Mikako Kobayashi, Yuhei Ichimaru, Takao Shimazoe, Shigenori Watanabe, Akihiro Funakoshi and Kyoko Miyasaka Itch-Associated Response Induced by Experimental Dry Skin in Mice Takayuki Miyamoto, Hiroshi Nojima, 285 Tomoko Shinkado, Takashi Nakahashi and Yasushi Kuraishi Effect of Methamphetamine and Imipramine on Cerebral Ischemia-Induced Hiroaki Araki, Takahiko Yamamoto, Yuri Kobayashi, 293 Hyperactivity in Mongolian Gerbils Koujiro Futagami, Hiromu Kawasaki and Yutaka Gomita Renal Protective Effect of Candesartan Cilexetil in Spontaneously Takanori Matsuo, Eiichiro Ishikawa, Masayuki Ohta, 300 Hypercholesterolemic Rats Yumiko Shibouta, Yoshimasa Ishimura, Yoshimi Imura and Yasuo Sugiyama Cardiac Effects of Clinically Available Kampo Medicine Assessed With Atsushi Sugiyama, Akira Takahara, Yoshioki Satoh, 307 Canine Isolated, Blood-Perfused Heart Preparations Masahiko Yoneyama, Yoshiki Saegusa and Keitaro Hashimoto Enhanced cAMP Response of Naturally Occurring Mutant of Human Masafumi Isogaya, Taku Nagao and Hitoshi Kurose 314 y^s-Adrenergic Receptor Methadone and Heroin Antinociception: Predominant 5-Opioid-Receptor Jodie J. Rady, Philip S. Portoghese 319 Responses in Methadone-Tolerant Mice and James M. Fujimoto Use of Anti-Platelet-Endothelial Cell Adhesion Molecule-1 Antibody Jun Ishikawa, Yohei Okada, Ian N. Bird, 332 in the Control of Disease Progression in Established Collagen-Induced Bharat Jasani, Julia H. Spragg Arthritis in DBA/1 J Mice and Toshimitsu Yamada Electrophysiological, Anatomical and Histological Remodeling of the Heart Atsushi Sugiyama, Yuko Ishida, Yoshioki Satoh, 341 to AV Block Enhances Susceptibility to Arrhythmogenic Effects Shigeki Aoki, Masaaki Hori, Yasuki Akie, of QT-Prolonging Drugs Yoshihiko Kobayashi and Keitaro Hashimoto Number 4 April 2002 Involvement of Glutamate Receptors Within the Central Nucleus Takeshi Watanabe, Takayuki Nakagawa, 399 of the Amygdala in Naloxone-Precipitated Morphine Withdrawal-Induced Rie Yamamoto, Akifumi Maeda, Masabumi Minami Conditioned Place Aversion in Rats and Masamichi Satoh Involvement of Adenosine Receptors in the Changes of Tissue Factor- Tohru Watanabe, Shogo Tokuyama, 407 Dependent Coagulant Activity Induced by Polymorphonuclear Leukocytes Masako Yasuda, Tadanori Sasaki in Endothelial Cells and Toshinori Yamamoto IV Contents Effects of a Typical Ik, Channel Blocker Sematilide on the Relationship Atsushi Sugiyama and Keitaro Hashimoto 414 Between Ventricular Repolarization, Refractoriness and Onset of Torsades de Pointes Prostate Apoptosis Rosponso-4 Involved in the Protective Effect Minke Tang and Juntian Zhang 422 of Salvianolic Acid B Against Amyloid p Peptide-Induced Damage in PC 12 Cells Characteristics of ATP-Induced Current Through PZX? Receptor Tomokazu Watano, Isao Matsuoka 428 in NG108-15 Cells: Unique Antagonist Sensitivity and Lack of Pore and Junko Kimura Formation Effects of Angiotensin II on the Renal Interstitial Concentrations Matiubur Rahman, Shoji Kimura, 436 of NO2/NO3 and Cyclic GMP in Anesthetized Rats Hirohito Yoneyama, Hiroaki Kosaka, Toshiki Fukui, Akira Nishiyama and Youichi Abe Dipeptidyl Peptidase IV Inhibition Improves Impaired Glucose Tolerance Hironobu Mitani, Misato Takimoto, 442 in High-Fat Diet-Fed Rats: Study Using a Fischer 344 Rat Substrain Thomas E. Hughes and Masaaki Kimura Deficient in Its Enzyme Activity Dipeptidyl Peptidase IV Inhibitor NVP-DPP728 Ameliorates Early Insulin Hironobu Mitani, Misato Takimoto 451 Response and Glucose Tolerance in Aged Rats but Not in Aged Fischer and Masaaki Kimura 344 Rats Lacking Its Enzyme Activity Short Communications Number 1 January 2002 Effect of Oral OPC-28326, a Selective Femoral Arterial Vasodilator, Kensuke Orito, Takashi Imaizumi, Kenji Yoshida, 119 on Hindlimb Subcutaneous Tissue Temperature in Conscious Dogs Under Masami Kishi, Hiroyuki Fujiki and Toyoki Mori Buprenorphine Sedation Gene Expression of Enzymes Comprising the Polyol Pathway in Various Rat Keiko Maekawa, Tsuyoshi Tanimoto 123 Tissues Determined by the Competitive RT-PCR Method and Satoshi Okada Number 2 February 2002 Antiproteinuric Effect of KD3-671, an Angiotensin II Type 1 Receptor Tadashi Nagamatsu, Toshiyuki Nagao, 213 Antagonist, in Rats With Accelerated Passive Heymann Nephritis Kazumi Hayashi and Yoshio Suzuki Abatement of Morphine-Induced Slowing in Gastrointestinal Transit Tomonori Nakamura, Akiko Sakai, Issei Isogami, 217 by Dai-kenchu-to, a Traditional Japanese Herbal Medicine Kazuhiro Noda, Koichi Ueno and Shingo Yano Glutamate Exacerbates Amyloid p\ - 42-lnduced Impairment Yasuhiro Nakagami and Tomiichiro Oda 223 of Long-Term Potentiation in Rat Hippocampal Slices Number 3 March 2002 Intradermal Cholinergic Agonists Induce Itch-Associated Response via Ms Takayuki Miyamoto, Hiroshi Nojima 351 Muscarinic Acetylcholine Receptors in Mice and Yasushi Kuraishi Effects of Puerariae radix on Cell Proliferation and Nitric Oxide Synthase Mi-Hyeon Jang, Min-Chul Shin, Joo-Ho Chung, 355 Expression in Dentate Gyrus of Alcohol-Intoxicated Sprague-Dawley Rats Hyun-Dae Shin, Yeunhee Kim, Ee-Hwa Kim and Chang-Ju Kim Cardiac Effects of a Selective Rho-Associated Kinase Inhibitor, Y-27632, Atsushi Sugiyama, Yutaka Yatomi, Akira Takahara, 359 Assessed in Canine Isolated, Blood-Perfused Heart Preparations Yoshioki Satoh and Keitaro Hashimoto Molecular Mechanisms of Cardiostimulatory Effects of Sildenafil Atsushi Sugiyama, Nobuyasu Takeuchi, 362 Yoshiki Saegusa, Masao Sugita and Keitaro Hashimoto Number 4 April 2002 Hyperpolarization-Activated Current Ih in Nucleus of Solitary Tract Yuki Iwahori, Yuji Ikegaya and Norio Matsuki 459 Neurons: Regional Difference in Serotonergic Modulation Inhibitory Effect of Olopatadine on Antigen-Induced Eosinophil Infiltration Nobuyuki Fukuishi, Motoko Matsuhisa, 463 and the LFA-1 and Mac-1 Expression in Eosinophils Takeshi Shimono, Nobutoshi Murata, Mari Iwanaga, Hidenori Sagara, Nobuaki Matsui and Masaaki Akagi