THE JAPANESE JOURNAL OF PHARMACOLOGY Volumes? 2001 Official Publication of The Japanese Pharmacological Society THE JAPANESE JOURNAL OF PHARMACOLOGY Published Monthly by The Japanese Pharmacological Society Volumes? 2001 Journal URL: http://www.pharmacol.or.jp/ On-line access to the full text is available at “J-STAGE” (http://jjp.jstage.jst.go.jp/ja/) Chief Editor European Editor Yasuyuki Nomura (Sapporo) Ezio Giacobini (Geneva, Switzerland) Press Editor North American Editor Yasushi Kuraishi (Toyama) Tony J.F. Lee (Springfield, IL, USA) Editors Hiroshi Iwao (Osaka) Editorial Advisory Board International Advisory Board Koichiro Kawashima (Tokyo) M. Akagi (Tokushima) K. Nakayama (Shizuoka) J. E. Brayden (Burlington, VT, USA) Miwa Misawa (Tokyo) K. Fuji (Kyoto) M. Nomoto (Ehime) P. Dominiak (Lubeck, Germany) Takamura Muraki (Tokyo) C. Hamada (Kyoto) S. Ohkuma (Kurashiki) A. Fisher (Ness Ziona, Israel) Ikunobu Muramatsu (Fukui) M. lino (Tokyo) K. Onodera (Okayama) E. Hamel (Montreal, Canada) Y. Imaizumi (Nagoya) H. Ozaki (Tokyo) M.D. Linnik (San Diego, CA, USA) Susumu Okabe (Kyoto) S. Kaneko (Kyoto) T. Suzuki (Tokyo) K. Ldffelholz (Mainz, Germany) Kohtaro Taniyama (Nagasaki) H. Kawasaki (Okayama) K. Takeuchi (Kyoto) G. Pepeu (Florence, Italy) Mitsuhiro Yoshioka (Sapporo) K. Kitamura (Fukuoka) K. Umemura (Hamamatsu) J. Tamargo (Madrid, Spain) S. Kobayashi (Kawasaki) Y. Yamaguchi (Tokyo) L. F. Tseng (Milwaukee, Wl, USA) Language Editor S. Kohno (Kyoto) Y. Yamazoe (Sendai) S.M. Jung K. Miyamoto (Kanazawa) T. Yanagisawa (Sendai) Editorial Assistant M. Miyazaki (Takatsuki) S. Yano (Chiba) Y. Takezaki K. Momose (Tokyo) Abstracted/Indexed in Biological Abstracts (BIOSIS), Chemical Abstracts, EMBASE/Excerpta Medica, Index Medicus (MEDLINE), Current Contents/Life Sci. (CC/LS), Reference Update (RIS), Elsevier BIOBASE/Current Awareness in Biological Sciences, ISI/BIOMED Editorial and Publishing Correspondence Editorial Office, The Japanese Pharmacological Society, Kantohya bldg, Gokomachi-Tbisugawa, Nakagyo-ku, Kyoto 604-0982, Japan TEL: +81-75-252-4641, FAX: +81-75-252-4618, E-mail: [email protected] Information for contributors is printed at the end of each issue. Subscription Information Volumes 85 - 87 (12 issues plus Supplement) will appear in 2001. Subscription orders can be entered only by calendar year. Subscription/Back issue orders and inquiries should be sent to: All orders inside Japan and individual orders outside Japan: the Editorial Office at the address given above. Annual subscription rate is ¥20,000 including postage. Institutional orders outside Japan: Maruzen Co., Ltd., Export Department, PO Box 5050, Tokyo International 100-3199, Japan TEL: +81-3-3273-3234, FAX: +81-3-3271-6076. 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(CCC), 222 Rosewood Drive, Danvers, MA 01923, USA TEL: +1-978-750-8400, FAX: +1-978-750-4744, http://www.copyright.com Copyright © The Japanese Pharmacological Society 2001 CONTENTS Volume 87 • 2001 Reviews Number 1 September 2001 — Current Perspective — 1 Potassium Channels of Glial Cells: Distribution and Function Yoshiyuki Horio — Current Perspective — /7-Adrenoceptors: Three-Dimensional Structures and Binding Sites for Ligands Takafumi Nagatomo, Toshio Ohnuki, ^ Masaji Ishiguro, Maruf Ahmed and Takashi Nakamura Number 2 October 2001 — Current Perspective — 97 Brain Drug Targeting and Gene Technologies William M. Pardridge — Current Perspective — 104 Neurobiology of the Edg2 Lysophosphatidic Acid Receptor Akira Yoshida and Hiroshi Ueda Number 3 November 2001 — Current Perspective — 171 Physiological and Pharmacological Role of Lysophosphatidic Acid as Modulator Hisayuki Ohata, Ken-ichi Tanaka, in Mechanotransduction Naoto Maeyama, Tadahiro Ikeuchi, Aya Kamada, Masayuki Yamamoto and Kazutaka Momose — Current Perspective — 177 Hepatoprotective Drugs for the Treatment of Virus-Induced Chronic Hepatitis: Toshihiro Okamoto, Kazunori Kajino and Okio Hino From Hypercarcinogenic State to Hypocarcinogenic State Number 4 December 2001 — Current Perspective — Dissecting Receptor-Mediated Ca^* Influx Pathways: TRP Channels Yasuo Mori, Ryuji Inoue, Masakazu Ishii, 245 and Their Native Counterparts Yuji Hara and Keiji Imoto — Current Perspective — Absence of Endothelium in Invertebrate Blood Vessels: Significance Tatsuro Shigei, Hiromichi Tsuru, Naohisa Ishikawa of Endothelium and Sympathetic Nerve/Medial Smooth Muscle and Koichi Yoshioka in the Vertebrate Vascular System Full Papers Number 1 September 2001 Gastric Acid Secretion by Central Injection of Dynorphin A-( 1 - 17), Satomi Ishihara, Shizuko Tsuchiya, Syunji Horie, 14 an Endogenous Ligand of r-Opioid Receptor, in Urethane-Anesthetized Rats Toshihiko Murayama and Kazuo Watanabe In Vivo Antiarrhythmic Profile of AP-792 Assessed in Different Canine Akira Takahara, Akira Hirasawa, Hideki Dohmoto, 21 Arrhythmia Models Masataka Shoji, Ryota Yoshimoto, Atsushi Sugiyama and Keitaro Hashimoto Effects of Antimuscarinic Drugs on Both Urinary Frequency Toshinori Oka, Koushi Nakano, Tsukasa Kirimoto 27 and Cognitive Impairment in Conscious, Nonrestrained Rats and Naosuke Matsuura Antiischemic Properties of Fesudil in Experimental Models of Vasospastic Shin-ichi Satoh, Ichiro Ikegaki, Toshio Asano 34 Angina and Hiroaki Shimokawa Contents The Upregulation by Peplomycin of Signal Transduction in Human Cells Tetsuya Yamamoto, Kazunori Yoneda, Eisaku Ueta 41 and Tokio Osaki Carboxy-PTIO Increases the Tetrahydrobiopterin Level in Mouse Brain Shunichi Shimizu, Masakazu Ishii, Michiko Iwasaki, 51 Microvascular Endothelial Cells Kazuhiro Shiota, Toshinori Yamamoto and Yuji Kiuchi Antioxidative Activity of Natural Isorhapontigenin Qing Li Wang, Mao Lin and Geng Tao Liu 61 Effects of Phytoestrogens on Acetylcholine- and Isoprenaline-Induced Kiyoshi Yamaguchi, Hideo Honda, Chiaki Wakisaka, 67 Vasodilation in Rat Aorta Atsushi Tohei and Hiroshi Kogo Acute Electropharmacological Effects of Intravenously Administered Atsushi Sugiyama, Yoshioki Satoh 74 Amiodarone Assessed in the In Vivo Canine Model and Keitaro Hashimoto Number 2 October 2001 Protective Effect of FR183998, a Na*/H^ Exchange Inhibitor, Against Fumihiro Ohara, Nobuhiro Yamamoto, 110 Postischemic Injury After Normothermic and Prolonged Hypothermic Kazuhiro Maeda, Toru Ozaki, Jiro Seki Ischemia in Isolated Perfused Rat Hearts and Toshio Goto Lowered Susceptibility of Muscarinic Receptor Involved in Salivary Secretion Masahito Watanabe, Hisako Yamagishi-Wang 117 of Streptozotocin-Induced Diabetic Rats and Mitsuru Kawaguchi Inhibition by Clonidine of the Carbachol-Induced Tension Development SeungSoo Chung, SeongChun Kwon, YunSuk Kim, 125 and Nonselective Cationic Current in Guinea Pig Ileal Myocytes DuckSun Ahn, YoungHo Lee and TaickSang Nam Role of Adenosine in Renal Protection Induced by a Brief Episode Haruko Sugino, Hideyo Shimada and Kanji Tsuchimoto 134 of Ischemic Preconditioning in Rats Effect of /7-Hydroxybutyrate, a Cerebral Function Improving Agent, Motohisa Suzuki, Mayumi Suzuki, Kazunori Sato, 143 on Cerebral Hypoxia, Anoxia and Ischemia in Mice and Rats Sekiko Dohi, Takashi Sato, Akihiro Matsuura and Atsushi Hiraide Efficacy of the Inflammatory Cell Infiltration Inhibitor IS-741 on Colitis Shuichi Yotsuya, Hiroshi Shikama 151 Induced by Dextran Sulfate Sodium in the Rat and Masashi Imamura Acidosis Inhibits Gallbladder Contraction Mediated by Protein Kinase C Yasuro Kataoka, Hidehisa Masui, Nobuo Iwata 158 Activation and Ichiro Wakabayashi Number 3 November 2001 Adenylate Cyclase / Protein Kinase A Signaling Pathway Enhances Hideki Amano, Kao Ando, Satoshi Minamida, 181 Angiogenesis Through Induction of Vascular Endothelial Growth Factor Izumi Hayashi, Michiko Ogino, Shohei Yamashina, In Vivo Hirokuni Yoshimura and Masataka Majima Assessment of Affinity and Dissociation Ability of a Newly Synthesized 5-HT2 Mamunur Rashid, Masatomo Watanabe, 189 Antagonist, AT-1015: Comparison With Other 5-HT2 Antagonists Mikio Nakazawa, Takashi Nakamura, Kaoru Hattori and Takafumi Nagatomo Deterioration of Spatial Learning Performances in Lipopolysaccharide- Ken Arai, Norio Matsuki, Yuji Ikegaya 195 Treated Mice and Nobuyoshi Nishiyama Activation of a Potassium Conductance by Extracellular Alkaline pH Shigeru Yoshida, Mizuko Yoshimura 202 in Oocytes of Xenopus laevis and Kohtaro Taniyama Effects of Calcium Antagonists on the Nitrergic Nerve Function in Canine Tomio Okamura, Hideyuki Fujioka 208 Corpus Cavernosum and Kazuhide Ayajiki A Novel Analgesic Compound OT-7100 Attenuates Nociceptive Responses Tsuneo Yasuda, Keiichiro Okamoto, Takeshi Iwamoto, 214 in Animal Models of Inflammatory and Neuropathic Hyperalgesia: Shinya Miki, Norihiro Yoshinaga, Seiji Sato, A Possible Involvement of Adenosinergic Anti-nociception Koichi Noguchi and Emiko Senba The Influence of the Protein Kinase A System in Differentiation Kenichi Shimada, Tomoyuki Abe, Mitsunobu Mio 226 of HL-6O-E0 Cells to Eosinophils Induced by Histamine and Chiaki Kamei Number 4 December 2001 Spinorphin, an Endogenous Inhibitor of Enkephalin-Degrading Enzymes, Motoko Honda, Hiroko Okutsu, Tomoyuki Matsuura, 261 Potentiates Leu-Enkephalin-Induced Anti-allodynic and Antinociceptive Tomohiro Miyagi, Yukio Yamamoto, Tadahiro Hazato Effects in Mice and Hideki Ono Contents iii Involvement of Potassium Channels in Spinal Antinociceptions Induced Isao Yamazumi, Takahiko Okuda and Yoshihisa Koga 268 by Fentanyl, Clonidine and Bethanechol in Rats Role of Dopaminergic System in Core Part of Nucleus Accumbens Izzettin Hatip-AI-Khatib, Funda Boliikbasi, 277 in Hyperlocomotion and Rearing Induced by MK-801 in Rats: A Behavioral Kenichi Mishima, Nobuaki Egashira, and In Vivo Microdialysis Study Katsunori Iwasaki and Michihiro Fujiwara Protective Effect of Salvia miltiorrhiza on Angiotensin ll-Induced Hypertrophic XinShou Ouyang, Kyoko Takahashi, 289 Responses in Neonatal Rat Cardiac Cells Katsuko Komatsu, Norio Nakamura, Masao Hattori, Akemichi Baba and Junichi Azuma Characteristics of Learning and Memory Impairment Induced Kenichi Mishima, Nobuaki Egashira, Nobue Hirosawa, 297 by ^’-Tetrahydrocannabinol in Rats Megumi Fujii, Yoshiaki Matsumoto, Katsunori Iwasaki and Michihiro Fujiwara Origin of Ca^^ Necessary for Carbachol-Induced Contraction in Longitudinal Tadayoshi Takeuchi, Masahiro Sumiyoshi, 309 Muscle of the Proximal Colon of Rats Munenori Kitayama, Nobue Hirayama, Akikazu Fujita and Fumiaki Hata A Potential Role of Bradykinin in Angiogenesis and Growth of S-180 Keiko Ishihara, Izumi Hayashi, Shohei Yamashina 318 Mouse Tumors and Masataka Majima Addition of Maitake D-fraction Reduces the Effective Dosage of Vancomycin Noriko Kodama, Maho Yamada and Hiroaki Nanba 327 for the Treatment of Z./5ferAa-lnfected Mice Short Communications Number 1 September 2001 Effects of Nipradilol, a Nitric Oxide-Releasing ^-Adrenoceptor Blocking Keishi Yamauchi, Koji Nakajima, Sachiko Ikeo, 83 Agent, on Phosphoenolpyruvate Carboxykinase Gene Transcription Yoshihiro Nishimura, Mitsuhisa Komatsu, in a Rat Hepatoma Cell Line Toru Aizawa and Kiyoshi Hashizume Dosing Time-Dependent Effect of Trandolapril on the Prevention of Cardiac Koh-ichi Sugimoto, Masami Ohmori, 86 Hypertrophy in Rats With Aortic Banding Atsuhiro Kawaguchi, Shuichi Tsuruoka and Akio Fujimura Inhibition of Expression of Ornithine Decarboxylase by c-myc Antisense Tomohiro Yano, Yoshihisa Yano, Saburo Horikawa, 90 Oligonucleotide at the Promotion Stage of Lung Tumorigenesis in Mice Haruna Satoh, Kiyokazu Hagiwara, Tomio Ichikawa and Shuzo Otani 2-Arachidonoylglycerol and Anandamide Oppositely Modulate Norepinephrine Junichi Kurihara, Michiru Nishigaki, 93 Release from the Rat Heart Sympathetic Nerves Shigeto Suzuki, Yoko Okubo, Yoshinobu Takata, Shinji Nakane, Takayuki Sugiura, Keizo Waku and Hitoshi Kato Number 2 October 2001 Beneficial Effect of a-Tocopherol in Renal Ischemia-Reperfusion in Rats Ernani Luis Rhoden, Luiz Pereira-Lima, 164 Claudio Teloken, Marcio Luis Lucas, Adriane Bello-Klein and Claudia Ramos Rhoden Effects of Olopatadine Hydrochloride on the Cutaneous Vascular Ken ichi Hayashi, Toshihiko Kaise, Kenji Ohmori, 167 Hyperpermeability and the Scratching Behavior Induced by Poly-L-Arginine Akio Ishii and Akira Karasawa in Rats Number 3 November 2001 A Comparative Study of the Fluoroquinolone Antibacterial Agents on the Action Takehiro Hagiwara, Sumie Satoh, Yoshio Kasai 231 Potential Duration in Guinea Pig Ventricular Myocardia and Kiyoshi Takasuna Activation of Background Membrane Conductance by the Tyrosine Kinase Toshitsugu Ogura, Sunao Imanishi 235 Inhibitor Tyrphostin A23 and Its Inactive Analog Tyrphostin A1 in Guinea and Toshishige Shibamoto Pig Ventricular Myocytes Ameliorative Effects of Azaindolizinone Derivative ZSET845 Yoshimasa Yamaguchi, Masaya Higashi, 240 on Scopolamine-Induced Deficits in Passive Avoidance and Radial-Arm Toshiyuki Matsuno and Seiichiro Kawashima Maze Learning in the Rat IV Contents Number 4 December 2001 Effects of a ir-Receptor Agonist U-50488 on Bulbar Respiratory Neurons Akira Haji and Ryuji Takeda 333 and Its Antagonistic Action Against the fi Receptor-Induced Respiratory Depression in Decerebrate Cats Protective Effects of Puerariae flos Against Ethanol-Induced Apoptosis Mi-Hyeon Jang, Min-Chul Shin, Youn-Jung Kim, 338 on Human Neuroblastoma Cell Line SK-N-MC Joo-Ho Chung, Sung-Vin Yim, Ee-Hwa Kim, Yeunhee Kim and Chang-Ju Kim NMDA Receptors in the Spinal Cord Exert Excitatory Influences on Spinal Mitsuo Tanabe and Tsugio Kaneko 343 Motor Output in Rats / I I I