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THE JAPANESE JOURNAL OF PHARMACOLOGY Volume 84 2000 Official Publication of The Japanese Pharmacological Society THE JAPANESE JOURNAL OF PHARMACOLOGY Published Monthly by The Japanese Pharmacological Society Volume 84 2000 http: wwwsoc. nacsis. ac. j p/t j ps/j jp Chief Editor European Editor Yasuyuki Nomura (Sapporo) Ezio Giacobini (Geneva, Switzerland) Press Editor North American Editor Yasushi Kuraishi (Toyama) Tony J.F. Lee (Springfield, IL, USA) Editors Hiroshi Iwao (Osaka) Editorial Advisory Board International Advisory Board Koichiro Kawashima (Tokyo) M. Akagi (Tokushima) K. Nakayama (Shizuoka) J. E. Brayden (Burlington, VT, USA) Miwa Misawa (Tokyo) K. Fuji (Kyoto) M. Nomoto (Kagoshima) P. Dominiak (Liibeck, Germany) Takamura Muraki (Tokyo) C. Hamada (Kyoto) S. Ohkuma (Kurashiki) A. Fisher (Ness Ziona, Israel) Ikunobu Muramatsu (Fukui) M. lino (Tokyo) K. Onodera (Sendai) E. Hamel (Montreal, Canada) Susumu Okabe (Kyoto) Y. Imaizumi (Nagoya) H. Ozaki (Tokyo) M.D. Linnik (San Diego, CA, USA) Kohtaro Taniyama (Nagasaki) S. Kaneko (Kyoto) T. Suzuki (Tokyo) K. Ldffelholz (Mainz, Germany) H. Kawasaki (Okayama) K. Takeuchi (Kyoto) G. Pepeu (Florence, Italy) Mitsuhiro Yoshioka (Sapporo) K. Kitamura (Fukuoka) T. Uematsu (Gifu) J. Tamargo (Madrid, Spain) S. Kobayashi (Kawasaki) K. Umemura (Hamamatsu) L. F. Tseng (Milwaukee, Wl, USA) Language Editor S. Kohno (Kyoto) Y. Yamaguchi (Tokyo) S.M. Jung K. Miyamoto (Kanazawa) Y. Yamazoe (Sendai) Editorial Assistant M. Miyazaki (Takatsuki) T. Yanagisawa (Sendai) Y. Takezaki K. Momose (Tokyo) S. Yano (Chiba) Abstracted/Indexed in Biological Abstracts (BIOSIS), Chemical Abstracts, EMBASE/Excerpta Medica, Index Medicus (MEDLINE), Current Contents/Life Sci. (CC/LS), Reference Update (RIS), Elsevier BIOBASE/Current Awareness in Biological Sciences, ISI/BIOMED Editorial and Publishing Correspondence Editorial Office, The Japanese Pharmacological Society, Kantohya bldg, Gokomachi-Ebisugawa, Nakagyo-ku, Kyoto 604-0982, Japan TEL: -1-81-75-252-4641, FAX: -(-81-75-252-4618, E-mail: LDB00573(^nifty.ne.jp Information for contributors is printed at the end of each issue. Subscription Information Volumes 82-84 (12 issues plus Supplement) will appear in 2000. Subscription orders can be entered only by calendar year. Subscription/Back issue orders and inquiries should be sent to: All orders inside Japan and individual orders outside Japan: the Editorial Office at the address given above. Annual subscription rate is ¥20,000 including postage. Institutional orders outside Japan: Maruzen Co., Ltd., Export Department, PO Box 5050, Tokyo International 100-3199, Japan TEL: -(-81-3-3273-3234, FAX: -(-81-3-3271-6076. 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(CCC), 222 Rosewood Drive, Danvers, MA 01923, USA TEL: + 1-978-750-8400, FAX: + 1-978-750-4744, www.copyright.com Copyright © The Japanese Pharmacological Society 20(X) Contents CONTENTS Volume 84 • 2000 Reviews Number 2 October 2000 Therapeutic Strategies in Alzheimer's Disease: M1 Muscarinic Agonists Abraham Fisher 101 Number 3 November 2000 — Current Perspective — Role of Cannabinoid Receptor in the Brain as It Relates to Drug Reward Tsuneyuki Yamamoto and Kohji Takada 229 — Current Perspective — The Parkinsonian Models: Invertebrates to Mammals Yoshihisa Kitamura, Shun Shimohama, 237 Akinori Akaike and Takashi Taniguchi Number 4 December 2000 — Current Perspective — Actions of Tachykinins Within the Heart and Their Relevance Donald B. Hoover, Yingzi Chang, John C. Hancock 367 to Cardiovascular Disease and Lili Zhang Regular Papers Number 1 September 2000 Positive Inotropic Effects of Imidazoline Derivatives Are Not Mediated Walter Raasch, K.R. Julian Chun, Andreas Dendorfer 1 via Imidazoline Binding Sites but ai-Adrenergic Receptors and Peter Dominiak Pharmacological Characterization of a Novel Sulfonylureid-Pyrazole Kayo Umekawa, Hirohiko Hasegawa, 7 Derivative, SM-19712, a Potent Nonpeptidic Inhibitor of Endothelin Yasushi Tsutsumi, Kimihiko Sato, Yasuo Matsumura Converting Enzyme and Naohito Ohashi Protective Effect of SM-19712, a Novel and Potent Endothelin Converting Yasuo Matsumura, Toshihiko Kuro, Yutaka 16 Enzyme Inhibitor, on Ischemic Acute Renal Failure in Rats Kobayashi, Kayo Umekawa, Naohito Ohashi and Masanori Takaoka Characterization of the Ca^^ Response Mediated by Activation Akihiro Nezu, Akihiko Tanimura and Yosuke Tojyo 25 of ^-Adrenoceptors in Rat Submandibular Ducts Effects of Perinatal Nicotine Exposure on Development Jun Zhu, Takanobu Taniguchi, Takashi Tanaka, 32 of [^H]Hemicholinium-3 Binding Sites in Rat Neonate Brain Fumiko Suzuki and Ikunobu Muramatsu In Vitro and In Vivo Long Term Release of Apomorphine From Polymer Walter Raasch, Carsten Slotty and Peter Dominiak 36 Matrices Cholecystokinin Acts as an Essential Factor in the Exacerbation Koji Yoshinaga, Masataka Washizuka 44 of Pancreatic Bile Duct Ligation-Induced Rat Pancreatitis Model and Yoshihide Segawa Under Non-fasting Condition Food Deprivation Depletes Gastric Mucus Glycoprotein in Streptozotocin- Shigeki Igarashi, Eisuke Kume, Hiroshi Narita 51 Induced Diabetic Rats and Mine Kinoshita Effects of Benidipine Hydrochloride on Cerebrovascular Lesions Hideo Ueno, Takuji Hara, Akio Ishi 56 in Salt-Loaded Stroke-Prone Spontaneously Hypertensive Rats: Evaluation and Katsuichi Shuto by Magnetic Resonance Imaging Contents Protection by Polaprezinc, an Anti-ulcer Drug, Against Indomethacin- Yasuyoshi Fujii, Tatsuya Matsura, Masachika Kai, 63 Induced Apoptosis in Rat Gastric Mucosal Cells Hironaka Kawasaki and Kazuo Yamada Number 2 October 2000 Alteration in Expression Profiles of a Series of Diabetes-Related Genes Akiko Suzuki, Toru Yasuno, Hitoshi Kojo, 113 in db/db Mice Following Treatment With Thiazolidinediones Jiro Hirosumi, Seitaro Mutoh and Yoshitada Notsu Calcium Signaling and c-Fos Gene Expression via M3 Muscarinic Takeshi Fujii and Koichiro Kawashima 124 Acetylcholine Receptors in Human T- and B-Cells Involvement of the Renal Kallikrein-Kinin System in Furosemide-Induced Tomoe Fujita, Yuji Kumagai, Yasuhiro Ikeda, 133 IMatriuresis in Rats Naoya Inamura, Tomonori Iwata, Michiko Ogino and Masataka Majima Intracellular Ca^"^ Increase in Neuro-2A Cells and Rat Astrocytes Yuri Ikeda, Akinori Ueno, Hiroaki Naraba, 140 Following Stimulation of Bradykinin B2 Receptor Norio Matsuki and Sachiko Oh-ishi Effect of Endothelin-1 (1-31) on Human Mesangial Cell Proliferation Masanori Yoshizumi, Shoji Kagami, Yuki Suzaki, 146 Koichiro Tsuchiya, Hitoshi Houchi, Tetsuhiro Hisayama, Hiroyuki Fukui and Toshiaki Tamaki Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Akira Nakatsuma, Hiromu Kawasaki, Yuji Kurosaki, 1 56 Nerve Function in the Mesenteric Artery of Spontaneously Hypertensive Rats Kojiro Futagami, Hiroaki Araki and Yutaka Gomita The Scopolamine-Induced Impairment of Spatial Cognition Parallels Kenichi Mishima, Katsunori Iwasaki, 163 the Acetylcholine Release in the Ventral Hippocampus in Rats Hiroshi Tsukikawa, Yoshiaki Matsumoto, Nobuaki Egashira, Kohji Abe, Takashi Egawa and Michihiro Fujiwara Investigation Into the 5-Hydroxytryptophan-Evoked Luminal Shu-ichi Kojima, Masashi Ikeda 174 5-Hydroxytryptamine Release From the Guinea Pig Colon and Yuichiro Kamikawa Involvement of Complexin II in Synaptic Plasticity in the CA1 Region Guang-Zhe Huang, Hisamitsu Ujihara, 179 of the Hippocampus: The Use of Complexin ll-Lacking Mice Sei-ichi Takahashi, Hideto Kaba, Takeshi Yagi and Shinpei Inoue Antinociceptive Activity of the Novel Fentanyl Analogue iso-Carfentanil Sonja Vuckovic, Milica Prostran, Milovan Ivanovic, 188 in Rats Zorana Ristovic and Radan Stojanovic Effect of SMP-300, a New Na^/H^ Exchange Inhibitor, on Myocardial Setsuko Yamamoto, Kazuki Matsui, Masao Sasabe, 196 Ischemia and Experimental Angina Models in Rats Masahumi Kitano and Naohito Ohashi Recombinant Adeno-associated Virus Vectors Efficiently Transduce Foreign Shinji Teramoto, Takeo Ishii, Takeshi Matsuse 206 Gene Into Bovine Aortic Endothelial Cells: Comparison With Adenovirus and Yoshinosuke Fukuchi Vectors Oxidation of Ranitidine by Isozymes of Flavin-Containing Monooxygenase Woon-Gye Chung, Chang-Shin Park, 213 and Cytochrome P450 Hyung-Keun Roh, Woon-Kee Lee and Young-Nam Cha Number 3 November 2000 Effects of Higenamine on Regulation of Ion Transport in Guinea Pig Distal Weixin Liu, Yoshihiko Sato, Yoshisuke Hosoda, 244 Colon Koki Hirasawa and Hiroyuki Hanai TAS-301 Blocks Receptor-Operated Calcium Influx and Inhibits Rat Vascular Eiji Sasaki, Yoshihisa Nozawa, Kazuhisa Miyoshi, 252 Smooth Muscle Cell Proliferation Induced by Basic Fibroblast Growth Factor Atsuhiro Kanda, Yasundo Yamasaki, and Platelet-Derived Growth Factor Hidekazu Miyake and Naosuke Matsuura Behavioral and Pharmacological Studies on Gluten Exorphin A5, a Newly Masakatsu Takahashi, Hiroko Fukunaga, 259 Isolated Bioactive Food Protein Fragment, in Mice Hiroshi Kaneto, Shin-ichi Fukudome and Masaaki Yoshikawa Contents iii Activation of Cerebral Function by CS-932, a Functionally Selective Nobuyoshi Iwata, Masao Kozuka, Takao Hara, 266 Partial Agonist: Neurochemical Characterization and Pharmacological Tsugio Kaneko, Toshiyuki Tonohiro, Studies Masahiko Sugimoto, Yoichi Niitsu, Yusuke Kondo, Tsuneyuki Yamamoto, Jun-ichi Sakai and Mitsuo Nagano Dexamethasone or Triamcinolone Increases Follicular Development Atsushi Tohei, Satoshi Sakamoto and Hiroshi Kogo 281 in Immature Female Rats Partial Agonistic Effects of Carteolol on Atypical ^-Adrenoceptors Takahiro Horinouchi and Katsuo Koike 287 in the Guinea Pig Gastric Fundus Effects of Maitake {Grifola frondosa) Polysaccharide on Collagen-Induced Kazunori Shigesue, Noriko Kodama 293 Arthritis in Mice and Hiroaki Nanba Pharmacological Characteristics of Inhibitory Action of the Selective Xiaoying Qiao, Ikuo Norota and Masao Endoh 301 ai-Antagonist JTH-601 on the Positive Inotropic Effect Mediated by ai-Adrenoceptors in Isolated Rabbit Papillary Muscle Effect of the Selective Adenosine Ai-Receptor Antagonist KW-3902 Kozo Yao, Yasuhiro Ina, Ken Nagashima, 310 on Lipopolysaccharide-Induced Reductions in Urine Volume and Renal Blood Tetsuji Ohno and Akira Karasawa Flow in Anesthetized Dogs Hypotensive Interaction of Sildenafil and Nicorandil in Rats Through Nobuhiko Ishizuka, Keiji Saito, Michitaka Akima, 316 the cGMP Pathway but Not by Katp Channel Activation Shuzo Matsubara and Motoo Saito Correlation Between Adenine Nucleotide-Induced Cyclic AMP Elevation Satoko Ohkubo, Junko Kimura and Isao Matsuoka 325 and Extracellular Adenosine Formation in NG108-15 Cells Mechanisms of [2,3-Butanedione Bis(/V‘*-Dimethylthiosemicarbazone)]zinc Megumi Kubota, Yasuhiko lida, Yasuhiro Magata, 334 (Zn-ATSM2)-lnduced Protection of Cultured Hippocampal Neurons Against Youji Kitamura, Hideaki Kawashima and Hideo Saji /V-Methyl-o-Aspartate Receptor-Mediated Glutamate Cytotoxicity Cortical Astrocytes Exposed to Tributyltin Undergo Morphological Changes In Satomi Mizuhashi, Yuji Ikegaya, 339 Vitro Nobuyoshi Nishiyama and Norio Matsuki Number 4 December 2000 Characteristics of Monkey Tryptase Purified From Cheek Pouch Vascular Masato Sakaguchi, Shinji Takai, Denan Jin, 375 Tissues Mayumi Yamada and Mizuo Miyazaki Effects of Adrenergic a2-Receptor Agonists on Urinary Bladder Contraction Hitoshi Kontani, Toshitsugu Tsuji and Satoko Kimura 381 in Conscious Rats Effects of S-Nitroso-Cysteine on Proteins That Regulate Exocytosis Tomoyoshi Naganuma, Mutsuko Maekawa, 391 in PC12 Cells: Inhibitory Effects on Translocation of Synaptophysin Toshihiko Murayama and Yasuyuki Nomura and ADP-Ribosylation of GTP-Binding Proteins Stimulation of High-Affinity GTPase Activity Through Group II Metabotropic Yuji Odagaki, Nobuyuki Nishi and Tsukasa Koyama 399 Glutamate Receptors in Rat Hippocampal and Striatal Membranes Enhancement of Peptone-Induced Gastric Acid Secretion in Streptozotocin- Akinobu Fujita, Kimihito Tashima, Masato Nishijima 405 Induced Diabetic Rats and Koji Takeuchi Increase of Calmodulin III Gene Expression by /i-Opioid Receptor Sanyoung Niu, Che-Hui Kuo, Yehua Gan, 412 Stimulation in PC12 Cells Etsuko Nishikawa, Tetsushi Sadakata, Hisashi Ichikawa and Naomasa Miki Role of 5-HTia Receptors in a Mouse Passive Avoidance Paradigm Nicoletta Galeotti, Carla Ghelardini 418 and Alessandro Bartolini Effects of Nitric Oxide on the Vestibular Functional Recovery After Unilateral Jong-Seong Park and Han-Seong Jeong 425 Labyrinthectomy Contents IV Role of Mobilization in Muscarinic Receptor-Mediated Membrane Toshihiro Unno, Tadafumi Inaba, Hidenori Ohashi, 431 Depolarization in Guinea Pig Ileal Smooth Muscle Cells Tadashi Takewaki and Seiichi Komori Enhancement of Intracellular Cl" Concentrations Induced by Extracellular ATP Zhong-Fang Lai and Katsuhide Nishi 438 in Guinea Pig Ventricular Muscle The Functional Ratio of Chymase and Angiotensin Converting Enzyme Denan Jin, Shinji Takai, Mayumi Yamada, 449 in Angiotensin l-Induced Vascular Contraction in Monkeys, Dogs and Rats Masato Sakaguchi and Mizuo Miyazaki Fasting Exacerbates Acute Pancreatitis by Occlusion of the Common Bile Duct Koji Yoshinaga, Masataka Washizuka 455 in Rats and Yoshihide Segawa Short Communications Number 1 September 2000 Serotonin Induces Apoptosis in PGT-^ Pineal Gland Tumor Cells Sung-Vin Yim, Kyung-Hwan Kim, Chang-Ju Kim 71 and Joo-Ho Chung Cardiac Angiotensin II Receptors Are Downregulated by Chronic Makoto Katoh, Kensuke Egashira 75 Angiotensin II Infusion in Rats and Akira Takeshita Repeated Adenosine Pre-treatment Potentiates the Acute Effect Atsuko Kawashimo, Takao Shimazoe, 78 of Methamphetamine in Rats Akiko Yoshimatsu and Shigenori Watanabe Captopril Increases the Affinity of Bradykinin Receptor Binding Sites Atsushi Miyamoto, Tomoko Matsuyama, 82 in Bovine Coronary Arterial Endothelial Cells Shigeru Ishiguro and Akira Nishio Effect of Intracerebroventricular Administration of Soybean Lecithin Satoru Suzuki, Akito Kataoka 86 Transphosphatidylated Phosphatidylserine on Scopolamine-Induced and Masayoshi Furushiro Amnesic Mice Effect of Mexiletine on Thermal Allodynia and Hyperalgesia in Diabetic Mice Junzo Kamei and Ko Zushida 89 The Effects of Soybean Transphosphatidylated Phosphatidylserine Hideyuki Yamatoya, Masashi Sakai 93 on Cholinergic Synaptic Functions of Mice and Satoshi Kudo Number 2 October 2000 Acetylcholine-Induced Smooth Muscle Contraction of Intrapulmonary Small Yoshihiko Chiba, Yuka Takada, Hiroyasu Sakai, 221 Bronchi Is Augmented in Antigen-Induced Airway Hyperresponsive Rats Hisao Takeyama and Miwa Misawa Non-competitive Inhibition of Kainate-Induced Currents by Diethylstilbestrol Hitoshi Ishibashi, Satoshi Okuya, Hideaki Shimada 225 in Acutely Isolated Mouse CA1 Hippocampal Neurons and Kazuo Takahama Number 3 November 2000 Effect of the Selective Adenosine ArReceptor Antagonist KW-3902 Kozo Yao, Nils Heyne and Hartmut Osswald 347 on Tubuloglomerular Feedback in Radiocontrast-Media-Induced Nephropathy in Rats With Chronic Nitric Oxide Deficiency Correction of Hyperglycemia and Insulin Sensitivity by T-1095, an Inhibitor Akira Oku, Kiichiro Ueta, Kenji Arakawa, 351 of Renal Na^-Glucose Cotransporters, in Streptozotocin-Induced Diabetic Rats Tomomi Kano-lshihara, Takeshi Matsumoto, Tetsuya Adachi, Koichiro Yasuda, Kinsuke Tsuda, Katsuo Ikezawa and Akira Saito Effect of APGW-Amide on (Ca^^li in Rat Pheochromocytoma PC12 Cells Xiao Yan Han, Yuzuru Ito, Yoshinori Nozawa, 355 Yifa Jiang and Kenichi Matsunami Contents Periarterial Electrical Nerve Stimulation-Induced Adrenergic Xiao-Ping Yang and Shigetoshi Chiba 360 Vasoconstriction Inhibited by Adrenergic aie-Receptor Blockade but Not by aiA-Blockade Xanthine Oxidase-Derived Reactive Oxygen Species Activate Nuclear Factor Nobuaki Matsui, Ikuko Satsuki, Yuka Morita, 363 Kappa B During Hepatic Ischemia in Rats Keiichi Inaizumi, Kazumi Kasajima, Reiko Kanoh, Nobuyuki Fukuishi and Masaaki Akagi Number 4 December 2000 Itch-Associated Responses of Afferent Nerve Innervating the Murine Skin: Tatsuya Maekawa, Hiroshi Nojima 462 Different Effects of Histamine and Serotonin in ICR and ddY Mice and Yasushi Kuraishi The Effects of Melatonin in Glutamate-Induced Neurotoxicity of Rat Akcahan Gepdiremen, Selma Duzenli, 467 Cerebellar Granular Cell Culture Ahmet HacimuftCioglu, Dilek Bulucu and Halis Suleyman Effect of Hydrogen Peroxide on Guinea Pig Nasal Mucosa Vasculature Tomohisa Hirai, Hiromichi Tsuru, Noriaki Tanimitsu, 470 Masaya Takumida, Hiroshi Watanabe, Koji Yajin and Masashi Sasa Rapid Communications Number 1 September 2000 SK4 Encodes Intermediate Conductance Ca^*-Activated Channels Susumu Ohya, Shunichi Kimura, Mika Kitsukawa, 97 in Mouse Urinary Bladder Smooth Muscle Cells Katsuhiko Muraki, Minoru Watanabe and Yuji Imaizumi Number 4 December 2000 Ca^^-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Ryo Yoshimoto, Masatoshi Hori, 474 Muscle Katsuhito Takahashi, Shun-ichiro Taniguchi, Motoya Katsuki, Hiroshi Ozaki and Hideaki Karaki bi