Jpn. J. Cancer Res Japanese Journal of 3 0910 550 Cancer Research Distribubty eEldsevi er Science Ltd., Irelan&d B usin r for Academic Societies Japa EINDEX Vol.88 1997 JAPANESE CANCER ASSOCIATION Japanese Journal of Cancer Research Vol.88 1997 JAPANESE CANCER ASSOCIATION Editor Deputy Editors Editor Emeritus Masaaki Terada Takao Sekiya Kumao Toyoshima Takashi Sugimura Kaoru Abe iki Kitagawa Nagahiro Saij« Yoshiyuki Hashır K uroki Masabumi Shibuya Setsuo Hirohas! Muramatsu Kunitada Shimotohn Yoshiaki It Nakamura Tomoyuki Shirai Tadao Kakiz u Nishimura Kazuo Sugamura Editorial Board Shinichi Aiz Kiyoshi Mukai Hitoshi Ak Yoshinori Murakami Sakakura Y I tsu Akiyama Tetsuichiro Mut SI ru Sakiyama Nobu I shiwe Andot Minako Nagao Masao S. Sasak Hiroyuki Tsuda S igetaka Asan Shigekazu Nagata Takuma Sasaki Shoi Tsugan I h if Azun 4 ıkatoshi Ishikawa Hitoshi Nakagama Takehiko Sasazuki Ss ozo Baba buyuki !t« Takashi Nakajima Tadashi Sawada Tsukagoshi N Aitsuru Emi ı Kamataki Toshifusa Nakajima Motoharu Seiki Tsukimot« Hiroyasu Esumi R Kannagi Kyoichi Nakamura Mutsuo Sekiguchi Shoichiro Tsukita Yoshiaki Fujii-Kuriyar Hiroshi K Toshikazu Nakamura Teruaki Sekine Kazuo Umezawa Hirota Fujiki Yo Kat Yoshiro Niitsu Hiroyuki Shimizu Toshikazu Ushijima Kei Fujinaga Motoya Katsuki Ohtsura Niwa Kenji Shimizu Kyosuke Ushi« Masanori Fukushima Tadamitsu Kishimoto Tetsuo Noda Nobuyoshi Shimizu Keiji Wakabayashi Shoji Fukushima Masaki Kitajima Kazuhir: Nomura Masanori Shimoyama Hiro Wakasugi Hirofumi Hamac Y ukihike Kitamura Shiro Nozawa Toshio Sofuni Minro Watanabe Toshiyuki Ham: Katsuro Koike Masuo Obinata Keize Sugimachi Shaw Watanab Aya Hanai Morio Koike Takahiro Ochiya Hidex Suzuki Ichiro Yahara Fumio Hanaoka Ryo Kominami Etsuro Ogata Nori Suzuki Masao Yan Ryohei Hasegawa Yoichi Konishi Katsuhiro Ogawa Kazuc Tajima Ken Yamaguchi Masanori Hatakeyama Tomoo Kosuge Makoto Ogawa Kenzo Takada Naohito Yamaguchi Kenshi Hayashi Yoshiyuki Kuchino Takeshi Ogura Masahide Takahashi Tadashi Yamamoto Yoshihide Hayashizaki Michihiko Kuwano Misao Ohki Michihito Takahashi Ken-ichi Yamamura Hikoya Hayatsu Hiroshi Maeda Hisanao Ohkura Toshi Takahashi Takao Yamori Hiroshi Hiai Masayoshi Mai Michio Oishi Toshitada Takahashi Junji Yodoi Okio Hine Masatoshi Makuuchi Shigeru Okada Yoshimi Takai Jun Yokota Shigeo Hino Keishi Matsumot« Shuichi Okada Tadaomi Takenawa Michihiro C. Yoshida Hisamaru Hirai Masanao Miwa Takashi Okamoto Tomio Takeuchi Osamu Yoshida Toshio Hirano Ki Miyazon Hiroto Okayama Kiyoji Tanaka Teruhiko Yoshida Shigeru Hisamichi Hideki Mori Mitsuo Oshimura Naoyuki Taniguchi Kunito Yoshiike Nam-ho Huh Michio Mori Keiya Ozawa Shun'ichir Taniguchi Takashi Yoshiki Masaaki lig« Shigeo Mori Izumu Saito Tadatsugu Taniguchi Hiroshi Yoshikura Yoji Ikawa Noriyuki Moriyama Masaki Saito Masac Tatematsu Yasuhito Yuasa Guest Editorial Members Stuart A. Aaronson Joseph F. Fraumeni, Jr Alfred G. Knudson, Jr Nicolas Odartchenko George F. Vande Woude Kari Alitalo Robert C. Gallo Jen-Kun Lin Kenneth Olden Alex J. van der Eb J. Carl Barrett R. Colin Garner Tomas Lindahl Arthur B. Pardee Peter K. Vogt Webster K. Cavene Jan-Ake Gustafsson David M. Livingston Henry C. Pitot Robert A. Weinberg Allan H. Conney Sen-itiroh Hakomori Lawrence A. Loeb Manfred F. Rajewsky I. Bernard Weinstein Carlo M. Croce Hidesaburo Hanafusa Shih Hsin, Lu Thomas J. Slaga John H. Weisburger Jeffrey Cummings Curtis C. Harris Paul A. Marks Radim J. Sram Harald zur Hausen Sandor Eckhardt Peter M Howley Enrico Mihich Dominique Stehelin Joseph G. Fortner Paul Kleihues Ulrich Mohr Steven R Tannenbaum Richard Fox George Klein Harold L. Moses Thomas Tursz Japanese Cancer Association c/o Cancer Institute, Kami-Ikebukuro 1-3 7-1, Toshima-ku, Tokyo 170, Japan CONTENTS Vol. 88 1997 No. 1 1-102 RAPID COMMUNICATION Isolation of STLV-I from Orangutan, a Great Ape Species in Southeast Asia, and Its Relation to Other HTLV-ls/STLV-ls K. Ibuki, E. Ido, S. Setiyaningsih, M. Yamashita, L. R. P. Agus, J. Takehisa, T. Miura, S. Dondin and M. Hayami REGULAR PAPERS Suppressive Effects of S-Methyl Methanethiosulfonate on Promotion Stage of Diethylnitrosamine-initiated and Phenobarbital-promoted Hepatocarcinogenesis Model S. Sugie, K. Okamoto, M. Ohnishi, H. Makita, T. Kawamori, T. Watanabe, T. Tanaka, Y. K. Nakamura, Y. Nakamura, I. Tomita and H. Mori Triazine Derivatives Inhibit Rat Hepatocarcinogenesis but Do Not Enhance Gap Junctional Intercellular Communication T. Hori, M. Asamoto, V. Krutovskikh, Y. Iwahori, M. Maeda, H. Toriyama-Baba, N. Takasuka and H. Tsuda Overexpression of Cyclin D1 in Rat Esophageal Carcinogenesis Model E. M. Youssef, T. Hasuma, Y. Morishima, N. Takada, H. Osugi, M. Higashino, S. Otani and S. Fukushima Contiguous Four-guanosine Sequence in c-myc Antisense Phosphorothioate Oligonucleotides Inhibits Cell Growth on Human Lung Cancer Cells: Possible Involvement of Cell Adhesion Inhibition Y. Saijo, B. Uchiyama, T. Abe, K. Satoh and T. Nukiwa Increased Radiosensitivity of p16 Gene-deleted Human Glioma Cells after Transfection with Wild-type p16 Gene J. Miyakoshi, K. Kitagawa, N. Yamagishi, S. Ohtsu, R. S. Day, III and H. Takebe Induction of p53-independent Apoptosis Associated with G2M Arrest Following DNA Damage in Human Colon Cancer Cell Lines D. Arita, M. Kambe, C. Ishioka and R. Kanamaru Immunocytochemistry of Apoptosis Induced by Bromodeoxyuridine in Human Leukemic HL-60 Cells K. Kondo and T. Makita Expression of Fas Antigen and Its Mediation of Apoptosis in Human Gastric Cancer Cell Lines H. Hayashi, S. Tatebe, M. Osaki, A. Goto, Y. Suzuki and H. Ito Features of DNA Oligonucleosomal Fragmentation in Human Tumor Cell Lines and Its Detection by Flow Cytometry: Utility and Limitations H. Kikuchi, S. Ujiie, A. Wakui, A. Yokoyama and R. Kanamaru A Defect in Cell-to-cell Adhesion via Integrin-Fibronectin Interactions in a Highly Metastatic Tumor Cell Line Y. Abe, T. Tsutsui, J.M u, A. Kosugi, H. Yagita, K. Sobue, O. Niwa, H. Fujiwara and T. Hamaoka Stromal Expression of MMP-9 and Urokinase Receptor Is Inversely Associated with Liver Metastasis and with Infiltrating Growth in Human Colorectal Cancer: A Novel Approach from Immune/Inflammatory Aspect S. Takeha, Y. Fujiyama, T. Bamba, T. Sorsa, H. Nagura and H. Ohtani Hypersensitivity to Mosquito Bites Conceals Clonal Lymphoproliferation of Epstein-Barr Viral DNA-positive Natural Killer Cells S. Ishihara, K. Ohshima, Y. Tokura, R. Yabuta, H. Imaishi, H. Wakiguchi, T. Kurashige, H. Kishimoto, I. Katayama, S. Okada and K. Kawa-Ha Establishment by Adriamycin Exposure of Multidrug-resistant Rat Ascites Hepatoma AH130 Cells Showing Low DT-diaphorase Activity and High Cross Resistance to Mitomycins S. Wakusawa, S. Nakamura and K. Miyamoto JPN. J. CANCER RES. 88, 1997 Experimental Studies on Potentiation of the Antitumor Activity of 5-Fluorouracil with 3 -Azido- 3 -deoxythymidine for the Gastric Cancer Cell Line MKN28 in vivo C. Yasuda, M. Kato, D. Kuroda and H. Ohyanagi 103-223 RAPID COMMUNICATIONS Expression of Human Telomerase RNA Is an Early Event of Stomach Carcinogenesis H. Kuniyasu, T. Domen, T. Hamamoto, H. Yokozaki, W. Yasui, H. Tahara and E. Tahara Effect of Glutathione Depletion on Cisplatin Resistance in Cancer Cells Transfccted with the 7-Glutamylcysteine Synthetase Gene H. Kurokawa, K. Nishio, T. Ishida, H. Arioka, K. Fukuoka, T. Nomoto, H. Fukumoto, H. Yokote and N. Saijo REGULAR PAPERS Inhibitory Effects of Dietary Protocatechuic Acid and Costunolide on 7,12-Dimethylbenz{[a ]anthracene- induced Hamster Cheek Pouch Carcinogenesis M. Ohnishi, N. Yoshimi, T. Kawamori, N. Ino, Y. Hirose, T. Tanaka, J. Yamahara, H. Miyata and H. Mori Overexpression of Integrin-associated Protein (CD47) in Rat Kidney Treated with a Renal Carcinogen, Ferric Nitrilotriacetate Y. Nishiyama, T. Tanaka, H. Naito, C. Mori, M. Fukumoto, H. Hiai and S. Toyokuni Demonstration of ras and p53 Gene Mutations in Carcinomas in the Forestomach and Intestine and Soft Tissue Sarcomas Induced by N-Methyl-N-nitrosourea in the Rat K. Matsumoto, T. Iwase, I. Hirono, Y. Nishida, Y. Iwahori, T. Hori, M. Asamoto, N. Takasuka, D. J Kim, T. Ushijima, M. Nagao and H. Tsuda Dual Infection of Rabbits with Human T Cell Lymphotropic Virus Types I and II H. Machida, N. Morishita, T. Ikezoe, T. Sawada, Y. Ohtsuki and I. Miyoshi Correlated Expression of Glutathione S-Transferase-z and c-Jun or Other Oncogene Products in Human Squamous Cell Carcinomas of the Head and Neck: Relevance to Relapse after Radiation Therapy K. Miura, S. Suzuki, J. Tanita, H. Shinkawa, K. Satoh and S. Tsuchida Transforming Growth Factor- and Hepatocyte Growth Factor Produced by Gastric Fibroblasts Stimulate the Invasiveness of Scirrhous Gastric Cancer Cells T. Inoue, Y.-S. Chung, M. Yashiro, S. Nishimura, T. Hasuma, S. Otani and M. Sowa Gene Mutation Analysis and Quantitation of DNA Topoisomerase I in Previously Untreated Non-small Cell Lung Carcinomas H. Takatani, M. Oka, M. Fukuda, F. Narasaki, R. Nakano, K. Ikeda, K. Terashi, A. Kinoshita, H. Soda, T. Kanda, E. Schneider and S. Kohno Direct Intratumoral Gene Transfer of the Herpes Simplex Virus Thymidine Kinase Gene with DNA-liposome Complexes: Growth Inhibition of Tumors and Lack of Localization in Normal Tissues K. Takakuwa, K. Fujita, A. Kikuchi, S. Sugaya, T. Yahata, H. Aida, T. Kurabayashi, I. Hasegawa and K. Tanaka Development and Elongation of Neurite-like Outgrowth on Small Cell Lung Cancer Cell Lines K. Tanaka and T. Terasaki Bovine Lactoferrin and Lactoferricin, a Peptide Derived from Bovine Lactoferrin, Inhibit Tumor Metastasis in Mice Y.-C. Yoo, S. Watanabe, R. Watanabe, K. Hata, K. Shimazaki and I. Azuma Cytotoxicity of Histocompatibility Leukocyte Antigen-DR8-restricted CD4* Killer T Cells against Human Autologous Squamous Cell Carcinoma A. Miyazaki, N. Sato, S. Takahashi, A. Sasaki, G.K ohama, A. Yamaguchi, A. Yagihashi and K. Kikuchi CONTENTS Histocompatibility Leukocyte Antigen-A2402-restricted Cytotoxic T Lymphocytes Recognizing Adenocarcinoma in Tumor-infiltrating Lymphocytes of Patients with Colon Cancer R. Gohara, M. Nakao, Y. Ogata, H. Isomoto, K. Oizumi and K. Itoh Decreased Renal Accumulation of Biotinylated Chimeric Monoclonal Antibody-Neocarzinostatin Conjugate after Administration of Avidin E. Otsuji, T. Yamaguchi, K. Yamamoto, H. Matsumura, H. Tsuruta, Y. Yata, H. Nishi, K. Okamoto, K. Kitamura and T. Takahashi Altered Expression of 7-Glutamylcysteine Synthetase, Metallothionein and Topoisomerase I or II during Acquisition of Drug Resistance to Cisplatin in Human Ovarian Cancer Cells Y. Kikuchi, J. Hirata, K. Yamamoto, K. Ishii, T. Kita, K. Kudoh, T. Tode, I. Nagata, K. Taniguchi and M. Kuwano Enhancement of Tumor Radio-response by Irinotecan in Human Lung Tumor Xenografts K. Tamura, M. Takada, I. Kawase, T. Tada, S. Kudoh, K. Okishio, M. Fukuoka, N. Yamaoka, \ Fujiwara and M. Yamakido 225-333 RAPID COMMUNICATIONS No Evidence of Mutation in the Human PTC Gene, Responsible for Nevoid Basal Cell Carcinoma Syndrome, in Human Primary Squamous Cell Carcinomas of the Esophagus and Lung K. Suzuki, Y. Daigo, S. Fukuda, T. Tokino, M. Isomura, K. Isono, B. Wainwright and Y. Nakamura Concomitant Presence of p16/Cyclin-dependent Kinase 4 and Cyclin D/Cyclin-dependent Kinase 4 Complexes in LNCaP Prostatic Cancer Cell Line N. Itoh, Y. Kakehi, T. Akao, H. Kinoshita, Y. Okada and O. Yoshida Suppression of Nitric Oxide Production in Lipopolysaccharide-stimulated Macrophage Cells by o3 Polyunsaturated Fatty Acids T. Ohata, K. Fukuda, M. Takahashi, T. Sugimura and K. Wakabayashi REGULAR PAPERS Dose-dependent Induction of Both Pepsinogen-altered Pyioric Glands and Adenocarcinomas in the Glandular Stomach of C3H Mice Treated with N-Methyl-N-nitrosourea M. Yamamoto, C. Furihata, Y. Fujimitsu, T. Imai, K. Inada, H. Nakanishi and M. Tatematsu Strain Differences in Sensitivity to the Promoting Effect of Sodium L-Ascorbate in a Two-stage Rat Urinary Bladder Carcinogenesis Model T. Murai, S. Mori, M. Hosono, A. Takashima, S. Machino, T. Oohara, H. Yamashita, S. Makino, T. Matsuda, H. Wanibuchi and S. Fukushima Intragenic Tsc2 Somatic Mutations as Knudson’s Second Hit in Spontaneous and Chemically Induced Renal Carcinomas in the Eker Rat Model T. Kobayashi, S. Urakami, Y. Hirayama, T. Yamamoto, M. Nishizawa, T. Takahara, Y. Kubo and O. Hino Infrequent Overexpression of p53 Protein in Epstein-Barr Virus-associated Gastric Carcinomas H. Ojima, T. Fukuda, T. Nakajima and Y. Nagamachi Inhibition by Protein Kinase C Inhibitor of Expression of Leukocyte Function-associated Antigen-1 Molecules in Rat Hepatoma AH66F Cells M. Nomura, N. Sugiura, S. Moritani and K. Miyamoto Immunoreaction at 43 kDa with Anti-ubiquitin Antibody in Breast Neoplasms K. Iwaya, H. Nishibori, T. Osada, Y. Matsuno, H. Tsuda, S. Sato, H. Kono, T. Fukutomi, M. Suzuki, C. Torikata, A. Iwamatsu and S. Hirohashi Bacillus Calmette-Guérin Enhances Production and Secretion of Type IV Collagenases in Peripheral Blood Mononuclear Cells Y. Kageyama, S. Kawakami, Y. Fujii, K. Kihara and H. Oshima JPN.J CANCER RES. 88, 1997 Induction of Specific Cytotoxic T Lymphocytes against Autelogous Brain Tumor by Crossreactive Allo-tumor Cell Stimulation S. Saitoh, M. Kurisaka, K. Mori, N. Maeda and S. Fujimoto Efficient Retrovirus-mediated Cytokine-gene Transduction of Primary-cultured Human Glioma Cells for Tumor Vaccination Therapy H. Wakimoto, Y. Yoshida, M. Aoyagi, K. Hirakawa and H. Hamada Antitumor Effects of 5 -Deoxy-5-fluorouridine in Combination with Recombinant Human Interleukin 2 on Murine Colon Carcinoma 26 K. Midoro, K. Gotoh, T. Houkan, K. Yukishige, K. Fujiwara and K. Ootsu Antitumor Activity of TZT-1027, a Novel Dolastatin 10 Derivative M. Kobayashi, T. Natsume, S. Tamaoki, J. Watanabe, H. Asano, T. Mikami, K. Miyasaka, K. Miyazaki, M. Gondo, K. Sakakibara and S. Tsukagoshi Application of Image Analysis and Neural Networks to the Pathology Diagnosis of Intraductal Proliferative Lesions of the Breast N. Fukushima, H. Shinbata, T. Hasebe, T. Yokose, A. Sato and K. Mukai 335-434 RAPID COMMUNICATIONS Analysis of the DPC4 Gene in Gastric Carcinoma S. Nishizuka, G. Tamura, C. Maesawa, K. Sakata, Y. Suzuki, T. Iwaya, M. Terashima, K. Saito and R. Satodate MAD-related Genes on 18q21.1, Smad2 and Smad4, Are Altered Infrequently in Esophageal Squamous Cell Carcinoma C. Maesawa, G. Tamura, S. Nishizuka, T. Iwaya, S. Ogasawara, K. Ishida, K. Sakata, N. Sato, K. Ikeda, Y. Kimura, K. Saito and R. Satodate REGULAR PAPERS A Randomized Controlled Trial for Chemoprevention of Gastric Cancer in High-risk Japanese Population; Study Design, Feasibility and Protocol Modification Y. Tsubono, S. Okubo, M. Hayashi, T. Kakizoe and S. Tsugane Decrease of Prestaglandin E, and 5-Bromo-2’-deoxyuridine Labeling but Not Prostate Tumor Development by Indomethacin Treatment of Rats Given 3,2’-Dimethyl-4-aminobiphenyl and Testosterone Propionate M. Kawabe, M. Shibata, M. Sano, Y. Takesada, S. Tamano, N. Ito and T. Shirai Inhibition by Green Tea Extract of Diethylnitrosamine-initiated but Not Choline-deficient, L-Amino Acid-defined Diet-associated Development of Putative Preneoplastic, Glutathione S-Transferase Placental Form-positive Lesions in Rat Liver K. Tamura, D. Nakae, K. Horiguchi, H. Akai, Y. Kobayashi, H. Satoh, T. Tsujiuchi, A. Denda and Y. Konishi Rare Occurrence of ras and p53 Gene Mutations in Mouse Stomach Tumors Induced by N-Methyl-N-nitrosourea C. Furihata, M. Tatematsu, M. Saito, S. Ishida, H. Nakanishi, K. Inada, H. Tei, M. Hattori, T. Ito and Y. Sakaki Antibodies to Human Papillomavirus 16, 18, 58, and 6b Major Capsid Proteins among Japanese Females K. Matsumoto, H. Yoshikawa, Y. Taketani, K. Yoshiike and T. Kanda Human Papillomavirus Infection and Risk Determinants for Squamous Intraepithelial Lesion and Cervical Cancer in Japan T. Sasagawa, Y. Dong, K. Saijoh, S. Satake, M. Tateno and M. Inoue Alternative Splicing of the FHIT Gene in Colorectal Cancers K. Hibi, M. Taguchi, H. Nakamura, A. Hirai, Y. Fujikake, T. Matsui, Y. Kasai, S. Akiyama, K. Ito and H. Takagi CONTENTS PRLTS Gene Alterations in Human Prostate Cancer A. Komiya, H. Suzuki, T. Ueda, S. Aida, N. Ito, T. Shiraishi, R. Yatani, M. Emi, K. Yasuda, J. Shimazaki and H. Ito Two Transcription Factors, ELAF and N-myc, Correlate with the Invasiveness of Neuroblastoma Cell Lines K. Taguchi, K. Yoshida, F. Sasaki and K. Fujinaga Expression of Interstitial Collagenase (Matrix Metalloproteinase-1) in Gastric Cancers Y. Sakurai, Y. Otani, K. Kameyama, Y. Hosoda, I. Okazaki, T. Kubota, K. Kumai and M. Kitajima Mutational Analysis of BRCAI Gene in Ovarian and Breast-ovarian Cancer Families in Japan M. Takano, H. Aida, I. Tsuneki, K. Takakuwa, I. Hasegawa, H. Tanaka, M. Saito, S. Tsuji, T. Sonoda, M. Hatae, J.-T. Chen, K. Takahashi, K. Hasegawa, N. Toyoda, N. Saito, M. Yakushiji, T. Araki and K. Tanaka Detection of MAGE-4 Protein in Sera of Lung Cancer Patients S. Shichijo, T. Hoshino, K. Koufuji, A. Hayashi, M. Kawamoto, M. Kikuchi, T. Higuchi, M. Ichiki, K. Oizumi and K. Itoh Detection of Residual Host Cells in Sex-mismatched Bone Marrow Transplantation in Various Hematological Diseases by Fluorescence in situ Hybridization M. Arif, K. Tanaka, T. S. Kumaravel, M. Eguchi, K. Iwato, H. Dohy and N. Kamada Radioimmunodetection with '''In-labeled Monoclonal Antibody Nd2 in Patients with Pancreatic Cancer Y.-S. Chung, T. Sawada, Y. Kondo, K. Hirayama, A. Inui, Y. Yamashita, B. Nakata, T. Okamura, H. Ochi, J. J. L. Ho, Y. S. Kim and M. Sowa 435-521 REGULAR PAPERS S-Methylcysteine and Cysteine Are Inhibitors of Induction of Glutathione S-Transferase Placental Form-positive Foci during Initiation and Promotion Phases of Rat Hepatocarcinogenesis N. Takada, Y. Yano, H. Wanibuchi, S. Otani and S. Fukushima Auraptene, a Citrus Coumarin, Inhibits 12-0-Tetradecanoylphorbol-13-acetate-induced Tumor Promotion in ICR Mouse Skin, Possibly through Suppression of Superoxide Generation in Leukocytes A. Murakami, W. Kuki, Y. Takahashi, H. Yonei, Y. Nakamura, Y. Ohto, H. Ohigashi and K. Koshimizu Protection by a@G-Rutin, a Water-soluble Antioxidant Flavonoid, against Renal Damage in Mice Treated with Ferric Nitrilotriacetate K. Shimoi, B. Shen, S. Toyokuni, R. Mochizuki, M. Furugori and N. Kinae Comparative Study on Germ Cell Mutation Induced by Urethane (Ethyl Carbamate) Gas and X-rays in Drosophila melanogaster T. Nomura and N. Kurokawa Evidence that Expression of a Mutated p53 Gene Attenuates Apoptotic Cell Death in Human Gastric Intestinal-type Carcinomas in vivo M. Ishida, Y. Gomyo, S. Ohfuji, M. Ikeda, H. Kawasaki and H. Ito Comparison of DNA Copy Numbers in Original Oral Squamous Cell Carcinomas and Corresponding Celli Lines by Comparative Genomic Hybridization T. Komiyama, K. Matsumura and N. Tsuchida Regulation of Vimentin Expression and Protease-mediated Vimentin Degradation during Differentiation of Human Monocytic Leukemia Cells K. Honke and Y. Wada In vivo Retrovirus-mediated Herpes Simplex Virus Thymidine Kinase Gene Therapy Approach for Adult T Cell Leukemia in a Rat Model K. Murata, M. Fujita, Y. Yamada, Y. Higami, I. Shimokawa, K. Tsukasaki, Y. Tanaka, M. Maeda, K. Furukawa, T. Yoshiki, H. Shiku and M. Tomonaga JPN. J. CANCER RES. 88, 1997 Interferon-7-inducing Factor Gene Transfection into Lewis Lung Carcinoma Cells Reduces Tumorigenicity in vivo H. Fukumoto, M. Nishio, K. Nishio, Y. Heike, H. Arioka, H. Kurokawa, T. Ishida, K. Fukuoka, T. Nomoto, Y. Ohe and N. Saijo Cell-killing Efficiency and Number of Platinum Atoms Binding to DNA, RNA and Protein Molecules of HeLa Cells Treated with Combinations of trans-Diaminedichloroplatinum(II) and Hyperthermia M. Akaboshi, K. Kawai, Y. Kinashi, S. Masunaga and K. Ono Effect of CPT-11 on Lipid Peroxide Level in Mouse Tissues Y. Sadzuka and S. Hirota Pharmacokinetic Study of Carboplatin Given on a 5-Day Intravenous Schedule Y. Ando, H. Minami, H. Saka, M. Ando, S. Sugiura, S. Sakai and K. Shimokata 523-613 RAPID COMMUNICATIONS Inhibition of Azoxymethane-initiated Colon Tumor by Bovine Lactoferrin Administration in F344 Rats K. Sekine, E. Watanabe, J. Nakamura, N. Takasuka, D. J. Kim, M. Asamoto, V. Krutovskikh, H. Baba-Toriyama, T. Ota, M. A. Moore, M. Masuda, H. Sugimoto, H. Nishino, T. Kakizoe and H. Tsuda A Novel Somatic Mutation in the RET Proto-oncogene in Familial Medullary Thyroid Carcinoma with a Germline Codon 768 Mutation A. Miyauchi, S. Egawa, H. Futami, K. Kuma, T. Obara and K. Yamaguchi REGULAR PAPERS Cytotoxin Genes of Helicobacter pylori in Chronic Gastritis, Gastroduodenal Ulcer and Gastric Cancer: An Age and Gender Matched Case-Control Study N. Matsukura, M. Onda, S. Kato, H. Hasegawa, K. Okawa, T. Shirakawa, A. Tokunaga, K. Yamashita and A. Hayashi Second Primary Cancers Following Non-Hodgkin’s Lymphoma in Japan: Increased Risk of Hepatocellular Carcinoma H. Tanaka, H. Tsukuma, H. Teshima, W. Ajiki, Y. Koyama, N. Kinoshita, T. Masaoka and A. Oshima Chemopreventive Efficacy of Piroxicam Administered Alone or in Combination with Lycopene and B-Carotene on the Development of Rat Urinary Bladder Carcinoma after N-Butyl-N-(4-hydroxybutyl)- nitrosamine Treatment E. Okajima, S. Ozono, T. Endo, T. Majima, M. Tsutsumi, T. Fukuda, H. Akai, A. Denda, Y. Hirao, E. Okajima, H. Nishino, Z. Nir and Y. Konishi Inhibitory Activity of Green and Black Tea in a Free Radical-generating System Using 2-Amino-3- methylimidazo[4,5-f Jquinoline as Substrate N. Hasaniya, K. Youn, M. Xu, J. Hernaez and R. Dashwood Microsatellite Instability in Lung Cancer Patients 40 Years of Age or Younger I. Sekine, T. Yokose, T. Ogura, K. Suzuki, K. Nagai, T. Kodama, K. Mukai, Y. Nishiwaki and H. Esumi Modulation of Motility and Proliferation of Glioma Cells by Hepatocyte Growth Factor S. Yamamoto, H. Wakimoto, M. Acyagi, K. Hirakawa and H. Hamada In vivo Effect of Recombinant Human Leukemia Inhibitory Factor in Primates Y. Akiyama, N. Kajimura, J. Matsuzaki, Y. Kikuchi, N. Imai, M. Tanigawa and K. Yamaguchi Protective Effect of Recombinant Human Leukemia Inhibitory Factor against Thrombocytopenia in Carboplatin-treated Mice Y. Akiyama, Y. Kikuchi, J. Matsuzaki, N. Kajimura, C. Ohue and K. Yamaguchi