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P1: OSO/OVY P2: OSO/OVY QC: OSO/OVY T1: OSO Printer: Prepress LWBK834-FM LWBK834-Irwin/Rippe LWBK834-Irwin-v1.cls June 30, 2011 21:57 S E V E N T H E D I T I O N V O L U M E 1 I rw in an d R ip p e’s IN T EN SIVE C AR E M ED IC IN E Editors Richard S. Irwin, MD, James M. Rippe, MD Master FCCP Professor of Biomedical Sciences, University of Central Florida Professor of Medicine and Nursing Orlando, Florida University of Massachusetts Associate Professor of Medicine (Cardiology), Worcester, Massachusetts Tufts University School of Medicine Chair, Critical Care Operations Boston, Massachusetts UMass Memorial Medical Center Founder and Director, Rippe Lifestyle Institute Worcester, Massachusetts Shrewsbury, Massachusetts Founder and Director, Rippe Health Evaluation Orlando, Florida i P1: OSO/OVY P2: OSO/OVY QC: OSO/OVY T1: OSO Printer: Prepress LWBK834-FM LWBK834-Irwin/Rippe LWBK834-Irwin-v1.cls July 18, 2011 15:45 Acquisitions Editor: Brian Brown Managing Editor: Nicole T. Dernoski Marketing Manager: Angela Panetta Production Manager: Alicia Jackson Senior Manufacturing Manager: Benjamin Rivera Design Coordinator: Teresa Mallon Compositor: Aptara, Inc. 7th Edition © 2012 by Richard S. Irwin, M.D. and James M. Rippe, M.D. 530 Walnut Street Philadelphia, PA 19106 LWW.com 6th Edition © 2008 by Richard S. Irwin, M.D. and James M. Rippe, M.D., 5th Edition © 2003 by Richard S. Irwin, M.D. and James M. Rippe, M.D., 4th Edition © 1999 by Richard S. Irwin, M.D., Frank B. Cerra, M.D., and James M. Rippe, M.D., 3rd Edition © 1996 by James M. Rippe, M.D., Richard S. Irwin, M.D., Mitchell P. Fink, M.D., and Frank B. Cerra, M.D., 2nd Edition © 1991 by James M. Rippe, M.D., Richard S. Irwin, M.D., Joseph S. Alpert, M.D., and Mitchell P. Fink, M.D., 1st Edition © 1985 by James M. Rippe, M.D., Richard S. Irwin, M.D., Joseph S. Alpert, M.D., and James E. Dalen, M.D. All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form or by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the publisher, except for brief quotations embodied in critical articles and reviews. For information write Lippincott Williams & Wilkins, 530 Walnut Street, Philadelphia, PA 19106-3780. Materials appearing in this book prepared by individuals as part of their of cial duties as U.S. government employees are not covered by the above-mentioned copyright. Printed in the China Library of Congress Cataloging-in-Publication Data Irwin and Rippe’s intensive care medicine / editors, Richard S. Irwin, James M. Rippe. — 7th ed. p. ; cm. Intensive care medicine Includes bibliographical references and index. ISBN 978-1-60831-183-5 (alk. paper) 1. Critical care medicine. I. Irwin, Richard S. II. Rippe, James M. III. Title: Intensive care medicine. [DNLM: 1. Intensive Care—methods. 2. Intensive Care Units. WX 218] RC86.7.I555 2011 616.02 8—dc23 2011021282 Care has been taken to con rm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of this information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant ow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in this publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice. To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300. Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service representatives are available from 8:30 am to 6 pm, EST. 10 9 8 7 6 5 4 3 2 1 ii P1: OSO/OVY P2: OSO/OVY QC: OSO/OVY T1: OSO Printer: Prepress LWBK834-FM LWBK834-Irwin/Rippe LWBK834-Irwin-v1.cls June 30, 2011 21:57 D E D I C A T I O N To Our Families Diane, Rachel, Sara, Catherine, Rebecca, John, Andrew K. Andrew M. and Adam; Stephanie, Hart, Jaelin, Devon, and Jamie iii P1: OSO/OVY P2: OSO/OVY QC: OSO/OVY T1: OSO Printer: Prepress LWBK834-FM LWBK834-Irwin/Rippe LWBK834-Irwin-v1.cls June 30, 2011 21:57 ■ C O N T R I B U T O R S Cynthia K. Aaron, MD, FACMT, FACEP Satya Allaparthi, MD Professor of Emergency Medicine and Pediatrics Fellow in Robotic and Laparoscopic Urology Program Director, Medical Toxicology Department of Urology/Surgery Department of Emergency Medicine UMass Memorial Medical Center Wayne State University School of Medicine Worcester, MA Detroit Medical Center Regional Poison Center at Children’s Hospital of Michigan Gilman B. Allen, MD Detroit, MI Assistant Professor Director, Medical Intensive Care Unit Wissam Abouzgheib, MD, FCCP Department of Medicine Attending Physician Division of Pulmonary and Critical Care Medicine Department of Pulmonary and Critical Care University of Vermont Sparks Health System Fletcher Allen Health Care Fort Smith, AR Burlington, VT Gregory A. Abrahamian, MD Luis F. Angel, MD Associate Professor of Surgery Associate Professor of Medicine Department of Surgery Department of Medicine University of Texas Health Science Center at San Antonio University of Texas Health Sciences Center at San Antonio San Antonio, TX San Antonio, TX Konstantin Abramov, MD Kevin E. Anger, PharmD, BCPS Assistant Professor of Medicine Clinical Pharmacy Specialist in Critical Care Division of Renal Medicine Department of Pharmacy Services UMass Memorial Medical Center Brigham and Women’s Hospital Worcester, MA Boston, MA Christopher D. Adams, PharmD, BCPS Derek C. Angus, MD, MPH Clinical Pharmacist Professor and Vice Chair for Research Department of Pharmacy Services Department of Critical Care Medicine Brigham and Women’s Hospital University of Pittsburgh Medical Center Boston, MA Pittsburgh, PA Suresh Agarwal, MD, FACS, FCCM Neil Aronin, MD Chief, Surgical Critical Care Professor of Medicine and Cell Biology Associate Professor of Surgery Chief of Endocrinology and Metabolism Boston Medical Center Department of Medicine Boston, MA University of Massachusetts Medical School Worcester, MA Lauren Alberta-Wszolek, MD Samuel J. Asirvatham, MD, FACC, FHRS Assistant Professor of Medicine Division of Dermatology Professor of Medicine and Pediatrics University of Massachusetts Medical School Division of Cardiovascular Diseases Worcester, MA Mayo Clinic College of Medicine Rochester, MN Alfred Aleguas Jr, PharmD, DABAT Seth M. Arum, MD, FACE Managing Director Northern Ohio Poison Center Assistant Professor of Medicine Rainbow Babies & Children’s Hospital Department of Endocrinology Cleveland, OH UMass Memorial Medical Center Worcester, MA v P1: OSO/OVY P2: OSO/OVY QC: OSO/OVY T1: OSO Printer: Prepress LWBK834-FM LWBK834-Irwin/Rippe LWBK834-Irwin-v1.cls June 30, 2011 21:57 vi Contributors Philip J. Ayvazian, MD Stephen L. Barnes, MD, FACS Assistant Professor Associate Professor and Chief, Division of Acute Department of Urology Care Surgery UMass Memorial Medical Center Department of Surgery Worcester, MA University of Missouri Columbia, MO Riad Azar, MD Suzanne J. Baron, MD Associate Professor of Medicine Department of Internal Medicine Cardiology Fellow Division of Gastroenterology Department of Cardiology Washington University School of Medicine Massachusetts General Hospital Barnes Jewish Hospital Boston, MA St. Louis, MO Thaddeus C. Bartter, MD, FCCP Ruben J. Azocar, MD Professor of Medicine Associate Professor and Residency Program Director Department of Medicine Department of Anesthesiology Division of Pulmonary and Critical Care Boston University Medical Center University of Arkansas for the Medical Sciences Boston, MA Little Rock, AR Ednan K. Bajwa, MD, MPH Amit Basu, MD Associate Director, Medical ICU Assistant Professor of Surgery and Attending Physician Department of Pulmonary and Critical Care Department of Surgery Massachusetts General Hospital University of Pittsburgh Medical Center Boston, MA Thomas E Starzl Transplantation Institute Pittsburgh, PA K.C. Balaji, MD Kenneth L. Baughman, MD (DECEASED) Professor, Department of Surgery Division of Urology UMass Memorial Medical Center Richard C. Becker, MD Worcester, MA Professor of Medicine Jerry P. Balikian, MD, FACR Department of Medicine Professor and Vice Chair of Radiology Duke University School of Medicine Department of Radiology Durham, NC University of Massachusetts Medical School Robert W. Belknap, MD Worcester, MA Assistant Professor of Medicine Ian M. Ball, MD, DABEM, FRCPC Division of Infectious Diseases Denver Health and Hospital Authority Assistant Professor University of Colorado Program in Critical Care Medicine and Denver, CO Departments of Clinical Pharmacology/Toxicology and Emergency Medicine Isabelita R. Bella, MD Queen’s University Kingston Associate Professor of Clinical Neurology Ontario, Canada Department of Neurology University of Massachusetts Medical School Meyer S. Balter, MD, FRCPC UMass Memorial Medical Center Professor Worcester, MA Department of Medicine University of Toronto Andrew C. Bernard, MD Director, Asthma Education Clinic Associate Professor of Surgery Mount Sinai Hospital Department of Surgery Toronto, Ontario, Canada University of Kentucky Healthcare Lexington, KY Gisela I. Banauch, MD, MS Assistant Professor of Medicine Division of Pulmonary, Megan Bernstein, MD Allergy, Critical Care and Sleep Medicine Resident University of Massachusetts Medical School Department of Dermatology UMass Memorial Medical Center University of Massachusetts Medical School Worcester, MA Worcester, MA Daniel T. Baran, MD Mary T. Bessesen, MD Region Medical Director Associate Professor of Medicine Merck Department of Medicine Adjunct Professor of Medicine, Cell Biology, and Orthopedics University of Colorado at Denver UMass Memorial Medical Center Department of Veterans Affairs Medical Center—Denver Worcester, MA Denver, CO P1: OSO/OVY P2: OSO/OVY QC: OSO/OVY T1: OSO Printer: Prepress LWBK834-FM LWBK834-Irwin/Rippe LWBK834-Irwin-v1.cls June 30, 2011 21:57 Contributors vii Michael C. Beuhler, MD Veronica Brito, MD Medical Director Pulmonary and Critical Care Medicine Fellow Department of Emergency Medicine Department of Medicine Carolinas Poison Center Winthrop-University Hospital Charlotte, NC Mineola, NY Bonnie J. Bidinger, MD Traci L. Buescher, RN Assistant Professor of Medicine Department of Heart Rhythm Services Department of Internal Medicine Mayo Clinic Division of Rheumatology Rochester, MN University of Massachusetts Medical School UMass Memorial Medical Center Keith K. Burkhart, MD, FACMT, FAACT, FACEP Worcester, MA Senior Advisor for Medical Toxicology FDA Center for Drug Evaluation and Research Steven B. Bird, MD Of ce of New Drugs Associate Professor Silver Spring, MD Department of Emergency Medicine Division of Medical Toxicology Michael J. Burns, MD, FACEP, FACMT University of Massachusetts Medical School Chief of Emergency Medicine Worcester, MA Saint Vincent Hospital Worcester, MA Bruce R. Bistrian, MD, PhD Division of Medical Toxicology Professor of Medicine Department of Emergency Medicine Harvard Medical School Beth Israel Deaconess Medical Center Department of Medicine Boston, MA Beth Israel Deaconess Medical Center Boston, MA Tuesday E. Burns, MD Assistant Professor of Psychiatry Robert M. Black, MD Department of Psychiatry Professor of Clinical Medicine Eastern Virginia Medical School UMass Medical School Norfolk, VA Chief, Nephrology Division of Renal Medicine Scott W. Byram, MD St. Vincent Hospital Assistant Professor of Anesthesiology Worcester, MA Department of Anesthesiology Ernest F.J. Block, MD, MBA, FACS, FCCM Loyola University Medical Center Maywood, IL Professor of Surgery, University of Central Florida Department of Acute Care Surgery Brian T. Callahan, MD Holmes Regional Medical Center Melbourne, FL Interventional Radiology Fellow Department of Radiology Jeremiah Boles, MD Harvard Medical School Beth Israel Deaconess Medical Center Hematology/Oncology Fellow Boston, MA Department of Medicine Division of Hematology/Oncology Christine Campbell-Reardon, MD University of North Carolina at Chapel Hill Chapel Hill, NC Associate Professor of Medicine Department of Pulmonary and Critical Care Naomi F. Botkin, MD Medicine Assistant Professor of Medicine Boston University School of Medicine Division of Cardiovascular Medicine Boston Medical Center UMass Memorial Medical Center Boston, MA Worcester, MA Christopher P. Cannon, MD Suzanne F. Bradley, MD TIMI Study Group Professor Cardiovascular Division Department of Internal Medicine Brigham and Women’s Hospital Division of Infectious Diseases and Geriatric Medicine Associate Professor of Medicine, Harvard Veterans Affairs Ann Arbor Medical School University of Michigan Healthcare Systems Boston, MA Ann Arbor, MI Jason P. Caplan, MD William F. Bria, MD Chief of Psychiatry Chief Medical Information Of cer Department of Psychiatry Department of Medical Affairs Creighton University School of Medicine at St. Joseph’s Shriners Hospital for Children Hospital and Medical Center Tampa, FL Phoenix, AZ P1: OSO/OVY P2: OSO/OVY QC: OSO/OVY T1: OSO Printer: Prepress LWBK834-FM LWBK834-Irwin/Rippe LWBK834-Irwin-v1.cls June 30, 2011 21:57 viii Contributors Raphael A. Carandang, MD Victor G. Cimino, MD, FACS Assistant Professor Associate Professor University of Massachusetts Medical School Department of Surgery Department of Neurology and Surgical Intensive Care Loyola University Medical Center UMass Memorial Medical Center Maywood, IL Worcester, MA Mary Dawn T. Co, MD Paul A. Carpenter, MD Assistant Professor of Medicine Associate Professor University of Massachusetts Medical School Clinical Research Division UMass Memorial Medical Center Fred Hutchinson Cancer Research Center Worcester, MA Seattle, WA Shawn Cody, MSN, MBA, RN Karen C. Carroll, MD Associate Chief Nursing Of cer for Critical Care Professor Pathology and Medicine UMass Memorial Medical Center Department of Pathology Worcester, MA Division of Medical Microbiology Johns Hopkins Hospital Felipe B. Collares, MD, MSc Baltimore, MD Interventional Radiologist Department of Radiology David A. Chad, MD Beth Israel Deaconess Medical Center Associate Professor of Neurology Instructor in Radiology Harvard Medical School Harvard Medical School Department of Neurology Boston, MA Massachusetts General Hospital Neuromuscular Diagnostic Center Bryan R. Collier, MD Boston, MA Assistant Professor of Surgery Division of Trauma & Surgical Critical Care Eugene Chang, MD Vanderbilt University Medical Center Martin Boyer Professor of Medicine Nashville, TN Department of Medicine, Section of Gastroenterology University of Chicago Nancy A. Collop, MD Chicago, IL Professor of Medicine Department of Medicine Steven Y. Chang, MD, PhD Emory University Assistant Professor of Medicine Atlanta, GA Division of Pulmonary & Critical Care Medicine Director of the Medical Intensive Care Unit John B. Cone, MD, FACS, FCCM University of Medicine & Dentistry of New Jersey— Professor of Surgery New Jersey Medical School Norma & Nolie Mumey Chair in General Surgery Newark, NJ Department of Surgery University of Hospital of Arkansas Michael L. Cheatham, MD, FACS, FCCM Little Rock, AR Director, Surgical Intensive Care Units Department of Surgical Education Sara E. Cosgrove, MD Orlando Regional Medical Center Associate Professor of Medicine Orlando, FL Division of Infectious Disease Sarah H. Cheeseman, MD Johns Hopkins Medical Institutions Baltimore, MD Professor of Medicine, Pediatrics, Microbiology and Molecular Genetics Filippo Cremonini, MD, PhD University of Massachusetts Medical School Attending Physician Division of Infectious Diseases Department of Gastroenterology UMass Memorial Medical Center Beth Israel Deaconess Medical Center Worcester, MA Harvard Medical School Annabel A. Chen-Tournoux, MD Boston, MA Cardiology Fellow Jonathan F. Critchlow, MD Department of Medicine Division of Cardiology Assistant Professor of Surgery Massachusetts General Hospital Harvard University Boston, MA Beth Israel Deaconess Medical Center Boston, MA William K. Chiang, MD Ruy J. Cruz Jr, MD, PhD Chief of Service and Associate Professor of Emergency Medicine Assistant Professor of Surgery Department of Emergency Department of Surgery Bellevue Hospital Center University of Pittsburgh Medical Center New York, NY Pittsburgh, PA P1: OSO/OVY P2: OSO/OVY QC: OSO/OVY T1: OSO Printer: Prepress LWBK834-FM LWBK834-Irwin/Rippe LWBK834-Irwin-v1.cls June 30, 2011 21:57 Contributors ix Frederick J. Curley, MD Gregory J. Della Rocca, MD, PhD, FACS Associate Professor of Medicine Assistant Professor University of Massachusetts Medical School Co-Director, Orthopaedic Trauma Service Lung, Allergy & Sleep Specialists Department of Orthopaedic Surgery Hopedale, MA University of Missouri Columbia, MO Armagan Dagal, MD, FRCA Thomas G. DeLoughery, MD, FACP Assistant Professor Department of Anesthesiology and Pain Medicine Professor of Medicine, Pathology and Pediatrics University of Washington, Harborview Medical Center Department of Hematology Seattle, WA Oregon Health and Science University Portland, OR Seth T. Dahlberg, MD Mario De Pinto, MD Associate Professor of Medicine and Radiology Department of Medicine and Radiology Assistant Professor University of Massachusetts Medical School Department of Anesthesiology Division of Cardiology University of Washington UMass Memorial Medical Center Harborview Medical Center Worcester, MA Seattle, WA Frank F. Daly, MBBS Mark Dershwitz, MD, PhD Clinical Toxicologist and Emergency Physician Professor and Vice Chair of Anesthesiology Department of Emergency Medicine Professor of Biochemistry & Molecular Pharmacology Royal Perth Hospital UMass Memorial Medical Center Western Australia, Australia Worcester, MA Jennifer S. Daly, MD Akshay S. Desai, MD Professor of Medicine Instructor in Medicine Clinical Chief, Infectious Diseases and Immunology Harvard Medical School Department of Medicine Associate Physician University of Massachusetts Medical School Cardiovascular Division Worcester, MA Department of Medicine Brigham and Women’s Hospital Lloyd E. Damon, MD Boston, MA Professor of Clinical Medicine Department of Medicine Asha Devereaux, MD, MPH University of California, San Francisco Pulmonary Physician San Francisco, CA Sharp Coronado Hospital Coronado, CA Raul E. Davaro, MD Associate Professor, Clinical Medicine Christopher R. DeWitt, MD Department of Medicine Medical Toxicologist and Emergency Physician University of Massachusetts Medical School Department of Emergency and British Columbia Worcester, MA Poison Center Saint Paul’s Hospital Wellington J. Davis III, MD University of British Columbia Assistant Professor of Surgery and Pediatrics Vancouver, BC Section of Plastic and Reconstructive Surgery St. Christopher’s Hospital for Children Peter Doelken, MD Philadelphia, PA Associate Professor Department of Medicine Ronald J. DeBellis, PharmD, FCCP Division of Pulmonary, Critical Care, Allergy & Professor and Chair Sleep Medicine Department of Pharmacy Practice Medical University of South Carolina Albany College of Pharmacy and Health Sciences—Vermont Charleston, SC Colchester, VT G. William Dec, MD Robert P. Dowsett, FACEM Chief, Cardiology Division Senior Staff Specialist Massachusetts General Hospital Department of Emergency Medicine Department of Cardiology Westmead Hospital Boston, MA Wentworthville, NSW, Australia Paul F. Dellaripa, MD David A. Drachman, MD Assistant Professor of Medicine Professor of Neurology Harvard Medical School Chairman Emeritus Division of Rheumatology Department of Neurology Brigham and Women’s Hospital University of Massachusetts Medical School Boston, MA Worcester, MA P1: OSO/OVY P2: OSO/OVY QC: OSO/OVY T1: OSO Printer: Prepress LWBK834-FM LWBK834-Irwin/Rippe LWBK834-Irwin-v1.cls June 30, 2011 21:57 x Contributors David F. Driscoll, PhD Timothy A. Emhoff, MD Vice President Chief, Trauma, Surgical Critical Care Stable Solutions LLC Department of Surgery Easton Industrial Park UMass Memorial Medical Center Easton, MA Worcester, MA Cathy Dudick, MD, FACS Jennifer L. Englund, MD Medical Director, Surgical Intensive Care Unit Medical Toxicology Fellow Department of Surgery Department of Emergency Medicine Jersey Shore University Medical Center Division of Medical Toxicology Neptune, NJ University of Massachusetts Medical School Worcester, MA David L. Dunn, MD, PhD Vice President for Health Sciences Robert M. Esterl Jr, MD Professor of Surgery, Microbiology and Immunology Professor of Surgery University at Buffalo, School of Medicine Biomedical Sciences Department of Surgery Buffalo, NY University of Texas Health Science Center at San Antonio Cheryl H. Dunnington, RN, MS, CCRN San Antonio, TX Operations Director, eICU Support Center Program Critical Care Operations Salomao Faintuch, MD, MSc UMass Memorial Medical Center Instructor in Radiology Worcester, MA Harvard Medical School Department of Interventional Radiology Kevin Dwyer, MD, FACS Beth Israel Deaconess Medical Center Director of Trauma Boston, MA Vice-Chair of Surgery Pang-Yen Fan, MD Stamford Hospital Stamford, CT Associate Professor of Medicine Division of Renal Medicine Steven B. Edelstein, MD University of Massachusetts Medical School Professor of Anesthesiology Medical Director, Renal Transplant Program Vice-Chairman Education & Compliance UMass Memorial Medical Center Department of Anesthesiology Worcester, MA Loyola University Medical Center James C. Fang, MD Loyola University Stritch School of Medicine Maywood, IL Professor of Medicine Cardiovascular Division W. Thomas Edwards, PhD, MD Case Western Reserve University Director, Fellowship in Pain Medicine Cleveland, OH Associate Professor of Anesthesiology John Fanikos, RPh, MBA Department of Anesthesiology University of Washington Assistant Director of Pharmacy Harborview Medical Center Department of Pharmacy Seattle, WA Brigham and Women’s Hospital Boston, MA Richard T. Ellison III, MD Harrison W. Farber, MD Professor of Medicine, Molecular Genetics and Microbiology Professor of Medicine University of Massachusetts Medical School Department of Pulmonary Center Department of Medicine Boston University School of Medicine Division of Infectious Diseases and Immunology Boston, MA UMass Memorial Medical Center Worcester, MA Khaldoun Faris, MD Associate Director of Surgical Intensive Care Unit Ashkan Emadi, MD, PhD Department of Anesthesiology Adjunct Faculty University of Massachusetts Medical School Division of Adult Hematology UMass Memorial Medical Center Department of Internal Medicine Worcester, MA Johns Hopkins Hospital Johns Hopkins University Alan P. Farwell, MD Baltimore, MD Associate Professor of Medicine Director, Endocrine Clinics Charles H. Emerson, MD Department of Endocrinology, Diabetes and Professor Emeritus of Medicine Nutrition Department of Medicine Boston University School of Medicine UMass Memorial Medical Center Boston Medical Center Worcester, MA Boston, MA