INVITED REVIEWERS-i 977 Ialways had the idea that when I was old I’d get frightfully clever. I’d get awfully learned. I’d get jolly sage. People would come to me for advice. But nobody ever comes to me for anything, and I don’t know a thing. -Ralph Richardson, distinguished British actor (quoted in The New Yorker) Temperamentally, an editor may be sanguine, phlegmatic, bilious, or melancholic-usually some combination of these. Whatever his predominant disposition, there are days when Sir Ralph’s sentiments are his, and he regretfully must disclaim omniscience in his specialty. Even though his task requires the professional aplomb of a cymbalist, his errors are (or at least seem to him to be) just as conspicuous. We strive for excellence, not perfection (the latter being the strait gate to ulcerdom and posthumous rewards). We do like what we publish to be correct ifpossible. Thus it is that we extend our thanks each year to the “saintly band” [I. Douglas- Wilson, former Lancet editor] ofinvited reviewers who have kept editor and contributors on their toes and have contributed substantially to whatever success this journal enjoys in performing its mission of conveying information clearly, accurately, and concisely. Fred P. Abramson George M. Bowers, Jr. Frank Doherty Louis Gluck Reginald F. Adams Russel 0. Bowman Richard J. Doisy Nathan Gochman S.Addanki H. Bryan Brewer, Jr. Basil T. Doumas Robert L. Golby Herman Adlercreutz Peter Brodelius Patricia Duncan D. M. Goldberg Charles C. Allain Phyllis R. Brown Leonard K. Dunikowski E. S. Golub Carl Alper George Bryson Murray Golub Nelson Alpert Giovanni Bucolo Graham Ellis Harold 0. Goodman Elias Amador Gregory J. Buffone P. B. Eriksen A.G. Gornall J. S. Amenta Steven N. BuM Gerhard Ertingshausen Harold J. Grady JosephW.Amshey, Jr. Robert E. Bunch Bruce Lee Evatt George F. Grannis Michael Anbar Robert E. Burch Johannes Everse Gerald Green 0. Andersen Robert W. Burnett Maurice Green Joseph S. Annino Carl A. Burtis James L. Fasching Michael R. Greenwood Eugene A. Arnold, Jr. Michael G. Busby Donald Feldbruegge John C. Griffiths Harold D. Appleton William C. Butts Bertram Felsher George G.Guilbault Kenneth L. Armstrong P. V. Fennessey Barry H. Gump Randall P. Ayer J. Paul Cali Alberto A. Fernandez Jan E. C. Gustafsson Donald C. Cannon William J. Ferrell William L. Gyure Arthur L. Babson Wendell T. Caraway Paul R. Finley Michael Badella R. Neill Carey William H. Fishman Robert L. Habig E.Eugene Baillie Ian H. Carlson Martin Fleisher Herry Hahn Lewis A.Barness Thomas P. Carter James Flood Adrian Hainline, Jr. M. L. Barrett A. Castro Donald T. Forman Elmer C. Hall Edward A. Barron Leo P. Cawley Robert B. Forney James A. Halsted Harold G. Barth Suckjoo Chang Egil Fosslien Gerald L. Hamilton Richard Bastiani Neil H. Chinh Lowell B. Foster Clive R. Hamlin John G. Batsakis W. L. Chiou Walter A. Franck T. L. Hanna Stanley Bauer J. Julian Chisolm, Jr. R. Frants William H. Hannon David D. Bayse Inder J. Chopra Alfred H. Free Hans J. Hansen Jack Becktel Thomas W. Clarkson Helen M. Free Eugene K. Harris Myrton F. Beeler Kathleen J. Clayson J. Frei David Hart Harold R. Behrman Dennis P. Cohn Louis Fridhandler Clara M. Heise William R. Beisel William L. Collinsworth Henry G. Friesen W. D. Hemphill Luc Belanger Rex B. Conn Christopher S. Frings Arthur R. Henderson G. M. B. Berger James D. Cook K. Frisland John Bernard Henry L. S. Berk Marilyn L. Cowger Mack J. Fulwyler Albert E. Herner Eleanor Berman Robert E. Cross G. Phillip Hicks Edward W. Bermes, Jr. Michael S. Croxson Richard H. Gadsden Kenneth E. Hill Bernard H. Berne Robert B. Cumming Robert S. Galen Charles S. Hirsch Henry R. Besch, Jr. Robert E. Curry S. Raymond Gambino David C. Hohnadel Norma F. Besch V. Garnys Charles S. Hollander B. H. Billing Bernard Davidow Philip J. Garry R. D. Hollifield Fritz Bischoff Ivan Davidson Charles W. Gehrke Judith A. Hopkins Robert V. Blanke George E. Davis Willie Gerhardt Evan C. Horning Elliott Block Leonard J. Deftos Richard K. Genung Joan H. Howanitz Thomas A.Blumenfeld Joseph A. De Grazia G. Gerbeck Charles Y.Huang Richard J. L. Bondar A.P. De Leenheer Joseph L. Giegel Ferenc Hutterer Donald Joe Boone James A.Demetriou Helen J. Gigliotti RobertO. Boat P. M. Dennis E. Melvin Gindler James A. Inkpen William D. Bostick Nicola Di Ferrante Hillel J. Gitelman Dionyssis S. Ithakissios R. Bouillon Warren F. Diven Anthony J. Glazko Joseph H. Boutwell, Jr. Richard F. Dods James F. Glenn Sanford H. Jackson 2360 CLINICAL CHEMISTRY, Vol. 23, No. 12, 1977 Robert A.Jacob Lawrence J. Marten T. C. Rains Bill C. Strever Bernard Jaffe Alan Mather Douglas Ramseth Cornelius F. Strittmatter George F. Johnson J. P. Matousek P. S. Rao Lila Sun Roy B. Johnson, Jr. G. L. Mattok Allen H. Reed Irving Sunshine s. J. S. Jolley T. Mayer N. N. Rehak L. Svod Don Carl Jones Edward A. McClatchie Miriam Reiner Dennis Sweat Morris Joselow Sharon MaClean Robert Rej Gabor Szasz Roger E. Juselius Patrick G. McCormick Thomas A.Rejent Ralph P. McCroskey Martin Resnick J. Tarver A. Clark Kahn, III Jay M. McDonald Robert F. Ritchie R. Tenhunen Alex Kaplan Jerry McHan A. Leonard Rhyne Norbert W. Tietz Nathan 0. Kaplan Richard A. McPherson Jacob Robbins Thomas 0. Tiffany Barry L. Karger Tom Mears E. Arthur Robertson Robert L. Tilden Arthur Karmen Samuel Meites Robert C. Rock William Thomas L. Donald Keith Hewlett E. Melton, Jr. David Rodbard Theodore F. Thurman, III Margaret Kenny Robert S. Melville Denis 0. Rodgerson Peter V. Tishler Leo Kesner Donald W. Mercer Alan Rodginan John Toffaletti Gerald Kessler Walter Mertz F. Lee Rodkey D. B. Tonks T. R. Keucher Donald S. Miyada Charles Roe F. Trivin J. x. Khym Edward W. Moore Sidney B. Rosalki Donald Tschudy Lawrence M. Killingsworth John J. Moore Thomas G. Rosano K. K. Tung Douglas Kirkwood Wells R. Moorehead Arthur F. Rosenthal Stanley L. Twomey Peter T. Kissinger Ferrin B. Moreland John Rosevear John Y. Kiyasu Stanley Morgenstern Sheldon P. Rothenberg Richard H. Underwood Bernard Klein Leo G. Morin J. I.Routh Mayo Uziel Joseph A. Knight D. W. Moss A. V.Roy William S. Knight Thomas P. Moyer Diane R. Russell Herman Van Belle Thomas R. Koch J. E. Mrochek F. L. Vandemark S. R. Koirtyohann Hiltrud S. Mueller Richard St. Clair W. J. A. VandenHeuvel C. H. Konings S. J. Mule Eric J. Sampson Raymond E. Vanderlinde A. P. Kraus James F. Myrtle Harold H. Sandstead Paul A. Van Dreal Bernard F. Krause Laszlo Sarkozi Helen Van Vunakis W. M. Krebs Herbert K. Naito Edward A. Sasse Claude Veillon Bruce Kroening Samuel Natelson Sylvan Sax Elliot S. Vesell Allen Kropf William E. Neeley Robert Schaffer G. Virella Norman P. Kubasik George H. Nelson Richard S. Schneider James R. Vogt Manjula S. Kumar Jerald Nelson Morton K. Schwartz Henry G. Kunkel John T. Nicoloff Charles D. Scott T. Phillip Waalkes Forrest Nielsen Ronald L. Searcy Clifford B. Walberg Jack H. Ladenson Henry C. Nipper David Seligson J. E. Wallace Ronald H. Laessig H. H. Nishi Leslie M. Shaw Chris Walker Kwok-Wai Lam Jerome S. Nisselbaum William Shaw William A. Warren A. A. Lamola Daniel C. Noonan Louis Shenkman Samuel Waxman Joel M. Lamon Vivian Shih Bruce D. Weintraub John Langan Lawrence Oliver Leonard Sideman Harry F. Weisberg Betty Lash Suzanne Oparil Harrison E. Sine Norman Weissman Fred Lasky Jack H. Oppenheimer Herman Siplet David C. Wenke Joseph F. Lawlor Gayle P. Orczyk D. S. Sitar Peter W. Wentz Alexander M. Lawson Raymond Oslapas Dean S. Skehey Mario Werner Norman Leake W. Roy Slaunwhite, Jr. James 0. Westgard H. Peter Lehman Kent Painter Charles H. Smith Graham M. Widdowson Robert C. Leif Robert C. Paule Elizabeth K. Smith Wanda Wilkes Victoria M. Leitz Gerald Penn James C. Smith, Jr. George Z. Williams Robert H. Lenox Billy W. Perry Robert E. Smith Gordon Williams L. Leon Amadeo J. Pesce Lloyd R. Snyder Charles L. Winek Kias Levin Michael A. Pesce Burton E. Sobel Seymour Winsten Lawrence Levine El M. Piall Steve J. Soldin W. M. Wise Lena A. James 0. Pierce Harvey M. Solomon Robert L. Wolen Otto E. Lobstein Sergio Piomelli Elizabeth Solow Wayne R. Wolf John A. Lott Charles F. Pippenger Salvador Martin Sosa Charles L. Woronick Marjorie F. Lou W. w. Pitt Carol Spencer David Plaut Herbert E. Spiegel Walid G. Yasmineh Ernest Maclin James B. Powell Francis W. Spierto Sidney Yaverbaum Robert MacPhee Ananda S. Prasad Charles Spurr Shyamal Maitra Rupi Prasad Jim Standefer Bennie Zak William B. Malarkey Dana Procsal Bernard Statland Alfred Zettner H. V. Mahnstadt G. Pu Clyde E. Stauffer Albert Zlatkis John Mandel Loren Steffen M. Zweig James E. March Stanley Stein Oren Zinder Donald M. Marcus Jeff Quint Steven J. Steindel Elizabeth Zygowicz F. Margolis Charles C. Stewart Sanford P. Markey Fredrick M. Rabel Lorraine G. Stewart (Complete through Oct. 30, 1977) CLINICAL CHEMISTRY, Vol. 23, No. 12. 1977 2361 Sendto Micromedic Systems, 102Witmer Rd., Horsham, PA19044 NAME TITLE HOSPITALORLABORATORY STREET @llfiafi@1ll Compiled by J. S. King, Executive Editor AACC Seeks First Collection ofblood specimens by skin phia, July 24-28, 1978. Contact: Prof. Congressional Science Fellow puncture involves several steps and Grafton D. Chase, Department of there may be variations. Therefore, it is Chemistry, Philadelphia College of The Association invites applications very important that a standard method Pharmacy and Science, Philadelphia, from its U.S. members for the first year for skin puncture specimen collection be Pa. 19104 (215/386-5800). of its Congressional Science Fellow adopted. The standard method just Radioimmunoassay and Other Program. Deadline for applications is published by NCCLS for skin puncture Competitive Radioassays. Lectures March 20, 1978. The award will be an- specimen collection will be useful in and/or laboratory. Philadelphia, July nounced on April 20, 1978. The term of general and specialty hospitals where 31-August 11, 1978. Contact: Prof. the appointment isone year, beginning blood specimens are obtained from Grafton D. Chase, Department of September 1, 1978. The purpose is to children, especially newborns, and from Chemistry, Philadelphia College of contribute to the continuing cross-edu- adults where venipunctures are difficult Pharmacy and Science, Philadelphia, cation of the Congress and the clinical or undesirable to perform. Pa. 19104 (215/386-5800). laboratory community through the PSH-3, Standard Procedures for the “Daltons” and “Molecular placement of a postdoctoral to mid- Collection of Diagnostic Blood Speci- career clinical chemist as a working mens by Venipuncture, has just been Weight” member of the staff of a member, com- published and is available at $8 each. By international authority [IUPAC: mittee, or office of the Congress con- Jean Slockbower, Ph.D. (Mayo Clinic) Pure Appl. Chem. 21, 1(1970)1, molec- cerned with matters having asignificant is chairman of the committee that pro- ular weight is ashort term for “molecu- scientific component. duced PSH-3. PSH-4, Standard Pro- lar weight ratio” and therefore has no The stipend will vary, depending on cedures for the Collection of Diagnostic units. The dalton, although not inter- the needs of the candidate. Blood Specimens by Skin Puncture, is nationally defined, is a mass equal to A prospective Fellow must have available at $6each. The committee that one-twelfth the mass of an atomic of demonstrated excellence in clinical produced PSH-4 ischaired by Thomas carbon-12; thus dalton is a unit of chemistry and possess a broad scientific A. Blumenfeld, M.D., of the College of mass. and technical background. He or she Physicians and Surgeons of Columbia Hence it iscorrect to say “the molec- must be literate, articulate, and able to University. ular weight of X is 106” or “the mass of work effectively with a wide variety of The universal acceptance and appli- X is 106 daltons,” but incorrect to say, people; be aware of social issues; exhibit cation of these standards will undoubt- “the molecular weight of protein X is 106 willingness and the flexibility to work in edly eliminate some current problems in daltons.” the political arena; have astrong interest the proper interpretation of both Biologists find the dalton a conve- in applying knowledge in the solution of chemical and hematological laboratory nient unit to use in the case ofstructures social problems; and have a strong in- data. Ultimately this must lead to ana- containing several sorts of molecules for terest in the objectives of the Associa- tional improvement in patient care. which the term “molecular weight” is tion. PSH-3 and PSH-4 are available from inappropriate, such as: “The mass of the Application forms and additional in- NCCLS, 771 E. Lancaster Ave., Villa- ribosome is 2.6 X 106 daltons.” formation are available from Dr. Wil- nova, Pa. 19085, postpaid at the prices liam Campbell, Executive Director, quoted above. For orders outside the Predictions for 1978 el seq., AACC, 1725 K Street, N.W., Washing- United States please add $1 per stan- from Market Researchers ton, D. C. 20006. dard for air mail. To keep operating New Publications from NCCLS costs as low as possible, NCCLS re- Arthur D. Little, Inc., Cambridge, quests a check with the order. Mass.: The rapid rise in health-care There is growing recognition that vari- expenditures will persist through 1981 ability in the collection of blood speci- Meetings and Continuing despite intensifying efforts to contain it. mens may lead to such changes in test Education During those years, health-care spend- values that interpretation of the mean- ing in the United States and Western ing of the results may be difficult. The Rocky Mountain Section, AACC. Third Europe will continue to grow more rap- National Committee for Clinical Labo- Annual Meeting, Stapleton Plaza Hotel, idly than GNP. Sales of health-care ratory Standards has assembled agroup Denver, March 15-18, 1978. Papers products in the United States and of individuals who, for the first time, (deadline Jan. 15) and exhibits invited. Western Europe will increase at an an- have addressed the factors that con- Contact Kent Painter, Ph.D., Western nual rate of 6%in constant 1976 dollars, tribute to variability of blood specimens Chemical Research Corp., Inc., 2300 N. from $36 billion in 1976 to $48 billion in as they relate to collection procedures. Highway 287, Fort Collins, Cob. 80521 1981. The standard that has been developed (303/493-8474). The U. S. and Western Europe rep- can be applied by anyone obtaining Concepts of Radiation Measurement. resent about half of world health-care blood by venipuncture. Lectures and/or laboratory. Philadel- product sales. Their market dominance CLINICAL CHEMISTRY, Vol. 23, No. 12, 1977 2363 will continue, even if sales increase more where instruments that do not satisfy market for QC materials and references, rapidly in some of the developing the necessary performance have either though not at the “phenomenal pace” countries. disappeared from the market or are in that occurred during the late ‘60s and Health-care product sales will average the process of dropping out. And those early ‘70s. Clinical lab equipment less- 5% real annual growth in the United instruments most likely to retain a ing, as opposed to outright purchasing, States during the next five years and 6% first-order relevance to laboratory op- comprises another trend. in Western Europe. The sales growth eration will have the flexibility to per- In addition, manufacturers have rates for pharmaceuticals, medical form both screening profiles and selec- begun to produce complete lab systems supplies, and medical equipment will tive, individual tests or test panels. that require use of proprietary reagents, approximate the overall averages. Put yet another way, laboratory au- a concept pioneered in North America However, clinical diagnostics will tomation will be increasingly tied to by Du Pont. This has prompted even spearhead rates of 11% real growth for technology-based performance im- Technicon Corp. to give less emphasis to “other” products in the United States, provements-such as selective discrete its bread-and-butter continuous-flow and 12% in Western Europe. analyses, integrated sample identifica- analysis technology. Instruments that Nationalization is not necessarily the tion, kinetic and uv measurements, and require unique packaged reagents rep- answer to cost containment, as evi- micro sampling-that lead to dimin- resent better returns than when appa- denced by recent developments in the ished reagent consumption, high test ratus is marketed by itself and control United Kingdom. There, price increases output, built-in computer control, sim- over reagent purchases is minimal. (25-30% in 1976 alone) have been the plified operation, and compatibility with Of all the clinical-laboratory sectors, highest in Western Europe. As a result, manual techniques. clinical chemistry, at 34% of the total Arthur D. Little foresees a stronger Yet another trend isthe swelling em- market, accounts for the largest reagent government role in price setting. The phasis on stat testing, with some 1000 market. New developments include government already is attempting to installations and representing a $75 improved antiserum, autoimmunopre- reduce costs by such measures as advo- million market. New stat units with cipitation, and enzyme immunoassay cating more at-home and outpatient improved features by Technicon and techniques. care, and eliminating waste. Instrumentation Laboratory, among Interestingly enough, a major factor other vendors, have begun to compete A Reculons et en Avant in health-care cost-control measures in against the Du Pont aca system that now the United States is a reduction in the dominates the market. By 1978, at least People in editorial offices suffer a sort of number of hospital beds. Yet, with 4.6 a half-dozen competitors will be in the temporal distemper. As this is being hospital beds per 1000 people, the stat marketplace. written, the autumn leaves have reached United States has fewer beds per capita The market for diagnostic reagents their peak of splendor and the mock- than any of the Western European and test kits in Western Europe will in- ingbird still sings outside our door (a countries examined in detail. The crease at a 16%annual clip through 1980 bucolic distinction enjoyed by no other United Kingdom has 5.6per 1000 capita, and then at a 20%annual rate over the editorial office I know of). Still, we have Italy 6.4, France 7.0, and West Germany following fiveyears toreach $893million begun work on the February issue and it 7.4. by 1985. Such an increase will be fuelled istime to wish you agood New Year, to Frost and Sullivan, New York City: by the advent of new tests and rise in count our blessings, and lick our wounds The market for clinical laboratory in- automated testing. as we complete volume 23. strumentation at $315 million in 1976 More than 100 suppliers to the Eu- I believe I speak for the Editors in will reach $450 million in 1980, and $477 ropean marketplace serve approxi- saying that we are rather proud of this million in 1986. mately 6400 hospitals and 4900 inde- volume and the good things it contains; The 11 instrumentation categories pendent clinical laboratories in Western there iseven reason to hope that some of analyzed account for about 90% of all Europe, and they carry out some 1.5 it will prove to be of unusually broad device sales, with a typical setup in a billion clinical chemistry tests each year. interest and lasting value, as scientific 300-bed hospital looking like this: a But the West European marketplace is papers go. Technicon SMA 12/60 to do routine not homogeneous, the study warns. We thank those who, during the year, screens; Abbott ABA-200 to do enzyme Equipment use varies greatly among have done us the kindness of taking the testing; Du Pont aca to do “off-hours” countries according to population, trouble to write and tell us how they and stat testing; and possibly a Beck- wealth, and health-service organization. think the journal ought to be improved, man glucose analyzer to do stat and The U. K. and the Scandinavian as well as those who expressed satisfac- other general tests. countries, for example, have compara- tion with it the way it is. We pay atten- The advent of large-scale integrated tively few laboratories, and these tend tion to criticism and, being human, bask circuits, and, more recently, the micro- to be very large and under public control in praise. processor, has resulted in the first big since they are operated by the national Iespecially thank the editorial assis- breakthrough in small-analyzer design. health services. tant and copy editor, for their continu- This market is becoming especially dy- In addition, test frequency differs ing diligence and patience, and our namic, according to the research study. among the different countries; e.g., the printer, who kept us reasonably well on The instant interfacing of memory number ofenzyme determinations done schedule during the year (aside from an storage and peripheral logic have im- in Germany is relatively high as com- electronic press problem in September, parted the control, speed, and simplicity pared to other countries. Overall, when several readers paid us the oblique that is necessary in an ideal small ana- countries outside of the European Eco- compliment of inquiring indignantly lyzer. nomic Community will have more hefty why the journal was so late). Indeed, small analyzers of all types growth rates through 1985 than will the Several surprises are already in store are coming to the market to do dedi- EEC countries, with Spain, Finland, and for you during 1978, over and above our cated jobs-a Perkin-Elmer Corp. Austria accounting for the most rapid usual fare, but Iwill not again make the amylase/lipase analyzer, for example, as growth rates of all. But after 1985, the optimistic error of saying what they will a screen for pancreatitis. clinical lab reagent markets throughout be and when they will appear! Trust The next few years promise to be West Europe will level off and growth us. critical to companies in this once glam- rates will begin to decline. Credit for the modest price of a sub- our industry. Clinical chemistry auto- Increasing pressure to achieve better scription of course goes in large part to mation has reached a state-of-the-art quality control will create avery healthy our advertisers, whose support we 2364 CLINICAL CHEMISTRY, Vol. 23, No. 12, 1977 warmly appreciate. Not one of them, to To our reviewers: my knowledge, has ever tried to influ- May wenever again send anexpert on ence what we publish in this journal, tadpoles a paper on general relativity. even though it must be a temptation And ifwe do may it never take a month when one of their products is receiving for him to let us know. hard knocks at the hands of some user- To our printers: author. May we come to some agreement on -J.S.K. the spelling of [cuvet]. To Professor [J. King]: May we never again call you [J. S. Some Seasonal Greetings King]. (adapted slightlyfrom Nature To our sub-editors: May you remember the difference 264, Dec. 9, 1976, p493) between partly and partially, and be- tween compared with and compared To book blurb writers: to. May all your wares continue to be of To our authors: interest to highly qualified specialists, May you put your conclusion in your students and the layman alike. first paragraph. To those eminences who require their After that can come the introduction. BECKMAN secretary to type after their name MA, The middle bit then goes at the end. PhD, ScD, FRIC, FInstP, FICE, CEng, ENZYMES& FRSEdin: Quote May you excuse the modesty of our BIOCHEMICALS. What is the problem with interpreting lab response. results? It seems to me that the difficulty that To all directors of big government lab- has led to this situation is simply that the Beckman offers in commercial oratories: development ofadequate population data is, quantities at competitive prices: May you never again need to be to most of us, a boring and tedious task. It Cholesterol Esterase thanked for granting permission to your requires clinical input, mass storage devices Cholesterol Oxidase staff to publish. and, above all, money. The financial consid- Creatine Phosphate eration is of greatest concern because labo- To all those whose notepaper is head- ratories that perform these tests are basically Creatininase ed: not interested in committing funds to Glucose Dehydrogenase US Department of Health, Education projects of this nature, feeling that the work Glucose Oxidase and Welfare, would be supplied through research efforts Glucose Oxidase/Peroxidase Federal Ventures Office, and federal support. On the other hand, re- Glucose-6-Phosphate Bureau of Diseases, search funding agencies look toward sup- Dehydrogenase Common Cold Eradication Program, porting projects that have some sparlde. After L-7- Glutamyl-p-Nitroanilide Viral Infection Project, all, they also have their own image and fed- Glycerol Kinase University of South Chicago, eral funding to consider. Furthermore, I’m a-Glycerol Phosphate Western Campus, sure they do not consider this type of docu- Dehydrogenase mentation and validation a rightful research Emily Smoot Building, agency charge, and feel it should be carried Hexokinase Department of Biochemistry, out bythe organizations that have large scale Nicotinamide Adenine Sub-department of Sneeze Research, clinical contacts and that benefit financially Dinucleotide, Trihydrate Room 3581 from performing the tests. p-Nitrophenyl Phosphate May you get a box number. Personally, Ifeel they are both wrong: the Peroxidase clinical laboratory performing the test 2-Phosphoenol Pyruvic Acid To all authors of rejected papers: should, indeed, be collecting adequate pop- Even though you are “naturally dis- Phosphoenol Pyruvate ulation data and it is certainly a proper Carboxylase appointed” by our decision, may you function of the funding agencies and the Pyruvate Kinase maintain your custom of “not being in professional societies to set up guidelines for Uricase the habit of writing to complain.” population studies that should be funded To all those who telephone us and find through grants orcontracts. The fact that the Thesehigh quality products are data isunavailable today is adequate testi- available with complete assay data. us unavailable: mony tothe failure ofthe current laissez-faire We ensure lot-to-lot consistency and May you ring us again; we won’t ring approach. offer technical support and a broad you. -R. F. Ritchie, in range of applications assistance. To all our readers: Adv. Automated Anal., Samples may be obtained for May your grumbles find their way to Technicon Int. Cong. 1976, evaluation. Send for Beckman us; we may not be on the same grapevine 1, pp 44-46 Catalog 6929A. as you. Beckman Instruments, Inc., To a scientific jet-setter: Biological &Fine Chemicals Division, May you look on the messages board Some Forthcoming Papers Microbics Operations, 6200 at Heathrow airport. We don’t send El Camino Real, Carlsbad, California letters to you at your department any Liquid-Chromatographic Procedure for 92008. (714) 438-9151 more. Tricyclic Drugs and Their Metabolite in To the editors of new journals: Plasma May there always be interdisciplinary F. L. Vandemark, Reginald F.Adams, subjects crying out for a new journal and G. J. Schmidt dedicated to rapid dissemination of re- Evaluation of the Harleco Micro CO2 sults; may you find a goodly number of System for Measurement of Total CO2 Nobel Laureates for your editorial in Serum or Plasma board. C. W. K. Lam and I. K. Tan CIrci. No.895 onR.ad.r’. Sirvlc. Card CLINICALCHEMISTRY,Vol.23,No.12,1977 2365 PLACEMENT SERVICE lnseit,o-Blo.cank ChomLst,Ph.D.AlA,radlore- FACULTY PoSmoNs-Two faculty positions captor, enzymatic assays; enzyme pwiflcation, available atthe assistant professor levelforanM.D. Members of the American Association for Clini- metabolic, kinetic studies; antibody production, and a Ph.D. ina universIty health center central cal Chemistry who are unemployed orare seeking estImation, radlolabeling, tissue distribution;syn- clinicalchemistry laboratory. Arecord ofscientific a change in position will beentitled to 3free in- thesisofterpenes. alkaloids, antimalarials, radio- achievements andcontinuingprogram ofresearch scearlteionndsar Uyeator.8Alidndeistioenaaclh ininstheirstiosnesctioanftedruritnhge a3 labeled compounds; tissue cuitire. Seeks respon- inbiochemistry and/or experimental pathology isa free ones will bemade at the non-member rate. sibleposition.Limited teachingwill aisobeconsid- must. Experience inclinical chemistry helpful. Reply ered. CC-12-9-77. withvitae to:Dr.AjitSanghvi, Department of Pa- SchSeernadgo aAdvsseortciisaintegs, Incco.p,y151an5dBrocaoddweday,re1p0ltihesFlotoo:r, Clinical Chemist. A.A.C.C.A,.S.M.T.,13yrsactive thology. University ofPIttsburgh School ofMedicine, New York, NY 10036.(The AACC expects that each supervisor, clinical exp.Inallphasesexcept Bacti., PIttsburgh, PA15621. AnEqualOpportunity/Affir- userofthis section consider himself morally obligated 4 yrsMtgRTAMaterials. Solid Technical &Admin. matlveActionEmployer. toacknowledge all replies tohis advertisement.) Bkgd. Heavy emphasis pen. chemistry. atomicab- Raiss: sorption, 0G. Sma12. Smac, Bloodgasanalysis. Assistant Research Biochemist, Department of Instrument evaluation andtrouble shootlng-.CDC Surgery. Ph.D.in Biochemistry. Chemistry, Physi- Situations Available: 5-Line minimum, $50.00; each additional line, $6.00. Box Number Service will GenLab.Supv.LIcenseandHa Supervisor.Ucense ology orBiologyandoneyearormore ofpostdoc- not be available as applicants will answer directly. inChemistry &Hematology. Presently enrolled ina toral research experience to participate inlarge “Blind” ads willnot be accepted. Master Management Proam. Challenging Super- research progam ingastrointestinal physiologyand Situations Wanted visor position inHosporIndustry. hormone isolation, liver physiology. pancreas Members: SeeLegendAbove C-12-10-77. physiology and pancreas transplantation fordiabe- Non-Members: 5-Line minimum, $25.00; each ad- CLINICAL CHEMIST, Master’s, NRCC certified, tes. Expertise Inclinical chemistry and peptide ditional line to maximum of8lines total $3.00per AACC. ACS. 19yearshospital and industrial expe- chemistry required. Send curriculumvitae,blbliog- line. Box Number $2.00. rience:R&D,method &reagent development quality raphy and names of 3 references to: Professor control,troubie-shootlng, techoical services, hospital Marshall J.0110ff,Chairman,DepartmentofSurgery, labmanagement, automatIon, disposables. Patents. UCSO MedicalCenter, 225 West Dickinson, San SITUATIONS WANTED Northern N.J.-Metro N.Y. only. No agencies. Diego, CA92103. Salary relatedtorank and step of CC-12-11.77. appointment withinestablished salary schedule of tCMpclIoinoeclCxndieritnuCinrceosisocntlel,raocdiaage.lCctlyechIoSarneerceRdmrhepoIikiAtruniieistn.gvditngoa,Iemtrae,srSmBealeswSuaucpnMbetotoiolooTcnlrhnm,saaeitsbmaCeoiltrsihgeiisuholeterptsnyfp.e,,oyrsMvesCpaiiCSetsri-soc.Ro1ri2naiy-n&h1li-oCcd7nDs7huhph..teioiintmeqsCapsulh.iiatseaeCltlmirx,tAyy-,, CefermcroxoonLepmuncInetNitpeirc,niuIseCetin.enActrecSteLhaleuceeCshdmkyieHni.nssgEptgoeMatesomdnlixSt(emsiiMorcT,aino/TnlIplto,iivrsngoaQtsynrhaaf,adodmUts,iNpvmURiOetInai,ACinlRv,,QgHeHsmpCEirod,eMiasvetphannISuoltdastdTlo)bas,,smbooPsarm.thdedIeeDdnEivnd,xeuep9lsleoaetylrnrpcaiyrd--b-s. aUEAPgrgmaCDotepSMuhlmnoooIyNdl.eoeInrgSe.AytmTn.wRpihAMtEhaTqs.ISuiVspa.ErlerIevnCOqioOpluuapiObrsoeoRrdrtauD/stPnouIIhNrptyy.eAD/rAT.vmfOisfIeoRprdmrr,iyecaDfiteniervearpeenadrd.tamnCdeAnlBitmncatciaicknooa--nfl CC-12-12-77. experience. IndividualreportstoLaboratoryDirector. ClinicalChemist. Ph.D. (1975): Completingsecond Responsibilities include management ofpersonnel yearofABCCapproved Postdoctoral Training.Two Biochemist, Ph.D., 1973. AACC.Postdoctorals in andgeneral operations ofclinicallaboratory; door- years tulitimeexperience in:a)routineanalysis, b) molecular bIology and toxicology.KnowledgeofRIA dinating.teachingandevaluatingmedicaltechnology QC,c)RIA,d)Endocrinology,e)Toxicology,I)new techniques, TLC,GC,fluorometry, enzyme assays, and continuing education propmms. Apply with method and lnslnanent evaluation, g)supervIsionand and neonatal screeningprocedires.Seeking either ctrrlcukjn vItaeandreferencesto:W.E.Maldonado, teaching. ABCCexamination inFall.Publications. supervisory orapplied research responsibilitiesin M.D., Director, Department ofPathOlOgy,1215East AACCmember, Seeking position inHospital or hospital orIndustry inclinicalchemistry ortoxicol- Michigan Avenue. Box30480. LansIng. MIchigan Commercial ClinicalLaboratory. CC-12-2-77. ogy. CC-i2-13-77. 48909. Biochemist, Ph.D..1973.ClinIcal Assistant Profes- QUALITY CONTROL SUPERVISOR ORCUNICAL 5cr. 20publications. Experience InAlA.Analytical CLINICALBIOCHEMISTfor Private Laboratory. Re- CHEMiST: MSC., MS.-Certified Specialist In techoiques. Enzyme pudficatlon, assays Estimation sponsible for overall supervision ofclinical testing Chemistry (ASCP).Broad research and clinicalex- ofMetabolites. Protein chemistry. Tissue culture. and administration oftechnicalpersonnel.Minimum perience IncludingQuality Control, teaching, new Immunochemistry. Eiectrophoresls. Fluorometer. requirements: Ph.D. InBiochemistry. 3yearsclinical method Implementation, instrumentation, automa- Gelchromatography. industrialandteaching expe- laboratory experience, extensive Involvement In tion,routine analysis Inspecial chemistry, publica- rience. CC-12-14-77. TechnicOnInStrUmentatiOn.Submitcurriculum vitae tions. Seeks position inhospital, college orIndustry CLINICAL BIOCtEMIST, M.T., PhD. (Biochem, toTerrence M.Hanson,GeneralManager.TheDl- inDetroit Micharea. CC-12-3-77. 1973), Certified Specialist inChemistry (ASCP), agnostic Laboratory, P.O.Box29106, PhoenIx, AZ. Member AACC,ASMT,ASCP. I’1CC eligible. Many 85038. AnEqualOpportunityEmployer. Clinical Biochemist, Ph.D.Member AACC.AAAS. years experience inlaboratoryservice. AlA,special Over 5years Clin. Chem. experience withvarious chem. automation, teaching andciinlcai research. Clinical Chemist-(MS orPhD)needed forexpand- manual procedires Inresearch and supervisory Seeks pathology lab/medical technology proam Inglaboratory forhighlyservice-oriented community capacity. Extensive experience inchromatogaphy position withmanagement responsibilIty,wIllrelo- hospItal. Responsible formanagementofchemistry (TLC.(LC),electrophoresis and methods develop- cate. P0 Box463, NorthChicago, III.80064. department, including R.and D.ofnewprocedures, amceindt.s.MSeeetakbionlgismposisttiuodnieisnhInoscphitoalel,sterpolrivateandlabbiloer SITUATIONS AVAILABLE teexapcahnindged iRn.IA.AS.CdPevealpopprmoevnetd, qscuhaloitoylcoofntrmoeld,icaanld Industry. CC-i1-9-77. technology. Clinicalfaculty appointment inmedical NATIONWIDE CLINICAL CHEMISTRY school. Opportunity forprofessional growth. Salary CLINICALCIEMIST, Ph.D., p.d.Dlpl.InClin.Chem.. POSITIONS BY KALVERT PERSONNEL negotiable. Prefer MT. (ASCP)background and PexrpeesreienntcleyMaInnaagllearroefapsvtolfabd.inB.encchheman.dmSousptleyrviasuotroy- Please see our ad page 2367 this Issue eMxpDe.r,ienScte. LianwmraennacgeemHoesnpti.talC,ontLaacnt:siLnego, WM.Wichailkgearn mated. to-gether RIA.Tox..Drug assay, Electroph., KALVERT PERSONNEL 48914. Immuno, Isoenzymes, OLCand some hematology, 147 W.42nd St.,N.Y.10036 (212)564-2244 serology andblood bank. Strong backound inlab Director ofClinical Chemistry Laboratories. Director management, Q.C.method develop, and computer. CLINICAL CHEMIST-Immediate full time career of aClinicalChemistry Laboratory ina UnIversity Publications. Seeks senior position inhosp. orIn- opportunity forClinicalChemist(ASCP)desiredwith MedIcalCenter withanexpanding proam InLab- dustry. CC-12-5-77 experience and special interest andknowledge In oratory MedicIne. Academic appointmentIn ap- quality control; maintenance and repair ofInstru- propriate medIcal school department. Training CLINICAL CHEMIST/TOXICOLOGIST: M.SC., ments and evaluation ofnew equipment and new progams InClinicalchemistry. clinical pathology and ASCP(C),member AACC, about 7yearsofexperi- techniquesrequired. Fullya.si1ed laboratory with medical technology. Research space available. ence Inall areas of Clinical Chemistry Including excellent facilities. Pleasant work atmosphere, Candidate must possess M.D.and/or Ph.D.degree special chemistry, toxicology, R&D,OC.(IC, TLC. competitive salary and outstanding employee ben- withexperience Indirectinglargeclinicalchemistry immunoassays, methods development. autoana- efIts.Submitcomplete resume toPersonnel Direc- laboratoryandwIthdemonstrated talent inteaching lyzers, spectrophotometry, fluorometry, electro- tor.Halifax HospitalMedical Center,P.O.Bo) 1990. andresearch. SendCurriculum VItae and 3refer- phoresls, teaching. Seeks position Inhospital, pri- Daytona Beach, FlorIda 32015. ences toDr.WilliamW.McLendon, Chairman, Do- vatelabor industry-CC-i2-6-77 Belgium based medical laboratory specialIzed in partment of Hospital Laboratories,N.C.Memorial hormonal clinicalanalyses Issearching forPhDlevel Hospital, The University ofNorth CarolinaatChapel MT(ASCP), MS., MemberAACC.5years chemistry specialist inradloimmunoassays toassist Inrapidly Hill,Chapel Hill,NorthCarolIna 27514. Anequal experience inlarge university computerIzed labo- expandingeuropean activities. Five years practical opportunity/affirmative actionemployer. ratory. Experience Includes automated routine experience inhormonal chemistry, proteinpurifi- chemistry, special chemistry, AlA,methods devel- cationandradioactivetracers preferred. Position opment and comparison, product and Instrument calls forimprovement ofstandard techniques and evaluation andclinicalfieldtrials.research andde- development of new Immunological methods for ve4opment continuing education, and qualitycontrol. potential commercial applications. Send urgently Local,regional andnationalworkshop experience. C.V.toM.Culot 3792FLogansFerryAd,Pittsburgh, Seeking challenging position. Highly motivated. Pa. 15239. Salary open,interviewpriorto 12-31- CC-i2-7-77 77. (Continuedonp.2367) 2366 CLINICAL CHEMISTRY, Vol. 23, No. 12, 1977 Index toAdvertisers SITUATIONS AVAILABLE ADVERTISER PAGE NO. CLINICAL CIMIST-Full time position inclinical chemistry section, KernCountyMedical Center. 266 Alpkem Corporation 28A bedsouthernCalIforniateaching hospital. introduce Forthcoming Papers newmethodologies,maintain Quality Controlstan- American Association for dards. train personnel and teach students Incollege ClinicalChemistry 16-17A, 30A Selective Staining of ai-Antitrypsin affiliatedmedicaltechnology program. Requires Masters degree in chemistry or biochemistry, a American Monitor Corporation 20A (aj-Protease Inhibitor) with Schiff’s California license oreligible InClinicalLaboratory Reagent after Separation from Serum Technology, SpecialistorBioanalyst.andoneyear Beckman Instruments, Inc. 37A,2365 by Analytical Isoelectrofocusing in clinical laboratory experience. Knowledge ofauto- Bectori Dickinson lmmunodiagnostlcs Polyacrylamide Gel mated instrumentation, QC and AlAessential; su- pervisory experience desirable. Contact KernCounty 21. 22, 23,24, 25, 26A Albert Hercz and Marcela Barton Personnel Department, 1120GoldenState Avenue, Bio-Dynamics 48-49A Variability among Commercially Bakersfield, CA93301. Available Digoxin Radioimmunoassay MEDICAL TECI*IOLOGIST(,A.S.C.P.).ifyouare BloAla 54A Kits in Cross-Reactivity to Dihydrodi- aA.S.C.P.registered or eligible forregistration with Brinkmann Instruments Inc. 1A goxin training and/or recent experience inallphases of laboratory medicine we would liketo discuss an College ofAmerican Pathologists 29A William G. Kramer, Nikki L.Kinnear, opportunity foryoutojoin ourstaffInamodern au- and H. Keith Morgan tomated laboratory. WhetdoesDaytona Beach offer ClinicalAssays 2A Applications of a New Instrument, the thatother Floridacitiesdonot?Offduty. A23mile strand ofthe world’s most famous beach, freeto Corning Medical 31A,43A, Cover3 Potentiophotometer dove,swim,sunandhave fun;Daytonainternational Wallace E. Carroll, R. 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Crowl, Dollar reward: Substantial finder fees paid forin- InstrumentationLaboratory 56A Wendy M. Eimstad, Mae W. Hu, Jean formatIon leadIng tothe buying orsellingofused Technicon orCouiter instrumentation. Please call KabiDiagnostica 51A K. Kam, Robert C.Ronald, Gerald L. I#. TirgayKayaat ScientificResources,Inc.,3300 Rowley, and Edwin F. Ullman Commercial Ave., Northbrook. III. 60062; (312) KalvertPersonnel 2367 498-2920 (collect). TheLondon Company 13A HaveYouConsidered Merck/DiagnostIcs 8A Micromedic Systems 2362 theServiceosfaSpecialist? MilesLaboratories 53A In theClinicalChemistry field,Kalvert Personnel isthe recognized ape- NewEngland Nuclear Cover 2 cialiatservicingboth thecompany andthe applicant Through special screening and evaluation techniques wehavedeveloped Nuclear Medical Systems Inc. 27A, 46A aleading reputation amongthe members ofthe ClinicalChemistry fra- ternity and the results aremoatgratifying tothe companies weservice P-I Biochemicals Inc. 54A and the applicants werecommend Asampling of our nationwide openinga Packard Instruments 14-15A QUALITY ASSURANCEand Rejulatory Affairs Director *35-40,000 Pharmacia Diagnostics, Sweden Cover4 MANAGER ofChemical Quality Control *28-32,000 MANUFACTURING Manager ma)or diagntk co *37-42,000 QUALITY Control Supervisor ClimcalChemistry 824-27,000 Picker Corp. 10-1IA PRODUCTION Manager major diagnostics en *26-30.000 MANUFACTURING Engineer process development *24-26,000 Precision Systems,Inc. 50A CLINICAL Chemist group leader product development *27-31.000 CLINICAL Chemistnewposition hematology reagents MSorPhD 818-24,000 CLINICAL Chemist senior scientist reajent development *22-26,000 PyeUnicamLtd. 12A CLINICAL Chemist research acientiat ff8/MS diag co *15-20,000 IMMUNOCHEMIST Group leader multi-disciplined bkgd 826-32,000 Radioassay Laboratory 54A IMMUNOLOGIST Tumor antigen bkgd 823-27.000 IMMUNOCHEMIST Techi director major instrument co 835-40,000 IMMUNOCHE*HST Research scientist BSAf5 diag co 815-20,000 Ralnin Instruments 47A RADIOIMMUNOASSAY Groupleader 823-27.000 RADIOIMMIJNOASSAY Supvsr PhD commercial reference lab . 824-28,000 Radioassay Systems Laboratories Inc. 47A RADIOIMMUNOASSAY Research ecientist BS/MS 815-20,000 BIOCHEMIST Plasmaprotein 820-25,000 BIOCHEMIST Organic chemist techl support RIA 822-25,000 Roche Diagnostics 40A,44-45A ANALY’IICAL Chemist Group Leader Techl support 823-26,000 Scientific Aesources 36A Allteesandexpensespaidbycompany. John &E.Sturge Ltd. 53A CallLeonardKalvert#{14(92}12) 5642244 UnionCarbide 32-33A, 41-42A Orsendresumei,nconfidencet,o: Upjohn Lab Procedures 34A PERSONNEL SERVICE Inc. 147 West 42nd Street. New York, N.Y. 10036 (212) 564-2244 ALLouncLaNTs ABEAFFMATIVE ACTIONEse’I.OVERS CLINICAL CHEMISTRY. Vol. 23, No. 12, 1977 2367 llfifi1ll Journalof the American fi Association for [iI{1 I}? Clinical Chemistry (I]fl( Volume 23, 1977 AUTHOR INDEX Abbasnezhad, Majid SeeYasmineh, Walid G. Auletta, Frederick J., 1094 Berenson, Gerald S. See Srinivasan, Sathanur Abbott, Donald C.SeeRocco,Richard M. Aumonier, P. See Rabinowitz, J. L. R. Abboud, Charles F. See Kao, Pai C. Azar, M.M.SeeSteele, B.W. Bergmeyer, H. U.;Bowers, George N., Jr.; Abele, J. See Khayam-Bashi, H. Baadenhuijsen, H.; Seuren.Jacobs, H. E. H.; Hoerder, M.; Moss, D. W., 887 -; Khayaxn-Bashi, H.;Walter, V. 1153 Jansen, A.P., 1275 Bergstroem, Torgil See Vesterberg, Olof Aberth, William SeeRobinson, Arthur B. Baba, Nobuhisa See Verrill, Harland L. Berk, Lee S.; Hillock, Ronald; Ewing, Carol; Ablin, Richard J.;Holder, IanAlan, 1155 Bablok, Wolfgang G. See Szasz, Gabor Recht, Judi A.; King, Raymond, 445 A-;daSmcsh,mRidetg,inGaaidryJF.;. SVeaendVeamndaermk,arkF,ranFkranLk., L. BBaabcsboon,rik,ArPthauurl SLe.e, 1L3i6p5pel, Kenneth -; HGillloacdkk,owRaoknia,ldK.HM.;.;RKecinhjt,, RJuadyimoAnd.;, 1122 1139 Baggio, Giovannella SeeNeubeck, Wolfgang Bermes, E.W.See Baker, C. Schmidt, GaryJ.;Vandemark, Frank L., Bailly, Michel See Bretaudiere, Jean.Pierre Bermes, Edward W. See Fareed, Jawed 1226 Baird, Marie A. See Burtis, CarlA. Bernstein, Larry H., 1928 Adams, T.H.See Menson, R. C. Bais, Renze; Prior, Michael P.; Edwards, John Berris, Bernet See McNeely, Michael D. D. Adams-Park, Helen R.;Fritsche, Herbert A., B.,1056 Berry, Arnold J. See Pedersen, Robert C. AdelmJra.,n,115R7ichard C., 1104 BBaakkekre,, C0..;MBe.rmSeese, NEet.teWla.n;dB,rooBk.s, M., 1126 -B;errPye,derDseanis,ileeRobHer.tSeCe.,B1r1e4w2ster, Marge A. Adolf, Paul K.;Koko, IlseS., 1161 Ballan, P. See Rabinowitz, J. L. Besemer, 0. M.; Chandler, J. R., 1163 Ahmed, Susan See Lippel, Kenneth Baluyot, E. S. See Bonder, Richard J. L. Bhattnagar, R. S. See Liu, T. Z. Ahuja, K. K. See Lasky,Fred D. Bands, Phillip W.;Sherry, Arletta E.;Blois,M. Bible, K.See Persoon, T. J. Akerkar, Anand See Gutcho, Sidney Scott, 1397 Bierenbaum, Marvin L. See Fleischman, Alan Albers, John J. See Lippel, Kenneth; Warnick, Banks, Geneva See Trotter, John L. G.Russell Bannister, Steve J.; Sternson, Larry A.;Repta, Billon, Bernard See Kelly, Anthea Alberti, K. G. M. M. See Price, C. P. Arnold J.;James, Gerard W., 2258 Bixler, David See Eastman, John Russell Alderman, Jeffrey A.;Cross, Robert E., 1160 Barash, Paul G. See Van Dyke, Craig Bjorkhem, Ingemar; Blomstrand, RoIf;Ohman, -; Cross,Robert E., 1917 Barbara, Luigi See Roda, Aldo Gosta, 2114 Aldini, Rita SeeRoda, Aldo Barbier, Fabrice See Versieck, Jacques Bjornsen, Robert E. See Rugg, Nancy E. Aldous, Kenneth M. SeeGarden, John S. Barbieri, Ann See Coleman, Larry H. Blair, A. James, Jr. See McCann, Daisy S. Alexander, George J.;Machiz, Sandra, 1921 Barboriak, Joseph, J. See Liao, John C. Blair, Doyce; Rumack, Harry H.,743 Alexander, Robert S.;Butler, Anthony R.; Barbour, H. M.;Beaumont, D.;Glenn, J. H.; Blois, M.Scott See Banda, Phillip W. Leitch, Elizabeth, 150 Rosalki, S. B.;Tarlow, D., 915 Blomqvist, Nils; Cederblad, Gitten; Alexander, Roy L., Jr., 1369 Barclay, Mel L. See McCann, Daisy S. Korsan.Bengtsen, Kristoffer; Wallerstedt, Algard, F. Thomas See van Netten, Johannes Barnett, Roy N. See Schoen, Irwin Sven, 1845 P. Barney, Ilene See Eisenberg, Richard B. Blomstrand, Rolf SeeBjorkhem, Ingemar Au, Mahmoud A. M. See Luxton, AllanW. Baron, Richard See Levy, Susanna Bluett, M.K.;Reiter, E.0.; Duckett, G.E.; Al-Tamer, Yassar Y.;Taylor, Andrew; Marks, Barrett, J. See Bell, A.Barbieri Root,A.W.,1644 Vincent, 2175 Barrett, Jack 0.; Eggena, Peter; Sambhi, Blumberg, William E.; Eisinger, Josef; Lamola, Altmiiler, Dale IL;Fowler,Michael W.,1138 Mohinder P.,464 AngeloA.;Zuckerman, DavidM.,270 -; Fowler, Michael W.,1146 Barrett, James See Coleman, Larry H. Blumenfeld, T. A. See Steinbrink, C.F. AAmmbserloiesmin,i, LRydicihaardSeeSBereetSatuodnieerr,e,RaJmeaonn-Pierre BBaarrtreolln,, RE.dwAa.rSdeeJN.eSleseonH,oJfm.aWn,. Lindsay F. -; SFtarerdka,,RV..I.J;.;GJeaomrgees,, J.L.DS.;.,D1y1r2e9nfurth, I.; Amshey, J. W., Jr. See Edwards, R.B. Bartels, Piet C.SeeGoedemans, WimTh. Blumenfeld, Thomas A., 1105 AnanRd,ayVmiornd0.;GD.;uLcahnacramsete,r,DoMnaallcdolmM.;CT.,ro1x1l7e6r, BBaassisni,skiA,.SD.aSneieelPiBet.r,og2r3an5d0e, M. -; H1e7r0te5lendy, William G.; Ford, Sylvia H., Andersen, Ivar See Torjussen, William Battle, J. 0., Jr. See Lewis, Lena A. Bodanszky, Miklos, 1098 Andersen, Ole; Eriksen, Peter Bonne, 751 Batya, Judy See Sealfon, Michael S. Bodey, G. P. See Brou&hton, Alan Anderson, Mary J. See Nye, Lynn Baue, Arthur E., 1091 Bodourian, Selma H. See Pesce, Michael A. Anderson, Robert J. See Sternberg, James C. Bauer, Martin L. SeeMrochek, John E. Bogdansky, Frances; Lee, Soohee;Mamaril, Andres, Rubin, 1104 Bauer, Stanley, 1174 Frank, 1118 AAnngsealroin,i,MiS;aSndarleom,SFee.AF.,rig1o1l5a2, Alberto BavinCt.oJn.,S.;P.LRea.,;VL,au1g9h4a0n, N.M.F.;Johnston, -; MRaomnaalrdil,, 1F1r2a3nk; Massari, Dolores; Quadrel, Arab, Chike See Newman, H. A. I. Bayse, D. D. See Carter, R.J. Bogden, John 0.; Troiano, Raymond A.; Archer, Juanita A.See Gambhir, Kanwal K. Bayse, David See Shaw, William Joselow, Morris M., 485 AArrnonol,d,C.E0..LS.;eeCiNttealdsoinno,, JC..WJ..,Jr., 1154 BayseE,ricDJa.vid D. See Liddle, John A.;Sampson, -B;oguJosslaeslokwi,, MRo.rrCis.SMee.,S1c5h0ro7eder, Hartmut R. Aronsson, Torsten See Westgard, James 0. Beaumont, 0. See Barbour, H.M. Boguslaski, Robert C. See Burd, John F. Anal, Rand See Lam, Robert W. Beckala, Harold See Larson, James H. Bond, Howard E. See Wei, Robert Artiss, J. D.; Thibert, R.J.;Zak, Bennie, 1153 Beckala, Harold R.;Leavelle, Dennis E.; Bond, Lawrence W. See Loshon, C.A. Ascan, William Q.,1109 Homburger, Henry A., 2177 Bondar, Richard J. L.;Baluyot, E.S.;Hsu, M., Ashby, C.Dennis, 1168 Behenna, Donald B.SeePurcell, GeorgeV. 1132, 1507 Assa, Shlomo, 126 Bell, A.Barbieri; Colemen, L.H.;David, B. Bonderman, Dean P. See Compton, Joyce Assarian, Gary S.; Oberleas, Donald, 1771 LeMat; Barrett, J., 1167 Bonitati, James, 1187 Atkinson, M. J. See Phillips, P. J. Bennett, Cleaves M. See MacPhee, Robert D. Booker, Harold E. See Viswanathan, C.T. Auckland, Paul See Muckle, Thomas J. Bennett, John M. See Pannall, Peter R. Bookis, Demostenes See Coutselinia, Anthony Aufrere, Michel B.; Hoener, Betty-ann; Vore, Bensinger, Thomas A.See Medina, Frank Boone, Joe; Griffin, Charles; Shaw, William, MaryE., 2207 Beppu, Hidehiro See Fujita, Keisuke 2180 2380 CLINICALCHEMISTRY, Vol.23, No. 12, 1977 Borek, Ernest SeeDavis, GeorgeE. Butte, W.; Spies, R.; Thomsen, S.; Klein, U. E., Colwell, John A.SeeLopes-Virella, Maria Bergen, Jan; Romslo, Inge, 1599 1191 Fernanda Bernet, Ulf See Szasz, Gabor Buttner, J.; Borth, R.;Boutwell, J.H.; Compton, Joyce; Ryder, Susan; McClure, Bent, Anton See Naus, Andre J. Broughton, P.M.G.;Bowyer,R.C.,1066 Cynthia Pinegar, Joy; Bonderman, Dean P.; Berth, R.SeeButtner, J. -; Borth, R.;Boutwell, J. H.;Broughton, P.M. Prokseh, GaryJ., 1121 Bos, J. F. See White, Robert M. G.;Bowyer,R.C.,1784 Conner, Kathy See King, Martin Bossenmaler, Irene See Pierach, Claus A. Button, Kenneth; Gambino, S. R., 1151 Constant, Irene; Byvoet, Paul, 1794 Bostick, William D.; Mrochek, John E., 1633 Butts, William C.;James, Gerald K.; Cook, Virginia P.; Cawley, Leo P.; Collier, Boudoulas, Ol(a SeeNewman, H.A.I. Keuhneman, Martha, 511 Harold W.,1159 Boukis, Deals SeeCoutselinis, Antonios Byck, Robert SeeVanDyke,Craig Coolen, Richard B.;Herbstman, R., 1142 Bouley, Anne M. See Hofman, Lindsay F. Byers, James M.,IIISeeFinley, Paul R. Coombes, Robert F., 1168 Bourke, E. See Hatch, Marguerite Byvoet, Paul SeeConstant, Irene Cooper, Gerald See Lippel, Kenneth Boutwell, J. H. See Buttner, J. Cali, J. P.;Schaffer, Robert; Mitchell, F. L., Cooper, Gerald R.; Haziehurst, Jacqueline S.; Bowers, George N., 709 1943 Duncan, Patricia H., 1153 Bowers, George N., Jr. See Bergmeyer, H. U.; Cannon, Donald C. See Woo, Jannie Cooper, J. Fenimore See Foti, Andras G. Hoerder, Mogens; Loshon, C. A. Cano, CarIes See Oliver, Lawrence K.;Woo, Copeland, William H. See Buhi, Steven N. -; Inman, Stanford R.,733 Jannie Corcoran, Richard M.; Durnan, Sandra M., -; McComb, R. B.; Kelley, M. L., 1149 Caragher, Timothy E.;Grannis, George F., 765 Bowie, Lemuel J.; Smith, Stephen; Gochman, 1120 Cordry, A. L See Nelson, J.W. Nathan, 128 -; Grannis, George F., 2011 Cornette, R.SeeMiller, Richard -; Carreathers, S.A.;Gochman, Nathan, 1144 Cardinal, Ruth See Pierach, Claus A. Costello, J. See Hatch,Marguerite Bowser, E. Nelson See Hargis, Gary K. Carey, L. C. See Marenberg, S. P. Cosyns-Duyck, M.-Cl.; Dc Leenheer, A.P., Bowyer, R. C. See Buttner, J. Carey, R. Neill See Gerber, Carl C. 1170 Bradeberry, Melissa See Sealfon, Michael S. Carl, Karen See Kumar, Manjula S. Coutselinla, Anthony; Bookis,Demostenes; Bradley, C. A.See Halpern, E. P. Carreathers, S. A.See Bowie, Lemuel J. Kalofoutis, Anastasios, 915 Brand, Michael J. 0. See Grima, Joseph M. Carrico, Robert J. See Burd, John F. Coutselinis, Antonios; Boukis, Denis; Braun, Theodor See Dods, Richard F. 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