Investigative Urology 3

289 Pages·1989·9.42 MB·English

by  B. J. Schmitz-Dräger

Investigative
Urology 3
Edited by
H.Riibben . D.Jocham . G.H.Jacobi
With 180 Figures and 42 Tables
Springer-Verlag Berlin Heidelberg New York
London Paris Tokyo Hong Kong
Volume 1 of the series "Investigative Urology" is "Experimentelle Urologie"
edited by R.Harzmann, G. H.Jacobi, L. WeiBbach, 1985
Professor Dr. HERBERT RUBBEN
Knappschaftskrankenhaus Bardenberg
Abteilung Urologie
Dr.-Hans-Bockler-Platz 1, D-5102 Wiirselen 1
Professor Dr. DIETER J OCHAM
Urologische Klinik und Poliklinik
Klinikum GroBhadern
Ludwig-Maximilian-UniversiHit Miinchen
Marchioninistr.15, D-8000 Miinchen 80
Professor Dr. GUNTHER H. JACOBI
Urologische Fachpraxis
Friedrich-Ebert-Str.176, D-4100 Duisburg 18
ISBN-13:978-3-642-74440-2 e-ISBN-13 :978-3-642-74438-9
001: 10.1007/978-3-642-74438-9
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© Springer-Verlag Berlin Heidelberg 1989
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2122/3130-543210 - Printed on acid-free paper
List of Contributors
The addresses are given at the beginning of each contribution
Ackermann, R. 3 Hannappel, J. 183
Albrecht, D. 183 Harasim, M. 17
Allhoff, E.P. 8 Hartung, R 143,271
Atay, z. 8 Hautmann, R. 129, 153
Aumuller, G. 87 Heckl, W. 25, 156
Bartos, B. 153 Heimann, G. 72
Becker, K. 25 Helmchen, U. 197
Beniers, A.J.M.C. 30 Hendriks, B. T. 30
Bichler, K.-H. 220,249 Hertle, L. 171
Bierth, F. 226 Hesse, A. 226,229,232
Birwe, H. 232 Hofmann, R 271
Blech, M. 197 Hofstactter, F. 120, 125
Bornhof, C. 146 Hohenfellner, R 107
Brendel, W. 191 Hommel, H. 209
Bretschneider, H. J. 197 Huber, R-D. 209
Brummer, F. 120 Iimori, H. 243
Buttner, R. 125 Jaeger, P. 254
Cevc, G. 143 Jonas, U. 8
Classen, A. 229 Jungblut, T. 87
Constantinides, C. 254 Kallerhoff, M. 197
Csapo, Z. 96 Kanazawa, T. 216
Dambacher, U. 177 Kehrer, G. 197
Debruyne, F.M.J. 30 Kishimoto, T. 216,243
deRiese, W. 8 Klossner, B. 156
Derouet, H. 60 Knuchel, R. 120, 125
Deutz, F.-J. 166 Konrad, G. 47
Diederichs, W. 53 Krege, s. 72
Engelhardt, R 262 Kropp, W. 143
Fabricius, P. G. 81 Kupper, W. 161
Fischer, N. 166 Langheinrich, M. 197
Florek, M. 39 Lehmer, A. 115
Fluchter, S.H. 249 Lenis, G. 8
Frenzel, H. 3 Leyh, H. 115
Gebhardt, T. 237 Liedke, S. 8
Gertz, B. 229 Loer, E. 17
Gothert, M. 67 Lue, T.F. 53
Halliger, B. 25, 156 Lutzeyer, W. 183
Hammer, C. 81 Maekawa, M. 243
Handt, S. 125 Malek, B. 87
VI List of Contributors
Markos-Pustai, S. 161 Schmitz-Drager, B.J. 3
Matouschek, E. 209 Schofer, O. 258
Matsui, U. 129 Schrott, K. M. 96
Matsumura, T. 216 Schueler, F. 191
Maurer-Schultze, B. 17 Schuller, J. 39
Melchior, H. 87 Seitz, G. 237
Meyer, W. 262 Senjyu, M. 243
Meyers, N. 166 Sinowatz, F. 81
Miersch, W.-D. 135 Spormann, H.-A. 183
Miller, K. 129, 153 Steffens, J. 60
Mlynek, M.-L. 143 Stein, T. 72
Molderings, G.J. 67 Steiner, R. 153
Mosier, B. 146 Steinmetz, M. 39
Musseler, P. 191 SWckle, M. 107
Nawrath, H. 171 Strittmatter, T. 47
Neisius, D. 237 Strohmaier, W. L. 220,
Nelde, H.J. 220 249
Ochi, H. 243 Sugimoto, T. 216, 243
Oehlert, P. 39 Tanke, H.J. 107
Osswald, H. 216 Terzis, A.J.A. 39
Otto, U. 30 Thomas, S. 39,262
Peelen, W. P. 30 Traub, O. 120
Pensel, J. 39,262 Valet, G. 115
Permanetter, V. 72 van Ahlen, H. 67
Persson-Jiinemann, C. 53 van Moorselaar, R.J.A. 30
Pohl, J. 177 Vecera, E. 146
Pohl, U. 8 Vogel, J. 135
Porst, H. 67 Voges, G. 107
Recker, F. 161 Wacker, U. 25
Reichel, E. 271 Wagener, C. 125
Riedmiller, H. 107,258 Walther, R. 96
Ringert, R. H. 197 Warnaar, S.O. 8
Rohde, D. 3 Weber, M. 191
Rohrmann, D. 183 Weiss, M. 191
Rommel, F. 81 Wilbert, D.M. 249,258
Rubben, H. 72,125,161,166,216 Wilgenbus, K. 120
Ruck, A. 153 Wirth, M. 17
Schalken, J. A. 30 Yamamoto, K. 216,243
Schmidt, E. 153 Ziegler, M. 60,237
Schmidt-Kloiber, H. 271 Zink, R. A. 191
Preface
The first symposium of the working group on experimental urology of the
German Society of Urology was held in Cologne in 1972. It was meant to
be a platform to present and, in particular, to discuss experimental studies
developing new diagnostic and therapeutic approaches, and to promote in
novation in urology in Germany. This plan was well received, and during
the last 16 years both the number of participants from other European and
overseas countries and the number and quality of presentations have been
continuously increasing. At the most recent meeting, held in Aachen in
1988, new data were presented on renal cell cancer, andrology, prostatic
cancer and adenoma, bladder cancer, urinary diversion, urodynamics,
renal pathophysiology, transplantation and the pathogenesis and treatment
of urolithiasis.
The present book contains 44 of the 109 papers given at the Aachen
meeting, covering both basic and clinical research. It will be of eminent
interest to all scientifically minded urologists, oncologists, neurophysiolo
gists, endocrinologists, and pathologists because it is a synopsis of all the
major scientific research currently being conducted in urology in Europe.
There are no other books available which offer as comprehensive a cover
age of recent experimental issues in urology. The aim of the series Inves
tigative Urology is to demonstrate the continuous development of research
in urology and to encourage all colleagues interested in experimental urol
ogy to continue their important activities and create new international co
operation.
Aachen H.RoBBEN
Munich D.JOCHAM
Duisburg G.H.JACOBI
Contents
I. Renal Cancer
Biological Markers in the Evaluation of Prognosis in Patients
with Renal Cell Carcinoma
B.J.SCHMITZ-DRAGER, D.RoHDE, H.FRENzEL, and R.AcKERMANN ... 3
Comparison of Human Normal Renal Cells and Malignant Renal
Cells In Vivo and In Vitro Using Cytological, Cytochemical,
and Immunocytochemical Methods
W.DERIESE, E.P.ALLHoFF, U.POHL, G.LENIS, S.LIEDKE, Z.ATAY,
U.JONAS, and S.O.WARNAAR (With 8 Figures) ............. 8
Growth and Cell Proliferation of Human Renal Cell Carcinomas
Xenografted into BALB/c nulnu Mice
M. HARASIM, E. LOER, M. WIRTH, and B. MAURER-SCHULTZE
(With 2 Figures) ..................... 17
Expression of Epidermal Growth Factor Receptors on Renal Cell
Carcinomas
W. HECKL, K. BECKER, U. WACKER, and B. HALLIGER (With 3 Figures) 25
In Vitro Sensitivity of Three Human Renal Tumor Xenografts
Towards Tumor Necrosis Factor and Alpha and Gamma Interferon
A. J. M. C. BENIERS, R. J. A. VAN MOORSELAAR, W. P. PEELEN,
B. T. HENDRIKS, U. OTTO, J. A. SCHALKEN, and F. M. J. DEBRUYNE
(With 4 Figures) ........................ 30
Water-Jet Cutting: A New Technique for Selective Parenchymal
Surgery of the Kidney
J. SCHOLLER, J. PENSEL, A. J. A. TERZIS, M. FLOREK, M. STEINMETZ,
S.THOMAs, and P. OEHLERT (With 4 Figures) .......... 39
II. Andrology and Testicular Cancer
Testicular Blood Supply with a View to Surgical Treatment
T. STRITTMATTER and G. KONRAD (With 1 Figure) ..... 47
Alteration of Penile Ultrastructure in Impotence:
Morphology and Clinical Correlation
C. PERSSON-JDNEMANN, W. DIEDERICHS, and T. F. LUE (With 4 Figures) 53
X Contents
The Erection Ring - A New Treatment Approach in Venogenic
Erectile Dysfunction
J.STEFFENS, H.DERouET, and M.ZIEGLER (With 5 Figures) 60
Inhibitory Presynaptic Alpha-Adrenoceptors
in the Human Corpus Cavernosum
H. VAN AHLEN, G. J. MOLDERINGS, H. PORST, and M. GOTHERT
(With 4 Figures) ..................... . 67
Intratesticular Concentration of Etoposide:
An Experimental Study
T. STEIN, S. KREGE, G. HEIMANN, and H. ROBBEN (With 2 Figures) 72
RI. BPH-Prostate Cancer
Diagnostic Studies Using Human BPH Tissues Transplanted
on Thymus-Dysplastic Mice
P. G.FABRICIUS, F. ROMMEL, F. SINOWATZ, V. PERMANETTER,
and C. HAMMER (With 7 Figures) . . . . . . . . . . . . . 81
Age-Dependency and Regional Distribution of Enkephalinergic
Nerves in the Human Prostate
T. JUNGBLUT, G.AUMOLLER, B.MALEK, and H.MELcmOR
(With 8 Figures) .................... 87
Tumor Marker Characterization in the Serially Transplantable
PC-EW Human Prostatic Carcinoma Line in Nude Mice
Z. CSAPO, K. M. SCHROTT, and R. WALTHER (With 8 Figures) 96
IV. Bladder Cancer
DNA Histogram of Invasive Bladder Carcinoma:
Comparison of Flow Cytometry and Automated Image Analysis
M.STOCKLE, H.J.TANKE, G.VOGES, H.RIEDMILLER,
and R. HOHENFELLNER (With 4 Figures) . . . . . . . . . . .. .. 107
Automatic Identification of Bladder Tumor Cells by Multiple
Parameters in Flow Cytometry
H. LEYH, G. VALET, and A. LEHMER (With 2 Figures) . . .. .... 115
Immunohistochemical and Functional Investigations
of Gap Junctions in Human Bladder Carcinoma Cell Lines
K.WILGENBUS, R.KNOCHEL, F.BROMMER, O.TRAUB, and F.HoFsTADTER
(With 2 Figures) ........................ 120
Investigations for a Point Mutation in the c-Ha-ras 1 Oncogene
in the Genome of Bladder Carcinomas by Southern Blot Analysis
S.HANDT, R.BDTTNER, R.KNOCHEL, H.RoBBEN, F.HoFSTADTER,
and C. WAGENER ........................... 125
Contents XI
Prevention of Hyperchloremic Acidosis Following
Ureterosigmoidostomy: The Functional Rectal Bladder
K. MILLER, U. MATSUI, and R. HAUTMANN (With 6 Figures) . . . . . . 129
Tumors Experimentally Produced in a Rat Model
for Carcinogenesis in Ureterosigmoidostomy
W-D. MIERscH and J. VOGEL (With 7 Figures) ...... 135
Efficacy of Systemic Chemotherapy in Metastatic Murine
Bladder Cancer
W. KRoPp, M.-L.MLYNEK, G.CEVC, and R.HARTUNG ... · .. 143
Selective Arterial Chemoembolization of the Urinary Bladder
with Reabsorbable cis-Platinum Microcapsules in the Dog
Using a Double Balloon Embolization Catheter
C. BORNHOF, E. VECERA, and B. MOSIER (With 4 Figures) ....... 146
Tissue Concentration of Chloraluminum-Phthalocyanine
in Xenotransplanted Human Bladder Cancer
K.MILLER, B.BARTOS, A.RucK, E.ScHMIDT, R.STEINER,
and R. HAUTMANN (With 1 Figure) .......... . . 153
Biological Effects of Recombinant Human Tumor Necrosis Factor
on Human Bladder Cancer Cells
W. HECKL, B. KLOSSNER, and B. HALLIGER (With 4 Figures) . . .. . 156
Influence of Immunomodulation on Chemically Induced Bladder
Tumors
F. RECKER, S. MARKOS-PUSTAI, W. KUPPER, and H. RUBBEN
(With 1 Figure) . . . . . . . . . . . . . . . . . . . . . . · .. 161
Effects of High Energy Shock Waves on BBN-Induced Bladder
Tumors in Rats
N.FISCHER, F.-J.DEuTz, N.MEYERs, and H.RuBBEN · .. 166
V. Urodynamics
Papaverine in Human Bladder Muscle
L.HERTLE and H.NAWRATH (With 5 Figures) .. 171
On the Locational Dependency and Diuresis Dependency of the
Ureteral Dynamic: An Experimental Study in the Endoureteral
Simultaneous Measurement of Pressure and Developed Force
J.POHL and U.DAMBAcHER (With 9 Figures) .......... .. 177
Detrusor Contractility and Its Relationship to Different Degrees
of Tension
D.RoHRMANN, H.-A.SpoRMANN, J.HANNAPPEL, D.ALBREcHT,
and W LUTZEYER (With 5 Figures) .................. 183
XII Contents
VI. Kidney Trauma, Pathophysiology, Urolithiasis
Renal Kinematics During Experimental Impact
R. A. ZINK, M. WEBER, M. WEISS, P. MDSSELER, W. BRENDEL,
and F. SCHUELER (With 4 Figures) ............ . 191
Improvement of In Situ Renal Protection Against Complete Ischemia
Through the Replacement of Chloride by Aspartate in the HTK
Solution of Bretschneider
M. KALLERHOFF, M. BLECH, G. KEHRER, M. LANGHEINRICH,
U.HELMCHEN, H.J.BRETSCHNEIDER, and R.H.RINGERT
(With 10 Figures) . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Investigations on the Crystallization Tendency in Urine
with AC-Impedance Measurements and Cyclic Voltammetry
R.-D.HuBER, H.HoMMEL, and E.MATOUSCHEK (With 10 Figures) .. 209
Autoradiographic Study of Oxalate in Rats
T. SUGIMOTO, H. OSSWALD, T. KISHIMOTO, K. YAMAMOTO, T. KANAZAWA,
H. RDBBEN, and T. MATSUMURA (With 2 Figures) ........... 216
Lactose-Induced Urolithiasis in the Rat
W. L. STROHMAIER, K.-H. BICHLER, and H. J. NELDE (With 3 Figures) . 220
Investigation of Annual Rhythms for the Excretion of Calcium,
Oxalic Acid, and Uric Acid in the 24-h Urine
A. HESSE and F. BIERTH (With 4 Figures) . . . . . . . . . . .. . 226
Calcium Binding by Various Brans: In Vitro Experiment with 4SCa
B. GERTZ, A. CLASSEN, and A. HESSE (With 2 Figures) . 229
Application of High-Performance Liquid Chromatography
for Determination of Cysteine and Cystine in Urine
H.BIRWE and A.HESSE (With 2 Figures) .......... . 232
Pathological-Anatomical Renal Alterations Following Application
of Extracorporeally Produced Piezoelectric Shock Waves
(Wolf-Piezolith): A Laboratory Animal Research Study
G. SEITZ, D. NEISIUS, T. GEBHARDT, and M. ZIEGLER (With 5 Figures) . 237
The Effect of Shock Wave Exposure on Kidney Function in Dogs
K. YAMAMOTO, T. KISHIMOTO, H.IIMORI, M. SENJYU, T. SUGIMOTO,
H.OCHI, and M. MAEKAWA (With 4 Figures) ......... .. 243
Urinary Proteins as Parameters of Renal Functional Changes
After Extracorporeal Shock Wave Lithotripsy
D. M. WILBERT, W. L. STROHMAIER, S. H. FLDCHTER, K.-H. BICHLER
(With 6 Figures) ..................... . . 249
Changes in Blood and Urine Chemical Parameters After
Extracorporeal Shock Wave Exposure of Canine Kidneys
P. JAEGER and C. CONSTANTINIDES ................... 254