Introduction to Proteins : Structure, Function, and Motion, Second Edition PDF
Preview Introduction to Proteins : Structure, Function, and Motion, Second Edition
INTRODUCTION TO PROTEINS STRUCTURE, FUNCTION, AND MOTION SECOND EDITION CHAPMAN & HALL/CRC Mathematical and Computational Biology Series Aims and scope: This series aims to capture new developments and summarize what is known over the entire spectrum of mathematical and computational biology and medicine. It seeks to encourage the integration of mathematical, statistical, and computational methods into biology by publishing a broad range of textbooks, reference works, and handbooks. The titles included in the series are meant to appeal to students, researchers, and professionals in the mathematical, statistical and computational sciences, fundamental biology and bioengineering, as well as interdisciplinary researchers involved in the field. The inclusion of concrete examples and applications, and programming techniques and examples, is highly encouraged. Series Editors N. F. Britton Department of Mathematical Sciences University of Bath Xihong Lin Department of Biostatistics Harvard University Nicola Mulder University of Cape Town South Africa Maria Victoria Schneider European Bioinformatics Institute Mona Singh Department of Computer Science Princeton University Proposals for the series should be submitted to one of the series editors above or directly to: CRC Press, Taylor & Francis Group 3 Park Square, Milton Park Abingdon, Oxfordshire OX14 4RN UK Published Titles An Introduction to Systems Biology: Bayesian Phylogenetics: Methods, Design Principles of Biological Circuits Algorithms, and Applications Uri Alon Ming-Hui Chen, Lynn Kuo, and Paul O. Lewis Glycome Informatics: Methods and Statistical Methods for QTL Mapping Applications Zehua Chen Kiyoko F. 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Wilkinson Golan Yona Big Data in Omics and Imaging: Big Data in Omics and Imaging: Association Analysis Integrated Analysis and Causal Momiao Xiong Inference Momiao Xiong Big Data Analysis for Bioinformatics and Biomedical Discoveries Shui Qing Ye INTRODUCTION TO PROTEINS STRUCTURE, FUNCTION, AND MOTION S E C O N D E D I T I O N AMIT KESSEL • NIR BEN-TAL CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2018 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed on acid-free paper Version Date: 20180208 International Standard Book Number-13: 978-1-4987-4717-2 (Hardback) This book contains information obtained from authentic and highly regarded sources. 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Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Contents ListofFigures xxi ListofTables xxxi ListofBoxes xxxiii Preface xxxv ChangesinSecondEdition xli Acknowledgments xliii Authors xlv PhysicalQuantitiesandConstants xlvii ListofAcronyms xlix Chapter 1 ■ Introduction 1 1.1 IMPORTANCEOFPROTEINSINLIVINGORGANISMS 1 1.1.1 Life,proteinsandmysteriousforces 1 1.1.2 Molecularorganizationoflivingorganisms 2 1.1.3 Proteinshavenumerousbiologicalroles 6 1.1.3.1 Catalysisofmetabolicprocesses 6 1.1.3.2 Energytransfer 8 1.1.3.3 Geneexpression 11 1.1.3.4 Transportofsolutesacrossbiologicalmembranes 13 1.1.3.5 Cellularcommunication 13 1.1.3.6 Molecularrecognition 16 1.1.3.7 Defense 17 1.1.3.8 Formingintracellularandextracellularstructures 19 1.1.3.9 Cell-andtissue-specificfunctions 20 1.1.4 Physiologicalandevolutionaryimportanceofproteins 22 1.1.5 Medical,industrial,andsocialimportanceofproteins 22 1.1.5.1 Proteinsasdrugtargets 22 1.1.5.2 Proteinsastoxintargets 23 1.1.5.3 Industrialapplicationsofproteins 24 1.2 STRUCTURALCOMPLEXITYANDITSEFFECTONPROTEINFUNCTION 25 ix
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