Introduction Session 1: Basic Toxicology

178 Pages·1997·1.44 MB·English

MA DEP/LSPA Spring Training Seminar

Understanding and Using the New VPH/EPH Approach

Introduction

Session 1:

Basic Toxicology

Michael S. Hutcheson

MA Department of Environmental Protection

Bureau of Strategic Planning and Technology

Office of Research and Standards

One Winter Street

Boston, MA 02108

phone: [phone]

fax: [phone]

email: [email protected]

WWW: http://www.state.ma.us/dep/
UUNNDDEERRSSTTAANNDDIINNGG &&UUSSIINNGG
TTHHEE NNEEWW VVPPHH//EEPPHH AAPPPPRROOAACCHH
IINNTTRROODDUUCCTTIIOONN -- HHuuttcchheessoonn
BBAASSIICC TTOOXXIICCOOLLOOGGYY -- HHuuttcchheessoonn
AANNAALLYYTTIICCAALL MMEETTHHOODDSS -- AAnnaassttaass
SSCCRREEEENNIINNGG -- DDuuggggaann
MMEETTHHOODDSS 11,,22 AANNDD 33 -- LLoocckkee
IIMMPPLLEEMMEENNTTAATTIIOONN IISSSSUUEESS -­
FFiittzzggeerraalldd
BBAASSIICC TTOOXXIICCOOLLOOGGYY

MMiicchhaaeell SS.. HHuuttcchheessoonn

OOffffiiccee ooff RReesseeaarrcchh aanndd SSttaannddaarrddss
RROOOOMM FFOORR IIMMPPRROOVVEEMMEENNTT

BBeelliieeff:: PPHHCC rriisskkss bbeeiinngg iinnccoommpplleetteellyy
cchhaarraacctteerriizzeedd
OOnnee--hhaallff ooff MMAADDEEPP//BBWWSSCC ssiitteess aarree
ppeettrroolleeuumm oonnllyy
AAnnootthheerr 1100%% ooff ssiitteess hhaavvee ppeettrroolleeuumm
ccoonnssttiittuueennttss
A
L
I
SATURATED HYDROCARBONS:
P
H
paraffins, alkanes, methanes. Straight, branched, cyclic
A
T
I
C
S
/
A ALKENES (olefins)
L
I
C
Y UNSATURATED HYDROCARBONS
C
at least 2 carbon atoms joined by 2 or
L
I
more double bonds.
C
S
ALKYNES
BENZENE: single aromatic ring
ALKYLBENZENES
AROMATICS
POLYNUCLEAR AROMATICS
A
L
I
SATURATED HYDROCARBONS:
P
H
paraffins, alkanes, methanes. Straight, branched, cyclic
A
T
I
C
S
/
A ALKENES (olefins)
L
I
C
Y UNSATURATED HYDROCARBONS
C
L at least 2 carbon atoms joined by 2 or
I
C more double bonds.
S
ALKYNES
BENZENE: single aromatic ring
ALKYLBENZENES
AROMATICS
POLYNUCLEAR AROMATICS
SATURATED HYDROCARBONS:

paraffins, alkanes, methanes. Straight, branched, cyclic

C C C C

C C
C
C
C C C C
C
C
A
L
I
SATURATED HYDROCARBONS:
P
H
paraffins, alkanes, methanes. Straight, branched, cyclic
A
T
I
C
S
/
A ALKENES (olefins)
L
I
C
Y UNSATURATED HYDROCARBONS
C
at least 2 carbon atoms joined by 2 or
L
I
more double bonds.
C
S
ALKYNES
BENZENE: single aromatic ring
ALKYLBENZENES
AROMATICS
POLYNUCLEAR AROMATICS
ALKENES
C C C C C
ALKYNES
C C C C
A
L
I
SATURATED HYDROCARBONS:
P
H
paraffins, alkanes, methanes. Straight, branched, cyclic
A
T
I
C
S
/
A ALKENES (olefins)
L
I
C
Y UNSATURATED HYDROCARBONS
C
at least 2 carbon atoms joined by 2 or
L
I
more double bonds.
C
S
ALKYNES
BENZENE: single aromatic ring
ALKYLBENZENES
AROMATICS
POLYNUCLEAR AROMATICS