Description:This book constitutes the refereed proceedings of the Second International Workshop on Internet and Network Economics, WINE 2006, held in Patras, Greece in December 2006.The 32 revised full papers presented together with 3 invited talks were carefully reviewed and selected from 79 submissions. The papers contain foundational and mathematical work from theories, methodologies, and applications in computer science, economics, mathematics, and management sciences for solving problems in internet technologies, grid computing, network communication protocols, as well as social economic issues in virtual communities enabled through the World Wide Web.