International Manual of Oncology Practice: (iMOP) - Principles of Medical Oncology PDF
Preview International Manual of Oncology Practice: (iMOP) - Principles of Medical Oncology
Ramon Andrade de Mello Álvaro Tavares Editors Giannis Mountzios International Manual of Oncology Practice (iMOP) - Principles of Medical Oncology International Manual of Oncology Practice Ramon Andrade de Mello Álvaro Tavares • Giannis Mountzios Editors International Manual of Oncology Practice (iMOP) - Principles of Medical Oncology Editors Ramon Andrade de Mello Álvaro Tavares Medical Oncology Biomedical Sciences and Medicine University of Algarve University of Algarve Faro , Portugal Faro, Portugal Giannis Mountzios Medical Oncology University of Athens Athens , Greece ISBN 978-3-319-21682-9 ISBN 978-3-319-21683-6 (eBook) DOI 10.1007/978-3-319-21683-6 Library of Congress Control Number: 2015957124 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. T he use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. T he publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper S pringer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com) Pref ace Dear Colleague, N owadays, cancer is a serious disease which presents normally with a high mortal- ity and important treatment sequels. The clinical approach of the cancer patients is really a challenge for the physicians, nurses, phycologists, and all subjects involved, namely, the patients and their family. Fortunately, the cancer sciences currently had been developing several strategies to overcome this issue: personalizing medicine, predictive and prognostic biomarkers, novel target therapies, and also innovative supportive therapies. Thus, the oncological treatment is a multimodal process which involves a comprehensive approach. More recently, the most important medical oncology societies are important key institutions to disseminate knowledge and establish clinical practice guidelines for the patient’s care. Also, they focus on an intensive task force to create a good and solid network education platform for young and senior medical oncologists’ updating. Nevertheless, medical oncology training directors and the national board examination council worldwide concurrently work to try to adapt the novel evidence to their reality and clinical practice. Taking into account all these paramount features, the I nternational Manual of Oncology Practice working group had developed a very comprehensive and evidence- based book to help the clinicians worldwide integrate the knowledge to fi t to their clinical practice. Experts from Europe, North America, Latin America, Asia, Middle East, and Oceania had stablished a solid and well-developed network platform to share experiences and write a consistent evidence-based book for the global oncology community, according to their local economical and sociocultural concerns. We hope you enjoy our work. Faro, Portugal Sincerely yours, Ramon Andrade de Mello, On behalf of all authors and editors v Biography Ramon Andrade de Mello , M.D., Ph.D. is board cer- tifi ed medical oncologist by the Portuguese Medical Association (Ordem dos Médicos Portuguesa), Lisbon, Portugal, with clinical and scientifi c interest in lung, GI and GU Tumors. He received the MD degree at the Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil, with MD recognition from University of Lisbon, Portugal, and holds the Certifi cate in Medical Oncology by has passed in the European examination of ESMO (European Society for Medical Oncology), Switzerland, and in the National Board Examination (ACSS), Lisbon, Portugal. He completed specialization in medicine and molecular oncology and his PhD in Oncology (lung cancer) at the Faculty of Medicine, University of Porto, Portugal (recognized by the Federal University of Ceará, Fortaleza, and by the Ministry of Education and Science (MEC), Brasilia, Brazil). He also completed the medical oncology training in Portugal supported by ACSS (Ministry of Health, Portugal) and a postdoctoral clinical research fellowship in lung cancer clinical trials at the Lung Unit, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom, supported by the ESMO. Currently, he teaches at the Department of Medicine of the University of Porto and School of Medicine, University of Algarve, Faro, Portugal. Ramon De Mello performs both basic and clinical research on angiogenesis, palliative medi- cine, internal medicine, gastro-intestinal tumors and lung cancer; further, he has an active offi ce working. He is editor of 3 books (International Manual of Oncology Practice, Springer 2015; Tamoxifen Concepts and Cancer: New Paradigms and Vimentin Concepts and Molecular Mechanisms, Nova Science, NY, USA, 2013), author of many scientifi c articles, chapters and comments on basic and clinical research. He presented more than 50 papers in congresses and conferences in sev- eral countries, such as United States, Sweden, Brazil, Portugal and Spain. Furthermore, he serves as editorial board of several reputed scientifi c journals, such vii viii Biography as PLoS ONE, Rare tumors, Oncology Reviews and scientifi c reviewer of the The Lancet, The British Journal of Cancer, Journal of Thoracic Oncology and Annals of Internal Medicine. He is expert reviewer for research grant applications at University of Coimbra, Portugal, National Science Centre, Kraków, Poland and British Lung Foundation London, England; Ramon is ad hoc consultant for the national program to support cancer care (PRONON) at Department of Science and Technology, Ministry of Health, Brasília, Brazil. He was selected to be an active member of the ESMO Young Oncologist Committee since January 2015. Álvaro Tavares born in 1964, obtained his degree in Biochemistry from the University of Lisbon, Portugal. He later obtained a M.Sc. in Molecular Biology from the New University of Lisbon and a Ph.D. in Biomedical Sciences from the University of Porto, Portugal. He then moved to Scotland, where for 5 years he was a postdoc at the Department of Anatomy and Physiology of the University of Dundee. In 1999, having been appointed professor at the Instituto Superior Técnico, Lisbon, he started his own research group at the Gulbenkian Science Institute. In 2009 he moved to the University of Algarve, to the newly formed Department of Biomedical Sciences and Medicine, where he cur- rently directs the Cell Division and Cancer Biology Research Group. In the course of his research career, Álvaro Tavares has studied proteolytic sys- tems in rat liver mitochondria, proteolysis regulation in differentiation in the plant Lupinus albus , genetic regulation and expression in yeast S . cereviseae , and molec- ular and genetic characterization of genes required for cell proliferation in Drosophila melanogaster. The underlying theme behind the current work of his laboratory is the basic biology of mitotic cell division, in particular the aspects regu- lating the formation of a bipolar mitotic spindle and the connection between centro- somes and cytokinesis. The ultimate goal is to understand how modifi cations of these processes contribute to the transformation of normal cells into cancer cells. These problems are approached through a combination of biochemical, genetic, and cytological techniques, taking advantage of D rosophila melanogaster genetics and human tissue-cultured cells. Biography ix Dr. Giannis Mountzios , M.D., M.Sc., Ph.D. w as born in Larissa, Greece, in 1974. He obtained his medical degree (MD) from the Aristotle University of Thessaloniki in 1998 with a scholarship from the Greek Ministry of Education and graduated from the Hellenic Military Medical Academy the same year. He completed his residency in Internal Medicine at the Airforce General Hospital of Athens and in Medical Oncology at the University of Athens School of Medicine, “Alexandra” University Hospital (Pr. M.A. Dimopoulos). He then obtained a master (MSc) in translational and clinical research in Oncology from the Institut Gustave-Roussy and the University Paris XI (Paris-Sud), France, in 2007 (Pr. Jean-Charles Soria) and became board-specifi ed in Medical Oncology in 2009. In 2010 he obtained his PhD in Medical Oncology from the University of Athens School of Medicine. He is currently working as a consultant Medical Oncologist at the University of Athens School of Medicine. Dr Mountzios has received fellowships from the American Society of Clinical Oncology (Young Investigator award), the European Society for Medical Oncology (Annual Fellowship for Translational Research in 2005, Annual Fellowship for Clinical Research in 2009) and the Hellenic Society for Medical Oncology (HESMO). He is currently member of the board of directors of HESMO, chair of the HESMO young medical oncologists committee and member of the steering committee of the young medical oncologists of ESMO.
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