INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY*PHYSICS Volume 40, 1998 List of Contents/Author Index/Subject Index INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY e¢ BIOLOGY ¢ PHYSICS EDITOR-IN-CHIEF: JAMES D. COX Senior Editor (Clinical): Eli Glatstein e Senior Editor (Biology): Eric J. Hall Senior Editor (Physics): James A. Purdy Founding Editor: Philip Rubin EDITORS Hassan Awwad Armando Gaitan-Gaitan Alan Horwich Timothy E. Schultheiss Harry Bartelink Edward L. Gillette Timothy J. Kinsella William U. Shipley Norman Bleehen Guillermo Gonzales Steven K. Leibel Ingela Turesson James R. Cassady Leonard L. Gunderson Allen S. Lichter Paul Van Houtte C. Norman Coleman Eric J. Hall C. Clifton Ling Todd H. Wasserman Jay S. Cooper Elizabeth Hammond Jens Overgaard Yin Wei-Bo Bernard J.C ummings Gerald E. Hanks Thomas F. Pajak Ralph R. Weichselbaum Sarah S. Donaldson Jay R. Harris Lester J. Peters H. Rodney Withers Francois Eschwege Waun Ki Hong A. Michael Rauth Mayer Zaharia Barbara L. Fowble Richard T. Hoppe Marvin Rotman Zvi Y. Fuks Jean-Claude Horiot Horst Sack ADVISORY EDITORS Mitsuyuki Abe John H. Glick Seymour H. Levitt Robert H. Sagerman Luther W. Brady Michael Goitein Carl M. Mansfield Dietmar W. Siemann Bruce Chabner Thomas W. Griffin Stanley E. Order Robert M. Sutherland Vincent T. De Vita, Jr Jacques Henry Colin G. Orton Liu Tai-fu Juan A. del Regato Lars R. Holsti Carlos A. Perez Maurice Tubiana Juliana Denekamp Robert F. Kallman Theodore L. Phillips Brigit van der Werf Messing Jerzy Einhorn Morton M. Kligerman Leonard R. Prosnitz Gu Xian Zhi Jack F. Fowler ASSOCIATE EDITORS Giorgio Arcangeli James Freyer Moshe H. Maor Chang W. Song Adrian Begg Frederic A. Gibbs, Jr. Karin Mattson Burton L. Speiser Hijad Bilge Michael T. Gillin William H. McBride Paul Stauffer David G. Bragg Robert J. Ginsberg W. Gillies McKenna Fiona Stewart Anders Brahme Perry W. Grigsby Nancy Price Mendenhall Joel E. Tepper Harold J. Brenner Edward C. Halperin William M. Mendenhall Stephen P. Tomasovic Roger W. Byhardt Louis B. Harrison Luka Milas Elizabeth L. Travis Felipe A. Calvo Richard P. Hill Bruce D. Minsky Susan L. Tucker Nicholas J. Cassissi Michael R. Horsman James B. Mitchell Fatih M. Uckun David J. Chaplin Hedvig Hricak John Moulder Riccardo Valdagni Richard Chappell David H. Johnson Diana F. Nelson Peter W. Vaupel Noah C. Choi H. Dieter Kogelnik Dattatreyudu Nori Raul V. Vera James C. H. Chu Cameron Koch David Otim-Oyet Everett E. Vokes Louis S. Constine Ritsuko Komaki Charn II Park Andrew C. von Eschenbach Walter J. Curran, Jr Larry E. Kun James T. Parsons Moody D. Wharam, Jr. Lawrence W. Davis Allan O. Langlands Richard E. Peschel Jeffrey F. Williamson Mark W. Dewhirst George E. Laramore Anthony H. Russell David P. Winchester Ralph E. Durand David A. Larson Omar M. Salazar Robert Wittes Patricia J. Eifel Anne W. M. Lee Steven A. Sapareto S. P. Yarmenko Bahman Emami Robert D. Lindberg William T. Sause Gunar K. Zagars Richard G. Evans Rita M. Linggood James G. Schwade Zhang Zhiyi Arlene A. Forastiere Bo Littbrand Edward G. Shaw Carolyn R. Freeman Jay S. Loeffler David S. Shimm Executive Editor: Colleen M. Hubona Department of Educational Publishing Services-227 The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd Houston, TX 77030 Int. J. Radiation Oncology Biol. Phys., Vol. 40, No. 5, pp. 1253-1263, 1998 Copyright © 1998 Elsevier Science Inc Printed in the USA. All rights reserved PII $0360-3016(98)00085-6 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY: PHYSICS VOLUME 40, NUMBER 1 JANUARY 1, 1998 TABLE OF CONTENTS @ EDITORIALS Paternalism, Informed Consent and Tuskegee J. D. Cox Establishing Trust after Tuskegee P. Talone @ CLINICAL INVESTIGATIONS The Study of Untreated Syphilis in the Negro Male O. W. Brawley Sociodemographic Analysis of Patients in Radiation Therapy Oncology Group Clinical Trials R. M. Chamberlain, K. A. Winter, S. Vijayakumar, A. T. Porter, M. Roach, III, O. Streeter, J. D. Cox and M. L. Bondy Prostate-Specific Antigen Levels are Higher in African-American than in White Patients in a Multicenter Registration Study: Results of RTOG 94-12 S. Vijayakumar, K. Winter, W. Sause, M. J. Gallagher, J. Michalski, M. Roach, A. Porter and M. Bondy Prognostic Significance of Cell Proliferation Markers and DNA-Ploidy in Head and Neck Tumors H. Struikmans, D. H. Rutgers, G. J. Hordijk, P. J. Slootweg, I. van der Tweel and J. J. Battermann Effect of Time, Dose, and Fractionation on Temporal Lobe Necrosis Following Radiotherapy for Nasopharyngeal Carcinoma A. W. M. Lee, W. Foo, R. Chappell, J. F. Fowler, W. M. Sze, Y. F. Poon, S. C. K. Law, S. H. Ng, S. K. O, S. Y. Tung, W. H. Lau and J. H. C. Ho Parotid Gland Tumors: A Comparison of Postoperative Radiotherapy Techniques using Three Dimensional (3D) Dose Distributions and Dose-Volume Histograms (DVHS) R. Yaparpalvi, D. P. Fontenla, S. K. Tyerech, L. R. Boselli and J. J. Beitler Validation and Predictive Power of Radiation Therapy Oncology Group (RTOG) Recursive Partitioning Analysis Classes for Malignant Glioma Patients: A Report Using RTOG 90-06 C. B. Scott, C. Scarantino, R. Urtasun, B. Movsas, C. U. Jones, J. R. Simpson, A. J. Fischbach and W. J. Curran, Jr Radiation Therapy and Hydroxyurea followed by the Combination of 6-Thioguanine and BCNU for the Treatment of Primary Malignant Brain Tumors M. D. Prados, D. A. Larson, K. Lamborn, M. W. McDermott, P. K. Sneed, W. M. Wara, S. M. Chang, E. E. Mack, H. G. J. Krouwer, K. L. Chandler, R. E. Warnick, R. L. Davis, J. E. Rabbitt, M. Malec, V. A. Levin, P. H. Gutin, T. L. Phillips and C. B. Wilson Survival Results from a Phase I Study of Etanidazole (SR2508) and Radiotherapy in Patients with Malignant Glioma E. L. Chang, J. S. Loeffler, N. E. Riese, P. Y. Wen, E. Alexander, III, P. McL. Black and C. N. Coleman Adenocarcinoma of the Fallopian Tube: Results of a Multi-Institutional Retrospective Analysis of 72 Patients A. H. Wolfson, K. S. Tralins, K. M. Greven, R. Y. Kim, B. W. Corn, M. R. Kuettel, C. Philippart, W. A. Raub, Jr. and M. E. Randall 1253 Effective Treatment of Stage I Uterine Papillary Serous Carcinoma with High Dose-Rate Vaginal Apex Radiation ('"*Ir) and Chemotherapy B. C. Turner, J. P. S. Knisely, B. M. Kacinski, B. G. Haffty, A. A.G umbs, K. B. Roberts, A. H. Frank, R. E. Peschel, T. J. Rutherford, B. Edraki, E. 1.K ohorn, S. K. Chambers, P. E. Schwartz and L. D. Wilson The Correlation of Acute Toxicity and Late Rectal Injury in Radiotherapy for Cervical Carcinoma: Evidence Suggestive of Consequential Late Effect (CQLE) C.-J. Wang, S. W. Leung, H.-C. Chen, L.-M. Sun, F.-M. Fang, E.-Y. Huang, C.-Y. Hsiung and C.-C. Changchien Chemo-Radiotherapy for Localized Pancreatic Cancer: Increased Dose Intensity and Reduced Acute Toxicity with Concomitant Radiotherapy and Protracted Venous Infusion 5-Fluorouracil J. C. Poen, H. L. Collins, J. E. Niederhuber, H. A. Oberhelman, M. A. Vierra, A. J. Bastidas, H. S. Young, E. A. Slosberg, B. R. Jeffrey, T. A. Longacre,G . A. Fisher, and D. R. Goffinet Utilization of Thermoluminescent Dosimetry in Total Skin Electron Beam Radiotherapy of Mycosis Fungoides J. A. Antolak, J. H. Cundiff and C. S. Ha Local Superficial Radiotherapy in the Management of Minimal Stage IA Cutaneous T-Cell Lymphoma (Mycosis Fungoides) L. D. Wilson, B. M. Kacinski and G. W. Jones Multiple Myeloma of an Extremity: Must the Entire Bone be Treated? D. Catell, Z. Kogen, B. Donahue and A. Steinfeld Efficacy of Radiochemotherapy with Platin Derivatives Compared to Radiotherapy Alone in Organ-Sparing Treatment of Bladder Cancer R. Sauer, S. Birkenhake, R. Kiihn, C. Wittekind, K. M. Schrott and P. Martus Elucidating the Etiology of Erectile Dysfunction after Definitive Therapy for Prostatic Cancer M. J. Zelefsky and J. F. Eid Prostate Brachytherapy in Patients with Inflammatory Bowel Disease 4. Grann and K. Wallner Radical Prostatectomy and Postoperative Irradiation in Patients with Pathological Stage C (T3) Carcinoma of the Prostate Z. Petrovich, G. Lieskovsky, B. Langholz, S. Formenti, L. Baert, O. Streeter and D. G. Skinner Radiotherapy Alone for Medically Inoperable Stage I Non-Small—Cell Lung Cancer: The Duke Experience G. S. Sibley, T. A. Jamieson, L. B. Marks, M. S. Anscher and L. R. Prosnitz Fraction Size and Dose Parameters Related to the Incidence of Pericardial Effusions M. K. Martel, W. M. Sahijdak, R. K. Ten Haken, M. L. Kessler and A. T. Turrisi Abdominal Irradiation in Unilateral Nephroblastoma and its Impact on Local Control and Survival M. Flentje, A. Weirich, N. Graf, R. Potter, H. Zimmerman and R. Ludwig Preoperative vs. Postoperative Radiation Prophylaxis of Heterotopic Ossification: A Rural Community Hos- pital’s Experience D. A. Kantorowitz and N. S. Muff @ BIOLOGY CONTRIBUTIONS Effects of Keratinocyte Growth Factor on the Proliferation and Radiation Survival of Human Squamous Cell Carcinoma Cell Lines in vitro and in vivo S. Ning, C. Shui, W. B. Khan, W. Benson, D. L. Lacey and S. J. Knox Hyperbaric Oxygen and Basic Fibroblast Growth Factor Promote Growth of Irradiated Bone X. Wang, I. Ding, H. Xie, T. Wu, N. Wersto, K. Huang and P. Okunieff @ PHYSICS CONTRIBUTIONS Image Registration: An Essential Part of Radiation Therapy Treatment Planning J. G. Rosenman, E. P. Miller, G. Tracton and T. 3. Cullip A Feasibility Study of Automated Inverse Treatment Planning for Cancer of the Prostate L. E. Reinstein, X.-H. Wang, C. M. Burman, Z. Chen, R. Mohan, G. Kutcher, S. A. Leibel and Z. Fuks Dose Variation at Bone/Titanium Interfaces using Titanium Hollow Screw Osseointegrating Reconstruction Plates A. S. Allal, M. Richter, M. Russo, M. Rouzaud, P. Dulguerov and J. M. Kurtz Portal Imaging Protocol for Radical Dose-Escalated Radiotherapy Treatment of Prostate Cancer C. D. Mubata, A. M. Bidmead, L. M. Ellingham, V. Thompson and D. P. Dearnaley 1254 Electron Wedges for Radiation Therapy E. P. Lief, Y.-C. Lo and J. L. Humm An Equation to QA Check the Total Treatment Time for Single-Catheter HDR Brachytherapy R. D. Rogus, M. J. Smith and H. D. Kubo Influence of Catheter Materials and Tissue Composition on Low Dose Rate Iridium-192 Seed Implant Dosimetry R. S. Sloboda and R. Wang @ LETTERS TO THE EDITOR Outcome of Hyperfractionated Radiation Therapy in Randomized Clinical Trials H. Willers, C. Liertz-Petersen, H.-H. Dubben, H.-P. Beck-Bornholdt In Response to Drs. Willers et al. M. Stuschke and H. Thames @ MEETINGS @ ERRATA @ ADVERTISING INDEX @ DIRECT RESPONSE VOLUME 40, NUMBER 2 JANUARY 15, 1998 TABLE OF CONTENTS @ CRITICAL REVIEW Pediatric Brain Stem Gliomas: A Review C. R. Freeman and J-P. Farmer ® CLINICAL INVESTIGATIONS Analysis of Neurological Sequelae from Radiosurgery of Arteriovenous Malformations: How Location Affects Outcome J. C. Flickinger, D. Kondziolka, A. H. Maitz and L. D. Lunsford Transient Metabolic Changes Observed with Proton MR Spectroscopy in Normal Human Brain after Radia- tion Therapy F. Estéve, C. Rubin, S. Grand, H. Kolodié and J-F. Le Bas Survival Benefit of Hyperthermia in a Prospective Randomized Trial of Brachytherapy Boost + Hyperthermia for Glioblastoma Multiforme P. K. Sneed, P. R. Stauffer, M.W . McDermott, C. J. Diederich, K. R. Lamborn, M. D. Prados, S. Chang, K. A. Weaver, L. Spry, M. K. Malec, S. A. Lamb, B. Voss, R. L. Davis, W. M. Wara, D. A. Larson, T. L. Phillips and P. H. Gutin Phase I Evaluation of Radiation Combined with Recombinant Interferon Alpha-2A and BCNU for Patients with High-Grade Glioma S. V. Rajkumar, J. C. Buckner, P. J. Schomberg, T. L. Cascino, P. A. Burch and R. P. Dinapoli Interrelationships of DNA-Ploidy and Cell Proliferation Markers with T-Stage and N-Stage in Primary Laryngeal Tumors H. Struikmans, D. H. Rutgers, G. J. Hordijk, P. J. Slootweg, I. van der Tweel and J. J. Battermann “Phosphorus Magnetic Resonance Spectroscopy in the Assessment of Head and Neck Tumors X. Maldonado, J. Alonso, J. Giralt, M. G. Cucurella, J. M. del Campo, A. Rovira, E. Felip, J. Capellades, E. Grivé, D. Rubio and J. Gili Close or Positive Margins after Surgical Resection for the Head and Neck Cancer Patient: The Addition of Brachytherapy Improves Local Control J. J. Beitler, R. V. Smith, C. E. Silver, A. Quish, S. M. Deore, E. Mullokandov, D. P. Fontenla, S. Wadler, M. K.Hayes and B. Vikram 1255 Similar Decreases in Local Tumor Control are Calculated for Treatment Protraction and for Interruptions in the Radiotherapy of Carcinoma of the Larynx in Four Centers C. Robertson, A. G. Robertson, J. H. Hendry, S. A. Roberts, N. J. Slevin, W. B. Duncan, R. H. MacDougall, G. R. Kerr, B. O'Sullivan and T. J. Keane Integration of Filgrastim into Chemoradiation for Limited Small Cell Lung Cancer: A Phase I Study B. Glisson, R. Komaki, J. S. Lee, D. M. Shin, F. Fossella, W. K. Murphy, J. Kurie, R. Perez-Soler, R. Schea and S. Vadhan-Raj Intervention with the Hypoxic Tumor Cell Sensitizer Etanidazole in the Combined Modality Treatment of Limited Stage Small-Cell Lung Cancer: A One-Institution Study R. C. Urtasun, M. Palmer, B. Kinney, A. Belch, J. Hewitt and J. Hanson Absence of Thoracic Radiation Myelitis after Hyperfractionated Radiation Therapy With and Without Concurrent Chemotherapy for Stage II] Nonsmall-Cell Lung Cancer B. Jeremic, Y. Shibamoto, B. Milicic, L. Acimovic andS . Milisavljevic Spinal Cord Localization in the Treatment of Lung Cancer: Use of Radiographic Landmarks R. C. Miller, J. A. Bonner, D. E. Wenger, R. L. Foote, K. L. Kisrow and E. G. Shaw Lobular Carcinoma in situ as a Component of Breast Cancer: The Long-Term Outcome in Patients Treated with Breast-Conservation Therapy M. Moran and B. G. Haffty Myocardial Infarction Among Women with Early-Stage Breast Cancer Treated with Conservative Surgery and Breast Irradiation L. E. Rutqvist, A. Liedberg, N. Hammar and K. Dalberg Superficial Hyperthermia and Irradiation for Recurrent Breast Carcinoma of the Chest Wall: Prognostic Factors in 196 Tumors H. K. Lee, A. G. Antell, C. A. Perez, W. L. Straube, G. Ramachandran, R. J. Myerson, B. Emami, E. P. Molmenti, A. Buckner and M. A. Lockett Hodgkin's Disease: Correlation of Clinical Characteristics with Probabilities for Negative Lymphangiogram vs. Negative Laparotomy Findings in Patients with Stage | Supradiaphragmatic Presentations vs. Those in Patients with Stage I L. M. Fuller, N. Q. Mirza, J. L. Palmer, B. R. Davis, C. S. Ha, M. A. Rodriguez, F. B. Hagemeister, F. Cabanillas, P. McLaughlin, J. J. Butler, L. B. North and R. G. Martin Place of Low-Dose Total Body Irradiation in the Treatment of Localized Follicular Non-Hodgkin’s Lymphoma: Results of a Pilot Study P. M. Richaud, P. Soubeyran, H. Eghbali, B. Chacon, G. Marit, A. Broustet and B. Hoerni High-Energy Total Body Irradiation as Preparation for Bone Marrow Transplantation in Leukemia Patients: lreatment Technique and Related Complications J. Bradley, C. Reft, S. Goldman, C. Rubin, J. Nachman, R. Larson and D. E. Hallahan Uterosacral Space Involvement in Locally Advanced Carcinoma of the Uterine Cervix K. S. Clifford Chao, J. F. Williamson, P. W. Grigsby and C. A. Perez Impact of the Extent of Parametrial Involvement in Patients with Carcinoma of the Uterine Cervix H-C. Hsu, S. W. Leung, E-Y. Huang, C-J. Wang, L-M. Sun, F-M. Fang and H-C. Chen Laparoscopic-Assisted Application of Interstitial Brachytherapy for Locally Advanced Cervical Carcinoma: Results of a Pilot Study F. O. Recio, M. S. Piver, R. E. Hempling, G. H. Eltabbakh and S. Hahn The use of Fluoroscopy to Guide Needle Placement in Interstitial Gynecological Brachytherapy S. Nag, R. Martinez-Monge, R. Ellis, G. Lewandowski, L. Vacarello, J. G. Boutselis and L. Copeland Outcome of Treatment of Upper Third Vaginal Recurrences of Cervical and Endometrial Carcinomas with Interstitial Brachytherapy C. Charra, P. Roy, R. Coquard, P. Romestaing, J. M. Ardiet and J. P. Gerard Treatment of Locally Recurrent Rectal Carcinoma—Results and Prognostic Factors C. S. Wong, B. J. Cummings, J. D. Brierley, C. N. Catton, M. McLean, P. Catton and Y. Hao In Search of a Dose-Response Relationship with Radiotherapy in the Management of Recurrent Rectal Carcinoma in the Pelvis: A Systematic Review K. S. R. Wong, G. Thomas, B. Cummings, P. Froud, W. Shelley, R. Withers and J. Williams Fractionated High Dose Rate Intraluminal Brachytherapy in Palliation of Advanced Esophageal Cancer R. K. Sur, B. Donde, V. C. Levin, F. F. Rad and A. Mannell 1256 Para-Aortic Irradiation Only Appears to be Adequate Treatment for Patients with Stage I Seminoma of the Testis K. Sultanem, L. Souhami, V. Benk, J-P. Bahary, T. Roman, G. Shenouda and C. Freeman A Survey of Current Clinical Practice of Permanent Prostate Brachytherapy in the United States B. R. Prestidge, J. J. Prete, T. A. Buchholz, J. L. Friedland, R. G. Stock, P. D. Grimm and W. S. Bice @ BIOLOGY CONTRIBUTIONS Partial Volume Rat Lung Irradiation: An Evaluation of Early DNA Damage M. A. Khan, R. P. Hill and J. Van Dyk Protection Against Irradiation-Induced Damage to Salivary Glands by Adrenergic Agonist Administration R. M. Nagler and D. Laufer @ PHYSICS CONTRIBUTIONS Potential Clinical Efficacy of Intensity-Modulated Conformal Therapy S. L. Meeks, J. M. Buatti, F. J. Bova, W. A. Friedman, W. M. Mendenhall and R. A. Zlotecki Comparison of Radiosurgery Treatment Modalities Based on Physical Dose Distributions L. J. Verhey, V. Smith and C. F. Serago Comparison of Radiosurgery Treatment Modalities Based on Complication and Control Probabilities V. Smith, L. Verhey and C. F. Serago 4 Conformal Index (COIN) to Evaluate Implant Quality and Dose Specification in Brachytherapy D. Baltas, C. Kolotas, K. Geramani, R. F. Mould, G. loannidis, M. Kekchidi and N. Zamboglou @ MEETINGS @ ADVERTISING INDEX @ DIRECT RESPONSE VOLUME 40, NUMBER 3 FEBRUARY 1, 1998 TABLE OF CONTENTS @ EDITORIAL The Efficacy of Postoperative Radiotherapy for Advanced Head and Neck Cancer: Quality of the Evidence L. J. Peters @ CLINICAL INVESTIGATIONS Combined Neck Dissection and Postoperative Radiation Therapy in the Management of the High-Risk Neck: A Matched-Pair Analysis R. E. Lundahl, R. L. Foote, J. A. Bonner, V. J. Suman, J. E. Lewis, J. L. Kasperbauer, T. V. McCaffrey and K. D. Olsen Treatment Results of Stage I and Il Oral Tongue Cancer with Interstitial Brachytherapy: Maximum Tumor Thickness is Prognostic of Nodal Metastasis K. Matsuura, Y. Hirokawa, M. Fujita, Y. Akagi and K. Ito Radiation Treatment of Glottic Squamous Cell Carcinoma, Stage I and II: Analysis of Factors Affecting Prognosis G. Franchin, E. Minatel, C. Gobitti, R. Talamini, G. Sartor, G. Caruso, G. Grando, D. Politi, M. Gigante, G. Toffoli, M. G. Trov and L. Barzan T4 Laryngeal Carcinoma: Radiotherapy Alone with Surgery Reserved for Salvage J. T. Parsons, W. M. Mendenhall, S. P. Stringer and N. J. Cassisi Laryngeal Tumor Volume Measurements Determined with CT: A Study of Intra- and Interobserver Variability R. Hermans, M. Feron, E. Bellon, P. Dupont, W. Van den Bogaert and A. L. Baert 1257 A Phase I Study of Daily Carboplatin and Simultaneous Accelerated, Hyperfractionated Chest Irradiation in Patients with Regionally Inoperable Non-small Cell Lung Cancer K. Kelly, M. Hazuka, Z. Pan, J. Murphy, J. Caskey, C. Leonard and P. A. Bunn, Jr High-Dose Preoperative Radiation and the Challenge of Sphincter-Preservation Surgery for Cancer of the Distal 2 cm of the Rectum M. Mohiuddin, W. F. Regine, G. J. Marks and J.W . Marks Interstitial lridium-192 Implantation Combined with External Radiotherapy in Anal Cancer: Ten Years Experience A. P. S. Sandhu, R. P. Symonds, A. G. Robertson, N. S. Reed, S. G. McNee and J. Paul Selective Internal Radiation Therapy for Nonresectable Hepatocellular Carcinoma with Intraarterial Infusion of *’Yttrium Microspheres W. Y. Lau, S. Ho, T. W. T. Leung, M. Chan, R. Ho, P. J. Johnson and A. K. C. Li Physician Resource Utilization in Radiation Oncology: A Model Based on Management of Carcinoma of the Prostate B. J. Kobeissi, M. Gupta, C. A. Perez, N. Dopuch, J. M. Michalski, G. Van Antwerp, R. Gerber and T. H. Wasserman Trends in the Use of Radiation and Chemotherapy in the Initial Management of Patients with Carcinoma of the Uterine Cervix A. H. Russell, H. M. Shingleton, W. B. Jones, A. K. Stewart, A. Fremgen, D. P. Winchester, R. Clive and J. S. Chmiel High Dose Rate Brachytherapy for Carcinoma of the Cervix: Risk Factors for Late Rectal Complications T. Uno, J. Itami, M. Aruga, K. Kotaka, H. Fujimoto, T. Sato, S. Minoura and H. Ito Effect of Customized Small Bowel Displacement System in Pelvic Irradiation S. J. Huh, D. H. Lim, Y. C. Ahn, D. Y. Kim, M. K. Kim, H. G. Wu and D. R. Choi Implementation of 3D-Virtual Brachytherapy in the Management of Breast Cancer: A Description of a New Method of Interstitial Brachytherapy F. A. Vicini, D. A. Jaffray, E. M. Horwitz, G. K. Edmundson, D. A. DeBiose, V. R. Kini and A. A. Martinez Individualizing Management of Aggressive Fibromatoses M. A. Spear, L. C. Jennings, H. J. Mankin, I. J. Spiro, D. S. Springfield, M. C.G ebhardt, A. E. Rosenberg, J. T. Efird and H. D. Suit Radiotherapy for Kimura’s Disease: The Optimum Dosage M. Hareyama, A. Oouchi, H. Nagakura, K. Asakura, A. Saito, M. Satoh, M. Tamakawa, H. Akiba, K-i. Sakata, S. Yoshida, K. Koito, K. Imai, A. Kataura and K. Morita Influence of Bromodeoxyuridine Radiosensitization on Malignant Glioma Patient Survival: A Retrospective Comparison of Survival Data from the Northern California Oncology Group (NCOG) and Radiation Therapy Oncology Group Trials (RTOG) for Glioblastoma Multiforme and Anaplastic Astrocytoma M. D. Prados, C. B. Scott, M. Rotman, P. Rubin, K. Murray, W. Sause, S. Asbell, R. Comis, W. Curran, J. Nelson, R. L. Davis, V. A. Levin, K. Lamborn and T. L. Phillips Fractionated Stereotactic Radiosurgery and Concurrent Taxol in Recurrent Glioblastoma Multiforme: A Preliminary Report G. Lederman, E. Arbit, M. Odaimi, E. Lombardi, M. Wrzolek and M. Wronski The Integral Biologically Effective Dose to Predict Brain Stem Toxicity of Hypofractionated Stereotactic Radiotherapy B. G. Clark, L. Souhami, C. Pla, A. S. Al-Amro, J-P. Bahary, J-G. Villemure, J-L. Caron, A. Olivier and E. B. Podgorsak Patterns of Recurrence in Brain Stem Gliomas: Evidence for Craniospinal Dissemination B. Donahue, J. Allen, J. Siffert, M. Rosovsky and R. Pinto @ BIOLOGY CONTRIBUTIONS Tolerance of Rat Spinal Cord to Continuous Interstitial Irradiation L. A. M. Pop, M. van der Plas, A. C. C. Ruifrok, L. J. M. Schalkwijk, A. E. J. Hanssen and A. J. van der Kogel The Effect of Radiation on the Expression of Intercellular Adhesion Molecule-1 of Human Adenocarcinoma Cells M. Hareyama, K. Imai, A. Oouchi, H. Takahashi, Y. Hinoda, M. Tsujisaki, M. Adachi, T. Shonai, K-i. Sakata and K. Morita 1258 @ PHYSICS CONTRIBUTIONS Report of the Ad Hoc Committee of the AAPM Radiation Therapy Committee on '**I Sealed Source Dosimetry H. Dale Kubo, B. M. Coursey, W. F. Hanson, R. W. Kline, S. M. Seltzer, R. E. Shuping and J. F. Williamson MR Image-Guided Portal Verification for Brain Treatment Field F.-F. Yin, Q. Gao, H. Xie, D. F. Nelson, Y. Yu, W. E. Kwok, S. Totterman, M. C. Schell and P. Rubin Dose Distribution for a **P-Impregnated Coronary Stent: Comparison of Theoretical Calculations and Mea- surements with Radiochromic Film D. M. Duggan, C. W. Coffey and S. Levit A Comparison of Multileaf-Collimator and Alloy-Block Field Shaping J. M. Galvin, K. Han and R. Cohen A Three-Field Arc Technique (3-FAT) for Treating Prostate Cancer M. D. Weil, B. Pickett, S. Kuerth and M. Roach, III New System for Linear Accelerator Radiosurgery with a Gantry-Mounted Video Camera E. Kunieda, M. Kitamura, O. Kawaguchi, T. Ohira, K. Ogawa, Y. Ando, K. Nakamura and A. Kubo Independent Technique of Verifying High-Dose Rate (HDR) Brachytherapy Treatment Plans C. B. Saw, L. J. Korb, B. Darnell, K. V. Krishna and D. Ulewicz @ LETTERS TO THE EDITOR Endowed Professorships in Radiation Oncology L. W. Brady Two Sides are Better than One T. Y. Eng @ MEETINGS @ ADVERTISING INDEX @ DIRECT RESPONSE VOLUME 40, NUMBER 4 MARCH 1, 1998 TABLE OF CONTENTS @ EDITORIALS Node-Positive Prostatic Cancer: Taps or a Call to Arms? S. L. Hancock The Nature of Arterial Restenosis after Angioplasty L. F. Fajardo L-G @ CLINICAL INVESTIGATIONS Ten-Year Outcomes for Pathologic Node-Positive Patients Treated in RTOG 75-06 G. E. Hanks, J. Buzydlowski, W. T. Sause, B. Emami, P. Rubin, J. A. Parsons, A. H. Russell, R. W. Byhardt, J. D. Earle and M. V. Pilepich Impact of Surgical Staging in Evaluating the Radiotherapeutic Outcome in RTOG #77-06, A Phase III Study for TIBNOMO (A,) and T2NOMO (B) Prostate Carcinoma S. O. Asbell, K. L. Martz, K. H. Shin, W. T. Sause, R. L. Doggett, C. A. Perez and M. V. Pilepich Urinary Incontinence in Patients Who Have a TURP/TUIP Following Prostate Brachytherapy K. Hu and K. Wallner Prognostic Biomarker Study in Pathologically Staged N1 Non-Small Cell Lung Cancer R. Komaki, L. Milas, J. Y. Ro, T. Fujii, P. Perkins, P. Allen, C. R. Sikes, C. F. Mountain and N. G. Ordonez Dose-Response Relationship for Prophylactic Cranial Irradiation in Small Cell Lung Cancer R. Suwinski, S. P. Lee and H. R. Withers 1259 Feasibility and Efficacy of External Beam Radiotherapy After Hyperthermic Isolated Limb Perfu- sion With TNF-a and Melphalan for Limb-Saving Treatment in Locally Advanced Extremity Soft-Tissue Sarcoma A. F. T. Olieman, E. Pras, R. J. van Ginkel, W. M. Molenaar, H. Schraffordt Koops and H. J. Hoekstra Magnetic Resonance Thermometry During Hyperthermia for Human High-Grade Sarcoma D. L. Carter, J. R. Macfall, S. T. Clegg, X. Wan, D. M. Prescott, H. C. Charles and T. V. Samulski The Role of Radiation Therapy in the Management of Dermatofibrosarcoma Protuberans M. T. Ballo, G. K. Zagars, P. Pisters and A. Pollack Boron Neutron-Capture Therapy (BNCT) for Glioblastoma Multiforme (GBM) Using the Epithermal Neutron Beam at the Brookhaven National Laboratory M. Chadha, J. Capala, J. A. Coderre, E. H. Elowitz, J.-i. Iwai, D. D. Joel, H. B. Liu, L. Wielopolski and 4. D. Chanana Direct Injection of "°Y MoAbs into Glioma Tumor Resection Cavities Leads to Limited Diffusion of the Radioimmunoconjugates into Normal Brain Parenchyma: A Model to Estimate Absorbed Radiation Dose K. Hopkins, C. Chandler, J. Eatough, T. Moss and J. T. Kemshead Ependymoma: Results, Prognostic Factors and Treatment Recommendations M. P. McLaughlin, R. B. Marcus, Jr., J.M . Buatti, W. Mark McCollough, J. P. Mickle, A. Kedar, B. L. Maria and R. R. Million Factors Determining Outcome for Breast-Conserving Irradiation With Margin-Directed Dose Escalation to the Tumor Bed D. E. Wazer, R. K. Schmidt-Ulirich, R. Ruthazer, C. H. Schmid, R. Graham, H. Safaii, J. Rothschild, J.M cGrath and J. K. Erban Local Recurrence After Breast-Conserving Therapy for Invasive Breast Cancer: High Incidence in Young Patients and Association With Poor Survival P. H. M. Elkhuizen, J. J. van de Vijver, J. Hermans, H. M. Zonderland, C. J. H. van de Velde and J.-W. H. Leer Does Delay in Breast Irradiation Following Conservative Breast Surgery in Node-Negative Breast Cancer Patients Have An Impact on Risk of Recurrence? O. Vujovic, F. Perera, A. R. Dar, L. Stit, E. Yu, S. M. Voruganti and P. T. Truong The Importance of Postoperative Radiation Therapy in Multimodality Management of Locally Advanced Breast Cancer: A Phase Il Trial of Neoadjuvant MVAC, Surgery, and Radiation M. Abdel-Wahab, A. Wolfson, W. Raub, C. Mies, A. Brandon, L. Morrell, Y. Lee, S. Ling and A. Markoe High-Dose-Rate Intracavitary Brachytherapy in the Management of Cervical and Vaginal Intraepithelial Neoplasia I. Ogino, T. Kitamura, H. Okajima and S. Matsubara Neoadjuvant Chemotherapy Followed by Radiotherapy Should Not Be a Standard Approach for Locally Advanced Cervical Cancer P.-W. Shueng, W.-L. Hsu, Y.-M. Jen, C.-J. Wu and H.-S. Liu How Successful is High-Dose (260 Gy) Reirradiation Using Mainly External Beams in Salvaging Local Failures of Nasopharyngeal Carcinoma? P. M. L. Teo, W. H. Kwan, A. T. C. Chan, W. Y. Lee, W. W. K. King and C. O. Mok Radiotherapeutic Management of Osseous Metastases: A Survey of Current Patterns of Care E. Ben-Josef, F. Shamsa, A. O. Williams and A. T. Porter External Radiotherapy in Macular Degeneration: Our Technique, Dosimetric Calculation, and Preliminary Results M. Akmansu, B. Dirican, B. Oztiirk, 1.E gehan, M. Subasi and M. Or @ BIOLOGY CONTRIBUTIONS Cellular and Molecular Mechanisms of Radiation Inhibition of Restenosis—Part I: Role of the Macrophage and Platelet-Derived Growth Factor P. Rubin, J. P. Williams, P. N. Riggs, S. Bartos, T. Sarac, R. Pomerantz, J.C astano, M. Schell and R. M. Green lumor Radiosensitization by High-Oxygen—Content Gases: Influence of the Carbon Dioxide Content of the Inspired Gas on PO,, Microcirculatory Function and Radiosensitivity S. A. Hill, D. R. Collingridge, B. Vojnovic and D. J. Chaplin Interferons Antagonize y-Ray-Induced Depression of Natural Immunity M. P. Fuggetta, M. Tricarico, G. Starace, R. Pepponi and E. Bonmassar 1260