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International Journal of Radiation Oncology, Biology, Physics 1991: Vol 20 Table of Contents PDF

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Preview International Journal of Radiation Oncology, Biology, Physics 1991: Vol 20 Table of Contents

VOLUME 20, NUMBER 2 FEBRUARY TABLE OF CONTENTS THIRD INTERNATIONAL CONFERENCE ON THE INTERACTION OF RADIATION THERAPY AND SYSTEMIC THERAPY Asilomar Conference Center Monterey, CA 10-12 March, 1990 Editors’ Note I. Tannock and T. Wasserman @ SESSION I: EFFECTIVENESS OF COMBINED TREATMENT: LABORATORY STUDIES Keynote Address: Mechanisms of Cellular Resistance to Cytotoxic Drugs and X-Irradiation J. Carmichael and I. D. Hickson In Vitro Radiation Survival Parameters of Human Colon Tumor Cells J. T. Leith, L. A. Faulkner, G. Papa, P. Quinn and S. Michelson 5-Fluorouracil Modulation of Radiosensitivity in Cultured Human Carcinoma Cells S. R. Smalley, B. F. Kimler and R. G. Evans Radiation Induction of Drug Resistance in RIF-1: Correlation of Tumor and Cell Culture Results J. E. Moulder, L. E.H opwood, D. M. Volk and B. M. Davies Radiation Response of Human Lung Cancer Cells With Inherent and Acquired Resistance to Cisplatin P. R. Twentyman, K. A. Wright and T. Rhodes Interaction of Platinum Drugs With Clinically Relevant X-Ray Doses in Mammalian Cells: A Comparison of Cisplatin, Carboplatin, Iproplatin, and Tetraplatin K. Skov and S. MacPhail Schedule-Dependent Therapeutic Gain From the Combination of Fractionated Irradiation Plus c-DDP and 5-FU or Plus c-DDP and Cyclophosphamide in C3H/Km Mouse Model Systems R. F. Kallman, D. Rapacchietta and M. S. Zaghloul @ SESSION II; EFFECTIVENESS OF COMBINED TREATMENT: CLINICAL STUDIES Keynote Address: A Critical Assessment of Trials of Neoadjuvant (Preemptive) Chemotherapy for Bladder Cancer: Lesson for Future Studies of Combined Modality Treatment D. Raghavan Combined Modality Treatment of Advanced Cancers of the Oral Cavity and Oropharynx W. Dobrowsky, E. Dobrowsky, H. Strassl, O. Braun, N. Gritzmann and V. Scheiber Combined Postoperative Radiotherapy and Weekly Cisplatin Infusion for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Preliminary Report of a Randomized Trial J.-M. Bachaud, J.-M. David, G. Boussin and N. Daly Pre-Treatment Prognostic Factors in Stage III] Non-Small Cell Lung Cancer Patients Receiving Combined Mo- dality Treatment P. Bonomi, M. Gale, K. Rowland, S. G. Taylor IV, S. Purl, S. Reddy, M. S. Lee, A. Phillips, C. F. Kittle, W. Warren and L. P. Faber @ SESSION IIIA: MICROENVIRONMENTAL FACTORS Keynote Address: The Influence of Microenvironmental Factors on the Activity of Radiation and Drugs R. E. Durand Effect of Host Age on Microenvironmental Heterogeneity and Efficacy of Combined Modality Therapy in Solid Tumors S. Rockwell, C. S. Hughes and K. A. Kennedy Radiosensitizing and Cytotoxic Properties of Mitomycin C in a C3H Mouse Mammary Carcinoma Jn Vivo C. Grau and J. Overgaard The Response of Hypoxic Cells in SCCVII Murine Tumors to Treatment With Cisplatin and X Rays R. Yan and R. E. Durand The Potential of Lactate and Succinate to Kill Nutrient Deprived Tumor Cells by Intracellular Acidification E. Dobrowsky, K. Newell and I. F. Tannock Inhibition of Recovery From Potentially Lethal Radiation Damage in A549 Cells by the K*/H* Ionophore Nigericin M. E. Varnes, H. J. Menegay and D. S. McKenna 281 Effects of Oxygenation and pH on Tumor Cell Response to Alkylating Chemotherapy D. W. Siemann, M. Chapman and A. Beikirch 287 The Measurement of Radiosensitizer-Induced Changes in Mouse Tumor Metabolism by *'P Magnetic Resonance Spectroscopy P. J. Wood, C. J. R. Counsell, J. C. M. Bremner, M. R. Horsman and G. E. Adams 291 @ SESSION IIIB: BIOLOGICAL AGENTS Keynote Address: Integration of Cytostatic Agents and Radiation Therapy: A Different Approach to “Proliferating” Human Tumors T. J. Kinsella, M. N. Gould, R. T. Mulcahy, M. A. Ritter and J. F. Fowler 295 Interleukin-la Protects Against the Toxicity Associated With Combined Radiation and Drug Therapy M. J. Evans, C. J. Kovacs, J. M. Gooya and J. P. Harrell 303 Altered Radioprotective Properties of Interleukin Ia (IL-1) in Non-Hematologic Tumor-Bearing Animals C. J. Kovacs, J. M. Gooya, J. P. Harrell, K.M . McGowan and M. J. Evans 307 Interleukin-1 Modification of the Effects of Cyclophosphamide and Fractionated Irradiation M. J. Dorie, R. F. Kallman and A. Cebulska-Wasilewska 311 Epidermal Growth Factor Modification of Radioresistance Related to Cell-Cell Interactions T. T. Kwok and R. M. Sutherland @ SESSION IV: NORMAL TISSUE TOXICITY Keynote Address: Modulation of Normal Tissue Toxicity by Combined Modality Therapy: Considerations for Improving the Therapeutic Gain F. A. Stewart Early and Late Effects of Cisplatin and Radiation at Acute and Low Dose Rates on the Mouse Skin and Soft Tissues of the Leg K. K. Fu and K. N. Lam Influence of Nephrotoxic Drugs on the Late Renal Toxicity Associated With Bone Marrow Transplant Conditioning Regimens J. E. Moulder and B. L. Fish Effect of Vincristine or Bleomycin on Radiation-Induced Cell Killing of Mice Spermatogonial Stem Cells: The Importance of Sequence and Time Interval P. V. Hansen and D. Sorensen Radiosensitivity of Jejunal Mucosa After Whole Abdomen Irradiation and CDDP Pretreatment A. M. Julia, J.-M. Bachaud, P. Canal and N. J. Daly Concomitant Evaluation of Efficiency, Acute and Delayed Toxicities of Combined Treatment of Radiation and CDDP on an Jn Vivo Model A. M. Julia, P. Canal, D. Berg, J.-M. Bachaud, N. J. Daly and R. Bugat Low-Dose Continuous Infusion Cisplatin Combined With External Beam Irradiation for Advanced Colorectal Adenocarcinoma and Unresectable Non-Small Cell Lung Carcinoma N. A. Ellerbroek, F. V. Fossella, T. A. Rich, J. A. Ajani, R. Komaki, J. A. Roth and P. Y. Holoye A Phase I Study of Prolonged Infusion 5-Fluorouracil and Concomitant Radiation Therapy in Patients With Squamous Cell Cancer of the Head and Neck B. Weppelmann, R. H. Wheeler, G. E. Peters, S. Stephens, S. A. Spencer, R. F. Meredith, R. Y. Kim and M. M. Salter @ SESSION V: MECHANISMS OF CELLULAR RESISTANCE Keynote Address: Multidrug Resistance: A Pleiotropic Response to Cytotoxic Drugs C. R. Fairchild and K. H. Cowan Marrow Antioxidant Enzyme Activity in Tumor-Bearing and Non-Tumor-Bearing Mice Following Vincristine Treatment R. M. Johnke, D. P. Loven, R. S. Abernathy, M. J. Bennett and S. A. Murphy Activity of Etoposide (VP-16) in Human Tumor Cells Under Different Growth Conditions J.-C. Chapuis, P. C. Keng and D. W. Siemann The Effects of Leucovorin and Dipyridamole on Fluoropyrimidine-Induced Radiosensitization T. S. Lawrence, D. K. Heimburger and D. S. Shewach @ /N MEMORIAM Dr. Raymond S. Bush M. Gospodarowicz and R. P. Hill @ MEETINGS VOLUME 20, NUMBER 3 MARCH 1991 TABLE OF CONTENTS Editor’s Note P. Rubin @ ORIGINAL CONTRIBUTIONS Long-Term Follow-Up of Ewing’s Sarcoma of Bone Treated With Combined Modality Therapy T. J. Kinsella, J. S. Miser, B. Waller, D. Venzon, E. Glatstein, L. Weaver-McClure and M. E. Horowitz Influence of the Fractionation of Total Body Irradiation on Complications and Relapse Rate for Chronic Myelogenous Leukemia G. Socie, A. Devergie, T. Girinsky, J. Reiffers, J. P. Vernant, J. P. Le Bourgeois, P. Herve, D. Guyotat, D. Maraninchi, B. Rio, M. Michallet, J. P. Jouet, N. Milpied, V. Leblond, J. Pico, M. Attal, C. Belanger, E. Gluckman and J. M. Cosset Twenty Years Experience of Interstitial Iridium Brachytherapy in the Management of Soft Tissue Sarcomas J. L. Habrand, A. Gerbaulet, M. H. Pejovic, G. Contesso, §. Durand, C. Haie, J. Genin, G. Schwaab, F. Flamant, M. Albano, D. Sarrazin, M. Spielmann and D. Chassagne Curative Radiotherapy Following Chemotherapy for Invasive Bladder Carcinoma (A Preliminary Report) R. Farah, G. W. Chodak, N. J. Vogelzang. A. M. Awan, C. A. Quiet. J. Moormeier, H. Schoenberg and R. R. Weichselbaum Intentions and Outcomes in the Radiotherapeutic Management of Epidemic Kaposi’s Sarcoma J. S. Cooper, A. D. Steinfeld and I. Lerch A Management Approach to Incompletely Excised Basal Cell Carcinomas of Skin F.-F. Liu, E. Maki, P. Warde, D. Payne and P. Fitzpatrick Fraction Size in External Beam Radiation Therapy in the Treatment of Melanoma W. T. Sause, J. S. Cooper, S. Rush, C. T. Ago, D. Cosmatos, C. T. Coughlin, N. JanJan and J. Lipsett Deterioration in Lung Function Following Hemithorax Irradiation for Pleural Mesothelioma P. Maasilta Definitive Radiation Therapy for Localized Prostatic Adenocarcinoma G. Arcangeli, A. Micheli, G. Arcangeli, V. Pansadoro, F. De Paula, D. Giannarelli and M. Benassi Interleukin 1 Alpha Stimulates Hemopoiesis but Not Tumor Cell Proliferation and Protects Mice From Lethal Total Body Irradiation L. S. Constine, S. Harwell, P. Keng, F. Lee, P. Rubin and D. Siemann Tumor Hypoxia Can Be Exploited to Preferentially Sensitize Tumors to Fractionated Irradiation J. M. Brown and M. J. Lemmon Muscle Injury Following Experimental Intraoperative Irradiation B. E. Powers, E. L. Gillette, S. L.M cChesney Gillette, R. A. LeCouteur and S. J. Withrow Reoxygenation in a Rat Rhabdomyosarcoma Tumor Following X-Irradiation S. M. Javed Afzal, T. S. Tenforde, K. S. Kavanau and S. B. Curtis Heterogeneity of Heat Response in Murine, Canine, and Human Tumors: Influence on Predictive Assays S. Y. Woo, R. L. Anderson, D. S. Kapp, I. van Kersen, G. C. Rice, D. N. Krag and G. M. Hahn The Role of Radiation Therapy in the Treatment of Locally Unresectable or Metastatic Carcinoid Tumors K. D. Schupak and K. E. Wallner The Response of the KHT Sarcoma to Radiotherapy as Measured by Water Proton NMR Relaxation Times: Relationships With Tumor Volume and Water Content C. A. Belfi, S. V. Medendorp and F. Q. H. Ngo The Effect of Lonidamine (LND) on Radiation and Thermal Responses of Human and Rodent Cell Lines G. P. Raaphorst, M. M. Feeley, C. E. Danjoux, L. Martin, J. Maroun and A. J. DeSanctis Stereotactic Target Point Verification of an X Ray and CT Localizer C. F. Serago, A. A. Lewin, P. V. Houdek, S. Gonzalez-Arias, G. H. Hartmann, A. A. Abitbol and J. G. Schwade Whole Body Hyperthermia: A Potent Radioprotector Jn Vivo R.-N. Shen, N. B. Hornback, H. Shidnia, B. Wu, L. Lu and H. E. Broxmeyer Characteristics of Improved Microwave Interstitial Antennas for Local Hyperthermia V. Sathiaseelan, L. Leybovich, B. Emami, P. Stauffer and W. Straube Effects of Amiloride on Intracellular pH and Thermosensitivity G. E. Kim, J. C. Lyons and C. W. Song @ PHASE I/II CLINICAL TRIALS Secondary External-Beam Radiotherapy and Hyperthermia for Local Recurrence After 125-lodine Implantation in Adenocarcinoma of the Prostate I. Kaplan, D. S. Kapp and M. A. Bagshaw Treatment of Cancers Involving the Liver and Porta Hepatis With External Beam Irradiation and Intraarterial Hepatic Fluorodeoxyuridine T. S. Lawrence, L. M. Dworzanin, S. C. Walker-Andrews, J. C. Andrews, R. K. Ten Haken, I. S. Wollner, A. S. Lichter and W. D. Ensminger @ SPECIAL FEATURE Professional Liability in Radiotherapy: Experience of the Fletcher Society N. E. Sherman, T. A. Rich and L. J. Peters @ BRIEF COMMUNICATIONS Biodistribution, With High Uptake by the Reproductive Tract, of an Intraperitoneally Infused Radiohalogenated Steroidal Estrogen-Receptor Ligand J. A. Holt, J. E. Artwohl, L. J. Mercer and P. G. Pryde Cancer of the Anal Canal: Report on the Experience of 61 Patients J. B. Dubois, J. M. Garrigues and H. Pujol The Morbidity of Salvage Surgery Following Conventional Radiotherapy and Continuous, Hyperfractionated Accelerated Radiotherapy (CHART) T. Rugg, E. Lartigau, R. Sanders, G. Glover, M. I. Saunders and S. Dische Local Recurrence of Soft Tissue Sarcoma Following Brachytherapy L. S. Gemer, D. R. Trowbridge, J. Neff. F. Lin, E. Reddy, R. G. Evans and R. Hassanein Blood Flow of Human Soft Tissue Sarcomas Measured by Thallium-201 Scanning: Prediction of Tumor Response to Radiation K. Nishizawa, P. Okunieff, D. Elmaleh, K. A. McKusick, H. W. Strauss and H. D. Suit @ TECHNICAL INNOVATIONS AND NOTES Relocatable Frame for Stereotactic External Beam Radiotherapy S. S. Gill, D. G. T. Thomas, A. P. Warrington and M. Brada Physical Aspects of Total Body Irradiation of Bone Marrow Transplant Patients Using 18 MV X Rays A. Niroomand-Rad A Method to Analyze 2-Dimensional Daily Radiotherapy Portal Images From an On-Line Fiber-Optic Imaging System M. L. Graham, A. Y. Cheng, L. Y. Geer, W. R. Binns, M. W. Vannier and J. W. Wong A New Device for Interstitial '**lodine Seed Implantation R. Hawliczek, J. Neubauer, W. F. O. Schmidt, P. Grunert and L. R. Coia Reduction in Radiation Exposure to Nursing Personnel With the Use of Remote Afterloading Brachytherapy Devices P. W. Grigsby, C. A. Perez, J. Eichling, J. Purdy and E. Slessinger @ EDITORIALS What Does Total Body Irradiation Do in Bone Marrow Transplants for Leukemia? R. P. Gale, A. Butturini and M. M. Bortin Future Analyses of Total Body Irradiation H. M. Vriesendorp, M. G. Herman and R. Saral Long-Term Follow-Up of Ewing’s Sarcoma of Bone R. D. T. Jenkin Hypoxia: New Mechanisms for Old? G. E. Adams @ CORRESPONDENCE Response to Vriesendorp et al. R. P. Gale, A. Butturini and M. M. Bortin Response to Adams J. M. Brown and M. Lemmon @ MEETINGS VOLUME 20, NUMBER 4 APRIL 1991 TABLE OF CONTENTS Editor’s Note P. Rubin @ ORIGINAL CONTRIBUTIONS Low-Dose Craniospinal Radiation Therapy for Medulloblastoma F. E. Halberg, W. M. Wara, L. F. Fippin, M. S. B. Edwards, V. A. Levin, R. L. Davis, M. B. Prados and C. B. Wilson External Irradiation of Growth Hormone Producing Pituitary Adenomas: Prolactin as a Marker of Hypothalamic and Pituitary Effects E. af Trampe, G. Lundell, I. Lax and S. Werner Delayed Split Whole Abdominal Irradiation in the Combined Modality Treatment of Ovarian Cancer A. R. Calkins, N. B. Rosenshein, M. G. Fox and S. E. Order Pretreatment and Treatment Factors Associated With Improved Outcome in Squamous Cell Carcinoma of the Uterine Cervix: A Final Report of the 1973 and 1978 Patterns of Care Studies R. M. Lanciano, M. Won, L. R. Coia and G. E. Hanks Radical Hysterectomy for Stage I and II Endometrial Carcinoma: A Retrospective Analysis of 179 Cases G. Calais, O. Le Floch, P. Descamps, L. Vitu and J. Lansac Radiotherapy for Carcinoma of the Esophagus in Patients Aged Eighty or Older Y. Hishikawa, K. Kurisu, M. Taniguchi, N. Kamikonya and T. Miura MRI and PET of Delayed Heavy-lon Radiation Injury in the Rabbit Brain E. H. Lo, R. L. DeLaPaz, K. A. Frankel, A. Poljak, M. H. Phillips, K. M. Brennan, K. H. Woodruff, P. E. Valk, G. K. Steinberg and J. I. Fabrikant Threshold Dose for Peripheral Neuropathy Following Intraoperative Radiotherapy (IORT) in a Large Animal Model T. J. Kinsella, A. M. DeLuca, M. Barnes, W. Anderson, R. Terrill and W. F. Sindelar Technique, Pharmacokinetics, Toxicity, and Efficacy of Intratumoral Etanidazole and Radiotherapy for Treatment of Spontaneous Feline Oral Squamous Cell Carcinoma S. M. Evans, F. LaCreta, S. Helfand, T. VanWinkle, W. J. Curran Jr., D. Q. Brown and G. Hanks Variations of the Hypoxic Fraction in the SCC VII Tumors After Single Dose and During Fractionated Radiation Therapy: Assessment Without Anesthesia or Physical Restraint of Mice Y. Kitakabu, Y. Shibamoto, K. Sasai, K. Ono and M. Abe Radiobiologic Studies Comparing Yttrium-90 Irradiation and External Beam Irradiation Jn Vitro J. ¥. C. Wong, L. E. Williams, A. J. Demidecki, B. W. Wessels and X. W. Yan Effect of pH, Oxygenation, and Temperature on the Cytotoxicity and Radiosensitization by Etanidazole B. A. Teicher, T. S. Herman and S. A. Holden Variation in Radiation Sensitivity During the Cell Cycle of Two Human Squamous Cell Carcinomas C. A. Quiet, R. R. Weichselbaum and D. J. Grdina Experimental Brain Hyperthermia: Techniques for Heat Delivery and Thermometry T. P. Ryan, P. J. Hoopes, J. H. Taylor, J. W. Strohbehn, D. W. Roberts, E. B. Douple and C. T. Coughlin The Response of Human and Rodent Cells to Hyperthermia L. Roizin-Towle and J. P. Pirro @ PHASE I/II CLINICAL TRIALS Hyperfractionated Irradiation for Adults With Brainstem Gliomas D. E. Linstadt, M. S. B. Edwards, M. Prados, D. A. Larson and W. M. Wara Neon Ion Radiotherapy: Results of the Phase I/II Clinical Trial D. E. Linstadt, J. R. Castro and T. L. Phillips @ BRIEF COMMUNICATIONS Olfactory Sensations Produced by High-Energy Photon Irradiation of the Olfactory Receptor Mucosa in Humans S. M. Sagar, R. J. Thomas, L. T. Loverock and M. F. Spittle The Role of Radiation Therapy in Inverted Papilloma of the Nasal Cavity and Paranasal Sinuses F. Guedea, W. M. Mendenhall, J. T. Parsons and R. R. Million The Role of Radiation Therapy in the Management of Ependymomas of the Spinal Cord B-C. Wen, D. H. Hussey, P. W. Hitchon, R. L. Schelper, A. P. Vigliotti, J. F.D oornbos and J. C. VanGilder Paraspinal Tumors: Techniques and Results of Brachytherapy J. G. Armstrong, D. E. Fass, M. Bains, B. Mychalezak, D. Nori, E. Arbit, N. Martini and L. B. Harrison Local Control and Complications After Radiation Therapy for Primary Orbital Lymphoma: A Case for Low- Dose Treatment K. J. Minehan, J. A. Martenson Jr., J. A. Garrity, P. J. Kurtin, P. M. Banks, M. G. Chen and J. D. Earle Non-Hodgkin’s Lymphoma Confined to the Nasal Cavity: Its Relationship to the Polymorphic Reticulosis and Resuits of Radiation Therapy J. Itami, M. Itami, A. Mikata, J-Il. Tamaru, T. Kaneko, H. Ogata, K. Uno and N. Arimizu AIDS-Related Non-Hodgkin’s Lymphoma: The Outcome and Efficacy of Radiation Therapy T. L. DeWeese, M. B. Hazuka, D. J. Hommel, J. J. Kinzie and W. E. Daniel Total Skin Electron Beam and Total Nodal Irradiation of Cutaneous T-Cell Lymphoma B. Micaily, O. Campbell, C. Moser, E. C. Vonderheid and L. W. Brady @ TECHNICAL INNOVATIONS AND NOTES Improved Dose Localization With Dual Energy Photon Irradiation in Treatment of Lateralized Intracranial Malignancies G. Cooley, M. T. Gillin, K. J. Murray, J. F. Wilson and N. A. Janjan Improved Dose Distributions for 3D Conformal Boost Treatments in Carcinoma of the Nasopharynx S. A. Leibel, G. J. Kutcher, L. B. Harrison, D. E. Fass, C. M. Burman, M. A. Hunt, R. Mohan, L. J. Brewster, C. C. Ling and Z. Y. Fuks Decreasing Gastrointestinal Morbidity With the Use of Small Bowel Contrast During Treatment Planning for Pelvic Irradiation S. H. Herbert, W. J. Curran Jr., L. J. Solin, P. M. Stafford, R. M. Lanciano and G. E. Hanks Virtual Simulation: Initial Clinical Results J. Rosenman, S. L. Sailer, G. W. Sherouse, E. L. Chaney and J. E. Tepper Abutment of High Energy Electron Fields W. B. Harms and J. A. Purdy A Unified Approach to the Optimization of Brachytherapy and External Beam Dosimetry T. Holmes, T. R. Mackie, D. Simpkin and P. Reckwerdt @ SPECIAL FEATURE Radiotherapy of Carcinoma of the Esophagus in China—A Review L. Taifu @ ONCOLOGY INTELLIGENCE Image Correlation of MRI and CT in Treatment Planning for Radiosurgery of Intracranial Vascular Malformations M. H. Phillips, M. Kessler, F. Y. S. Chuang, K. A. Frankel, J. T. Lyman, J. I. Fabrikant and R. P. Levy Stereotactic Angiography: An Inadequate Database for Radiosurgery? F. J. Bova and W. A. Friedman @ EDITORIALS Medulloblastoma—Caution Regarding New Treatment Approaches L. E. Kun and L. S. Constine Ewing’s Sarcoma—A Local or Systemic Problem? R. B. Marcus Jr. Management of Incompletely Excised Carcinoma of the Skin C. A. Perez The Optimal Radiation Dose Per Fraction for the Treatment of Malignant Melanomas K.-R. Trott @ CORRESPONDENCE Anaesthetic Technique for Radiotherapy in Young Children C. Ferguson and P. Kirkbride Anesthesia for Twice-Daily Infant Irradiation W. J. Murray and M. J. Murray Twice-Daily Anesthesia in Children J. A. Belli, P. J. Eifel, L. Menache and D. Kennamer @ MEETINGS VOLUME 20, NUMBER 5 TABLE OF CONTENTS Editor’s Note P. Rubin @ ORIGINAL CONTRIBUTIONS High-Dose-Rate Afterloading Technique in the Radiation Treatment of Uterine Cervical Cancer: 399 Cases and 9 Years Experience in Taiwan M.-S. Chen, F.-J. Lin, C.-H. Hong, C.-P. Tu, J.-H. Lan, S. G. Tang, W.-M. Leung and T.-R. Wang High Dose Rate Afterloading Intracavitary Therapy in Carcinoma of the Cervix T. N. Roman, L. Souhami, C. R. Freeman, C. Pla, M. D. C. Evans, E. B. Podgorsak and K. Mendelew High Dose Rate Intracavitary Brachytherapy for Recurrent Cervical Cancer of the Vaginal Stump Following Hysterectomy H. Ito, H. Kumagaya, N. Shigematsu, I. Nishiguchi, T.N akayama and S. Hashimoto Cervical Stump Carcinoma J. J. Kovalic, P. W. Grigsby, C. A. Perez and M. A. Lockett Intraperitoneal Radioactive Phosphate in Early Ovarian Carcinoma: An Analysis of Complications L. A. Walton, A. Yadusky and L. Rubinstein Radiation Therapy Following Resection of Non-Small Cell Bronchogenic Carcinoma J. D. Slater, N. A. Ellerbroek, H. T. Barkley Jr., C. Mountain, M. J. Oswald, J. A. Roth and L. J. Peters A Randomized Prospective Trial Comparing Full Dose Chemotherapy to '*'I Antiferritin: An RTOG Study S. Order, T. Pajak, S. Leibel, S. Asbell, P. Leichner, D. Ettinger, G. Stillwagon, J. Herpst, T. Haulk, K. Kopher, C. Frazier and J. Klein Split Course Interstitial Brachytherapy With a Source Shift: The Results of a New Iridium Implant Technique Versus Single Course Implants for Salvage Irradiation of Base of Tongue Cancers in 55 Patients M. Housset, F. Baillet, S. Delanian, P. Brunel, C. Maulard, P. Michel-Langlet, J. Huart, C. Maylin and G. Boisserie Procollagen-III in Serum, Plasminogen Activation and Fibronectin in Bronchoalveolar Lavage Fluid During and Following Irradiation of Human Lung P. Maasilta, E.-M. Salonen, A. Vaheri, L. Kivisaari, L. R. Holsti and K. Mattson Radiation Sensitivity of Copenhagen Rat Prostatic Carcinoma (R3327-AT and R3327-MATLyLu) B. R. Rao, B. J. Slotman, A. A. Geldof and C. A. Perez 981 A Comparison of Radiosensitization by Etanidazole and Pimonidazole in Mouse Tumors H. B. Stone, V. K. Hirst, R. Cribbs, Y. H. Luu and J. M. Brown 987 Efficacy of I.V. or I.P. Injected Cytotoxic Drugs on Proliferating and Non-Proliferating Hair Follicles of the Mouse V. Vegesna and H. R. Withers 997 Effect of Hydralazine on the Blood Flow in Tumors and Normal Tissues in Rats T. Hasegawa and C. W. Song 1001 Precooling Prevents Overheating of Subcutaneous Fat in the Use of RF Capacitive Heating J. G. Rhee, C. K. K. Lee, J. Osborn, S. H. Levitt and C. W. Song 1009 Hyperthermia in Eccentrically Located Pelvic Tumors: Excessive Heating of the Perineal Fat and Normal Tissue Temperatures H. J. Feldmann, M. Molls, S. Adler, M. Meyer-Schwickerath and H. Sack 1017 Sensitization to Hyperthermia Induced in a Normal Tissue by Step-Down Heating J. C. Lindegaard and O. S. Nielsen 1023 Effect of Environmental Conditions (pH, Oxygenation, and Temperature) on Misonidazole Cytotoxicity and Radiosensitization Jn Vitro and In Vivo in FSalIC Fibrosarcoma S. A. Holden, B. A. Teicher and T. S. Herman 1031 Effects of Tamoxifen and Protein Kinase C Inhibitors on Hyperthermic Cell Killing R. B. Mikkelsen, T. Stedman, R. Schmidt-Ullrich and P.-S. Lin 1039 @ PHASE I/II CLINICAL TRIALS Rapidly Alternating Radiotherapy and High Dose Cisplatin Chemotherapy in Stage IIIB Non-Small Cell Lung Cancer: Results of a Phase I/II Study D. R. Gandara, F. H. Valone, E. A. Perez, A. B. Deisseroth, M. Roach III, D. K. Ahn and T. Phillips 1047 @ BRIEF COMMUNICATIONS Early Changes in Tumor Metabolism After Treatment: The Effects of Stereotactic Radiotherapy J. M. Rozental, R. L. Levine, M. P. Mehta, T. J. Kinsella, A. B. Levin, O. Algan, M. Mendoza, J. M. Hanson, D. A. Schrader and R. J. Nickles @ TECHNICAL INNOVATIONS AND NOTES A New Applicator, Positionable to the Center of Tracheobronchial Lumen for HDR-IR-192-Afterloading of Tracheobronchial Tumors P. Fritz, P. Schraube, H. D. Becker, E. Loffler, M. Wannenmacher and O. Pastyr The Objective Evaluation of Alternative Treatment Plans: II. Score Functions S. Shalev, D. Viggars, M. Carey and P. Hahn A New Device to Stabilize Templates for Transperineal I-125 Implants K. Wallner, S. Chiu-Tsao, J. Roy, M. Rosenstein, H. Smith and Z. Fuks Interstitial Ir-192 Implants of the Oral Cavity: The Planning and Construction of Volume Implants R. Schmidt-Ullrich, R. D. Zwicker, A. Wu and K. Kelly Dosimetry and Physical Treatment Planning for Iodine Eye Plaque Therapy W. Alberti, B. Pothmann, P. Tabor, K. Muskalla, K.-P. Hermann and D. Harder Planning of Radiotherapy for Patients With Hip Prosthesis M. Erlanson, L. Franzén, R. Henriksson, B. Littbrand and P.-O. Léfroth @ SPECIAL FEATURES RTOG Quality Assurance Guidelines for Clinical Trials Using Hyperthermia Administered by Ultrasound F. M. Waterman, M. W. Dewhirst, P. Fessenden, T. V. Samulski, P. Stauffer, B.E mami, P. Corry, S. D. Prionas, M. Sapozink, T. Herman, D. S. Kapp, R. J. Myerson, T. Ryan, S. A. Sapareto and P. Shrivastava RTOG Quality Assurance Guidelines for Clinical Trials Using Hyperthermia for Deep-Seated Malignancy M. D. Sapozink, P. M. Corry, D. S. Kapp, R. J. Myerson, M. W. Dewhirst, B. Emami, T. Herman, S. Prionas, T. Ryan, T. Samulski, S. Sapareto, P. Shrivastava, P. Stauffer and F. Waterman RTOG Quality Assurance Guidelines for Interstitial Hyperthermia B. Emami, P. Stauffer, M. W. Dewhirst, S. Prionas, T. Ryan, P. Corry, T. Herman, D. S. Kapp, R. J. Myerson, T. Samulski, S. Sapareto, M. Sapozink, P. Shrivastava and F. Waterman @ ONCOLOGY INTELLIGENCE Prediction of Severe Late Complications in Fractionated, High Dose-Rate Brachytherapy in Gynecological Applications M. Van Lancker and G. Storme @ EDITORIALS HDR: Forget Not “Time” and “Distance” C. G. Orton Advantages of High Dose Rate Remote Afterloading Systems: Physics or Biology B. Speiser Controversies in the Role of Postoperative Radiotherapy in Stages II and IIIA Resected Non-Small Cell Lung Carcinoma N. C. Choi Progress in Hyperthermia? J. R. Oleson @ CORRESPONDENCE Response to Dr. Oleson’s Comments D. S. Kapp, T. A. Barnett, R. S. Cox, E. R. Lee, A. Lohrbach and P. Fessenden @ RAPID COMMUNICATION Hyperthermia and Radiation Therapy of Local-Regional Recurrent Breast Cancer: Prognostic Factors for Response and Local Control of Diffuse or Nodular Tumors D. S. Kapp, T. A. Barnett, R. S. Cox, E. R. Lee, A. Lohrbach and P. Fessenden @ MEETINGS @ ERRATUM VOLUME 20, NUMBER 6 TABLE OF CONTENTS Editor’s Note P. Rubin @ 1990 ASTRO SPECIAL FEATURES Presidential Address: The Past is Prologue C. R. Bogardus Jr. Keynote Address: Contributions of Pediatric Oncology: Examples Derived From Advances Made in the Treatment of Rhabdomyosarcoma and Neuroblastoma J. R.Cassady @ ORIGINAL CONTRIBUTIONS ASTRO Plenary: Effect of Chemotherapy on Locally Advanced Non-Small Cell Lung Carcinoma: A Randomized Study of 353 Patients R. Arriagada, T. le Chevalier, E. Quoix, P. Ruffie, H. de Cremoux, J.-Y. Douillard, M. Tarayre J.-P. Pignon and A. Laplanche ASTRO Plenary: Interfraction Interval is a Major Determinant of Late Effects, With Hyperfractionated Radiation Therapy of Carcinomas of Upper Respiratory and Digestive Tracts: Results From Radiation Therapy Oncology Group Protocol 8313 J. D. Cox, T. F. Pajak, V. A. Marcial, L. Coia, M. Mohiuddin, K. K. Fu, H. Selim, P. Rubin, H. Ortiz and the Radiation Therapy Oncology Group Clinical Radiobiology of Squamous Cell Carcinoma of the Oropharynx S. M. Bentzen, L. V. Johansen, J. Overgaard and H. D. Thames Al3 Local Control in T3 Laryngeal Cancer Treated With Radical Radiotherapy, Time Dose Relationship: The Concept of Nominal Standard Dose and Linear Quadratic Model C. H. J. Terhaard, A. B. M. F. Karim, W. J. Hoogenraad, R. Tjho-Heslinga, R. B. Keus, D. M. Mehta, B. A. Reichgelt and G. J. Hordijk Radiotherapy of T1 Glottic Cancer With 6 MeV X Rays Y. Akine, N. Tokita, T. Ogino, I. Tsukiyama, S. Egawa, M. Saikawa, W. Ohyama, T. Yoshizumi and S. Ebihara Subclinical Pulmonary Function Defects Following Autologous and Allogeneic Bone Marrow Transplantation: Relationship to Total Body Irradiation and Graft-Versus-Host Disease R. C. Tait, A. K. Burnett, A. G. Robertson, S. McNee, B. M. S. Riyami, R. Carter and R. D. Stevenson Role of Brachytherapy in Recurrent Extremity Sarcoma in Patients Treated With Prior Surgery and Irradiation D. Nori, K. Shupak, M. H. Shiu and M. F. Brennan Effectiveness in Inhibition of Recovery of Cell Survival by Cisplatin and Carboplatin: Influence of Treatment Sequence J. H. M. Schwachéfer, R. P. M. A. Crooijmans, J. Hoogenhout, H. B. Kal and A. G. M. Theeuwes The Lower Radiosensitivity of Mouse Kidney Cells Irradiated Jn Vivo Than In Vitro: A Cell Contact Effect Phenomenon Y.-M. Jen, C. M. L. West and J. H. Hendry @ ONCOLOGY INTELLIGENCE A Fluorinated 2-Nitroimidazole, KU-2285, as a New Hypoxic Cell Radiosensitizer K. Sasai, S. Nishimoto, K. Shimokawa, Y. Hisanaga, Y. Kitakabu, Y. Shibamoto, L. Zhou, J. Wang, M. Takahashi, T. Kagiya and M. Abe Blood Flow in Human Tumors During Local Hyperthermia F. M. Waterman, L. Tupchong, R. E. Nerlinger and J. Matthews Tumor-Targeted Delivery of 8-Hydroxyquinoline T. P. Monson, K. J. Henle, W. A. Nagle and A. Mansouri Effects of Hyperthermia and/or Hyperglycemia on pH and pO, in Well Oxygenated Xenotransplanted Human Sarcoma S. Roszinski, G. Wiedemann, S. Z. Jiang, G. Baretton, Th. Wagner and C. Weiss Combined Treatment With Interstitial Hyperthermia and Interstitial Radiotherapy in an Animal Tumor Model A. C. C. Ruifrok, P. C. Levendag, R. F. Lakeman, I.-K. K. Deurloo and A. G. Visser @ BRIEF COMMUNICATIONS Radiosurgery for Solitary Brain Metastases Using the Cobalt-60 Gamma Unit: Methods and Results in 24 Patients R. J. Coffey, J. C. Flickinger, D. J. Bissonette and L. D. Lunsford Reduced Incidence of Bone Metastases in Irradiated Areas After External Radiation Therapy of Prostatic Car- cinoma H. Jacobsson and I. Naslund Sequelae of Lateral Ovarian Transposition in Irradiated Cervical Cancer Patients S. K. Chambers, J. T. Chambers, R. Kier and R. E. Peschel @ TECHNICAL INNOVATIONS AND NOTES Three-Dimensional Treatment Planning of Astrocytomas: A Dosimetric Study of Cerebral Irradiation A. F. Thornton Jr., T. J. Hegarty, R. K. Ten Haken, B. R. Yanke, M. L. LaVigne, B. A. Fraass, D. L.M cShan and H. S. Greenberg Treatment Planning Issues Related to Prostate Movement in Response to Differential Filling of the Rectum and Bladder R. K. Ten Haken, J. D. Forman, D. K. Heimburger, A. Gerhardsson, D. L. McShan, C. Perez-Tamayo, S. L. Schoeppel and A. S. Lichter Evaluation of Radiosurgery Techniques With Cumulative Dose Volume Histograms in Linac-Based Stereotactic External Beam Irradiation M. C. Schell, V. Smith, D. A. Larson, A. Wu and J. C. Flickinger Physical Aspects of the Angle-@ Concept in Electron Arc Therapy M. Pla, E. B. Podgorsak, C. Pla, C. R. Freeman, L. Souhami and J. Guerra Al4

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