International Classification of Rodent Tumors. The Mouse PDF
Preview International Classification of Rodent Tumors. The Mouse
Ulrich Mohr (Editor) International Classification of Rodent Tumors: The Mouse Springer-Verlag Berlin Heidelberg GmbH WHO· International Agency for Research on Cancer Ulrich Mohr (Editor) International Classification of Rodent Tumors The Mouse Editorial Board U. Mohr (Germany) P. Greaves (England) N. Ito (Japan) c.c. Capen (USA) J.E Hardisty (USA) P.H. Long (USA) D.L. Dungworth (USA) Y. Hayashi (Japan) G. Krinke (Switzerland) With 402 Figures in Color Springer Professor Dr. Ulrich Mohr Institut fur Experimentelle Pathologie Medizinische Hochschule Hannover Carl-Neuberg-Strasse 1 30625 Hannover Germany ISBN 978-3-642-08422-5 ISBN 978-3-662-07973-7 (eBook) DOI 10.1007/978-3-662-07973-7 Library of Congress Cataloging-in-Publication Data International classification of rodent tumors. The mouse/[edited by] Ulrich Mohr. p. cm. Includes bibliogaphical references and index. 1. Tumors-Classification. 2. Tumors-Animal models. 3. Mice-Diseases. 4. Tumors in animals-Classification. I. Mohr, U. (Ulrich) RC258.I4462 2001 616.99'2'0012-dc21 00-064092 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustra tions, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of th is publication or parts thereof is permitted only under the provision of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag Berlin Heidelberg GmbH. Violations are liable for prosecution under the German Copyright Law. http:/ /www.springer.de © Springer-Verlag Berlin Heidelberg 2001 Originally published by Springer-Verlag Berlin Heidelberg New York in 2001 The use of designations, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher can not guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literat ure. Cover-Design: Erich Kirchner, Springer-Verlag Heidelberg Typesetting: Data conversion by Springer-Verlag Heidelberg Printed on acid-free paper. SPIN 10678562 24/3130 ih -5 4 3 2 1 o Preface The standardized nomenclature of murine neoplasms presented in this monograph continues the series that was initiated by WHO/IARC with the publication of the International Classification of Rodent Tumors, Part I, The Rat. As with the previous volumes, the purpose is to provide diagnos tic criteria and a standardized, widely accepted nomenclature for neoplas tic and pre-neoplastic lesions. The classification reflects the consensus of an international panel of expert pathologists and of science societies from many countries that worked together in the Organ System Committees. The major objective of this classification is to harmonize and improve tumor diagnosis in murine carcinogenesis studies, since the rodent bio assay is still a major investigative tool for prediction of carcinogenic risk to humans of a large variety of exposures, including drugs, pollutants, and food additives. It provides an internationally accepted uniform standard for establishing contemporary databases that are necessary for an accurate interpretation of lesions induced in experimental carcinogenesis studies. A standardized nomenclature and diagnostic criteria will also facilitate the identification of tumors and related proliferative lesions in genetically engineered transgenic and knock-out mice that are increasingly used in biomedical research. IARC is pleased to present Part II of the International Classification of Rodent Tumors. We are confident that it will contribute to significantly reduce the traditional inter-pathologist variability in the histopathological diagnosis of murine tumors that has confused much work in the past. Dr. Ulrich Mohr Director, Institute of Experimental Pathology, Hannover Medial School Dr. Paul Kleihues Director, International Agency for Research on Cancer World Health Organization v I ntrod uction History A long-term goal of scientists working in the field of toxicologic patholo gy has been the standardization and harmonization of nomenclature and diagnostic criteria for lesions observed in laboratory rats and mice. Initia tives were started in the late 1980s in the United States by the STP (Society of Toxicologic Pathologists) and in Europe by the RITA data base group (Registry of Industrial Toxicology Animal-data). These initiatives resulted in the internationally-recognized publications (SSNDC: Guides for Toxico logic Pathology, and WHO/IARC: International Classification of Rodent Tumors, Part I, The Rat). In 1994 the Joint STPs/ILSI Committee on International Harmonization of Nomenclature and Diagnostic Criteria in Toxicologic Pathology was established. The objective of the committee was to coordinate the interna tional activities for the standardization of diagnostic criteria of tumors and other proliferative lesions in mice and to reconcile the already pub lished nomenclature of proliferative lesions in rats. The committee con sisted of representatives from the European RITA database group (Regis try of Industrial Toxicology Animal-data), the STP (Society of Toxicologic Pathologists, USA), the BSTP (British Society of Toxicologic Pathologists), JSTP (Japanese Society of Toxicologic Pathologists), and the GTP (Gesell schaft fur Toxikologische Pathologie - German-speaking Society of Toxi cologic Pathology). The steering committee established organ system committees for the development of nomenclature and diagnostic criteria for the mouse, largely through the STP (USA) and the RITA database group (Europe). To obtain world-wide comments and acceptance, succes sive drafts of manuscripts were reviewed according to procedures devel oped by the STP in the USA (poster and platform presentations), and were reviewed by the RITA database group and representatives of the Societies of Toxicologic Pathology in Japan and the UK. This monograph represents the product of all that effort. Description Included in this classification are tumors and potentially pre-neoplastic lesions of the mouse organized according to organ systems. Most of the lesions are illustrated, but in a few instances satisfactory images were not available. Each chapter is divided into "data sheets", each of which represents the essential information on a particular lesion. Furthermore, each data sheet VII INTRODUCTION is prepared in a standard layout, always starting on a new page with a header section. On the left side of each header section, the lesion name (the preferred term) appears followed in parenthesis by an indication of the biological behavior of the lesion, according to the following codes: (H) hyperplastic and pre-neoplastic lesion (B) benign tumor (M) malignant tumor (5) systemic tumor If modifiers are defined for a particular lesion, they are printed in italics below the lesion name. On the right-hand side of the header, the organ in which the lesion occurs is mentioned. If the same criteria are used for a lesion at several topographical sites, all these organ sites are included here. All lesion names used in the headers and in the synonym(s) and "Differ ential Diagnosis" sections are presented with the pathological disposition (such as hyperplasia, tumor, adenoma, etc.) placed first, followed by terms describing a sub-topography, a growth pattern, a cell type, etc., separated by commas. This ordering of words constitutes the structure of preferred terms. Use of this terminology facilitates the identification and grouping of lesions with the same biological behavior, especially when using a com puterized pathology data system. In the text and the figure legends, the ordering of words is usually changed to the more common "speaking form"; thus if the preferred term is called "adenoma, bronchiolo-alveolar" this lesion is referred to in the text as "bronchiolo-alveolar adenoma". The descriptions of the diagnostic features comprise only the main histo pathological features of the specified lesion, in the form of a concise list. In several cases, modifiers are included for a more precise subclassifica tion to define a specific growth pattern (e.g., papillary, solid, cystic, etc.) or to subdivide findings by cell type (e.g., pheochromocytoma type, small cell type, etc.). The criteria which are specific for modifiers are listed un der subheadings. Because illustrations are essential in pathology, most le sions are documented with at least one micrograph. These illustrations have been selected from either spontaneous or induced lesions. The section "Differential Diagnosis" is also kept as short as possible and includes only the main diagnostic criteria used in distinguishing lesions. In the reference section of each data sheet only numbers are printed. These refer to the numbered list of references at the end of the chapter. Only the most recently published and important papers are included in the literature references. An 'electronic' version of this classification with a more extensive range of coloured illustrations will be issued once the monograph is published. This will enhance the speed and facility of access to the information re quired for accurate diagnosis. VIII INTRODUCTION Acknowledgements The Editorial Board thanks the following colleagues for providing ad ditional illustrative material and helping in the preparation of the manu scripts and figure legends: Dr. L. Anderson, NCI, USA; Dr. G. Boorman, NTP, USA; Dr. A. Bube, Aventis Pharma GmbH, Germany; Dr. C. Dawe, Harvard Medical School, USA; Dr. L. Elcock, Bayer Corporation, USA; Dr. M. Enomoto, Biosafety Research Center, Japan; Dr. H. Ernst, Fraunhofer Institute of Toxicology and Aerosol Research, Germany; Dr. S.R. Frame, DuPont, USA; Dr. K. Heider, Novartis AG, Switzerland; Dr. H. Iwata, Biosafety Research Center, Japan; Dr. M.P. Jokinen, NTP archive (Pathology Associates International), USA; Dr. A. Luz, GSF-Forschungszentrum fur Umwelt und Gesundheit GmbH, Germany; Dr. D. Morton, Monsanto, USA; Dr. Y. Nomura, Biosafety Research Center, Japan; Dr. A. Nyska, NIEHS, USA; Dr. S. Rittinghausen, Fraunhofer Institute of Toxicology and Aerosol Research, Germany; Dr. B. Stuart, Bayer Corporation, USA; Dr. S. Yamamoto, Biosafety Research Center, Japan Particular thanks are due to Dipl.-Ing. Gerd Morawietz (Fraunhofer Insti tute of Toxicology and Aerosol Research, Germany) for establishing the structure of the nomenclature, suitable for electronic data processing, for preparing the proofs, and for carrying out the technical editing. IX Contents Integumentary System ... 1 R. Bruner, K. Kiittler, R. Bader, W. Kaufmann, A. Boothe, M. Enomoto, J.M. Holland, W.E. Parish Gastrointestinal Tract ... 23 G.R. Betton, L.O. Whiteley, M.R. Anver, R. Brown, U. Deschl, M. Elwell, P.-G. Germann, E Hartig, K. Kiittler, H. Mori, T. Nolte, H. Piischner, K. Tuch Liver, Gallbladder, and Exocrine Pancreas ... 59 U. Deschl, R.C. Cattley, T. Harada, K. Kiittler, J.R. Hailey, E Hartig, B. Leblanc, D.S. Marsman, T. Shirai Respiratory System and Mesothelium ... 87 D.L. Dungworth, S. Rittinghausen, L. Schwartz, J.R. Harkema, Y. Hayashi, B. Kittel, D. Lewis, R.A. Miller, U. Mohr, K.T. Morgan, S. Rehm, M.V. Slayter Urinary System ... 139 G.e. Hard, B. Durchfeld-Meyer, B. Short, A. Bube, K. Krieg, D. Creasey, J. Everitt, e.H. Frith, J. Glaister, J.e. Seely, H. Tsuda, V.S. Turusov Male Genital System ... 163 S. Rehm, J.H. Harleman, M. Cary, D. Creasy, R.A. Ettlin, S.L. Eustis, G.L. Foley, J.-L. LeNet, A. Maekawa, K. Mitsumori, R.E McConnell, G. Reznik (t) Female Genital System ... 211 B. Davis, J.H. Harleman, M. Heinrichs, A. Maekawa, R.E McConnell, G. Reznik (t), M. Tucker Endocrine System ... 269 e.e. Capen, E. Karbe, U. Deschl, C. George, P.-G. Germann, e. Gopinath, J.E Hardisty, J. Kanno, W. Kaufmann, G. Krinke, K. Kiittler, B. Kulwich, e. Landes, B. Lenz, L. Longeart, 1. Paulson, E. Sander, K. Tuch Central Nervous System ... 323 G. Krinke, A. Fix, W. Kaufmann, L.J. Ackerman, R.H. Garman, e. George, B.S. Jortner, J.R. Leininger, K. Mitsumori, K.T. Morgan, 1. Paulson, M. Robinson Eye and Harderian Gland ... 347 G. Krinke, A. Fix, M. Jacobs, J. Render, 1. Weisse (t) XI
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