Intercellular Signaling in Development and Disease: Cell Signaling Collection

549 Pages·2011·8.74 MB·English

by  Ralph A. Bradshaw, Edward A. Dennis

I ntercellular Signaling in
Development and Disease
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I ntercellular Signaling in
Development and Disease
E ditors-in-Chief

E dward A. D ennis
D epartment of Chemistry and Biochemistry,
Department of Pharmacology, School of Medicine,
University of California, San Diego,
La Jolla, California
R alph A. B radshaw
D epartment of Pharmaceutical Chemistry,
University of California, San Francisco,
San Francisco, California

A MSTERDAM • BOSTON • HEIDELBERG • LONDON • NEW YORK • OXFORD
PARIS • S AN DIEGO • SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO
A cademic Press is an imprint of Elsevier
Academic Press is an imprint of Elsevier
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First edition 2011
Copyright © 2011 Elsevier Inc. All rights reserved
Material in the work originally appeared in Handbook of Cell Signaling, Second Edition, edited by Ralph A. Bradshaw and Edward A. Dennis (Elsevier,
Inc. 2010)
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Editorial Advisory Board
Marilyn G. Farqhuar
Department of Cellular and Molecular Medicine
University of California, San Diego
Tony Hunter
Molecular and Cellular Biology Laboratory
Salk Institute for Biological Studies
Michael Karin
Department of Pharmacology
University of California, San Diego
Murray Korc
Departments of Medicine and Pharmacology & Toxicology
Dartmouth Medical School
Suresh Subramani
Division of Biological Sciences
University of California, San Diego
E. Brad Thompson
Department of Biochemistry & Molecular Biology
University of Texas, Medical Branch, Galveston
James A. Wells
Departments of Pharmaceutical Chemistry and Cellular & Molecular Pharmacology
University of California, San Francisco
v
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Contents
Section A – Overview 1 10. Calcium Signaling in Cardiac Muscle 77
K.M. Dibb, A.W. Trafford and D.A. Eisner
1. Signaling in Development and
11. Calcium Signaling in Smooth Muscle 81
Disease 3
Edward A. Dennis, Ralph A. Bradshaw Susan Wray
12. Trophic Effects of Gut Hormones in the
Section B – Cell-Cell Signaling 9
Gastrointestinal Tract 99
Kanika A. Bowen and B. Mark Evers
2. Overview of Cell–Cell and
Cell–Matrix Interactions 11
13. Cell–Cell and Cell–Matrix Interactions
E. Brad Thompson and Ralph A. Bradshaw
in Bone 109
Lynda F. Bonewald
3. Integrin Signaling: Cell Migration,
Proliferation, and Survival 13
14. Cell–Cell Signaling in the Testis and
J. Thomas Parsons, Jill K. Slack-Davis,
Robert W. Tilghman, Marcin Iwanicki Ovary 125
and Karen H. Martin Michael K. Skinner, Eric E. Nilsson
and Ramji K. Bhandari
4. The Focal Adhesion: A Network of
15. Kidney 141
Molecular Interactions 23
William J. Arendshorst and Elsa Bello-Reuss
Jianxin A. Yu, Nicholas O. Deakin
and Christopher E. Turner
16. Cytokines and Cytokine Receptors
5. Cadherin Regulation of Adhesive Regulating Cell Survival,
Interactions 29 Proliferation, and Differentiation in
Barbara Ranscht Hematopoiesis 167
Fiona J. Pixley and E. Richard Stanley
6. In vivo Functions of Heterotrimeric
17. CD45 177
G Proteins 43
Stefan Offermanns Michelle L. Hermiston, Vikas Gupta and Arthur Weiss
7. G-Protein Signaling in Chemotaxis 51 18. Signal Transduction in T Lymphocytes 183
Jonathan Franca-Koh, Stacey Sedore Willard Rolf König
and Peter N. Devreotes
19. Signal Transduction via the B Cell
8. Interactive Signaling Pathways in the Antigen Receptor: A Crucial Regulator of
Vasculature 59 B Cell Biology 193
Lucy Liaw, Igor Prudovsky, Volkhard Lindner, Louis B. Justement
Calvin Vary and Robert E. Friesel
20. Signaling Pathways Regulating
9. Signaling Pathways Involved in Growth and Differentiation of
Cardiogenesis 67 Adult Stem Cells 203
Deepak Srivastava and Chulan Kwon Larry Denner, Margaret Howe and Randall J. Urban
vii
viii Contents
Section C – Signaling In Development 213 31. Regulation of Synaptic Fusion by
Heterotrimeric G Proteins 289
21. Wnt Signaling in Development 215 Simon Alford, Edaeni Hamid, Trillium Blackmer
Stefan Rudloff, Daniel Messerschmidt and Tatyana Gerachshenko
and Rolf Kemler
32. The Role of Receptor Protein
22. Interactions between Wnt/β-Catenin/ Tyrosine Phosphatases in Axonal
Fgf and Chemokine Signaling in Lateral Pathfi nding 297
Line Morphogenesis 221 Andrew W. Stoker
Tatjana Piotrowski
33. Neurotrophin Signaling in
23. Integration of BMP, RTK, and Development 303
Wnt Signaling Through Smad1 Katrin Deinhardt and Moses V. Chao
Phosphorylations 227
Luis C. Fuentealba, Edward Eivers, 34. Attractive and Repulsive Signaling in
Hojoon X. Lee and E. M. De Robertis Nerve Growth Cone Navigation 309
Guo-li Ming and Mu-ming Poo
24. Hedgehog Signaling in Development
and Disease 233 35. Semaphorins and their Receptors in
Frederic de Sauvage Vertebrates and Invertebrates 315
Eric F. Schmidt, Hideaki Togashi
25. Regulation of Vertebrate Left-Right and Stephen M. Strittmatter
Axis Development by Calcium 239
Adam D. Langenbacher and Jau-Nian Chen 36. Signaling Pathways that Regulate Cell
Fate in the Embryonic Spinal Cord 321
26. LIN-12/Notch Signaling: Induction, Matthew T. Pankratz and Samuel L. Pfaff
Lateral Specifi cation, and Interaction
with the EGF/Ras Pathway 245 Section D – Signaling In Disease 329
Sophie Jarriault
37. Ras and Cancer 331
27. Proteolytic Activation of Notch Frank McCormick
Signaling: Roles for Ligand Endocytosis
38. Targeting Ras for Anticancer Drug
and Mechanotransduction 251
James T. Nichols and Gerry Weinmaster Discovery 335
Jen Jen Yeh, James P. Madigan,
Paul M. Campbell, Patrick J. Roberts,
28. Vascular Endothelial Growth Factors
Lanika DeGraffenreid and Channing J. Der
and Receptors: Signaling in Vascular
Development 259
39. The Roles of Ras Family Small
Anna Dimberg, Charlotte Rolny,
GTPases in Breast Cancer 357
Laurens A. van Meeteren and
Ariella B. Hanker and Channing J. Der
Lena Claesson-Welsh
40. Signaling Pathways in the Normal and
29. BMPs in Development 271
Kelsey N. Retting and Karen M. Lyons Neoplastic Breast 367
Tushar B. Deb, Danica Ramljak, Robert B. Dickson,
Michael D. Johnson and Robert Clarke
30. Signaling from Fibroblast Growth
Factor Receptors in Development and
41. Aberrant Signaling Pathways in
Disease 279
Pancreatic Cancer: Opportunities for
Kristine A. Drafahl, Christopher W. McAndrew
and Daniel J. Donoghue Targeted Therapeutics 375
Alixanna Norris and Murray Korc
Contents ix
42. Regulatory Signaling in Pancreatic 48. Protein Serine/Threonine
Organogenesis: Implications for Aberrant Phosphatase Inhibitors and Human
Signaling in Pancreatic Cancer 391 Disease 457
Catherine Carrière and Murray Korc Shirish Shenolikar and Matthew H. Brush
43. Angiogenesis Signaling Pathways as 49. Signal Transduction in Rheumatoid
Targets in Cancer Therapy 401 Arthritis and Systemic Lupus
Chery A. Whipple and Murray Korc Erythematosus 463
Thomas Dörner and Peter E. Lipsky
44. Clinical Applications of Kinase
Inhibitors in Solid Tumors 413 50. Translational Concepts in
William Pao and Nicolas Girard Vasculitis 477
Daniel A. Albert and David B. Talmadge
45. Adipokine Signaling: Implications for
Obesity 431 51. Translational Implications of
Rexford S. Ahima and Gladys M. Varela Proteomics 489
Sam Hanash
46. CXC Chemokine Signaling in Interstitial
Lung Diseases 441 52. Translational Implications of
Borna Mehrad and Robert M. Strieter MicroRNAs in Clinical Diagnostics and
Therapeutics 495
47. ER and Oxidative Stress: Implications in
Lorenzo F. Sempere and Sakari Kauppinen
Disease 447
Jyoti D. Malhotra and Randal J. Kaufman Index 513