Interactions of Ethanol and Methadone

168 Pages·2016·5.26 MB·English

by  Vijay Aggarwal

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Theses and Dissertations Graduate School
1977
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Vijay Aggarwal
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INTERAOCFTE ITHOANANSNO MDLE THADONE
by
VijAagyg arwal
B.AC.a,sW ee stReersne Urnviev er1s9i7t0y ,
Thesis
submiitnpt aerdt fiuallf ilolftm herene tq uirfeomtreh net s
DegroefDe o ctoofPr h iloisnot phDheey p arotfmP ehmnacatro logy
att hMee diCcoalll oefVg ier ginia
VirgiConmimao nUwneiavletrhs ity
RichmVoinrdg,i nia
Decem1b9e7r7,
ABSTRACT
INTERACTOIFEO TNHSA ANNOMDLE THADONE
VijAagyg arwPahl.,D .
MediCcoalllo efVg ier g-iVniirag Cionmmioan wUenailvtehr1 s9i7t7y.,
MajPorro fesDsro.rJ :.BR a.t h
Theef feocfet tsh aandomlti rnaitsointo hnae n tinocaiccteipvt-ive
•i tyl,e tphrapole rtainebdsr acionn cenotfrm aettinhoeawn,de o rien ves­
tigatTehedef. f oefcet t haonnto hlae n tinocaiccteipovtfimi tevyet ha­
donweaa ss sebsyst ehhdeo t-panldta atei l-tfelsitcCsko. n centrations
ofm ethaidnto hnbeer awienrd ee tenbnyti hnuees doe f3 H -methaasd one
welalsb yg alsi qcuhirdo mataongarlaypTshhiisescut . ds yh owtehda t
modedroastoeefes t hadniondlo a tl tteari l-ofrhl oitc-kp rleastpeo nse
byt hemseHlovweeswv.he ecrno, m bwiintmehed t haedtohnaepn,ro old uced
as ignifiinccarinentat shaeen tinoceifccfetepitvieovnfeme estsh adone
asm easbuyrb eodta dh e crienat shEeeD 5o0fm ethaadnbodyn an ei n­
creaisnetde nasnpidrt oyl odnugreadot fim oent haadnotnien ociception.
Ethainnoclr etahasene tdi nocaiccteipovtfiim tveyet heai dnbo ontnha ive
anmde thadonem-itcoTelh.ei irsna cnrtea acsteidwv ainsto ydt u teo
simpalded iotfis ounb threefsfheoocflet dts h annoowrla i std uteoa n
ethanol-imnecdriieanawt sheeobd lr ea in·conocfem nettrhaatdIioton nes.
ish ypothtehsatithzi een dc reaansteidn ooaiccteipwvtaiitstvh yere e ­
sulotfa ne thanol-imnecdriieanact seeend tn revarolus sy ssteenms itiv�
ittyot haen tinocaiccteipovtfimi tevyte h adone.
1
Ethapnroelt repartomdesunictge ndi fi1oc waebnrrt alciyon n centra­
tioonfms e thacdomopnaetr oec do ntwrhoemlnes t hawdaoasnd emi nistered
subtcauneouWshlebyno. td hr uwgesra ed ministereetdh aanodor­la lly,
ministrreastuiilontbn er dac ionn centorfma ettihoandso ne initially less
thacno ntarnoadlt l atteirm es tghraecnao ntterrIo nbl o.te ht hanol
anwda ter-prmeitcree atthaeenedr x ec ewlcaloser nrte lbaettiwtoehnee n
whoblrea cionn centorfma ettihoaandn oadnn et inoceifcfeepbctutit,v e
thaen ntoicc eipv tei efaftae ncbytr a cionn cenotfrma ettihoawnda osn e
greaitnee trh anol-pmriecteAr.le tahteoetudhg ahpn roold suicgendi fi­
canatl teraitnti hobenr sac ionn cenotfrm aettihoatndh obenr ea,ci onn ­
centroafet tihoanwn aogsle nernaoaltll tye bryme edt haaddomnien istra­
tionI.n vestiogfta hteeix ocnrseo tfmi eotnh aadniodtn msee tabolites
antdh hea lf-olfmi efteh aidnto hnbeer afiani lteord e veaanslyi gnif­
icaentth anola-litnedruacteido ns.
Ad osoefe thawnhoilic nhc retahasene tdi nocaiccteipovtfii tvye
methaddinodon atel ttehroe r aolrs ubcuta5n0oe fom eutsh aLadDlo­ne,
thomuighct eh adti eadsa r esoufle tt haannomdle thaaddomnien istra­
tiodni eadtl owwehro blrea cionn centorfma ettihoatndhsoa tnnhe o se
thadti eadsa r esoulfmt e thaadloonnTeeh .Le D ofe thawnaossli g­
50
nificdaenctrleiyan ms iecmdea intoania mn eetdh addoosonef1e 0 m0/g
kg/d.a y
2
Thitsh esbiyVs i jAagyg ariwsaa clc epitnie tdsp resent
foramss atisftyhitenh ge sriesq uirfeomtreh ndete groefe .
Doc.tooPfrh ilosophy
Date: Approved:
lffe.x
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ii
To Bobbi
iii
CURRIVCIUTLAUEM

iv
V
ACKl�O\JLEDGEMENTS
Mya ppreciisae txipornet soDs reR.da ymBoantdmh ya, d visor,
foir1 einsc ouraagnaeddm veindctue r itnhgei snev estigations.
Ia lswoi sthot haDnrkR. o rbteB lanfkoheri asd viacned
counasneDdlr W.i llDieawmfe oyhr i gsu idaanncdco en cdeurrni ng
thfei nsatla goefts h per eperoaftt hiimosan n usacsrw ieplatls
fotrh ues oef h ilsa borfaatcoiirtlye s.
Spectihaalna krJseu teh mea nfyr ieanndmdse mboefmr ys
famiwlhyos suep pmoarditet p ossfiobmrlee t ou nderatnadk e
compltehtipser oject.
Theef foorfLt lsa Cvliadar nkTd e reJsaami ents y ping this
manusacrrgeir patt eafcuklnloyw ledged.
Finanscuipap\lo, raptsr ovfirdoetmdhT eo xicTorlaoignye e
posiitnit ohnBe u reoafFu o reSncsiiecn Ccoemsm,o nwealth of
Virginia.
vi
TABOLFCE O NTENTS
TITPLAEG E
DEDICATION .iii
CURRIVCIUTLAUEM .i v
ACKNOWLEDGEMENTS .v i
TABOLFCE O NT.E NTS .vii
LISOTFT ABL.E S .i x
LISOTFF IGURES .x i
IJffROD.U C.T IOii 1
A)M ethadone 1
B)E thanol 8
C)E thaannoOdlt hDerru gs 12
D)O ther aDnMrdeu tghsa done 17
E)E thaannoMdle thadone 19
F)P resent Study 22
MATERAIlAMiLEDST HODS 24
A)M aterials 24
B)M eth.o ds .2 5
RESULTS .4 1
A)A ntinociAccetpitovifiEv tteyh anol .4 1
B)E ffeocfEt t haonnMo elt haAdnotnien ocicept4i4o n,
C)E ffeocfEt t haonnMo elt haDditosrnieb u.t io.n .4 7
D)C orrelBaettiwBoernea nCi onn centorfMa ettihoand one
anAdn tinociEcfefpetc.it. v e .. .. . .. 5 4. . . .
vii