ebook img

Inflammation, Aging, and Oxidative Stress PDF

406 Pages·2016·6.89 MB·English
Save to my drive
Quick download
Download
Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.

Preview Inflammation, Aging, and Oxidative Stress

Oxidative Stress in Applied Basic Research and Clinical Practice Stephen C. Bondy Arezoo Campbell Editors Infl ammation, Aging, and Oxidative Stress Oxidative Stress in Applied Basic Research and Clinical Practice Editor-in-Chief Donald Armstrong More information about this series at http://www.springer.com/series/8145 Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief Stephen C. Bondy • Arezoo Campbell Editors Inflammation, Aging, and Oxidative Stress Editors Stephen C. Bondy Arezoo Campbell Department of Medicine Department of Pharmaceutical Sciences Center for Occupational and Environmental College of Pharmacy Health Western University of Health Sciences University of California Pomona, CA, USA Irvine, CA, USA ISSN 2197-7224 ISSN 2197-7232 (electronic) Oxidative Stress in Applied Basic Research and Clinical Practice ISBN 978-3-319-33484-4 ISBN 978-3-319-33486-8 (eBook) DOI 10.1007/978-3-319-33486-8 Library of Congress Control Number: 2016949388 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland Preface Aging carries inherent risk upon which distinct diseases are superimposed. Normal physiological processes tend to develop pathological aspects, which further disrupt declining tissue function. These age-related diseases often exaggerate the typical cellular changes accumulating with time, which are associated with senescence. For this reason, there has been a gradual merging of concepts regarding normal aging and specific disorders. The aim of this book is to describe this interface, emphasizing two components (tissue damage by oxidant free radicals and chronic inflammation) which are associ- ated with both aging and, more pronouncedly, age-related disease. It is remarkable how these processes appear to represent a commonality between apparently unre- lated diseases. Oxidant and inflammatory phenomena often represent aberrations of the common effective functioning of reactive oxygen species and the immune sys- tem, in signaling and bactericidal events and in dispersal of materials of exogenous origin. In this book, we have emphasized cardiovascular and neurodegenerative disorders. The chapters that have been assembled are focused on oxidative stress and inflammatory events in both normal and aberrant aging, and how these may interact. Several chapters describe the underlying mechanistic basis of oxidative stress and inflammation. The promotion of these events by environmental factors is considered in other chapters. The oxidant and inflammatory phenomena discussed appear to be inescapable components of the aging process and lay a foundation for many diseases which are present only in the elderly. The last section of this book provides several chapters that discuss the alleviation of these inevitable changes. These include lifestyle changes such as dietary, behavioral, and exercise-based strategies. Such measures can improve the length and quality of life for the elderly and are also likely to impact the incidence of specific age-linked diseases. The last two of Shakespeare’s “Seven Ages of Man” read as follows: “The sixth age shifts into the lean and slippered pantaloons, with spectacles on nose and pouch on side… and his big manly voice, turning again toward childish treble, pipes and whistles in his sound,” followed by “Last scene of all, that ends this strange eventful v vi Preface history, is second childishness and mere oblivion, sans teeth, sans eyes, sans taste, sans everything.” These stages, while undesirable, are obviously inescapable. By appropriate envi- ronmental and dietary means, it is hoped that the earlier stages can be prolonged while these last phases can be collapsed into a relatively short time. Irvine, CA, USA Stephen C. Bondy Pomona, CA, USA Arezoo Campbell Contents Part I Age-Related Cellular Events Metal Toxicity, Inflammation and Oxidative Stress ..................................... 3 Stephen C. Bondy Exosomes in the Preservation of Cellular Homeostasis ............................... 17 Francesc Baixauli and Maria Mittelbrunn Microglia: Features of Polarization and Aging ............................................ 47 G. Jean Harry and Christopher A. McPherson Modifiable Factors Influencing Telomere Length and Aging ..................... 67 Frej Y. Fyhrquist and Outi J. Saijonmaa Tyrosine Kinase Inhibitors and Neurodegenerative Disorders .................. 81 Syed Jafar Mehdi, Steven W. Barger, Merle G. Paule, Syed F. Ali, and Syed Z. Imam Part II Role of Inflammatory and Oxidative Processes in Age Related Diseases Oxidative and Inflammatory Pathways in Age- Related Chronic Disease Processes .............................................................................. 95 Arezoo Campbell and Parrisa Solaimani Aging and Microglial Activation in Neurodegenerative Diseases ............... 107 Esteban A. Oyarzabal, Yen-Yu Ian Shih, and Jau-Shyong Hong Ambient Particles and Cerebrovascular Disease ......................................... 133 Mark R. Miller and Anoop S.V. Shah Particle-Induced Inflammation and Cardiovascular Diseases.................... 161 Jesus A. Araujo and Gajalakshmi Ramanathan vii viii Contents Oxidative Stress and Alzheimer’s Disease .................................................... 189 Sandeep Kumar Singh, Rudy Castellani, and George Perry Reactive Oxygen Species and Protein Oxidation in Neurodegenerative Disease ........................................................................ 199 Edward H. Sharman Oxidative Stress Is a Driver of Normal and Pathological Ovarian Aging ................................................................................................. 213 Ulrike Luderer Part III Retardation of Cellular Aging Anti-Oxidants, the Aging Brain and Age- Related Brain Disorders ........... 241 Michel Baudry and Bernard Malfroy-Camine Antioxidants and Redox-Based Therapeutics in Parkinson’s Disease ....... 261 Dilshan S. Harischandra, Huajun Jin, Anamitra Ghosh, Vellareddy Anantharam, Arthi Kanthasamy, and Anumantha G. Kanthasamy Simultaneous Activation of Nrf2 and Elevation of Dietary and Endogenous Antioxidants for Prevention and Improved Management of Parkinson’s Disease ............................................................. 277 Kedar N. Prasad Modulation of Hallmarks of Brain Aging by Environmental Enrichment ...................................................................................................... 303 Nancy Bartolotti and Orly Lazarov Protective Effect of Exercise on Age-Related Oxidant and Inflammatory Events ............................................................................... 321 Nada Sallam and Ismail Laher Deacceleration of Brain Aging by Melatonin ............................................... 345 Rüdiger Hardeland Redox Based-Peripheral Biomarkers in Alzheimer’s Disease: Challenges, Limits and Prospects .................................................................. 377 Morgane Perrotte, Joel Pincemail, Mohammed Haddad, and Charles Ramassamy Index ................................................................................................................. 399 Contributors Syed F. Ali Division of Neurotoxicology, National Center for Toxicological Research/US FDA, Jefferson, AR, USA Vellareddy Anantharam Parkinson’s Disorder Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA Jesus A. Araujo Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Department of Environmental Health Sciences, Fielding School of Public Health, UCLA, Los Angeles, CA, USA Francesc Baixauli Signaling and Inflammation Program, Spanish National Center for Cardiovascular Research Carlos III (CNIC), Madrid, Spain Immunology, La Princesa Health Research Institute, Madrid, Spain Steven W. Barger Geriatric Research Education and Clinical Center, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA Nancy Bartolotti Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, Chicago, IL, USA Michel Baudry Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, USA Stephen C. Bondy Department of Medicine, Center for Occupational and Environ- mental Health, University of California, Irvine, CA, USA Arezoo Campbell Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA Rudy Castellani Department of Pathology, School of Medicine, University of Maryland, Baltimore, MD, USA ix

Description:
The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardio
See more

The list of books you might like

Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.