Table Of Content

Infectious Diseases Infectious Diseases F o u r t h E d i t i o n Edited by Jonathan Cohen, William G. Powderly, Steven M. Opal, MD MB, FRCP, FRCPE, MD, FRCPI Professor of Medicine FRCPath, FMedSci J. William Campbell Professor of Medicine Infectious Disease Division Alpert Medical School of Brown University Larry J Shapiro Director, Institute for Emeritus Professor of Infectious Diseases Providence, RI, USA Public Health Brighton and Sussex Medical School Co-director, Division of Infectious Diseases Brighton, UK Washington University in St Louis St Louis, MO, USA Section Editors Thierry Calandra, MD, PhD Roy M. Gulick, MD, MPH Didier Raoult, MD, PhD Chairman, Department of Medicine Rochelle Belfer Professor in Medicine Professor, Faculté de Médecine, Director of Head, Infectious Diseases Service Chief, Division of Infectious Diseases the Foundation Mediterranee Infection CHUV (Centre Hospitalier Department of Medicine Unité des Rickettsies Universitaire Vaudois) Weill Cornell Medical College WHO Collaborative Center for Rickettsial Lausanne, Switzerland New York, NY, USA Reference and Research Marseille, France Nathan Clumeck, MD, PhD Andy I.M. Hoepelman, Robert T. Schooley, MD Professor of Infectious Diseases MD, PhD Honorary Head, Department of Professor and Head Professor in Medicine, Infectious Infectious Diseases Division of Infectious Diseases Diseases Specialist Saint-Pierre University Hospital Academic Vice Chair Head, Department of Internal Medicine and Brussels, Belgium Department of Medicine Infectious Diseases University of California San Diego Jeremy Day, MA, DTM&H, University Medical Center San Diego, CA, USA Utrecht, The Netherlands PhD, FRCP Jos W.M. van der Meer, Kieren A. Marr, MD Head, CNS–HIV Infections Research Group MD, PhD, FRCP, Oxford University Clinical Research Unit Professor of Medicine and Oncology Wellcome Trust Major Overseas Director, Transplant and Oncology Infectious FRCP(Edin), FIDSA, MAE Programme Vietnam Diseases Program Emeritus Professor of Medicine Ho Chi Minh City, Vietnam Johns Hopkins University School of Medicine Radboud University Medical Center Associate Professor Baltimore, MD, USA Nijmegen, The Netherlands Centre for Tropical Medicine Nuffield Department of Medicine Jeanne Marrazzo, MD, Richard J. Whitley, MD University of Oxford MPH, FACP, FIDSA Oxford, UK Distinguished Professor Director, Division of Infectious Diseases Loeb Chair in Pediatrics Jeremy Farrar, FRS, FRCP, Professor of Medicine Professor of Pediatrics, Microbiology, University of Alabama at Birmingham Medicine and Neurosurgery FMedSci, DPhil, OBE School of Medicine University of Alabama Director, The Wellcome Trust Birmingham, AL, USA Birmingham, AL, USA London, UK Associate Editors (Educational Content) Courtney D. Chrisler, MD Bethany Davies, MRCP, Instructor in Medicine FRCPath Division of Infectious Diseases Specialist Registrar in Infectious Diseases and Washington University in St Louis Medical Microbiology St Louis, MO, USA Brighton and Sussex University Hospitals NHS Trust Brighton, East Sussex, UK For additional online content visit expertconsult.com © 2017, Elsevier Limited. All rights reserved. © Henry J. C. de Vries retains copyright of his original figures in Chapter 13. © David A. Warrell retains copyright of his original figures in Chapter 131 and Chapter 171. First edition 1999 Second edition 2004 Third edition 2010 The right of Jonathan Cohen, William G. Powderly & Steven M. Opal to be identified as author of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. ISBN: 978-0-7020-6285-8 E-book: 978-0-7020-6338-1 Inkling: 978-0-7020-6339-8 Content Strategist: Belinda Kuhn Content Development Specialist: Sharon Nash Content Coordinator: Trinity Hutton Project Manager: Joanna Souch Design: Miles Hitchen Illustration Manager: Brett MacNaughton Marketing Manager: Melissa Fogarty Printed in China Last digit is the print number: 9 8 7 6 5 4 3 2 1 CONTENTS Prefatcoet heF ourtEhd itioxni v 11 NecrotizFiansgc iiGtaissG ,a ngrene, Lisotf C ontributxovr s Myositainsd M yonecros9i5s Dedicatixoxnx v11 DENNIS l.S TEVENS I MICHAEL J.A LDAPE I AMY E.B RYANT VOLUME 1 12 ArthropVoedc toorfsM edical Importance1 04 JEAN-MICHEL BERENGERI PHILIPPPAER OLA a Introducttioo n SECTION 13 DermatoloMgainci festatoifSo ynsst emic InfectiDoiusse ases Infectio1n1s3 CHANTALP .B LEEKER-ROVEIR HSE NRYJ .CD.E VRIES 1 TheE volutioofK no ch'Pso stulates JONATHAN COHEN 14 Superficial IFnufnegcatli o1n2s2 DAVIDW . WARNOCK I TOM M. CHILLER 2 Naturaen dP athogeniocfi ty Micro-organi4s ms PPl Managemenotf I nfectDeida betic JOSHUAF IEREIRD AVIDL OONEY IJ EAN-CLAUDEP ECHfORE' FootU lcer1s3 0 EDGAR J.GP.E TERSI BENJAMIN A.L IPSKY 3 HostR esponsteosI nfecti2o6n CARA C.W ILSON IR OBERTT .S CHOOLEY PP2 Managintgh eP atiewnitt hR ecurring SkiInn fectio1n3s3 4 Emerginagn dR e-emergiPnagt hogeannsd THUSHAN I.D E SILVAI S TEPHENT .G REEN Diseaseasn,dH ealtCho nsequencoefsa ChanginCgl imat4e0 TheL ymphatSiycs tem1 36 PHILIMP. POLGREEN IE VELYNl .P OLGREEN 15 Lymphadenopat1h3y6 5 MathematiMcoadle lisn I nfectiDoiusse ase ETHANR UBINSTIEN' IY OAV KEYNAN Epidemiolo4g9y PETERJ .W HITE PP3 EvaluatainodnM anagement oft heS olitEanrlya rged 6 InfectPiroenv entainodnC ontroaln,d LymphN ode 146 AntimicroSbtieawla rdsh5i4p YOAV KEYNAN I ETHANR UBINSTEIN1 RANDYA .T APLITIZ M ICHELE l.R ITIER I FRANCESCAJ .T ORRIANI TheE ye 150 7 BacterGieanlo mes 62 PIERRE-EDOUAFRODU RNIERI DIDIERRA OULT 16 ConjunctivKietriast,ia tnids InfectioofPn esr iorbital 8 TheM icrobioimneI nfectiDoiusse ase6s8 Structur1e5s0 MAKEDONKA MITREVA MICHELD RANCOURT IM ARIEB OULZEP ANKERTI LOUISH OFFART IJ SECTION Syndromebsy 17 Endophthalmi1t5i8s Body System MICHELD RANCOURT I FREDERIMCA TONTI Skina ndS oftT issue7 5 18 InfectiRoeutsi niatnidUs v eiti1s6 5 MICHELD RANCOURT 9 ViraElx anthem7s5 PP4 Managemenotf R edE ye 175 ADILIWAA RRISI FRANKP .K ROON MICHELD RANCOURTI OLUISH OFFART 10 CelluliPtyiosd,e rmAab,s cesseasn,dO ther TheC entraNle rvouSsy stem1 77 Skiann dS ubcutaneoIunsf ectio8n4s DENNISl .S TEVENS 19A cutaen dC hroniMce ningit1i7s7 1Decaesed MATIHIJCS. B ROUWER ID IEDERIVKA N DE BEEK v Copyrighmtaetde rial vi Contents 20 EncephalaintdiM sy elit1i8s9 34 Managemenotft heI nfectCeyds tic KARENC .B LOCH IC AROLA .G LASERI ALLAN R.T UNKEL FibrosPiast ien3t0 0 HEATHER STRAHI DANIEL ROSENBLUTH 21 BraiAnb scesasn dO therFo caPly ogenic Infectiooftn hse C entrNaelr vous PP7 InvestigaotfPi loenu ral System1 98 Discharge/F3l0u3i d ITZHAKB ROOK SAMIH RAIECHI BENOITD 'JOURNOI LAURENT PAPAZIAN 22 Tetanuasn dB otulis2m0 8 PP8 Whent oU seC orticosteirnoN iodnsc entral AIMEEC .H ODOWANEC IT HOMAS P.B LECK NervouSsy steTmu berculo3s0i6s GUY THWAITES 23 TransmissSipbolneg ifoErnmc ephalopathies ofH umansa ndA nimals2 14 PP9 How toM anagea Patieonnt A nti-TB SIMONM EAD IJ OHN COLLINGEI SARAHJ .T ABRIZI Therapwyi tAhb normaLli ver Enzymes3 08 24 InfectiionHn ysd rocephaSlhuusn ts2 21 L.P ETERO RMEROD IT HOMAS C.B AILEY ROGERB AYSTONI VAIN PELEGRIN PPIOU se oAfn tibioftoircE sx acerbatoifo ns PPS Roloef R apiVdi raDle tectiionn COPD 310 Meningit2i2s5 JOHANNESM .A.D ANIELSI MENNO M. VAN DERE ERDEN REMIN .C HARREL TheG astrointesStyisntaelm 3 12 PP6 InvestigaotfPi soync hiaMtarniicf estations ofE ncephali2t2i7s 35 OrocerviIcnafle cti3o1n2 DAVIDB .C LIFFORD ROBERTC .R EAD TheR espiratSoyrsyt em2 29 36 GastriPteipst,iU cl ceratainodnR elated Conditio3n2s1 25 LaryngiEtpiisg,l otatnidtP ihsa ryngi2t2i9s JONATHANR .W HITEI R ICHARD J.M.I NGRAMI LUU-LPYH AM I RAFIKB OURAYOUI JOHN C.A THERTON VALtRIMEA GHRAOUl-SLIM I SIABELEL KONt-PAUT 37 Food-BorDniea rrhIelalln e3s2s8 26 OtitiSsi,n usiatnidRs e latCeodn ditio2n3s6 CHRISTOPHERP .C ONLON LUU-LPYH AM I RAFIKB OURAYOUI VALtRIMEA GHRAOUl-SLIM I SAIBELLE KONt-PAUT 38 AcutDei arrhe3a3 5 MICHEL DRANCOURT 27 BronchiBtriosn,c hiect2a4s3i s MARCUSW BUTLERI MICHAEL P.KE ANE 39 ChroniDci arrhe3a4 1 FLORENCEF ENOLLAR 28 Community-AcquPinreeudm onia2 51 RICHARD G.W UNDERINK 40 Clostriddiiuffmi cIinlfee ctiionHn oss pitals andC ommunity3 51 29 Hospital-AcqHueiarletdh,c are-Associated MARTIJIPN. B AUERI ED J.K UIJPER andV entilator-AssPonceiuamtoendi a2 58 ANTOINER OCH IG UILLEMETITEH OMAS IS AMIH RAIECHI LAURENTP APAZIANI WILLIAGM. P OWDERLY 41 Intra-abdoSmeipnsailPs e,r itonitis, PancreatHietpiast,o bilainadrF yo cal 30 LungA bscessaensd P leurAabls cesse2s6 3 SplenIincf ecti3o5n5 CHRISTINLAI SCYNESKIYJ ULIEE. M ANGINO P.RO NAN O'CONNELLI G ERARDS HEEHAN 31 Tuberculo2s7i1s 42 CliniMcaanli festatoifAo cnust aen dC hronic REINOUT VAN CREVELI PHILICP. H ILL Hepatit3i6s3 DAVIDW YLESI JENNIFELRI N 32 NontuberculMoyucso bacterial Disease2s8 5 PP11T raveleDrisa'r rhe3a7 5 JAKKOV AN INGEN PHILIPGPAEU TRETI P HILIPPE PAROLA 33 FungaPln eumonia2s9 2 PP12F ebriTlrea nsaminoifVt iirsa Elt iolog3y7 7 CAROLA .K AUFFMAN STEVEN J.LA WRENCE Copyrimgahtteerdi al Contents vii PPB Managemenotf C APD Peritoni3t8i0s 55 ComplicatiofoP nrse gnancMya:t ernal CARLOS A.Q.S ANTOS Perspecti4v9e8s GUILLA UME DURAND IF LORENCEB RETELLIE FLORENCE FENOLLAR Bonea ndJ oints3 82 56 FetaI!m plicatoifoM nast ernIanlf ectiionn s 43 InfectainvdeR eactiAvret hrit3i8s2 ARJUNG UPTAI E LIFE. B ERBARIIJ AMESM .S TECKELBERIG Pregnanc5y0 5 DOUGLASR .O SMON ARIB ITNUNI H YTHEMA L-SUM IG REG RYAN 44 Acutaen dC hroniOcs teomyeli3t8i8s PP16T reatmeonfta PositiTvoex oplasTmiat eirn SHIREESHOAH ANIREDDYI S ANTIAGON EME Pregnanc5y1 7 RONALDA .N ICHOLSI T HEODORE B.J ONES 45 InfectioofPn rso stheJtoiicn atnsd R elated Problem3s9 9 PP17A PregnaPnatt iewnitt ah Previous SHADIP ARSAEIIJ AMESK EENEYI J ONASM ARSCHALL PregnanCcoym plicatbeydG roupB StreptocoDcicsaela sient heI nfan5t2 0 46 LymeD iseas4e0 5 UPTON D.A LLEN JOHN N.A UCOTT IB ENJAMINJ .L UFT UrinarTyr act5 23 BloodstreaHme,a rta ndV essels4 15 57 CystiatnidsU rethrSayln drome5s2 3 47 Sepsis4 15 STEPHENT .C HAMBERSI S ARAHC .M ETCALF TOM VAN DERP OLLI W ILLEM JOOST WIERSINGA 58 ProstatEiptiidsi,d ymaintdiO sr chit5i3s2 48 InfectiAosnsso ciatweidt hl ntravascular FLORIAN M.E.W AGENLEHNERI A DRIANP ILATIZ Lineasn dG rafts4 27 WOLFGANG WEIDNER IK URTG .N ABER WINFRIED V.K ERN 59 ComplicatUerdi naIrnyf ectiIonnc,l uding 49 SystemCiacn didias4i3s9 PostsurgaincdaC la theter-Related BENOITP ILMIS IZ Hl-TAYOA NG IF ANNYLA NTERNIERI Infectio5n3s9 OLIVIELOR RTHOLARY LINDSAY E.N ICOLLE 50 MyocardiatnidsP ericard4i4t6i s 60 PyelonepharnidtA ibss cessoefst he ADAM Z.BA NKS IG .R ALPH COREY Kidney5 47 ELODIJ .D IELUBANZA IR ICHARDS.M ATULEWICZI 51 Endocardi4t5i6s ANTHONY J.S CHAEFFER FRANCKT HUNY IG ILBERHTA BIBI D IDIERRA OULT I PIERRE-EDOUAFRODU RNIER PP18T uberculosis oft heU rogeniTtraalc t5 55 DAVIDJ .H ORNE IE LIZBAETHA NN MISCH 52 RheumatFiecv er4 71 ABBYD OUGLASI K UMAR VISVANATHAN PP19U rinaTrrya cItn fectiionKn isd neTyr ansplant Recipien5t5s7 PP14M anagemenotfP ericarEdffiuas!i o4n7 8 KATHLEENG .J ULIANI E MILYA .B LUMBERG FREDERIQUGEO URIETI P IERRE-YVES LEVY PP15M ediastiannidtS itse rnal SexualTlrya nsmittDeids ease5s5 9 Osteomyeli4t8i1s CHRISTOPH SCHIMMERI R AINER G.L EYH 61 Syphil5i5s9 KHALIGL. G HANEM Obstetraincd G ynecologic Infectio4n8s3 62 GenitHaelr pes5 67 CHRISTINJEO HNSTON I ANNA WALD 53 VaginiVtuilsv,i tCiesr,v icaintdiC su taneous VulvaL!e sion4s8 3 63 HumanP apillomavIinrfuesc tio5n7s5 JACKD .S OBEL VIKRANT V.S AHASRABUDDHEI S TENH .V ERMUND 54 Infectiooftn hse F emalPee lviIsn,c luding 64 LymphogranulVoemnae reumC,h ancroid SeptiAcb ortion4 92 andG ranulomlan guina5l8e5 PAULN YIRJESIYK .A SHLEYB RANDT PAULA .M ACPHERSONI D .W ILLIACMA MERON Copyrimgahtteerdi al viii Contents 65 Managemenotf G onorrhe5a9 2 75 BioterroarnidsB mi odefens6e7 0 JEANNEM ARRAZZO ANDREW W. ARTENSTEIN 66 Chlamydtiraa chomaItnifse cti5o9n7 PP24I nfectiAosnsso ciatweidt hD rowning6 80 STEPHENJ .J ORDAN IW ILLAIM M. GEISLER ALASTAIRM ILLER PP20P ersistaenndtR ecurreNnotn gonococcal PP25M anagemenotf H umanB ites6 82 Urethri6t0i3s ELENIP ATROZOU REBECCAA .L ILLIIS D AVIDH .M ARTIN NosocomiIasls ue6s8 4 II 76 InfectiCooumsp licatiFoonlsl owiSnugr gery SECTION SpeciParlo blems in andT rauma6 84 InfectiDoiusse ase HEATHER L.E VANSI EILEEN M. BULGER Practice 77 Controlling TranosfAm nitsisbiioont ic­ Fever6 05 ResistBaanctt eriinIa C US etting6s9 3 MARC J.M.B ONTEN 67 PathogeneosfiF se ver6 05 PP26I nfectiinoB nu rns6 98 MOHAMMAD M. SAJADII PHILIAP.M ACKOWIAK DAVIDJ .B ARILLO IK EVINK .C HUNG IC LINTONK .M URRAY 68 Feveorf U nknownO rigi(nF UO)6 11 PP27T ransfusion-RIenlfaetcetdi 7on0s1 CHESTONB .C UNHA IB URKEA .C UNHA NAJAM A.Z AIDI 69 TheP otentRioalleo fI nfectious Agentisn D iseasoefsU nknown Etiolog6y2 5 II SECTION Infectiionnt sh e STEVENM . OPAL lmmunocompromised 70 ChroniFca tigSuyen drome6 31 Host JOSW .M.V AN DER MEER IG IJSB LEIJNEBERG 78 Immunodeficien7c0i5e s PP21F actitiaonudFs r audulent F6e3v6e r STEVENM . HOLLANDI S ERGIO D.R OSENZWEIG I ALICEC HIJIOKEEZ IEFULA RICHARDF .S CHUMACHERI L UIGDI. N OTARANGELO PP22I nfection-RHeelmaotpehda gocytic 79 Infectiiontn hse C ancePra tien7t2 3 Syndrome6s 38 OSCARM ARCHETTI IF REDERITCI SSOTI THIERRCYA LANDRA DENNIS W. SIMON IJ OSEPHA .C ARCILLO 80 InfectiionHn esm atopoieSttiecmC ell PP23K awasaDkiis eas6e4 0 TransplRaencti pien7t3s9 KARIA .S IMONSEN KIERENA .M ARR EnvironmenatnadOl c cupational 81 HeartL,u nga ndH eart-Lung Factor6s4 3 Transplanta7t4i6o n PATRICIAM UNOZ IM ADDALENAG IANNELLAI EMILIBOO UZA 71 RecreatiIonnfaelc tio6n4s3 PAVITHRNAA TARAJANI ALASTAIRM ILLER 82 LiveTrr naspalntatio7n5 1 RAYMUND R.R AZONABLE 72 OccupatioInnafle cti6on4s7 TAR-CHINGA W IIA IN BLAIR IH ILARYM .B ABCOCK 83 IntestTirnaanls planta7t5i6o n KLARA M. POSFAY-BARBE IM ARIANG .M ICHAELS I 73 InfectifornosmP ets6 56 MICHAEL D.G REEN ELLEI J.CG.O LDSTEIN I FREDRICK M. ABRAHAMIAN 84 Kidneayn dP ancreTarsa nsplant 74 InfectiAocnqsu irferdo mA nimalOst her Recipien7t6s2 ThanP ets6 63 ORIOLM ANUEL CIH RISTIAN TOSO I DANIEL S.S HAPIRO MANUELA .P ASCUAL Copyrimgahtteerdi al Contents ix 85 VasculaintdiO st heIrm munologically 94 OpportuniIsntfiecc tiMoannsa:g emenatn d MediateDdi sease7s7 0 Preventi8o5n0 JONATHANC OHEN STEPHANDEE WITI N ATHAN CLUMECK 86 SplenectoamnydS plenDiycs functi7o7n5 95 ImmuneR econstituDtiisoonr deirnPs a tients STEVENM .O PAL withH IVI nfecti8o5n9 MARTYNA .F RENCHI G RAEME MEINTJES 87 Vaccinatoifot nh el mmunocompromised Patien7t8 0 96 TuberculionsHi IsV 865 BERNARDP .V AUDAUXI S ILJA BUHLER I STEPHEND .LA WN IR OBINW OOD CHRISTIAN VAN DELDEN IC HRISTOPH BERGER 97 NeoplasDtiisce ase8 74 88 InfectiAosnsso ciatweidt h CHRISTIAN HOFFMANN lmmunobiolog7i9c6s JULIDEE LALOYEI C URDINC ONRAD I MICHELG ILLIEIT 98 Dermatologic ManifoefsH tIaVt ions GIUSEPPPEA NTALEOI C AMILLOR IBI Infection/A8I7D9S MISHA M.M UTIZWA I MILAN J.AN ADKAT PP28I nfectiDoiusse asTersa nsmitbtye d Graft8s0 5 99 HIV/AIDS-Related iPnrL oobwl-aenmds ANDREAJ .Z IMMERI OLRA D.T HOMAS Middle-IncCoomuen trie8s8 8 STEVENJ .R EYNOLDSI A LEXANDERC .B ILLIOUIX PP29E valuatoifot nh eH IV-UninfeAcdtueldwt i th THOMAS C.Q UINN SuspectIemdm unodeficie8n0c8y SARAHK .B ROWNE PP31H ow toM anageH epatiBt iVsi ruisnt heH IV CoinfectPeadt ien8t9 6 JURGENK URTR OCKSTROH IK ARINELA COMBE VOLUME2 PP32H ow toM anageH epatiCt iVsi ruisnt heH IV CoinfectPeadt ien8t9 8 IJ SECTION HIVa nd AIDS JURGENK URTR OCKSTROH I KARINEL ACOMBE 89 EpidemioloofgH yI VI nfecti8o1n2 RENNATUSM DODO IA NDREAA .K IMI KEVINM . DE COCK AIDSi nW omen andI nfant9s0 0 Preventio8n2 4 100H IVI nfectiinoC nh ildre9n0 0 STEPHANE BLANCHE 90 Bio-behaviIonrtaelr venttiooP nrse venHtI V Transmissi8o2n4 101S peciParlo blemisnW omen Who HaveH IV KENNETHH .M AYER I MATIHEW J.MI MIAGAI Diseas9e0 5 STEVENA .S AFREN BEVERLY E.S HA I CONSTANCEA .B ENSON 91 HIVV accinePsa:s tF ailuarnedsF uture ScientCihfailcl enge8s2 9 HIVT herapy9 12 BRUCEL .G ILLIAIMR OBERT R.R EDFIELIDB ARRYS .P ETERS 102P rincipolfMe asn agemenotf H IVi nt he PP30H IVP ostexposPurroep hylax8i3s5 IndustriaWloirzledd9 12 ERNIE-PAULB ARRETIE I GEROME V.E SCOTAI R UPAP ATEL MARK W. HULLI MARIANNEH ARRISI JULIOS .GM.O NTANER Pathogenes8i3s7 103A ntiviTrhaelr apy9 18 92 Thel mmunopathogenoefsH iIsV -1 JOSEI .B ERNARDINOI J OSER .A RRIBAS Infecti8o3n7 RACHELP RESTI IG IUSEPPE PANTALEO 104I ssueisnt heA gingH IV-Positive Patien9t2 7 CliniPcraels entati8o4n6 PATRICWK. M ALLON I WILLIAGM. P OWDERLY 93 PrimarHyI VI nfecti8o4n6 105E radicatainodCn u reo fH IV 931 BERNARDH IRSCHEL STEPHEN J.K ENT Copyrimgahtteerdi al X Contents PP33A ntiretroMvainraagle menitn MajorT ropicSayln dromeSsy:s temic Low-andM iddle-Income Infectio1n0s1 4 Countrie9s3 6 SOMNUEKS UNGKANUPARPH ll7M alari1a0 14 ARJENM .D ONDORP IL ORENZ VON SEIDLEIN m ll8S chistosomi1a0s2i6s SECTION InternatiMoendailc ine ALAN FENWICK PrincipolfeI sn ternational ll9C estodaen dT rematode Health9 38 Infectio1n0s3 2 DAVIDJ .D IEMERT 106G eographoyfI nfectiDoiusse ase9s3 8 MARYE LIZABETWHI LSON 120E chinococco1s0i3s8 BRUNO GOTISTEIING UIDOB ELDI 107T raveMle dicin9e4 8 JANEN .Z UCKERMAN 121 Filrai aIln fectio1n0s4 6 THOMASB .N UTMAN MajorT ropicSayln dromeSsk:i na nd Soft Tissue9 54 122I nfectiaonndts h eC ommon Inherited Hemoglobin Disorde1r0s 53 108L epros9y5 4 THOMASN .W ILLAIMS ID AVIDJ .W EATHERALL WARWICK J.B RITION 109E ndemiTcr eponematos9e6s1 123L eishmania1s0i5s9 NICK J.B EECHING ROBERTN .D AVIDSON 124C hagaDsi seas(eA merican MajorT ropicSayln dromeTsh:e C entral Trypanosomia1s0i6s5) NervouSsy stem 966 MICHAEL A.M ILES llOH umanA fricTarny panosomia9s6i6s 125M elioido1si0s7 3 CHRISTIABNU RRII J OHANNES BLUM SHARONJ .P EACOCKI DIREK LIMMATHUROTSAKUL lll EosinophMielniicn git9i7s1 126P lague1 078 BRIANJ OHN ANGUS KENNETHL .G AGE IC .B EN BEARD 112 EyeI nfectiiontn hse T ropic9s7 9 ROBINB AILEY 127T ularemi1a0 85 JEANNINE M.P ETERSEIND AVIDT .D ENNIS I C.B EN BEARD MajorT ropicSayln dromeTsh:e GastrointesTtriancatl9 84 128S cruTby phuasn dO theTrr opical Rickettsi1o0s9es1 ll3A pproactho E osinophiinla i Tar avelferro m NICHOLAPS. JD.A Y IP AULN .N EWTON theT ropic9s8 4 ANDREW P.U STIANOWSKI IJ OOPE .A RENDS 129B rucello1s0i9s8 NICK J.B EECHIGN IH AKAN ERDEM ll4P arasiItnifce ctiooftn hse G astrointestinal Tract9 89 130L eptospiro1s1i0s2 PAULK ELLYI M ABLE MUTENGO NICHOLAS P.DJA.Y llST yphoiFde vearn dO therE nteric 131R elapsiFnegv ers1 105 Fevers1 002 DAVIDA .W ARRELL CHRISTIANE DOLECEK 132V iraHle morrhagFiecv ers1 110 ll6A mebicI nfecti1on0s0 8 AMANDA ROJEKI G AIL CARSONI Y ASUYUKIK ATO I DAVIDC .W ARHURST PETERW . HORBYI H AKANL EBLEBICIOGLU Copyrimgahtteerdi al

Description:
Drs. Cohen, Powderly and Opal, three of the most-respected names in infectious disease medicine, lead a diverse team of international contributors to bring you the latest knowledge and best practices. Extensively updated, the fourth edition includes brand-new information on advances in diagnosis of
ebook img

Infectious Diseases PDF

2240 Pages·2016·427.56 MB·English
by  Jonathan Cohen
Save to my drive
Quick download
Download
Upgrade Premium
Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.

Preview Infectious Diseases

Infectious Diseases Infectious Diseases F o u r t h E d i t i o n Edited by Jonathan Cohen, William G. Powderly, Steven M. Opal, MD MB, FRCP, FRCPE, MD, FRCPI Professor of Medicine FRCPath, FMedSci J. William Campbell Professor of Medicine Infectious Disease Division Alpert Medical School of Brown University Larry J Shapiro Director, Institute for Emeritus Professor of Infectious Diseases Providence, RI, USA Public Health Brighton and Sussex Medical School Co-director, Division of Infectious Diseases Brighton, UK Washington University in St Louis St Louis, MO, USA Section Editors Thierry Calandra, MD, PhD Roy M. Gulick, MD, MPH Didier Raoult, MD, PhD Chairman, Department of Medicine Rochelle Belfer Professor in Medicine Professor, Faculté de Médecine, Director of Head, Infectious Diseases Service Chief, Division of Infectious Diseases the Foundation Mediterranee Infection CHUV (Centre Hospitalier Department of Medicine Unité des Rickettsies Universitaire Vaudois) Weill Cornell Medical College WHO Collaborative Center for Rickettsial Lausanne, Switzerland New York, NY, USA Reference and Research Marseille, France Nathan Clumeck, MD, PhD Andy I.M. Hoepelman, Robert T. Schooley, MD Professor of Infectious Diseases MD, PhD Honorary Head, Department of Professor and Head Professor in Medicine, Infectious Infectious Diseases Division of Infectious Diseases Diseases Specialist Saint-Pierre University Hospital Academic Vice Chair Head, Department of Internal Medicine and Brussels, Belgium Department of Medicine Infectious Diseases University of California San Diego Jeremy Day, MA, DTM&H, University Medical Center San Diego, CA, USA Utrecht, The Netherlands PhD, FRCP Jos W.M. van der Meer, Kieren A. Marr, MD Head, CNS–HIV Infections Research Group MD, PhD, FRCP, Oxford University Clinical Research Unit Professor of Medicine and Oncology Wellcome Trust Major Overseas Director, Transplant and Oncology Infectious FRCP(Edin), FIDSA, MAE Programme Vietnam Diseases Program Emeritus Professor of Medicine Ho Chi Minh City, Vietnam Johns Hopkins University School of Medicine Radboud University Medical Center Associate Professor Baltimore, MD, USA Nijmegen, The Netherlands Centre for Tropical Medicine Nuffield Department of Medicine Jeanne Marrazzo, MD, Richard J. Whitley, MD University of Oxford MPH, FACP, FIDSA Oxford, UK Distinguished Professor Director, Division of Infectious Diseases Loeb Chair in Pediatrics Jeremy Farrar, FRS, FRCP, Professor of Medicine Professor of Pediatrics, Microbiology, University of Alabama at Birmingham Medicine and Neurosurgery FMedSci, DPhil, OBE School of Medicine University of Alabama Director, The Wellcome Trust Birmingham, AL, USA Birmingham, AL, USA London, UK Associate Editors (Educational Content) Courtney D. Chrisler, MD Bethany Davies, MRCP, Instructor in Medicine FRCPath Division of Infectious Diseases Specialist Registrar in Infectious Diseases and Washington University in St Louis Medical Microbiology St Louis, MO, USA Brighton and Sussex University Hospitals NHS Trust Brighton, East Sussex, UK For additional online content visit expertconsult.com © 2017, Elsevier Limited. All rights reserved. © Henry J. C. de Vries retains copyright of his original figures in Chapter 13. © David A. Warrell retains copyright of his original figures in Chapter 131 and Chapter 171. First edition 1999 Second edition 2004 Third edition 2010 The right of Jonathan Cohen, William G. Powderly & Steven M. Opal to be identified as author of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. ISBN: 978-0-7020-6285-8 E-book: 978-0-7020-6338-1 Inkling: 978-0-7020-6339-8 Content Strategist: Belinda Kuhn Content Development Specialist: Sharon Nash Content Coordinator: Trinity Hutton Project Manager: Joanna Souch Design: Miles Hitchen Illustration Manager: Brett MacNaughton Marketing Manager: Melissa Fogarty Printed in China Last digit is the print number: 9 8 7 6 5 4 3 2 1 CONTENTS Prefatcoet heF ourtEhd itioxni v 11 NecrotizFiansgc iiGtaissG ,a ngrene, Lisotf C ontributxovr s Myositainsd M yonecros9i5s Dedicatixoxnx v11 DENNIS l.S TEVENS I MICHAEL J.A LDAPE I AMY E.B RYANT VOLUME 1 12 ArthropVoedc toorfsM edical Importance1 04 JEAN-MICHEL BERENGERI PHILIPPPAER OLA a Introducttioo n SECTION 13 DermatoloMgainci festatoifSo ynsst emic InfectiDoiusse ases Infectio1n1s3 CHANTALP .B LEEKER-ROVEIR HSE NRYJ .CD.E VRIES 1 TheE volutioofK no ch'Pso stulates JONATHAN COHEN 14 Superficial IFnufnegcatli o1n2s2 DAVIDW . WARNOCK I TOM M. CHILLER 2 Naturaen dP athogeniocfi ty Micro-organi4s ms PPl Managemenotf I nfectDeida betic JOSHUAF IEREIRD AVIDL OONEY IJ EAN-CLAUDEP ECHfORE' FootU lcer1s3 0 EDGAR J.GP.E TERSI BENJAMIN A.L IPSKY 3 HostR esponsteosI nfecti2o6n CARA C.W ILSON IR OBERTT .S CHOOLEY PP2 Managintgh eP atiewnitt hR ecurring SkiInn fectio1n3s3 4 Emerginagn dR e-emergiPnagt hogeannsd THUSHAN I.D E SILVAI S TEPHENT .G REEN Diseaseasn,dH ealtCho nsequencoefsa ChanginCgl imat4e0 TheL ymphatSiycs tem1 36 PHILIMP. POLGREEN IE VELYNl .P OLGREEN 15 Lymphadenopat1h3y6 5 MathematiMcoadle lisn I nfectiDoiusse ase ETHANR UBINSTIEN' IY OAV KEYNAN Epidemiolo4g9y PETERJ .W HITE PP3 EvaluatainodnM anagement oft heS olitEanrlya rged 6 InfectPiroenv entainodnC ontroaln,d LymphN ode 146 AntimicroSbtieawla rdsh5i4p YOAV KEYNAN I ETHANR UBINSTEIN1 RANDYA .T APLITIZ M ICHELE l.R ITIER I FRANCESCAJ .T ORRIANI TheE ye 150 7 BacterGieanlo mes 62 PIERRE-EDOUAFRODU RNIERI DIDIERRA OULT 16 ConjunctivKietriast,ia tnids InfectioofPn esr iorbital 8 TheM icrobioimneI nfectiDoiusse ase6s8 Structur1e5s0 MAKEDONKA MITREVA MICHELD RANCOURT IM ARIEB OULZEP ANKERTI LOUISH OFFART IJ SECTION Syndromebsy 17 Endophthalmi1t5i8s Body System MICHELD RANCOURT I FREDERIMCA TONTI Skina ndS oftT issue7 5 18 InfectiRoeutsi niatnidUs v eiti1s6 5 MICHELD RANCOURT 9 ViraElx anthem7s5 PP4 Managemenotf R edE ye 175 ADILIWAA RRISI FRANKP .K ROON MICHELD RANCOURTI OLUISH OFFART 10 CelluliPtyiosd,e rmAab,s cesseasn,dO ther TheC entraNle rvouSsy stem1 77 Skiann dS ubcutaneoIunsf ectio8n4s DENNISl .S TEVENS 19A cutaen dC hroniMce ningit1i7s7 1Decaesed MATIHIJCS. B ROUWER ID IEDERIVKA N DE BEEK v Copyrighmtaetde rial vi Contents 20 EncephalaintdiM sy elit1i8s9 34 Managemenotft heI nfectCeyds tic KARENC .B LOCH IC AROLA .G LASERI ALLAN R.T UNKEL FibrosPiast ien3t0 0 HEATHER STRAHI DANIEL ROSENBLUTH 21 BraiAnb scesasn dO therFo caPly ogenic Infectiooftn hse C entrNaelr vous PP7 InvestigaotfPi loenu ral System1 98 Discharge/F3l0u3i d ITZHAKB ROOK SAMIH RAIECHI BENOITD 'JOURNOI LAURENT PAPAZIAN 22 Tetanuasn dB otulis2m0 8 PP8 Whent oU seC orticosteirnoN iodnsc entral AIMEEC .H ODOWANEC IT HOMAS P.B LECK NervouSsy steTmu berculo3s0i6s GUY THWAITES 23 TransmissSipbolneg ifoErnmc ephalopathies ofH umansa ndA nimals2 14 PP9 How toM anagea Patieonnt A nti-TB SIMONM EAD IJ OHN COLLINGEI SARAHJ .T ABRIZI Therapwyi tAhb normaLli ver Enzymes3 08 24 InfectiionHn ysd rocephaSlhuusn ts2 21 L.P ETERO RMEROD IT HOMAS C.B AILEY ROGERB AYSTONI VAIN PELEGRIN PPIOU se oAfn tibioftoircE sx acerbatoifo ns PPS Roloef R apiVdi raDle tectiionn COPD 310 Meningit2i2s5 JOHANNESM .A.D ANIELSI MENNO M. VAN DERE ERDEN REMIN .C HARREL TheG astrointesStyisntaelm 3 12 PP6 InvestigaotfPi soync hiaMtarniicf estations ofE ncephali2t2i7s 35 OrocerviIcnafle cti3o1n2 DAVIDB .C LIFFORD ROBERTC .R EAD TheR espiratSoyrsyt em2 29 36 GastriPteipst,iU cl ceratainodnR elated Conditio3n2s1 25 LaryngiEtpiisg,l otatnidtP ihsa ryngi2t2i9s JONATHANR .W HITEI R ICHARD J.M.I NGRAMI LUU-LPYH AM I RAFIKB OURAYOUI JOHN C.A THERTON VALtRIMEA GHRAOUl-SLIM I SIABELEL KONt-PAUT 37 Food-BorDniea rrhIelalln e3s2s8 26 OtitiSsi,n usiatnidRs e latCeodn ditio2n3s6 CHRISTOPHERP .C ONLON LUU-LPYH AM I RAFIKB OURAYOUI VALtRIMEA GHRAOUl-SLIM I SAIBELLE KONt-PAUT 38 AcutDei arrhe3a3 5 MICHEL DRANCOURT 27 BronchiBtriosn,c hiect2a4s3i s MARCUSW BUTLERI MICHAEL P.KE ANE 39 ChroniDci arrhe3a4 1 FLORENCEF ENOLLAR 28 Community-AcquPinreeudm onia2 51 RICHARD G.W UNDERINK 40 Clostriddiiuffmi cIinlfee ctiionHn oss pitals andC ommunity3 51 29 Hospital-AcqHueiarletdh,c are-Associated MARTIJIPN. B AUERI ED J.K UIJPER andV entilator-AssPonceiuamtoendi a2 58 ANTOINER OCH IG UILLEMETITEH OMAS IS AMIH RAIECHI LAURENTP APAZIANI WILLIAGM. P OWDERLY 41 Intra-abdoSmeipnsailPs e,r itonitis, PancreatHietpiast,o bilainadrF yo cal 30 LungA bscessaensd P leurAabls cesse2s6 3 SplenIincf ecti3o5n5 CHRISTINLAI SCYNESKIYJ ULIEE. M ANGINO P.RO NAN O'CONNELLI G ERARDS HEEHAN 31 Tuberculo2s7i1s 42 CliniMcaanli festatoifAo cnust aen dC hronic REINOUT VAN CREVELI PHILICP. H ILL Hepatit3i6s3 DAVIDW YLESI JENNIFELRI N 32 NontuberculMoyucso bacterial Disease2s8 5 PP11T raveleDrisa'r rhe3a7 5 JAKKOV AN INGEN PHILIPGPAEU TRETI P HILIPPE PAROLA 33 FungaPln eumonia2s9 2 PP12F ebriTlrea nsaminoifVt iirsa Elt iolog3y7 7 CAROLA .K AUFFMAN STEVEN J.LA WRENCE Copyrimgahtteerdi al Contents vii PPB Managemenotf C APD Peritoni3t8i0s 55 ComplicatiofoP nrse gnancMya:t ernal CARLOS A.Q.S ANTOS Perspecti4v9e8s GUILLA UME DURAND IF LORENCEB RETELLIE FLORENCE FENOLLAR Bonea ndJ oints3 82 56 FetaI!m plicatoifoM nast ernIanlf ectiionn s 43 InfectainvdeR eactiAvret hrit3i8s2 ARJUNG UPTAI E LIFE. B ERBARIIJ AMESM .S TECKELBERIG Pregnanc5y0 5 DOUGLASR .O SMON ARIB ITNUNI H YTHEMA L-SUM IG REG RYAN 44 Acutaen dC hroniOcs teomyeli3t8i8s PP16T reatmeonfta PositiTvoex oplasTmiat eirn SHIREESHOAH ANIREDDYI S ANTIAGON EME Pregnanc5y1 7 RONALDA .N ICHOLSI T HEODORE B.J ONES 45 InfectioofPn rso stheJtoiicn atnsd R elated Problem3s9 9 PP17A PregnaPnatt iewnitt ah Previous SHADIP ARSAEIIJ AMESK EENEYI J ONASM ARSCHALL PregnanCcoym plicatbeydG roupB StreptocoDcicsaela sient heI nfan5t2 0 46 LymeD iseas4e0 5 UPTON D.A LLEN JOHN N.A UCOTT IB ENJAMINJ .L UFT UrinarTyr act5 23 BloodstreaHme,a rta ndV essels4 15 57 CystiatnidsU rethrSayln drome5s2 3 47 Sepsis4 15 STEPHENT .C HAMBERSI S ARAHC .M ETCALF TOM VAN DERP OLLI W ILLEM JOOST WIERSINGA 58 ProstatEiptiidsi,d ymaintdiO sr chit5i3s2 48 InfectiAosnsso ciatweidt hl ntravascular FLORIAN M.E.W AGENLEHNERI A DRIANP ILATIZ Lineasn dG rafts4 27 WOLFGANG WEIDNER IK URTG .N ABER WINFRIED V.K ERN 59 ComplicatUerdi naIrnyf ectiIonnc,l uding 49 SystemCiacn didias4i3s9 PostsurgaincdaC la theter-Related BENOITP ILMIS IZ Hl-TAYOA NG IF ANNYLA NTERNIERI Infectio5n3s9 OLIVIELOR RTHOLARY LINDSAY E.N ICOLLE 50 MyocardiatnidsP ericard4i4t6i s 60 PyelonepharnidtA ibss cessoefst he ADAM Z.BA NKS IG .R ALPH COREY Kidney5 47 ELODIJ .D IELUBANZA IR ICHARDS.M ATULEWICZI 51 Endocardi4t5i6s ANTHONY J.S CHAEFFER FRANCKT HUNY IG ILBERHTA BIBI D IDIERRA OULT I PIERRE-EDOUAFRODU RNIER PP18T uberculosis oft heU rogeniTtraalc t5 55 DAVIDJ .H ORNE IE LIZBAETHA NN MISCH 52 RheumatFiecv er4 71 ABBYD OUGLASI K UMAR VISVANATHAN PP19U rinaTrrya cItn fectiionKn isd neTyr ansplant Recipien5t5s7 PP14M anagemenotfP ericarEdffiuas!i o4n7 8 KATHLEENG .J ULIANI E MILYA .B LUMBERG FREDERIQUGEO URIETI P IERRE-YVES LEVY PP15M ediastiannidtS itse rnal SexualTlrya nsmittDeids ease5s5 9 Osteomyeli4t8i1s CHRISTOPH SCHIMMERI R AINER G.L EYH 61 Syphil5i5s9 KHALIGL. G HANEM Obstetraincd G ynecologic Infectio4n8s3 62 GenitHaelr pes5 67 CHRISTINJEO HNSTON I ANNA WALD 53 VaginiVtuilsv,i tCiesr,v icaintdiC su taneous VulvaL!e sion4s8 3 63 HumanP apillomavIinrfuesc tio5n7s5 JACKD .S OBEL VIKRANT V.S AHASRABUDDHEI S TENH .V ERMUND 54 Infectiooftn hse F emalPee lviIsn,c luding 64 LymphogranulVoemnae reumC,h ancroid SeptiAcb ortion4 92 andG ranulomlan guina5l8e5 PAULN YIRJESIYK .A SHLEYB RANDT PAULA .M ACPHERSONI D .W ILLIACMA MERON Copyrimgahtteerdi al viii Contents 65 Managemenotf G onorrhe5a9 2 75 BioterroarnidsB mi odefens6e7 0 JEANNEM ARRAZZO ANDREW W. ARTENSTEIN 66 Chlamydtiraa chomaItnifse cti5o9n7 PP24I nfectiAosnsso ciatweidt hD rowning6 80 STEPHENJ .J ORDAN IW ILLAIM M. GEISLER ALASTAIRM ILLER PP20P ersistaenndtR ecurreNnotn gonococcal PP25M anagemenotf H umanB ites6 82 Urethri6t0i3s ELENIP ATROZOU REBECCAA .L ILLIIS D AVIDH .M ARTIN NosocomiIasls ue6s8 4 II 76 InfectiCooumsp licatiFoonlsl owiSnugr gery SECTION SpeciParlo blems in andT rauma6 84 InfectiDoiusse ase HEATHER L.E VANSI EILEEN M. BULGER Practice 77 Controlling TranosfAm nitsisbiioont ic­ Fever6 05 ResistBaanctt eriinIa C US etting6s9 3 MARC J.M.B ONTEN 67 PathogeneosfiF se ver6 05 PP26I nfectiinoB nu rns6 98 MOHAMMAD M. SAJADII PHILIAP.M ACKOWIAK DAVIDJ .B ARILLO IK EVINK .C HUNG IC LINTONK .M URRAY 68 Feveorf U nknownO rigi(nF UO)6 11 PP27T ransfusion-RIenlfaetcetdi 7on0s1 CHESTONB .C UNHA IB URKEA .C UNHA NAJAM A.Z AIDI 69 TheP otentRioalleo fI nfectious Agentisn D iseasoefsU nknown Etiolog6y2 5 II SECTION Infectiionnt sh e STEVENM . OPAL lmmunocompromised 70 ChroniFca tigSuyen drome6 31 Host JOSW .M.V AN DER MEER IG IJSB LEIJNEBERG 78 Immunodeficien7c0i5e s PP21F actitiaonudFs r audulent F6e3v6e r STEVENM . HOLLANDI S ERGIO D.R OSENZWEIG I ALICEC HIJIOKEEZ IEFULA RICHARDF .S CHUMACHERI L UIGDI. N OTARANGELO PP22I nfection-RHeelmaotpehda gocytic 79 Infectiiontn hse C ancePra tien7t2 3 Syndrome6s 38 OSCARM ARCHETTI IF REDERITCI SSOTI THIERRCYA LANDRA DENNIS W. SIMON IJ OSEPHA .C ARCILLO 80 InfectiionHn esm atopoieSttiecmC ell PP23K awasaDkiis eas6e4 0 TransplRaencti pien7t3s9 KARIA .S IMONSEN KIERENA .M ARR EnvironmenatnadOl c cupational 81 HeartL,u nga ndH eart-Lung Factor6s4 3 Transplanta7t4i6o n PATRICIAM UNOZ IM ADDALENAG IANNELLAI EMILIBOO UZA 71 RecreatiIonnfaelc tio6n4s3 PAVITHRNAA TARAJANI ALASTAIRM ILLER 82 LiveTrr naspalntatio7n5 1 RAYMUND R.R AZONABLE 72 OccupatioInnafle cti6on4s7 TAR-CHINGA W IIA IN BLAIR IH ILARYM .B ABCOCK 83 IntestTirnaanls planta7t5i6o n KLARA M. POSFAY-BARBE IM ARIANG .M ICHAELS I 73 InfectifornosmP ets6 56 MICHAEL D.G REEN ELLEI J.CG.O LDSTEIN I FREDRICK M. ABRAHAMIAN 84 Kidneayn dP ancreTarsa nsplant 74 InfectiAocnqsu irferdo mA nimalOst her Recipien7t6s2 ThanP ets6 63 ORIOLM ANUEL CIH RISTIAN TOSO I DANIEL S.S HAPIRO MANUELA .P ASCUAL Copyrimgahtteerdi al Contents ix 85 VasculaintdiO st heIrm munologically 94 OpportuniIsntfiecc tiMoannsa:g emenatn d MediateDdi sease7s7 0 Preventi8o5n0 JONATHANC OHEN STEPHANDEE WITI N ATHAN CLUMECK 86 SplenectoamnydS plenDiycs functi7o7n5 95 ImmuneR econstituDtiisoonr deirnPs a tients STEVENM .O PAL withH IVI nfecti8o5n9 MARTYNA .F RENCHI G RAEME MEINTJES 87 Vaccinatoifot nh el mmunocompromised Patien7t8 0 96 TuberculionsHi IsV 865 BERNARDP .V AUDAUXI S ILJA BUHLER I STEPHEND .LA WN IR OBINW OOD CHRISTIAN VAN DELDEN IC HRISTOPH BERGER 97 NeoplasDtiisce ase8 74 88 InfectiAosnsso ciatweidt h CHRISTIAN HOFFMANN lmmunobiolog7i9c6s JULIDEE LALOYEI C URDINC ONRAD I MICHELG ILLIEIT 98 Dermatologic ManifoefsH tIaVt ions GIUSEPPPEA NTALEOI C AMILLOR IBI Infection/A8I7D9S MISHA M.M UTIZWA I MILAN J.AN ADKAT PP28I nfectiDoiusse asTersa nsmitbtye d Graft8s0 5 99 HIV/AIDS-Related iPnrL oobwl-aenmds ANDREAJ .Z IMMERI OLRA D.T HOMAS Middle-IncCoomuen trie8s8 8 STEVENJ .R EYNOLDSI A LEXANDERC .B ILLIOUIX PP29E valuatoifot nh eH IV-UninfeAcdtueldwt i th THOMAS C.Q UINN SuspectIemdm unodeficie8n0c8y SARAHK .B ROWNE PP31H ow toM anageH epatiBt iVsi ruisnt heH IV CoinfectPeadt ien8t9 6 JURGENK URTR OCKSTROH IK ARINELA COMBE VOLUME2 PP32H ow toM anageH epatiCt iVsi ruisnt heH IV CoinfectPeadt ien8t9 8 IJ SECTION HIVa nd AIDS JURGENK URTR OCKSTROH I KARINEL ACOMBE 89 EpidemioloofgH yI VI nfecti8o1n2 RENNATUSM DODO IA NDREAA .K IMI KEVINM . DE COCK AIDSi nW omen andI nfant9s0 0 Preventio8n2 4 100H IVI nfectiinoC nh ildre9n0 0 STEPHANE BLANCHE 90 Bio-behaviIonrtaelr venttiooP nrse venHtI V Transmissi8o2n4 101S peciParlo blemisnW omen Who HaveH IV KENNETHH .M AYER I MATIHEW J.MI MIAGAI Diseas9e0 5 STEVENA .S AFREN BEVERLY E.S HA I CONSTANCEA .B ENSON 91 HIVV accinePsa:s tF ailuarnedsF uture ScientCihfailcl enge8s2 9 HIVT herapy9 12 BRUCEL .G ILLIAIMR OBERT R.R EDFIELIDB ARRYS .P ETERS 102P rincipolfMe asn agemenotf H IVi nt he PP30H IVP ostexposPurroep hylax8i3s5 IndustriaWloirzledd9 12 ERNIE-PAULB ARRETIE I GEROME V.E SCOTAI R UPAP ATEL MARK W. HULLI MARIANNEH ARRISI JULIOS .GM.O NTANER Pathogenes8i3s7 103A ntiviTrhaelr apy9 18 92 Thel mmunopathogenoefsH iIsV -1 JOSEI .B ERNARDINOI J OSER .A RRIBAS Infecti8o3n7 RACHELP RESTI IG IUSEPPE PANTALEO 104I ssueisnt heA gingH IV-Positive Patien9t2 7 CliniPcraels entati8o4n6 PATRICWK. M ALLON I WILLIAGM. P OWDERLY 93 PrimarHyI VI nfecti8o4n6 105E radicatainodCn u reo fH IV 931 BERNARDH IRSCHEL STEPHEN J.K ENT Copyrimgahtteerdi al X Contents PP33A ntiretroMvainraagle menitn MajorT ropicSayln dromeSsy:s temic Low-andM iddle-Income Infectio1n0s1 4 Countrie9s3 6 SOMNUEKS UNGKANUPARPH ll7M alari1a0 14 ARJENM .D ONDORP IL ORENZ VON SEIDLEIN m ll8S chistosomi1a0s2i6s SECTION InternatiMoendailc ine ALAN FENWICK PrincipolfeI sn ternational ll9C estodaen dT rematode Health9 38 Infectio1n0s3 2 DAVIDJ .D IEMERT 106G eographoyfI nfectiDoiusse ase9s3 8 MARYE LIZABETWHI LSON 120E chinococco1s0i3s8 BRUNO GOTISTEIING UIDOB ELDI 107T raveMle dicin9e4 8 JANEN .Z UCKERMAN 121 Filrai aIln fectio1n0s4 6 THOMASB .N UTMAN MajorT ropicSayln dromeSsk:i na nd Soft Tissue9 54 122I nfectiaonndts h eC ommon Inherited Hemoglobin Disorde1r0s 53 108L epros9y5 4 THOMASN .W ILLAIMS ID AVIDJ .W EATHERALL WARWICK J.B RITION 109E ndemiTcr eponematos9e6s1 123L eishmania1s0i5s9 NICK J.B EECHING ROBERTN .D AVIDSON 124C hagaDsi seas(eA merican MajorT ropicSayln dromeTsh:e C entral Trypanosomia1s0i6s5) NervouSsy stem 966 MICHAEL A.M ILES llOH umanA fricTarny panosomia9s6i6s 125M elioido1si0s7 3 CHRISTIABNU RRII J OHANNES BLUM SHARONJ .P EACOCKI DIREK LIMMATHUROTSAKUL lll EosinophMielniicn git9i7s1 126P lague1 078 BRIANJ OHN ANGUS KENNETHL .G AGE IC .B EN BEARD 112 EyeI nfectiiontn hse T ropic9s7 9 ROBINB AILEY 127T ularemi1a0 85 JEANNINE M.P ETERSEIND AVIDT .D ENNIS I C.B EN BEARD MajorT ropicSayln dromeTsh:e GastrointesTtriancatl9 84 128S cruTby phuasn dO theTrr opical Rickettsi1o0s9es1 ll3A pproactho E osinophiinla i Tar avelferro m NICHOLAPS. JD.A Y IP AULN .N EWTON theT ropic9s8 4 ANDREW P.U STIANOWSKI IJ OOPE .A RENDS 129B rucello1s0i9s8 NICK J.B EECHIGN IH AKAN ERDEM ll4P arasiItnifce ctiooftn hse G astrointestinal Tract9 89 130L eptospiro1s1i0s2 PAULK ELLYI M ABLE MUTENGO NICHOLAS P.DJA.Y llST yphoiFde vearn dO therE nteric 131R elapsiFnegv ers1 105 Fevers1 002 DAVIDA .W ARRELL CHRISTIANE DOLECEK 132V iraHle morrhagFiecv ers1 110 ll6A mebicI nfecti1on0s0 8 AMANDA ROJEKI G AIL CARSONI Y ASUYUKIK ATO I DAVIDC .W ARHURST PETERW . HORBYI H AKANL EBLEBICIOGLU Copyrimgahtteerdi al

Description:
Drs. Cohen, Powderly and Opal, three of the most-respected names in infectious disease medicine, lead a diverse team of international contributors to bring you the latest knowledge and best practices. Extensively updated, the fourth edition includes brand-new information on advances in diagnosis of
See more

The list of books you might like

Upgrade Premium
Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.
DMCA & Copyright: Dear all, most of the website is community built, users are uploading hundred of books everyday, which makes really hard for us to identify copyrighted material, please contact us if you want any material removed.
Copyright @ PDFdrive.to, 2022 | We love our users