Impact of Abiotic and Biotic Parameters of the Human Gut on Enterohemorrhagic Escherichia coli ... PDF
Preview Impact of Abiotic and Biotic Parameters of the Human Gut on Enterohemorrhagic Escherichia coli ...
Impact of Abiotic and Biotic Parameters of the Human Gut on Enterohemorrhagic Escherichia coli Survival and Virulence Stéphanie Blanquet-Diot Associate professor, University of Clermont Auvergne, France IAFP's 13th European Symposium on Food Safety 29th March 2017, Brussels, Belgium Introduction Abiotic factors Biotic factors Conclusion Université Clermont Auvergne, Clermont-Ferrand, France UMR UCA-INRA 454 MEDIS « Microbiota, Digestive Environment and Health » Pr. Pierre Peyret Clermont-Ferrand Introduction Abiotic factors Biotic factors Conclusion Université Clermont Auvergne, Clermont-Ferrand, France UMR UCA-INRA 454 MEDIS « Microbiota, Digestive Environment and Health » Pr. Pierre Peyret Intestinal microbiota : main functions and impact on human and animal health Galenic formulation Aerobic/anaerobicmicrobiology Bioinformatics ARTIFICIAL DIGESTION / Molecular tools FERMENTATION Analytic infrastructure Gnotobioticanimals Introduction Abiotic factors Biotic factors Conclusion Université Clermont Auvergne, Clermont-Ferrand, France UMR UCA-INRA 454 MEDIS « Microbiota, Digestive Environment and Health » Pr. Pierre Peyret Intestinal microbiota : main functions and impact on human and animal health 3 main research axes ► Food and xenobiotic metabolism ► Host-microbiota interactions ► Food-borne zoonotic diseases Introduction Abiotic factors Biotic factors Conclusion ENTEROHEMORRHAGIC ESCHERICHIA COLI (EHEC) (O157:H7) 1982 Major food-borne pathogens Karmaliet al., Lancet, 1983 → Bloody diarrhea, hemorrhagic colitis → Life-threatening systemic complications Real public health problem Tarret al., Lancet, 2005 Pennington, Lancet, 2010 Introduction Abiotic factors Biotic factors Conclusion P HYSIOPATHOLOGY TRANSMISSION VIA CONTAMINATED FOOD AND WATER RESERVOIRS Introduction Abiotic factors Biotic factors Conclusion P HYSIOPATHOLOGY TRANSMISSION VIA CONTAMINATED FOOD AND WATER RESERVOIRS ACID RESISTANCE Introduction Abiotic factors Biotic factors Conclusion P HYSIOPATHOLOGY TRANSMISSION VIA CONTAMINATED FOOD AND WATER RESERVOIRS ACID RESISTANCE ATTACHMENT AND EFFACEMENT LESIONS INTIMIN SHIGA TOXINS WATERY DIARRHEA BLOODY DIARRHEA Introduction Abiotic factors Biotic facMAtPoKrs Conclusion P HYSIOPATHOLOGY IL8 TRANSMISSION VIA CONTAMINATED FOOD AND WATER Etienne-Mesmin et al., PLoSOne, 2011 Schüller, Toxins, 2011 CROSS THE INTESTINAL BARRIER RESERVOIRS M cell Macrophage T Lymphocyte ACID RESISTANCE PEYER’S PATCHES B Lymphocyte ATTACHMENT AND BLOODSTREAM EFFACEMENT LESIONS INTIMIN SHIGA TOXINS WATERY DIARRHEA BLOODY DIARRHEA Introduction Abiotic factors Biotic factors Conclusion P HYSIOPATHOLOGY TRANSMISSION VIA CONTAMINATED HEMOLYTIC UREMIC FOOD AND WATER SYNDROME (HUS) TROMBOTIC RESERVOIRS TROMBOCYTOPENIC PURPURA (PTT) KIDNEY ACID RESISTANCE BRAIN ATTACHMENT AND BLOODSTREAM EFFACEMENT LESIONS INTIMIN SHIGA TOXINS WATERY DIARRHEA BLOODY DIARRHEA
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