Immunology of Milk and the Neonate PDF
Preview Immunology of Milk and the Neonate
IMMUNOLOGY OF MILK AND THE NEONATE ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 304 REGULATION OF SMOOTH MUSCLE CONTRACTION Edited by Robert S. Moreland Volume 305 CHEMOTACTIC CYTOKINES: Biology of the Inflammatory Peptide Supergene Family Edited by J. Westwick, I. J. D. Lindley, and S. L. Kunkel Volume 306 STRUCTURE AND FUNCTION OF THE ASPARTIC PROTEINASES: Genetics, Structures, and Mechanisms Edited by Ben M. Dunn Volume 307 RED BLOOD CELL AGING Edited by Mauro Magnani and Antonio De Flora Volume 308 CELLULAR AND MOLECULAR MECHANISMS IN HYPERTENSION Edited by Robert H. Cox Volume 309A PURINE AND PYRIMIDINE METABOLISM IN MAN VII, Part A: Chemotherapy, ATP Depletion, and Gout Edited by R. Angus Harkness, Gertrude B. Elion, and Nepomuk Zollner Volume 309B PURINE AND PYRIMIDINE METABOLISM IN MAN VII, Part B: Structural Biochemistry, Pathogenesis, and Metabolism Edited by R. Angus Harkness, Gertrude B. Elion, and Nepomuk Zollner Volume 310 IMMUNOLOGY OF MILK AND THE NEONATE Edited by Iiri Mestecky, Claudia Blair, and Pearay L. Ogra A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. IMMUNOLOGY OF MILKANDTHE NEONATE Edited by Jiri Mestecky University of Alabama at Birmingham Birmingham, Aiabama Claudia Blair National Institutes of Health Bethesda, Maryland and Pearay L. Ogra University of Texas Galveston, Texas SPRINGER SCIENCE+BUSINESS MEDIA, LLC Llbrary of Congress Cataloglng-ln-Publlcatlon Oata Symposium on Immunology of Milk and the Neonate (1990 : Mlaml, Fla.) Immunology of milk and the neonate / edited by Jiri Mestecky, Claudla Blalr, and Pearay L. Ogra. p. cm. -- (Advances In experimental mediclne and blology ; v. 310) "Proceedlngs of a Symposium on Immunology of Milk and the Neonate, held October 14-17, 1990, In Mini, Florlda"--T.p. verso. Includes blbllographical references and index. ISBN 976-1-4613-6713-0 ISBN 978-1-4615-3836-7 (eBook) 0011010071978-1-4615-3836-7 1. Infants--Nutrltlon--Immunologlcal aspects--Congresses. 2. Breast feed I ng--Immuno 1o g I ca 1 aspe"cts--Congresses. 3. Immunologlc diseases In chlldren--Nutrltlonal aspects- -Congresses. I. Mestecky, Jlri, 1941- 11. Blalr, Claudla. 111. Ogra, Pearay L. ~V. Tltle. V. Serles. [ONLM: 1. Breast feedlng--congresses. 2. Infant, Newborn -congresses. 3. Milk, Human--Immunology--congresses. Wl A0559 v. 310 I WS 125 598931] RJ216.S945 1990 616.92·0079--dc20 ONLM/OLC for Llbrary of Congress 91-39674 CIP Proceedings of a symposium on Immunology of Milk and the Neonate, held October 14-17, 1990, in Miami, Florida ISBN 978-1-4613-6713-0 © 1991 by Springer Science+Business Media New York Originally published by Plenum Press New York in 1991 Softcover reprint of the hardcover 1s t edition 1991 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher PREFACE In the course of history, humans have attempted to interrupt the physiological and psychological bond formed between a nursing mother and her child by substituting breastfeeding with artificial formulas. A growing body of evidence indicates that breast milk, quite apart from its unsurpassed nutritive value, contains a large number of substances that protect the offspring from common infectious agents and allergens and promote the maturation of the gastrointestinal tract and the immune system. In addition to well described milk antibodies and soluble mediators of innate immunity, milk cells and pluripotent secreted factors - cytokines - are currently in the forefront of extensive research with respect to their importance in milk immunology. The purpose of this conference was to critically evaluate the current state of our knowledge concerning the protective role of immune agents found in milk, to provide up-to-date information of milk factors with respect to their role in the maturation of immunological defense systems in the neonate, and to reassess the importance of breastfeeding in the prevention of allergies in formula-fed infants. We hope that the work presented by international participants will prompt many new ideas and stimulate further research in this important area. This conference was sponsored primarily by the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. We would like to thank Drs. Sumner Yaffe and Delbert Dayton for their efforts with the organization, planning, and support of this conference. Furthermore, we would like to acknowledge the Carnation Cooperation, Procter & Gamble, Bristol-Myers, Ross Laboratories, and Stolle Milk Biologics for their financial support. We would like to thank Ms. Arline Sanchez for her competent attention to many of the details that made it possible to bring this group of researchers together. The organization of this meeting and publication of this book would not have been possible without the expert skills and dedication of Ms. Maria Bethune. J. Mestecky C. Blair P.L.Ogra v CONTENTS SESSION I: BREASTFEEDING AND MATERNAL-NEONATAL INTERACTIONS. EPIDEMIOLOGICAL ASPECTS OF BREASTFEEDING CHARACTERISTICS OF HUMAN MILK ANTIBODIES AND THEIR EFFECT IN RELATION TO THE EPIDEMIOLOGY OF BREASTFEEDING AND INFECTIONS IN A DEVELOPING COUNTRy........................................................ 1 L. A. Hanson, F. Jalil, R Ashraf, S. Bernini, B. Carlsson, J. R Cruz, T. Gonzalez, M. Hahn-Zoric, L. Mellander, Y. Minoli, G. Moro, F. Nave, S. Zaman, 1. Mata, J. Karlberg, and B. S. Lindblad T CELL DEVELOPMENT IN THE FETUS AND NEONATE. . . . . . . . . . . . 17 C. B. Wilson, D. B. Lewis and B. K. English GROWTH FACTORS AND THE DEVELOPMENT OF NEONATAL HOST DEFENSE. . . . . . .. . . . . . .... . . . . .. . . . . . . . . . . . . . . . 31 J. E. Bines and W. A. Walker SESSION II: DEVELOPMENT OF THE NEONATAL IMMUNE SYSTEM AMNIOTIC FLIDD: THE FIRST FEEDING OF MUCOSAL IMMUNEFACTORS...................... ........................ 41 M. G. Cleveland, M. A. Bakos, S. M. Hilton and R M. Goldblum ONTOGENY OF THE SECRETORY IgA SYSTEM IN IIDMANS........................................................ 51 I. Moro, I. Saito, M. Asano, T. Takahashi and T. Iwase IgA-SECRETING CELLS IN THE BLOOD OF PREMATURE AND TERM INFANTS: NORMAL DEVELOPMENT AND EFFECT OF INTRAUTERINE INFECTIONS. . . . . . . . . . . . . . . . . . . . 59 A. Nahmias, B. Stoll, E. Hale, C. lbegbu, H. Keyserling, W. Innis Whitehouse, R Holmes, T. Spira, C. Czerkinsky and F. Lee DEVELOPMENT OF T CELLS WITH MEMORY PHENOTYPE ININFANCY ..................................................... 71 A. R Hayward and J. Groothuis THE EFFECT OF HUMAN MILK, PROTEIN-FORTIFIED HUMAN MILK AND FORMULA ON IMMUNOLOGIC FACTORS OF NEWBORN INFANTS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 D. Kokinopoulos, S. Photopoulos, N. Varvarigou, L. Kafegidakis and M. Xanthou vii ONTOGENY OF THE MUCOSAL IMMUNE RESPONSE IN CHILDREN. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 A. W. Cripps, M. Gleeson and R L. Clancy SESSION III: FUNCTION OF CYfOKINES IN THE DEVELOPMENT OF THE IMMUNE SYSTEM ARE CYTOKINES IN HUMAN MILK? .............................. 93 A. S. Goldman, H. E. Rudloff and F. C. Schmalstieg THE DEVELOPING GASTROINTESTINAL TRACT AND MILK- BORNE EPIDERMAL GROWTH FACTOR .......................... 99 O. Koldovsky, J. Britton, D. Davis, T. Davis, J. Grimes, W. Kong, R. Rao and P. Schaudies GROWTH FACTOR SIGNAL TRANSDUCTION IN HUMAN INTESTINAL CELLS ...................................... 107 S. W. Chu and W. A. Walker ROLE OF IL-6 IN HUMAN ANTIGEN-SPECIFIC AND POLYCLONAL IgA RESPONSES. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 113 J. R. McGhee, K. Fujihashi, C. Lue, K. W. Beagley, J. Mestecky and H. Kiyono IMMUNOLOGICAL PROPERTIES AND DIFFERENTIATION POTENTIAL OF HUMAN COLOSTRAL LYMPHOCYTES OF B CELL LINEAGE .................................................. 123 J. Mestecky, Z. Moldoveanu, S. J. Prince, W. H. Kutteh, R. Kulhavy, J. R. McGhee, I. Moro and S. S. Crago SESSION IV: INNATE IMMUNE FACfORS THE EFFECTS OF COLOSTRUM ON NEUTROPHIL FUNCTION: DECREASED DEFORMABILITY WITH INCREASED CYTOSKELETON-ASSOCIATED ACTIN. . . . . . . .. ................... 131 E. S. Buescher PEROXIDASES IN HUMAN MILK . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 137 K. M. Pruitt, F. Rahemtulla, B. Mcinsson-Rahemtulla, D. C. Baldone and G. T. Laven LACTOFERRIN BINDING TO ITS INTESTINAL RECEPTOR. . . . . . . . .. 145 B. Lonnerdal FREE FATTY ACIDS AND MONOGLYCERIDES: ANTI-INFECTIVE AGENTS PRODUCED DURING THE DIGESTION OF MILK FAT BY THE NEWBORN. .................................................. 151 M. Hamosh viii THE ROLE OF MILK-DERIVED ANTIMICROBIAL LIPIDS AS ANTIVIRAL AND ANTIBACTERIAL AGENTS. . . . . . . . . . . . . . . . . . . . 159 C. E. Isaacs and H. Thormar ANTI-ADHESIVE MOLECULES IN HUMAN MILK . . . . . . . . . . . . . . . . .. 167 C. Svanborg, G. Aniansson, J. Mestecky, H. Sabharwal and A. Wold THE EFFECT OF HUMAN MILK ON THE ADHERENCE OF ENTEROHEMORRHAGIC E. cau TO RABBIT INTESTINAL CELLS ............................................................ 173 S. Ashkenazi, D. S. Newberg and T. G Cleary SESSION V: SPEOFIC IMMUNE FAcrORS IDENTIFICATION AND USE OF PROTECTIVE MONOCLONAL IgA ANTIBODIES AGAINST VIRAL AND BACTERIAL PATHOGENS ..................................................... 179 M. Neutra, R Weltzin, L. Winner, J. Mack, P. Michetti, L. Morrison, B. N. Fields, J. J. Mekalanos and J.-P. Kraehenbiihl PRODUCTION AND USE OF MONOCLONAL IgA ANTIBODIES COMPLEXED WITH RECOMBINANT SECRETORY COMPONENT FOR PASSIVE MUCOSAL PROTECTION. . . . . . . . . . . . . . . . . . . . . . . . . . .. 183 P. Michetti, R Hirt, R Weltzin, N. Fasel, E. Schaerer, M. R. Neutra and J.-P. Kraehenbiihl EPITHELIAL TRANSPORT OF IgA IMMUNE COMPLEXES ........... 187 M. E. Lamm, J. K. Robinson, C. K. Rao, J.-P. Vaerman and C. S. Kaetzel ASSOCIATION OF HUMAN MILK SIgA ANTIBODIES WITH MATERNAL INTESTINAL EXPOSURE TO MICROBIAL ANTIGENS ....................................................... 193 J. Cruz, F. Cano and P. Caceres SERUM AND BREAST MILK ANTIBODIES TO FOOD ANTIGENS IN AFRICAN MOTHERS AND RELATION TO THEIR DIET. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. .............. 201 F. Mascart-Lemone, P. Donnen, B. Paluku, D. Brasseur, J. Van den Broeck, J.-P. Vaermall, P. Hennart and J. Duchateau MODULATION OF THE IMMUNE RESPONSE BY MATERNAL ANTIBODY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 207 M.A. Keller, C. J. Palmer, M. T. Jelonek, C. H. Song, A. Miller, E. E. Sercarz, G. B. Calandra and J. L. Brust MATERNAL DETERMINANTS OF NEONATAL IMMUNE RESPONSE: EFFECT OF ANTI-IDIOTYPE IN THE NEONATE. . . . . . . .. 215 Y. Okamoto ix IMMUNOGLOBULIN G SUBCLASSES IN HUMAN COLOSTRUM AND MILK . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 223 P. D. Mehta, C. E. Isaacs and P. K. Coyle SECRETORY DEFENSES AGAINST GIARDIA LAMBLIA. ............. 227 F. D. Gillin, R W. Cooper, D. S. Reiner and S. Das SESSION VI: ANTIVIRAL IMMUNITY EPIDEMIOLOGICAL PERSPECTIVE OF BREASTFEEDING AND ACUTE RESPIRATORY ILLNESSES IN INFANTS .................... 235 W. P. Glezen SEROTYPES OF ROTAVIRUS THAT INFECT INFANTS SYMPTOMATICALLY AND ASYMPTOMATICALLY ................. 241 L. K. Pickering and M. O'Ryan IMMUNE RESPONSE TO ROTAV IRUS VACCINES AMONG BREAST-FED AND NONBREAST-FED CHILDREN. . . . . . . . . . . . . . . . .. 249 R I. Glass, D. J. lng, B. J. Stoll and R T. Ing RECENT ADVANCES IN DEVELOPMENT OF A ROTAV IRUS VACCINE FOR PREVENTION OF SEVERE DIARRHEAL ILLNESS OF INFANTS AND YOUNG CHIULDREN .................. 255 A. Z. Kapikian, J. Flores, T. Vesikari, T. Ruuska, H. P. Madore, K. Y. Green, M. Gorziglia, Y. Hoshino, R. M. Chanock, K. Midthun and I. Perez-Schael ROTAV IRUS SPECIFIC BREAST MILK ANTmODY IN TWO POPULATIONS AND POSSmLE CORRELATES OF PROTECTION .................................................. 265 G. A. Losonsky and H. D. de Rimer HUMAN MILK AND HIV INFECTION: EPIDERMIOLOGIC AND LABORATORY DATA ........................................ 271 M. K. Davis CHARACTERIZATION OF A HUMAN MILK FACTOR THAT INHIBITS BINDING OF HIV GP120 TO ITS CD4 RECEPTOR. . . . . . . . .. . 281 D. S. Newburg and R H. Yolken BREAST MILK TRANSMISSION OF CYTOMEGALOVIRUS (CMV) INFECTION. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 293 C. Alford ANTmODY RESPONSES TO CYTOMEGALOVIRUS IN SERUM AND MILK OF NEWLY DELIVERED MOTHERS. . . . . . . . . . . . . . . . . . . .. 301 P. Juto and S. Holm x PROTECTION OF NEONATAL MICE FROM FATAL REOVIRUS INFECTION BY IMMUNE SERUM AND GUT DERIVED LYMPHOCYTES. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 307 C. F. Cuff, C. K. Cebra, E. Lavi, E. H. Molowitz, D. H. Rubin and J. J. Cebra PASSIVE IMMUNE PROTECTION FROM DIARRHEA CAUSED BY ROTAV IRUS OR E. COLI: AN ANIMAL MODEL TO DEMONSTRATE AND QUANTITATE EFFICACY .................... 317 C. T. Cordle, J. P. Schaller,T. R. Winship, E. L. Candler, M. D. Hilty, K. L. Smith, L. J. Saif, E. M. Kohler and S. Krakowka SESSION VII: ANTIBACTERIAL IMMUNITY THE ANTIBODY RESPONSE IN INFANTS AFTER COLONIZATION OF THE INTESTINE WITH E. COLI 083. ARTIFICIAL COLONIZATION USED AS A PREVENTION AGAINST NOSOCOMIAL INFECTIONS.. . .. . .. . .. . .. . .. . .. . .. . .. . . .. .. . . . . ... 329 R. Lodinova-Zadnikova, H. Tlaskalova and Z. Bartakova ANTIBODIES TO STREPTOCOCCI PNEUMONIAE IN SERA AND SECRETIONS OF MOTHERS AND THEIR INFANTS. . . . . . . . . .. 337 B. M. Gray, R. B. Polhill, Jr. and D. W. Reynolds THE POTENTIAL IMPACT OF GROUP B STREPTOCOCCAL ANTIBODIES IN BREAST MILK .................................... 345 L. E. Weisman and F. M. Dobson IgA PROTEASES OF HEMOPHILUS INFLUENZAE DIVIDING IN HUMAN MILK ARE INHIBITED BY IgA1 ANTIBODY IN THE MILK. ........................................................ 353 A. G. Plaut, J. Qiu, F. J. Grundy and A. Wright BOVINE LACTOGENIC IMMUNITY AGAINST PEDIATRIC ENTEROPATHOGENS ............................................. 361 M. Boesman-Finkelstein and R. A. Finkelstein MILK SECRETORY IgA RELATED TO SHIGELLA VIRULENCE ANTIGENS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 369 T. G. Cleary, K. Hyani, D. K. Winsor and G. Ruiz-Palacios CORTISONE STRENGTHENS THE INTESTINAL MUCOSAL BARRIER IN A RODENT NECROTIZING ENTEROCOLITIS MODEL ........................................................... 375 E. J. Israel, E. J. Schiffrin, E. A. Carter, E. Frieberg and W. A. Walker THE RELEVANCE OF IMMUNOGLOBULIN IN THE PREVENTION OF NECROTIZING ENTEROCOLITIS. ................. 381 H. M. Wolf and M. M. Eibl xi
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