Table Of Content

Contents VOLUME 82, ISSUE 1, FEBRUARY 2004 Review Articles Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis? LK Stamp, MJ James and LG Cleland Alternative routes of mucosal immunization in large animals BJ Sedgmen, ELT Meeusen and SA Lofthouse Research Articles Neuronal antigens modulate the immune response associated with experimental autoimmune encephalomyelitis AL Degano, Y Ditamo and GA Roth Differences in nocturnal basal and rhythmic prolactin secretion in untreated compared to treated HIV-infected men are associated with CD4+ T-lymphocytes A Parra, G Reves-Teran, J Ramirez-Peredo, B Jacquemin, V Quiroz, M Cardenas, MC Garcia-Sancho and F Larrea Decreased apoptosis of f.- integrin-deficient bovine neutrophils H Nagahata, H Higuchi, H Teraoka, K Takahashi, O Inanami and M Kuwabara Lack of CD28 expression on HIV-specific cytotoxic T lymphocytes is associated with disease progression J Gamberg, I Pardoe, MI Bowmer, C Howley and M Grant 38 Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2 M Fogel-Petrovic, JA Long, DA Knight, PJ Thompson and JW Upham Special Features: T-Cell Activation Modelling the impact of antigen kinetics on T-cell activation and response DL Chao, MP Davenport, S Forrest and AS Perelson On the dynamics of T-cell activation in lymph nodes M Hommel Automatic generation of lymphocyte heterogeneity: Division-dependent changes in the expression of CD27, CCR7 and CD45 by activated human naive CD4 T cells are independently regulated CS Ma, PD Hodgkin and SG Tangye Profiling the CD8™ phenotype, an alternative career choice for CD8 T cells during primary differentiation N Kienzle, A Baz and A Kelso Helper T cells, dendritic cells and CTL Immunity G Behrens, M Li, CM Smith, GT Belz, J Mintern, FR Carbone, and WR Heath Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm NS Wilson and JA Villadangos Book Reviews Corrigendum VOLUME 82, ISSUE 2, APRIL 2004 Research Articles CD4° T cells cross-compete for MHC class II-restricted peptide antigen complexes on the surface of antigen presenting cells JD Hayball, BWS Robinson and RA Lake 103 Type I interferon genes from the egg-laying mammal, Jachyglossus aculeatus (short-beaked echidna) GA Harrison, KA Mclnol and EM Deane Type I IFN-B gene therapy suppresses cardiac CD8° T-cell infiltration during autoimmune myocarditis EJ Bartlett, JC Lenzo, S Sivamoorthy, JP Mansfield, VS Cull and CM James Theoretical Article Some scaling principles for the immune system FW Wiegel and AS Perelson Contents Brief Communications CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection GJ Logan, A Spinoulas, SI Alexander, JA Smythe and IE Alexander Special Features: Fenner Conference 2003 — Adventures in Immunology and Microbiology Memories of virus-specific CD8* T cells PC Doherty and SJ Turner Living with the ups and downs of the two signal model P Bretscher From immune system to health systems — Challenges for health research T Pang Gene expression signatures in lymphoid tumours UR Kees Granzymes in cytolytic lymphocytes — to kill a killer? M Regner and A Miillbacher Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice Y Wang, M Lobigs, E Lee and A Miillbacher Routes of inoculation and the immune response to a resolving genital flavivirus infection in a novel murine model SA Burke, L Wen and NJC King Evidence that a mechanism for efficient flavivirus budding upregulates MHC class I GM Lobigs, A Miillbacher and E Lee Ovine atadenovirus: a review of its biology, biosafety profile and application as a gene delivery vector GW Both Innate versus adaptive immunity in Candida albicans infection RB Ashman, CS Farah, S Wanasaengsakul, Y Hu, G Pang and RL Clancy The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes RV Blanden, A Franklin and EJ Steele Genesis oft he strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes EJ Steele, A Franklin and RV Blanden Human DNA polymerase-n, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase A Franklin, PJ Milburn, RV Blanden and EJ Steele Book Reviews Important Announcement Corrigendum Abstracts Abstracts from the 22nd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand VOLUME 82, ISSUE 3, JUNE 2004 Research Articles Proinflammatory effects of copper deficiency on neutrophils and lung endothelial cells D Lominadze, JT Saari, SS Percival and DA Schuschke Rapid downregulation of antigen processing enzymes in ex vivo generated human monocyte derived dendritic cells occur endogenously in extended cultures RK Ishri, S Menzies, P Hersey and GM Halliday Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies S P Berzins, K Kyparissoudis, DG Pellicci, K Hammond, S Sidobre, A Baxter, MJ Smyth, M Kronenberg and DI Godfrey Contents Brief Communication Normal levels of immunocompetence in possums (7richosurus vulpecula) exposed to different laboratory housing conditions post capture D Begg, R Kemp and F Griffin A web application to manage a database for liquid nitrogen tanks C Picard and D Picard Special Feature: T Cell Activation T cell activation: in vivo veritas B Fazekas De St. Groth, AL Smith and CA Higgins Special Feature: NKT Cells Parallels and distinctions between T and NKT cell development in the thymus SP Berzins, AP Uldrich, DG Pellicci, F Mcnab, Y Hayakawa, MJ Smyth and DI Godfrey Genetic control of NKT cell numbers MA Jordan, J Fletcher and AG Baxter Antigen specificity of semi-invariant CD1d-restricted T cell receptors: the best of both worlds? JE Gumperz The Third Way: progress on pathways of antigen processing and presentation by CD1 AP Lawton and M Kronenberg CD 1d-restricted T-cell subsets and dendritic cell function in autoimmunity PL Bollyvky and SB Wilson Natural killer T cells as targets for immunotherapy of autoimmune diseases L Van Kaer Regulation of antitumour immunity by CD1d-restricted NKT cells J Swann, NY Crowe, Y Havakawa, DI Godfrey and MJ Smyth NKT cells and viral immunity SLH Van Dommelen and Mariapia A Degli-Esposti Corrigendum VOLUME 82, ISSUE 4, AUGUST 2004 Burnet Oration On ‘reactivity’ versus ‘tolerance’ RM Zinkernagel Review Article Prostanoids and their receptors that modulate dendritic cell-mediated immunity N Gualde and H Harizi Research Articles Investigation of the immunocompetent cells that bind early pregnancy factor and preliminary studies of the early pregnancy factor target molecule S Athanasas-Platsis, MJ Somodevilla-Torres, H Morton and AC Cavanagh Changes in the immune functions and susceptibility to Listeria monocytogenes infection in mice fed dietary lipids MA Puertollano, E Puertollano, A Ruiz-Bravo, M Jiménez-Valera, MA De Pablo and GA De Cienfuegos Mycobacterium tuberculosis induces high production of nitric oxide in coordination with production of tumour necrosis factor-a in patients with fresh active tuberculosis but not in MDR tuberculosis S Sharma, M Sharma, S Roy, P Kumar and M Bose Pseudomonas aeruginosa-induced production of free radicals by IFN-y plus TNF-a activated human endothelial cells: mechanism of host defense or of bacterial pathogenesis? M-C De Assis, AM Saliba, LA Vidipo, JB. De Salles and M-C Plotkowski Germline transcription of multiple 7CR-VB genes in cloned T-cell lines JL Abbey and HC O'Neill Contents Bioassay detects soluble MAdCAM-1 in body fluids E Leung, KB Lehnert, JR Kanwar, Y Yang, Y Mon, HP McNeil and GW Krissansen Double-stranded RNA enhances the expression of galectin-9 in vascular endothelial cells A Ishikawa, T Imaizumi, H Yoshida, N Nishi, T Nakamura, M Hirashima and K Satoh Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons M De Martinis, M Modesti and L Ginaldi Effect of IL-12 and soluble IL-4 receptor on the herpesvirus infection in human SCID chimeras whose Th2 cells predominate T Katakura, M Kobayashi, DN Herndon and F Suzuki An arthritogenic monoclonal antibody to type II collagen, CII-C1, impairs cartilage formation by cultured chondrocytes SF Amirahmadi, MH Pho, RE Gray, DE Crombie, SF Whittingham, BB Zuasti, M-P Van Damme and MJ Rowley The CD11/CD18 (B,) integrins modulate neutrophil caspase activation and survival following TNF-a or endotoxin induced transendothelial migration SR Yan, K Sapru and AC Issekutz Theoretical Article Evaluation of immunotherapy to reverse sequestration in the treatment of severe Plasmodium falciparum malaria JP Dean Goldring Book Reviews VOLUME 82, ISSUE 5, OCTOBER 2004 Research Articles Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation TJ Stewart, GJP Fernando, IH Frazer and GR Leggatt The multidrug resistance gene mdr/a influences resistance to ectromelia virus infection by mechanisms other than conventional immunity D Xu, M Regner, D Smith, J Ruby, R Johnstone and A Miillbacher ‘Proliferative’ and ‘synthetic’ airway smooth muscle cells are overlapping populations MB Sukkar, AJ Stanley, AE Blake, PD Hodgkin, PRA Johnson, CL Armour and JM Hughes Interaction of soluble CD163 with activated T lymphocytes involves its association with non-muscle myosin heavy chain type A M Timmermann, F Buck, C Sorg and P Hégger Special Feature: Immunological Adjuvants Vaccine adjuvants: Current state and future trends N Petrovsky and JC Aguilar Aluminium compounds for use in vaccines EB Lindblad Vaccines that facilitate antigen entry into dendritic cells A Gamvrellis, D Leong, JC Hanley, SD Xiang, P Mottram and M Plebanski Increased adjuvant activity of minimal CD8 T cell peptides incorporated into lipid-core-peptides K White, P Kearns, I Toth and S Hook Immunostimulatory CpG motifs induce CTL responses to HIV type I oligomeric gp140 envelope protein \. Rao, GR Matyas, TC Vancott, DL Birx and CR Alving Liposome-stabilized oil-in-water emulsions as adjuvants: Increased emulsion stability promotes induction of cytotoxic T lymphocytes against an HIV envelope antigen RL Richards, M Rao, TC Vancott, GR Matyas, DL Birx and CR Alving Development of a nasal vaccine for chronic hepatitis B infection that uses the ability of hepatitis B core antigen to stimulate a strong Th! response against hepatitis B surface antigen JC Aguilar, Y Lobaina, V Muzio, D Garcia, E Penton, E Iglesias, D Pichardo, D Urquiza, D Rodriguez, D Silva, N Petrovsky and G Guillén Effect of incorporation of the adjuvant Quil A on structure and immune stimulatory capacity of liposomes PH Demana, C Fehske, K White, T Rades and S Hook Book Review Contents VOLUME 82, ISSUE 6, DECEMBER 2004 Review Article On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes A Franklin and RV Blanden Research Articles Effect of retinoic acid in experimental diabetic nephropathy S-¥ Han, G-A So, Y-H Jee, K-H Han, Y-S Kang, H-K Kim, S-W Kang, D-S Han, J-Y Han and D-R Cha Human growth hormone presented by K14hGH-transgenic skin grafts induces a strong immune response but no graft rejection J Zhong, K Matsumoto, R De Kluvver, GJP Fernando, GR Leggatt and 1H Frazer Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses C Ortega, P Romero, A Palma, T Orta, J Petia, A Garcia-Vinuesa, lJ Molina and M Santamaria Special Feature: Immunological Adjuvants Shaping of adaptive immune responses to soluble proteins by TLR agonists: A role for IFN-a/f V Durand, SYC Wong, DF Tough and A Le Bon Novel adjuvant based on a proteoliposome-derived cochleate structure containing native lipopolysaccharide as a pathogen-associated molecular pattern O Pérez, G Bracho, M Lastre, N Mora, J del Campo, D Gil, C Zavas, R Acevedo, D Gonzalez, JA Lopez, C Taboada and RL Solis Inulin-derived adjuvants efficiently promote both Th! and Th2 immune responses DG Silva, PD Cooper and N Petrovsky Mucosal adjuvants and delivery systems for protein-, DNA- and RNA-based vaccines M Vajdy, I Srivastava, J Polo, J Donnelly, D O'Hagan and M Singh Adjuvant synergy: The effects of nasal coadministration of adjuvants SA Moschos, VW Bramwell, S Somavarapu and HO Alpar Cytokines as adjuvants for avian vaccines M Asif. KA Jenkins, LS Hilton, WG Kimpton, AGD Bean and JW Lowenthal Challenges facing adjuvants for cancer immunotherapy C Mesa and LE Fernandez Book Reviews Corrigendum