Immunological and Clinical Aspects of Multiple Sclerosis: The Proceedings of the XXV Anniversary Symposium of the Belgian Research Group for Multiple Sclerosis

505 Pages·1983·13.23 MB·English

by  E. Hooghe-Peters

Immunological and Clinical Aspects
of Multiple Sclerosis
Published in cooperation with
ARS MEDICI
International Journal for Practical Therapy
Medical Media International
Avenue A. van Beceleare 28B
1070 Brussels
Belgium
Editor-in-chief J. de Castro MD
Immunological and
Clinical Aspects of
Multiple Sclerosis
The Proceedings of the XXV Anniversary
Symposium of the Belgian Research Group for
Multiple Sclerosis
Edited by
R. E. Gonsette and
P. Delmotte
PRESS LIMITED
-"'~ MTP
.. a member of the KLUWER ACADEMIC PUBLISHERS GROUP
LANCASTER / BOSTON / THE HAGUE / DORDRECHT
Published in the UK and Europe by
MTP Press Limited
Falcon House
Lancaster, England
British Library Cataloguing in Publication Data
Immunological and clinical aspects of multiple sclerosis.
1. MUltiple sclerosis
I. Delmotte, P. II. Gonsette, R.E.
III. Belgian Research Group for Multiple Sclerosis
616.8' 34 RC377
lSBN-13: 978-94-011-6354-5 e-ISBN-13: 978-94-011-6352-1
001: 10.1007/978-94-011-6352-1
Published in the USA by
MTP Press
A division of Kluwer Boston Inc
190 Old Derby Street
Hingham, MA 02043, USA
Copyright © 1984 MTP Press Limited
Softcover reprint of the hardcover 1s t edition 1984
All rights reserved. No part of this publication may be reproduced, stored in a
retrieval system, or transmitted in any form or by any means, electronic,
mechanical, photocopying, recording or otherwise, without prior permission from
the publishers.
Typeset by Georgia Origination, Liverpool
Printed by McCorquodale (Scotland) Ltd.
Contents
List of Participants xiv
Foreword xxv
Section I Immunological Aspects of Multiple Sclerosis: Basic
Observations
Auto-immunity 3
E. L. Hooghe-Peters and R. J. Hooghe
2 Occurrence of an internal image of measles haemagglutinin in
an anti-idiotype immune response 7
J. Gheuens and A. Lowenthal
3 Studies on the intrathecal humoral immunity in multiple
sclerosis 10
C. J. M. Sindic, M. P. Chalon, C. L. Cambiaso, E. C. Lattere
and P. L. Masson
4 Antibody to viral antigens in multiple sclerosis demonstrated
by ELISA method 15
M. Clanet, J. Puel, F. Brette, M. Abbal, A. Blancher and
A. Rascol
5 Cerebrospinal fluid antibodies detect brain antigens 16
A. A. Vandenbark, F. Van Rompaey, D. Nijst, H. Hey/igen and
J. Raus
6 Immune complexes and the complement factors C4 and C3 in
cerebrospinal fluid and serum from patients with mUltiple
sclerosis 20
A. Heltberg, H. Jans, I. Zeeberg, J. Halkjaer Kristensen,
N. E. Raun and T. Fog
7 Characterization of circulating immunocomplexes in multiple
sclerosis 23
J. Clausen and M. Unger
CONTENTS
8 Immunoelectrophoretic characterization of immune com-
plexes from CSF of multiple sclerosis patients 24
I. R. Pedersen and I. Zeeberg
9 Neurosurgery in the rehabilitation of hyperspasmodic and
painful paraplegia in multiple sclerosis. Functional results in
selective posterior rhizotomy 28
M. F. Millet, C. Beneton, M. Sindou, M. Eyssette and
D. Boisson
10 Immunological aspects of multiple sclerosis 29
J. Mertin
11 Myelin basic protein and its antibodies in the cerebrospinal
fluid in experimental allergic encephalopyelitis, multiple
sclerosis and other diseases 39
E. C. Alvord Jr, S. Hruby, C. M. Shaw and J. Slimp
12 Identification of myelin basic protein (MBP) as an antigenic
component of circulating immune complexes (CIC) in MS
patients 40
M. K. Dasgupta, T. A. McPherson, I. Catz, K. G. Warren and
J. B. Dossetor
13 Sensitization of cerebrospinal fluid and peripheral blood
lymphocytes to brain glycolipids in mUltiple sclerosis 47
A. Czlvnkowska and Z. Rzepecki
14 Interferon production and natural killer (NK) activity in
mUltiple sclerosis 55
G. Vervliet, H. Claeys, H. Van Haver, H. Carton, C. Vermylen
and A. Billiau
15 a-Albumin in cerebrospinal fluid of patients with mUltiple
sclerosis and other neurological diseases - comparison with
other brain specific proteins 59
R. Crols, M. Noppe and A. Lowenthal
16 The Transferrin-Tau ratio of the CSF 63
B. Tavolato, P. Gallo and C. De Zanche
17 Auto-antibodies to brain specific proteins 70
M. Noppe, J. MeIse, R. Crols, J. Gheuens and A. Lowenthal
18 The effect of monoclonal anti-T cell antibodies on the clinical
course of experimental allergic encephalomyelitis in rats 72
C. J. J. Brinkman, H. J. ter Laak and O. R. Hommes
19 Changes of polymorphonuclear neutral proteinase activity in
multiple sclerosis patients before and after plasma exchanges 75
B. M. Guarnieri, L. Amaducci, F. Cambi, R. Capparelli,
C. Arfaioli, G. Avanzi and C. Franco
vi
CONTENTS
20 Acid phosphatase activity of cerebrospinal fluid cells in
multiple sclerosis and related neurological disorders 83
J de Reuck, W. de Coster and H. Vander Eecken
21 Influence of human allergic encephalitogenic peptide on
platelet aggregation in multiple sclerosis 88
M. Prosiegel and I. S. Neu
22 The effect of dietary supplementation of enriched marine oil
on serum levels of w-3 and w-6 polyunsaturated fatty acids in
multiple sclerosis 91
M. Rosnowska and W. Cendrowski
Section II Treatment of the Disease
23 Immunological treatments in multiple sclerosis 101
O.R. Hommes
24 Multiple sclerosis incidence material data used in the design
of clinical trials 110
O. Andersen
25 Long-term treatment with azathioprine in mUltiple sclerosis
patients 11 9
K. Lauer, W. Firnhaber and D. John
26 Long-term immunotherapy in MS 125
E. C. Laterre, H. Heulle and C. J M. Sindic
27 Immunosuppression with cyclophosphamide in mUltiple
sclerosis 126
R. E. Gonsette, L. Demonty, Y. de Smet and P. Delmotte
28 Treatment of progressive multiple sclerosis by the combined
application of antilymphocyte serum, azathioprine and
prednisone 135
H. De Saxce, R. Marteau and F. Lhermitte
29 Clinical trials of a synthetic polypeptide (copolymer 1) for the
treatment of mUltiple sclerosis 144
M. B. Bornstein, A. /. Miller, S. Slag/e, V. Spada, R. Arnon,
M. Sela and D. Teitelbaum
30 Lympho-plasmapheresis in multiple sclerosis: effect on
clinical and immunological parameters 151
B. Kennes, C.-P. Leroy, J-P. Dumont, D. Brohee, J Jacquy,
G. Noel and P. Neve
31 Plasmapheresis in multiple sclerosis: cerebrospinal fluid
changes after treatment 157
R. Capparelli, D. Inzitari, D. Sita, B. Guarnieri, L. FratigJioni,
L. Amaducci, G. A vanzi, C. Franco and R. Lombardo
vii
CONTENTS
32 Transfer factor treatment in multiple sclerosis: a 3 year
prospective double-blind study (1982-1985) 161
H. van Haver, F. Lissoir, P. Theys, Chr Droissart, J. van Hees,
P. Ketelaer, H. Carton, K. Gautama, I. Vandeputte and
C. Vermylen
33 Experiences with immunoglobulin-G infusions in the treat-
ment of acute mUltiple sclerosis 166
W. Guenther, I. S. Neu, N. Koenig and U. Rothfelder
34 Dietary supplementation with polyunsaturated fatty acids in
acute remitting multiple sclerosis 176
R. H. Dworkin, D. Bates, J. H. D. Mil/ar, D. W. Paty and
D.A. Shaw
35 Essential fatty acids in the serum and cerebrospinal fluid of
multiple sclerosis patients 184
I. S. Neu
36 The effect of large dose prednisone therapy on intrathecallgG
production in multiple sclerosis 195
M. Wender, A. Wajgt, G. Michalowska and E. Tokarz
37 Changes in T-cell subsets according to the course of MS and
immunosuppressive treatment 202
W. Soukop, E. Sluga, H. Tschabitscher and H. Liska
38 T-Iymphocyte subsets in the CSF in various stages of MS 206
A. Guseo
Section III Spinal Cord Dysfunctions in Multiple Sclerosis
39 Clinical and paraclinical assessment of spinal cord
dysfunction 213
B. Conrad and R. Benecke
40 Functional testing of the spinal cord
P. J. Delwaide 214
41. Increased flexor reflex and spastic contracture in flexion;
mechanisms and management 215
E. Pedersen
42 Tizanidine, a new antispastic agent: 6 years clinical
experience in 152 MS patients 219
R. E Gonsette, Y. De Smet and L. Demonty
43 Objective assessment of the myorelaxant properties of
tizanidine 226
R. Benecke, B. Conrad and K. Lunser
viii
CONTENTS
44 Is electrical stimulation of the spinal cord useful in MS
patients? 227
J. Gybels and D. van Roost
Section IV Monitoring of the Disease
45 A silica gel radioimmunoassay determination of cerebrospinal
fluid myelin basic protein levels of various demyelinating
disease syndromes associated with mUltiple sclerosis 237
K. G. Warren, I. Catz and T. A. McPherson
46 T-Iymphocyte sub populations in patients with MS: a study of
84 cases 240
N. Genetet, B. Pouliot, M. Madigand, O. Sabouraud and
B. Genetet
47 Multiple sclerosis cerebrospinal fluid lymphocytes secretion
in vitro: effect on myelinated cultures 246
J. Jacques Hauw, O. de Brunier, J. M. Boutry, E. Schuller,
E. Roullet, R. Marteau, F. Lhermitte and O. L yon-Caen
48 Isotopic cisternography in multiple sclerosis: possible
correlations with disease course 250
D. Inzitari, R. Capparelli, D. Sita, F. Barontini, P. Marini and
L. Amaducci
49 Management of acute mUltiple sclerosis by a long acting intra-
thecally administered corticosteroid 253
/. S. Neu, N. H. Koenig and W. Guenther
50 Diagnostic value of <X2-macroglobulin crossed immuno-
electrophoresis in multiple sclerosis 257
B. Yordanov, E. Tzvetanova and O. Grigorova
51 The IgG index and the diagnosis of MS: a Bayesian approach 262
H. K. van Walbeek, E. A. H. Hische and H. J. van der Helm
52 Neuro-urological problems in MS: diagnosis and treatment 263
H. van Poppel, P. Ketelaer and R. L. Vereecken
Section V Ophthalmological Aspects of Multiple Sclerosis
53 Central nervous system involvement in clinically pure optic
neuritis (a pilot study in 25 patients) 273
E. A. C. M. Sanders, J. P. H. Reulen and L. A. H. Hogenhuis
54 Prognostic value of CSF IgG in monosymptomatic optic
neuritis. 278
H. /. Schipper, S. Poser, H. Wuzel and W. Behrens-Baumann
ix
CONTENTS
55 Cerebrospinal fluid findings in isolated optic neuritis
compared to multiple sclerosis 282
U. Wurster, U. Patzold and J. Haas
56 Ophthalmological manifestations in multiple sclerosis: a
statistical review of 1728 cases (1180 confirmed cases) 292
S. Bervoets and H. A. De Laet
57 Flight of colours-test in MS and NRB patients 300
J. M. Minderhoud, M. Y. Smits, J. Kuks and G. ter Steege
58 The early diagnostic yield of multi modality evoked potentials:
a 4.8 year prospective study on 171 patients 302
P. Deltenre, C. van Nechel, S. Strul, A. Capon and P. Ketelaer
59 Effect of heating on VER of multiple sclerosis patients
apparently free of optic neuritis 309
M. P. Delplace and J. Guil/aumat
Section VI Free Communications
60 Multiple sclerosis: a case-control study. A preliminary report 319
D. Caputo, P. Ferrante, G. Del Como, M. Zaffaroni and
C. L. Cazzul/o
61 Numerical classification of multiple sclerosis 327
C. M. Poser
62 HLA-determination in twins with multiple sclerosis 333
A. Heltberg
63 Multiple sclerosis and myasthenia gravis 337
A. Herode and S. Borenstein
64 Intellectual impairment in multiple sclerosis 342
L. De Smedt, M. Swerts, J. Geutjens and R. Medaer
65 Multiple sclerosis: a conceptual reappraisal 346
E. J. Field
66 A rarely reported multifocal demyelinating disease:
pancreatic encephalopathy 362
J. M. Brucher, Y. De Smet and R. E. Gonsette
67 Plaques, necrotic myelopathy and Rosenthal fibre reaction:
I glial pathology in MS 363
P. C. Blumbergs and J. F. Hal/pike
68 Comments on MS-compensation in West Germany 364
H. J. Bauer
x