Immunoglobulin Genes PDF
Preview Immunoglobulin Genes
Immunoglobulin Genes Second edition Immunoglobulin Genes Second edition Dedicated to the memory of Georges Kohler Immunoglobulin Genes Second edition Edited by T. Honjo Kyoto University, Japan F. W. AIt Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston ACADEMIC PRESS Harcourt Brace & Company, Publishers L London, San Diego, New York, Boston, Sydney, Tokyo, Toronto ACADEMIC PRESS LIMITED 24-28 Oval Road LONDON NW1 7DX, UK U. S. Edition Published by ACADEMIC PRESS INC. San Diego, CA 92101, USA This book is printed on acid-free paper Copyright (cid:14)9 1995 ACADEMIC PRESS LIMITED All rights reserved B lympohocyte tolerance in the mouse, pages 365-378, and Immunoglobulin variable region gene segments in human autoantibodies, pages 379-396, are US government works in the public domain and not subject to copyright. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical including photocopying, recording, or any information storage and retrieval system without permission in writing from the publisher A catalogue record for this book is available from the British Library ISBN 0 12 053640 4 Typeset by Phoenix Photosetting, Chatham Printed and bound by Hartnolls Ltd, Bodmin, Cornwall Contents Contributors vii Foreword xi Preface to first edition xv Preface to second edition xvii PART I: B CELLS 1 B-cell differentiation in humans P D Burrows, H W Schroeder Jr and M D Cooper 2 The role of B cell and pre-B-cell receptors in development and growth control of the B-lymphocyte cell lineage 33 F Melchcrs 3 The maturation of the antibody response 57 C Milstein and C Rada 4 Development of B-cell subsets 83 S M Wells, A M Stall, A B Kantor and L A Herzenberg 5 Regulation of B-cell differentiation by stromal cells 103 E A Faust, D C Saffran and O N Witte 6 Antigen receptors on B lymphocytes 129 M Reth PART II: ORGANIZATION AND REARRANGEMENT OF IMMUNOGLOBULIN GENES 7 Immunoglobulin heavy chain loci of mouse and human 145 T Honjo and F Matsuda 8 The human immunoglobulin ~= genes 173 H G Zachau 9 Immunoglobulin ~ genes 193 E Selsing and L E Daitch vi Contents 10 The variable region gene assembly mechanism 205 A Okada and F WAlt 11 Regulation of class switch recombination of the immunoglobulin heavy chain genes 235 J Zhang, F Alt and T Honjo 12 Generation of diversity by post-rearrangement diversification mechanisms: the chicken and the sheep antibody repertoires 267 J-C Weill and C-A. Reynaud 13 Immunoglobulin heavy chain genes of rabbit 289 K L Knight and C Tunyaplin 14 The structure and organization of immunoglobulin genes in lower vertebrates 315 J P Rast, M K Anderson and G W Litman PART III" IMMUNOGLOBULIN GENE EXPRESSION 15 Ig gene expression and regulation in Ig transgenic mice 345 U Storb 16 B-lymphocyte tolerance in the mouse 365 D Nemazee 17 Immunoglobulin variable region gene segments in human autoantibodies 379 K N Potter and J D Capra 18 Regulation of immunoglobulin gene transcription 397 K Calame and S Ghosh Index 423 Contributors FW AIt Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA MK Anderson Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street South, St Petersburg, FL 33701-4899, USA PD Burrows Division of Developmental and Clinical Immunology, Departments of Micro- biology, Medicine and Pediatrics, University of Alabama at Birmingham, 263 Wallace Tumor Institute, UAB Station, Birmingham, AL, USA K Calame Columbia University College of Physicians and Surgeons, Department of Microbiology, 701 West 168th Street, New York, NY 10032-2704, USA JD Capra Southwestern Medical School, Department of Microbiology, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA MD Cooper Howard Hughes Medical Institute, Department of Pediatrics and Microbiology, University of Alabama at Birmingham, 263 Wallace Tumor Institute, UAB Station, Birmingham, AL 35294, USA LE Daitch Tufts University School of Medicine, Department of Pathology, 136 Harrison Avenue, Boston, MA 02111, USA EA Faust Howard Hughes Medical Institute Research Laboratories, University of California, Los Angeles, 5-748 MacDonald Building, 10833 Le Conte A venue, Los Angeles, CA 90024-1662, USA S Ghosh Howard Hughes Medical Institute, Yale University, 295 Congress Avenue, 154 BCMM, New Haven, CT 06510, USA LA Herzenberg Stanford University School of Medicine, Department of Genetics, Immuno- genetics and Ceil Sorting Laboratory, Stanford, CA 94305-1662, USA viii Contributors T Honjo Faculty of Medicine, Department of Medical Chemistry, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606, JAPAN AB Kantor Department of Microbiology, College of Physicians & Surgeons, Columbia University, New York, NY, USA KL Knight Loyola University Chicago, Stritch School of Medicine, Department of Micro- biology and Immunology, 2160 South First Avenue, Maywood, IL 60153, USA GW Litman Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street South, St Petersburg, FL 33701-4899, USA F Matsuda Kyoto University, Center for Molecular Biology and Genetics, Shogo-in Kawaharacho 53, Sakyo-ku, Kyoto 606, JAPAN F Melchers Basel Institute for Immunology, Grenzacherstrasse 487, Posffach, CH-4005 Basel, SWITZERLAND C Milstein Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, UK D Nemazee National Jewish Center, Department of Pediatrics, 1400 Jackson Street, Denver, CO 80206, USA A Okada Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA KN Potter Southwestern Medical School, Department of Microbiology, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA C Rada Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, UK JP Rast Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street South, St Petersburg, FL 33701-4899, USA M Reth MPI fur Immunbiologie, Posffach 79011, D-7800 Freiburg, GERMANY Contributors ix C-A Reynaud Institut Necker, Facult6 de Medicine, Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris cedex 15, FRANCE DC Saffran Howard Hughes Medical Institute Research Laboratories, University of California, Los Angeles, 5-748 MacDonald Building, 10833 Le Conte A venue, Los Angeles, CA 90024-1662, USA HW Schroeder, Jr Division of Developmental and Clinical Immunology, Departments of Micro- biology, Medicine and Pediatrics, University of Alabama at Birmingham, 263 Wallace Tumor Institute, UAB Station, Birmingham, AL, USA E Selsing Tufts University School of Medicine, Department of Pathology, 136 Harrison A venue, Boston, MA 02111, USA AM Stall Department of Microbiology, College of Physicians & Surgeons, Columbia University, New York, NY, USA U Storb University of Chicago, Department of Molecular Genetics and Cell Biology, 920 East 58th Street, Chicago, IL 60637, USA C Tunyaplin Loyola University Chicago, Stritch School of Medicine, Department of Micro- biology and Immunology, 2160 South First Avenue, Maywood, IL 60153, USA J-C Weill Institut Necker, Facult6 de Medicine, Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris cedex 15, FRANCE SM Wells Department of Microbiology, College of Physicians & Surgeons, Columbia University, New York, NY, USA ON Witte Howard Hughes Medical Institute Research Laboratories, University of California, Los Angeles, 5-748 MacDonald Buil~'ng, 10833 Le Conte A venue, Los Angeles, CA 90024-1662, USA HG Zachau InstitEit for Physiologische Chemie der Universit~t MEmchen, MEmchen, Germany. J Zhang :' The Rockefeller University, 1230 York Avenue, Box 167, New York, NY 10021, USA.
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