Table Of ContentImmunogenetics: Advances and Educatio n
The First Congress of the Slovak Foundation
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3. High Technology - Vol. 35
Immunogenetics:
Advances an d Educatio n
The First Congress of the Slovak Foundatio n
edited by
Alejandro J. Madrigal
Anthony Nolan Research Institute,
Royal Free Hospital,
London, U.K.
Margita Bencovä
Slovak Foundation Education in Immunogenetics,
Bratislava, Slovak Republic
Derek Middleto n
Northern Ireland Tissue Typing Centre,
City Hospital,
Belfast, Ireland, U.K.
and
Dominique Charro n
HLA et M6decine,
12th IHWC Office,
Institute des Cordeliers,
Paris, France
technical editor
Tibor Nänäsi
Slovak Academy of Sciences,
Bratislava, Slovak Republic
Springer Science+Business Media, B.V.
Proceedings of the NATO Advanced Research Workshop on
The First Congress of the Slovak Foundation Education in Immunogenetics
Castä-PapierniCka, Bratislava, Slovak Republic
September 5-9,1996
A C.I.P. Catalogue record for this book is available from the Library of Congress
ISBN 978-94-010-6308-1 ISB N 978-94-011-5486-4 (eBook)
DOI 10.1007/978-94-011-5486-4
Printed on acid-free paper
All Rights Reserved
© 199 7 Springer Science+Business Media Dordrecht
Originally published by Kluwer Academic Publishers in 1997
Softcover reprint of the hardcover 1st edition 1997
No part of the material protecte d by this copyright notic e may be reproduced or
utilized in any form or by any means, electronic or mechanical, including photo-
copying, recording or by any information storage and retrieval system, without written
permission from the copyright owner.
v
CONTENTS
Contents v
Preface xi
Acknowledgements xv
Introduction XVll
Report xix
Haiku xxi
Organizing Committee XXII
List of Participants XXlll
PART I Accreditation with European and American
Histocompatibility Immunogenetics Organizations 1
The Slovak Foundation: Education in Immunogenetics
M. Bencova, J. Benca and O. Nanasiova 3
Accreditation in Europe
J. Hors and M. Jeannet 13
Accreditation - A Personal View
D. Middleton 21
PART II HLA Diversity and Applications 25
HLA Diversity of Alleles and Haplotypes. The Contribution
of the 12th International Histocompatibility Workshop
R. Fauchet, C.M.Th. Schreuder, 5.C.E. Marsh and D. Charron 27
The Associated Polymorphism of HLA-DR2: Genotyping of DRB1,
DRB5, DQBl loci in Slovakia Caucasian Population
M. Bencova, J. Benca and A. Kimura 33
Paternity Testing -- Past, Present, Future
M. Bohinjec 37
VI
PART III HLA and Diseases 59
The Molecular Basis of the HLA Association in Celiac Disease.
A Model Disease for Type1 Diabetes and other HLA
Associated Disease
L.M.Sollid, B.H. Johansen, K.E.A. Lundin, 0. Molberg, H. Scott,
F. Vartdal and E. Thorsby 61
Immunogenetics of Graves' Disease - An Overview
B.J. Manfras, P. Kiinl, G. Semana and B.D. Boehm 71
Assessing Prognosis in Rheumatoid Arthritis Using Monoclonal
Antibodies and Flow Cytometry
W.H. Marshall, S. Drover, B.A. Larsen, D. Codner, M.D. Copp,
J. Gamberg, E. Keystone, D. Gladman and J. Wade 87
Hashimoto's Thyroiditis and HLA-DR-DQ Haplotypes Associated
with Control of Disease Resistance
M. Bencovci, J. Benca, A. Kimura and J. Podoba 99
Detection of the Tick Borne Encephalitis Virus in the Ticks and
the Study of HLA Associations with the Tick Borne
Encephalitis Onset
M.L. Sartakova,V.I. Konekov, L.Q. Chernitsina, V.F. Prokofiev,
S. Alekseenko and I. Yu. Korotkova 103
Immunogenetic Prognosis for Susceptibility to the Stomach
Cancer Onset
V.I. Konekov, G.A. Arzshba, K.V. Vardosanidze, I.Yu. Korotkova
and M.L. Sartakova 105
PART IV Bone Marrow Transplantation 107
Permissible Mismatches, Acceptable Mismatches and Tolerance:
New Trends in Decision Making
J.J. van Rood, E.L. Lagaaij, I. Doxiadis, D. Roelen, G.G. Persijn
and F.H.J. Claas 109
The Application of Cellular Tests in the Selection of Unrelated
Donors for Bone Marrow Transplantation
M.Oudshoorn, J.J. van Rood, D. Lio, J.L.W.T. Lie, B. Koene,
M.B. Ruigrok, M.F.J.V.D. Voort Maarschalk and F.H.J. Claas 121
HLA Typing at the Molecular Level in the Process of Donor
Selection for Bone Marrow Transplantation
J.A. Madrigal 135
VB
Bone Marrow Transplantation at Princess Margaret Hospital,
University of Toronto
J.n. Lipton 141
Transatlantic Bone Marrow Transplantation
M. Bencova and J. Benca 149
PART V Transplantation, HLA and non-HLA Aspects 151
The Role ofHLA-DR, DQ, DP Subregions Compatibility
in the Induction of Cytotoxic T Lymphocytes in Kidney
Transplantation from Living Donor
M. Bencova, A. Kimura, M. Yoshida, S. Hoshino, S. Porubska,
M. Buc, J. Reznicek and T. Sasazuki 153
Microsatellite Testing of the Major Histocompatibility Complex
in Human
J. Wade and M. Carrington 159
NCOl Polymorphism within the TNFa Promotor Region and the
First Intron of TNF,8 Gene in Association with DRB1
Specificities in Healthy Volunteers
K. Bogunia-Kubik, C. Swider, M. Polak, T. Pacuszko and A. Lange 163
PART VI Solid Organ end Eye Cornea Transplantation 169
HLA in Kidney Transplantation
D. Middleton 171
Facts and Figures of Eurotransplant
G.G. Persijn and J.M.J. De Meester 175
Affect of ClassI and ClassII HLA Groups on Graft and Patient
Survivals in Kidney Transplant Patients
M. Turan, G. Moray, N. Bilgin and M. Haberal 193
The First Kidney Transplantation in Slovakia
V. Zvara, J. Reznicek and J. Breza 201
HLA ClassI and ClassII Matched Donor Material for Improved
Corneal Allograft Survival
H.J. Volker-Dieben and J. D'Amaro 203
viii
PARTVII HLA USERS 215
HLA Typing from Serology to Molecular Biology
D. Middleton 217
HLA-DP Epitope Typing Using Monoclonal Antibodies
W.H. Marshall, S. Drover, D. Codner, J. Gamberg, M.D. Copp,
H-W. Liu, 1.T. Deng and H.B. Younghusband 223
Evolution of Molecular HLA Typing
P. Merel 233
Internet Application in the Histocompatibility Laboratory
P. Merel 243
Author's Index 255
Subject Index 257
I
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Xl
PREFACE
M.BENcovA
Slovak Foundation Education in Immunogenetics
Kopanice 25, 821 04 Bratislava
Slovak Republic
Short History of Slovakia
After the end of the 5th century, the major part of Central Europe was
dominated by Slavs (Slovaks). They had already in the 7th century settle
ments in the vicinity oftowns Bratislava, Devin, Nitra to create the Slovak's
state formation with the name "The Empire of Sam", territory of which
corresponded to that of Slovakia of present. The Empire of Sam was also
the first state formation in the Central Europe (as present states Czech
Republic, Poland, Hungary, Slovakia etc.)
Very important town of this state was Nitra, with the biggest Castle in
the Central Europe with his Duke Pribina. The first Church of the Central
Europe was built here in the year 830, and it is now considered to be the
"Slovak Bethlehem". In the year 880, Nitra also became the first Office of
Bishops.
Later, the Slovak Duke Pribina and Moravian Duke Mojmir (Moravia
corresponded to eastern part of the present Czech Republic) joined their
formations to common state "Greate Moravian Empire". The strongest
King ofthe Great Moravian Empire was Svatopluk (864 A.D.), who spread
his empire over Czech Republic, Hungary and part of Poland, Ukraine and
eastern Germany of present, which at that time still did not exist as state
formations. His seat was in the southern Slovakia, at the Castle Devin
on the river Danube. The near situated Bratislava Castle was one of the
important centres of political and cultural life with the big church, too. It
was also the seat ofone ofthe prominent Great Moravian princes, Braslav,
Svatopluk's third-born son, which gave the castle its name "Braslavgrad"
(today Bratislava).
