Imaging of Neurodegenerative Disorders PDF
Preview Imaging of Neurodegenerative Disorders
TPS23x31-2|12.09.15-13:03 TPS23x31-2|12.09.15-13:03 TPS23x31-2|12.09.15-13:03 Kanekar, Imaging of Neurodegenerative Disorders (ISBN 978-1-60406-854-2), copyright © 2016 Thieme Medical Publishers All rights reserved. Usage subject to terms and conditions of license. TPS23x31-2|12.09.15-13:03 Imaging of Neurodegenerative Disorders Best Evidence Recommendations 2nd Edition Sangam G. Kanekar, MD Associate Professor of Radiology and Neurology Milton S. Hershey Medical Center Penn State University College of Medicine Hershey, Pennsylvania Seung-Ho Shin, MD Assistant Professor of Otology and Neurotology Department of Otolaryngology–Head and Neck Surgery Cha University Seongnam, Republic of Korea 1874 illustrations Thieme New York • Stuttgart • Delhi • Rio de Janeiro Kanekar, Imaging of Neurodegenerative Disorders (ISBN 978-1-60406-854-2), copyright © 2016 Thieme Medical Publishers All rights reserved. Usage subject to terms and conditions of license. TPS23x31-2|12.09.15-13:03 ThiemeMedicalPublishers,Inc. Importantnote:Medicineisanever-changingscienceundergoing 333SeventhAvenue continual development. Research and clinical experience are con- NewYork,NewYork10001 tinuallyexpandingourknowledge,inparticularourknowledgeof propertreatmentanddrugtherapy.Insofarasthisbookmentions ExecutiveEditor:WilliamLamsback anydosageorapplication,readersmayrestassuredthattheauthors, ManagingEditor:J.OwenZurhellenIV editors,andpublishershavemadeeveryefforttoensurethatsuch Director,EditorialServices:MaryJoCasey referencesareinaccordancewiththestateofknowledgeatthetime InternationalProductionDirector:AndreasSchabert ofproductionofthebook. VicePresident,EditorialandE-Product Nevertheless,thisdoesnotinvolve,imply,orexpressanyguar- Development:VeraSpillner anteeorresponsibilityonthepartofthepublishersinrespecttoany InternationalMarketingDirector:FionaHenderson dosage instructions and forms of applications stated in thebook. InternationalSalesDirector:LouisaTurrell Every user is requested toexaminecarefullythemanufacturers’ DirectorofSales,NorthAmerica:MikeRoseman leafletsaccompanyingeachdrugandtocheck,ifnecessaryincon- SeniorVicePresidentandChiefOperating sultationwithaphysicianorspecialist,whether thedosagesche- Officer:SarahVanderbilt dules mentioned therein or the contraindications stated by the President:BrianD.Scanlan manufacturersdifferfromthestatementsmadeinthepresentbook. Suchexaminationisparticularlyimportantwithdrugsthatareeither LibraryofCongressCataloging-in-PublicationData rarelyusedorhavebeennewlyreleasedonthemarket.Everydosage Imaging of neurodegenerative disorders / [edited by] Sangam G. scheduleoreveryformofapplicationusedisentirelyattheuser’s Kanekar. own risk and responsibility. The authors and publishers request p.;cm. everyusertoreporttothepublishersanydiscrepanciesorinaccu- Includesbibliographicalreferencesandindex. raciesnoticed.Iferrorsinthisworkarefoundafterpublication,errata ISBN978-1-60406-854-2(hardcover:alk. paper)–ISBN978-1- willbepostedatwww.thieme.comontheproductdescriptionpage. 60406-855-9(ebook) Some of the product names, patents, and registered designs I.Kanekar,SangamG.,editor. referredtointhisbookareinfactregisteredtrademarksorpropri- [DNLM:1. NeurodegenerativeDiseases–diagnosis.2. Neuroimaging– etarynameseventhoughspecificreferencetothisfactisnotalways methods. WL358.5] made in the text. Therefore, the appearance of a name without RC376.5 designationasproprietaryisnottobeconstruedasarepresentation 616.8'307548–dc23 2014034741 bythepublisherthatitisinthepublicdomain. Copyright©2016byThiemeMedicalPublishers,Inc. 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TPS23x31-2|12.09.15-13:03 Idedicatethisbookto “MahaSaraswati” andtomyparentsGurudasandthelateMeerabaiKanekar Kanekar, Imaging of Neurodegenerative Disorders (ISBN 978-1-60406-854-2), copyright © 2016 Thieme Medical Publishers All rights reserved. Usage subject to terms and conditions of license. TPS23x31-2|12.09.15-13:03 Kanekar, Imaging of Neurodegenerative Disorders (ISBN 978-1-60406-854-2), copyright © 2016 Thieme Medical Publishers All rights reserved. Usage subject to terms and conditions of license. TPS23x31-2|12.09.15-13:03 Contents Foreword 1............................................................................................xi Foreword 2...........................................................................................xiii Preface................................................................................................ xv Acknowledgments.................................................................................. xvii Contributors..........................................................................................xix Part I. Introduction Chapter 1: Overview of Neurodegenerative Diseases ...................................................... 2 SangamG.KanekarandMayaL.Lichtenstein Part II. Imaging Techniques Chapter 2: Structural Imaging of Dementia................................................................14 SangamG.KanekarandVijayMittal Chapter 3: Magnetic Resonance Spectroscopy in Neurodegenerative Disorders........................24 TusharChandra,SuyashMohan,SanjeevChawla,andHarishPoptani Chapter 4: SPECT and PET Imaging of Neurotransmitters in Dementia..................................34 MateenMoghbel,AndrewNewberg,MijailSerruya,andAbassAlavi Chapter 5: DiffusionTensor Imaging in Neurodegenerative Disorders...................................42 DhirajBaruah,SuyashMohan,andSumeiWang Chapter 6: Functional Imaging of the Brain................................................................51 LeslieHartmanandAaronS.Field Chapter 7: Role of Noninvasive Angiogram and Perfusion in the Evaluation of Neurodegenerative Disorders ........................................................................................60 SangamG.KanekarandPuneetDevgun Part III. Normal Aging Chapter 8: Imaging of the Normal Aging Brain............................................................70 RuthA.Wood,LudovicoMinati,andDennisChan Chapter 9: Iron Accumulation and Iron Imaging in the Human Brain....................................80 StefanRopeleandChristianLangkammer Part IV. Alzheimer’s Disease Chapter 10: Mild Cognitive Impairment....................................................................90 KeiYamadaandKojiSakai vii Kanekar, Imaging of Neurodegenerative Disorders (ISBN 978-1-60406-854-2), copyright © 2016 Thieme Medical Publishers All rights reserved. Usage subject to terms and conditions of license. TPS23x31-2|12.09.15-13:03 Contents Chapter 11: Overview of Alzheimer’s Disease ........................................................... 113 LeonardoCruzdeSouzaandMarieSarazin Chapter 12: Genetics, Neuropathology, and Biomarkers in Alzheimer’s Disease...................... 119 MariaMartinez-LageAlvarezandRashmiTondon Chapter 13: Imaging of Alzheimer’s Disease: Part 1..................................................... 124 DonaldG.McLaren,GuofanXu,andVivekPrabhakaran Chapter 14: Imaging of Alzheimer’s Disease: Part 2..................................................... 133 ChristianLa,WolfgangGaggl,andVivekPrabhakaran Chapter 15: Magnetic Resonance Imaging and Histopathological Correlation in Alzheimer’s Disease.......................................................................... 139 MarkD.MeadowcroftandQingX.Yang Part V. Non-Alzheimer’s Cortical Dementia Chapter 16: Dementia with Lewy Body Disease......................................................... 150 AristidesA.CapizzanoandToshioMoritani Chapter 17: Frontotemporal Lobar Degeneration....................................................... 157 AristidesA.CapizzanoandToshioMoritani Part VI. Dementia with Extrapyramidal Syndromes Chapter 18: Parkinson’s Disease.......................................................................... 166 JenniferG.Goldman,JohnW.Ebersole,DouglasMerkitch,andGlennT.Stebbins Chapter 19: Atypical Parkinsonian Syndromes........................................................... 180 NicolaPaveseandDavidJ.Brooks Chapter 20: Secondary Parkinsonism .................................................................... 186 ThyagarajanSubramanian,KalaVenkiteswaran,andElisabethLucassen Part VII. Vascular Dementia Chapter 21: Vascular Dementia........................................................................... 194 A.M.BarrettandVahidBehravan Chapter 22: Neuroimaging of Vascular Dementias...................................................... 199 AmitAgarwalandSangamG.Kanekar Chapter 23: Imaging of Specific Hereditary Microangiopathies ........................................ 210 KennethLuryandMauricioCastillo Chapter 24: Vasculitis and Dementia..................................................................... 216 SampsonK.Kyere,OlaguokeAkinwande,DheerajGandhi,andGauravJindal viii Kanekar, Imaging of Neurodegenerative Disorders (ISBN 978-1-60406-854-2), copyright © 2016 Thieme Medical Publishers All rights reserved. Usage subject to terms and conditions of license.
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