Imaging Inside the Human Body ggy with Light ggy with Light

41 Pages·2011·4.33 MB·English

Imaging Inside the Human Body
withi Ltighht L i g h t
Arjun G. Yodh
University of Pennsylvania
Department of Physics & Astronomy
U n i v e r s i t y o f P e n n s y l v a n i a
Goals
• Dreams
• Red/Near-infrared Transmission Window
• Why is this hard?
• How does light travel in the body?
• Random Walks / Diffusion Models
• Spectroscopy, Imaging, Blood Flow Monitoring
• Primer on Blood Dynamics
• Examples
Breast Cancer Imaging, Stroke Monitoring
U n i v e r s i t y o f P e n n s y l v a n i a
The Dream.
from: Star Trek
from: Minority Report
U n i v e r s i t y o f P e n n s y l v a n i a
Red/Near-infrared Transmission Window
• Near Infrared Light
Penetrates Tissue
• Non-invasive, safe,
rapid, portable,
continuous,
inexpensive ...
U n i v e r s i t y o f P e n n s y l v a n i a
Why is this hard?
Ice in Water Ice in Milk?
U n i v e r s i t y o f P e n n s y l v a n i a
Why is this hard?
Water Water + Little Milk Milk
Light doesn’t get Absorbed, it Scatters
U n i v e r s i t y o f P e n n s y l v a n i a
How does light travel in the body?
"Random" Walk
U n i v e r s i t y o f P e n n s y l v a n i a
Random Walks and Diffusion
U n i v e r s i t y o f P e n n s y l v a n i a
Example: Random Walks from
Philadelphia’s City Hall
U n i v e r s i t y o f P e n n s y l v a n i a
Example: Random Walks from
Philadelphia’s City Hall
U n i v e r s i t y o f P e n n s y l v a n i a