Imaging in Stem Cell Transplant and Cell-based Therapy PDF
Preview Imaging in Stem Cell Transplant and Cell-based Therapy
Stem Cell Biology and Regenerative Medicine Tarun Pandey Editor Imaging in Stem Cell Transplant and Cell-based Therapy Stem Cell Biology and Regenerative Medicine Series Editor Kursad Turksen, Ph.D. More information about this series at http://www.springer.com/series/7896 Tarun Pandey Editor Imaging in Stem Cell Transplant and Cell-based Therapy Editor Tarun Pandey Department of Radiology University of Arkansas for Medical Sciences Little Rock, AR, USA ISSN 2196-8985 ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-3-319-51831-2 ISBN 978-3-319-51833-6 (eBook) DOI 10.1007/978-3-319-51833-6 Library of Congress Control Number: 2017935379 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface Stem cell therapy has made rapid strides in recent years and has generated consider- able interest among scientific communities, clinicians and general public. A lot of attention emanates from the great promise offered by this technique, most notably with regard to the application of stem cell therapy for diseases that are currently difficult to treat or incurable. Hence, study of stem cells and cell-based therapies, that was traditionally viewed as a core research area and thought to be of interest mainly to the researchers and scientists, is fast getting into the paradigm of clinical care. For diagnostic and interventional radiologists, it is particularly advantageous to be actively involved in the bench to bedside development of these therapies. While diagnostic radiologists can become experts in imaging, tracking, and monitoring of stem cells and in the assessment of engraftment efficiency, the interventional radi- ologist can play an important role in targeted stem cell delivery by means of differ- ent routes (percutaneous, selective intravenous, or intra-arterial). The prevailing literature in stem cell therapy predominantly targets the core researchers. Also, the subject matter is complex, has abundant technical jargon that is somewhat difficult to comprehend for an average clinician. This book will present a simplified review of stem cell and cell-based therapies with a focus on imaging. The current volume will provide a review of imaging techniques and applications in stem cell transplantation and other cell-based therapies. The basis of different molecular imaging techniques will be explained in detail. Applications of stem cell transplant in different organ systems will be discussed, with reference to imaging wherever feasible. The reader can expect to get comprehensive information on the role of clinical and molecular imaging in stem cell therapy from this book. This book will provide opportunities to learn the current gamut of stem cell applications in adults and pediatric populations, understand the scope of molecular imaging in stem cell and cell-based therapies, understand role of clinical imaging in stem cell therapy and gain knowledge in several state of the art applications in this field like use of nanotechnology in stem cell applications, stem cell use in cardiology, cancer and angiogenesis. This information will be presented in a simplified form that will generate reader interest in this technology. v vi Preface The work is primarily targeted towards radiologists and physicians involved in molecular imaging who are interested in developing a basic understanding of stem cell imaging and applications of stem cells and cell-based therapies. However, it will also be of interest to clinical scientists and researchers alike. A variety of physi- cians can benefit from this volume including, but not limited to, radiologists, cardi- ologists, hematologists, interventionists and transplant physicians. PhD researchers involved in stem cell labeling, tracking and imaging, cancer therapy, angiogenesis and cardiac regeneration will find this issue highly useful. The book is organized in two main sections. Section 1 provides overview of stem cell indications and techniques in adult and pediatric population with review of molecular imaging techniques and shall discuss role of newer applications like use of nanotechnology in stem cell transplant. Section 2 is devoted to review common applications in stem cell and cell-based therapies. Overall, the objective is to pro- vide a unique resource, focusing on imaging in stem cell and cell-based therapies with review of stem cell therapy applications and to provide simplified explanation of technical concepts and terminology. The text is written from a clinician’s per- spective that will help the average physician to keep abreast with stem cell research and encourage him/her to adopt this technology. While each section will have a hierarchical organization of reviews encompass- ing basic to advanced topics, each chapter will be self-sufficient enough so that it can be reviewed independently of one another. The text is compiled by a variety of authors who bring in years of experience in stem cell research and clinical imaging. The cross-disciplinary expertise of the con- tributors will ensure that the book will present a balanced perspective. The authors of this book are national leaders in their respective areas and well known interna- tionally through their work and citations. The contributors span the entire length and breadth of United States with several overseas contributors as well. Also, they rep- resent premier organizations and universities in the United States and abroad, well known for quality academics and research work in stem cells. I hope that this work will accomplish its objectives. Like any similar book proj- ect this would not have reached fruition but for the support from the contributing authors. I wish to thank all authors for their hard work in compiling the chapters and sharing their expertise with the world. I am extremely grateful to the Series Editor of Stem Cell Biology and Regenerative Medicine, Dr. Kursad Turksen for giving me this opportunity to edit this series. Last but not the least, I am ever grateful to my parents, lovely wife and sons for their continued support, and to my students who have kept me motivated all these years! Little Rock, AR, USA Tarun Pandey Contents Part I Imaging in Stem Cell Transplant 1 Current Indications and Overview of Molecular Imaging Techniques in Stem Cell Transplantation ................. 3 Tarun Pandey 2 Nanotechnology-Based Stem Cell Applications and Imaging ........ 17 Hanna A. Jensen, Elizabeth M. Martin, Morten O. Jensen, Francesco Romeo, Aldo Di Carlo, Jin-Woo Kim, and Jawahar L. Mehta 3 Radiologic Procedures Used in Pediatric Stem Cell Transplantation ......................................... 37 Mohammad Atiq, Terry Harville, Nishi Shah, Paulette Mehta, Tarun Pandey, and Yogesh S. Jethava 4 Clinical Applications of Stem Cell Transplant in Treating Non-Hematologic Conditions .................................. 51 Roopa Ram, Kedar Jambhekar, and Tarun Pandey Part II Applications in Stem Cell and Cell Based Therapies 5 Stem Cell Transplantation for Multiple Myeloma ................. 73 Sharmilan Thanendrarajan and Tarun K. Garg 6 Simultaneous MRI and 18F-FDG-PET Imaging in Multiple Myeloma: A Model for Evaluation of the Disease and Therapeutic Changes in SCID-hu Mice ..................... 87 Tarun K. Garg and Tarun Pandey 7 The Emerging Role of Cardiac Stem Cells in Cardiac Regeneration .............................................. 101 Savneet Kaur, Impreet Kaur, and C.C. Kartha vii viii Contents 8 Cardiac Imaging and Stem Cell Transplantation ................ 119 Sameer Raina, Tarun Pandey, and Jawahar L. Mehta 9 Bone Marrow Cell Therapy for Ischemic Heart Disease and the Role of Cardiac Imaging in Evaluation of Outcomes ...... 133 Anweshan Samanta, Muhammad R. Afzal, and Buddhadeb Dawn 10 Uterine Stem Cells and Their Future Therapeutic Potential in Regenerative Medicine .................................... 153 K.G. Aghila Rani and Taruna Madan Contributors Muhammad R. Afzal, M.B.B.S. Division of Cardiovascular Diseases, Cardio- vascular Research Institute, University of Kansas Medical Center and Hospital, Kansas City, KS, USA Midwest Stem Cell Therapy Center, University of Kansas Medical Center and Hospital, Kansas City, KS, USA K.G. Aghila Rani, Post Doc Fellow Department of Innate Immunity, National Institute for Research in Reproductive Health (ICMR), Parel, Mumbai, India Mohammad Atiq, M.D. Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA Aldo Di Carlo, Ph.D. Department of Electronic Engineering, University of Rome, Tor Vergata, Rome, Italy Buddhadeb Dawn, M.D. Division of Cardiovascular Diseases, Cardiovascular Research Institute, University of Kansas Medical Center and Hospital, Kansas City, KS, USA Midwest Stem Cell Therapy Center, University of Kansas Medical Center and Hospital, Kansas City, KS, USA Tarun K. Garg, Ph.D. Myeloma Institute, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA Terry Harville, Ph.D. Department of Pathology, University of Arkansas, Little Rock, AR, USA Kedar Jambhekar, M.D. Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Hanna A. Jensen, M.D., Ph.D. Department of Biomedical Engineering, The University of Arkansas, Fayetteville, AR, USA Morten O. Jensen, Ph.D., Dr., Med. Department of Biomedical Engineering, The University of Arkansas, Fayetteville, AR, USA ix x Contributors Yogesh S. Jethava, M.D. Department of Internal Medicine (Hem-Onc), University of Arkansas, Little Rock, AR, USA C.C. Kartha, M.D., F.R.C.P. Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Center for Biotechnology, Kerala, India Savneet Kaur, Ph.D. School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India Impreet Kaur, M.Sc. School of Biotechnology, Gautam Buddha University, Greater Noida, Uttar Pradesh, India Jin-Woo Kim, Ph.D. Institute for Nanoscience and Engineering, The University of Arkansas, Fayetteville, AR, USA Taruna Madan, Ph.D. Department of Innate Immunity, National Institute for Research in Reproductive Health (ICMR), Parel, Mumbai, India Elizabeth M. Martin, Ph.D. Institute for Nanoscience and Engineering, The University of Arkansas, Fayetteville, AR, USA Paulette Mehta, M.D., M.P.H. Department of Internal Medicine (Hem-Onc), University of Arkansas, Little Rock, AR, USA Jawahar L. Mehta, M.D., Ph.D. Department of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Tarun Pandey, M.D., F.R.C.R. Department of Radiology, University of Arkansas, Little Rock, AR, USA Sameer Raina, M.D., F.A.C.C. Department of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Roopa Ram, M.D. Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Francesco Romeo, M.D. Department of Cardiology and Interventional Cardiology, The University of Rome, Tor Vergata, Rome, Italy Anweshan Samanta, M.B.B.S. Division of Cardiovascular Diseases, Cardiovascular Research Institute, University of Kansas Medical Center and Hospital, Kansas City, KS, USA Midwest Stem Cell Therapy Center, University of Kansas Medical Center and Hospital, Kansas City, KS, USA Nishi Shah, M.D. Department of Internal Medicine, University of Arkansas, Little Rock, AR, USA Sharmilan Thanendrarajan, M.D. Dr. Med. (GER) Myeloma Institute, Univer sity of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA
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