Practical Issues in Geriatrics Series Editor: Stefania Maggi Giuseppe Guglielmi Mario Maas Editors Imaging in Geriatrics Practical Issues in Geriatrics Series Editor Stefania Maggi, Aging Branch CNR-Neuroscience Institute, Padua, Italy This practically oriented series presents state of the art knowledge on the principal diseases encountered in older persons and addresses all aspects of management, including current multidisciplinary diagnostic and therapeutic approaches. It is intended as an educational tool that will enhance the everyday clinical practice of both young geriatricians and residents and also assist other specialists who deal with aged patients. Each volume is designed to provide comprehensive information on the topic that it covers, and whenever appropriate the text is complemented by additional material of high educational and practical value, including informative video-clips, standardized diagnostic flow charts and descriptive clinical cases. Practical Issues in Geriatrics will be of value to the scientific and professional community worldwide, improving understanding of the many clinical and social issues in Geriatrics and assisting in the delivery of optimal clinical care. Giuseppe Guglielmi • Mario Maas Editors Imaging in Geriatrics Editors Giuseppe Guglielmi Mario Maas Clinical and Experimental Medicine Department of Radiology and Nuclear University of Foggia Medicine Foggia, Italy University of Amsterdam Amsterdam, Noord-Holland The Netherlands ISSN 2509-6060 ISSN 2509-6079 (electronic) Practical Issues in Geriatrics ISBN 978-3-031-14876-7 ISBN 978-3-031-14877-4 (eBook) https://doi.org/10.1007/978-3-031-14877-4 © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and trans- mission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publica- tion does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface Demographic changes, due to the longer lifespan and the improvement of the qual- ity of life, led to an aging society, where developing high-quality healthcare for older people becomes increasingly important. Nowadays the elderly population is more informed and more demanding of bet- ter care through cutting-edge technology and treatment. Specifically, radiologists play an increasingly important role and occupy a frontline position in the evaluation of this cohort of patients, who necessitate definitive imaging. In this perspective, the complex relationship between geriatrics and radiology must be redefined. Imaging in Geriatrics is the result of a teamwork of radiologists, experts in the field, with the aim to provide guidance for the appropriate use of imaging in modern geriatric care, describing how to recognize pathology from para- physiological findings in the elderly population. The study of diagnostic imaging in geriatrics, enriched by traditional and modern imaging methods, is primarily oriented to the clinical and radiological analysis most frequently encountered in these patients and, above all, to the not easy distinction between “normal” and “pathological,” especially in situations in which para-physi- ological changes resulting from aging processes are associated with alterations related to comorbidity and chronicity. This volume includes a multidisciplinary approach, and it covers all major medi- cal issues related to aging, divided by apparatus. In particular, it encloses the main pathologies in the neurological, cardiovascular, pulmonary, gastrointestinal, uro- genital, hematologic, and musculoskeletal field. This book considers all imaging techniques that have been the cornerstones of radiology, but also modern innovations. Conventional radiography is still the first approach in the diagnosis of a frequent variety of pathological conditions of elderly patients, such as fractures, often due to osteoporosis, pneumothorax, or heart fail- ure. On the other hand, Computer Tomography (CT), with its intrinsic resolution power, allows radiologists to detect a possible ischemic or hemorrhagic cerebral focus, as well as neoplastic metastases for the staging of the primary pathology. Spinal cord injuries are best identified with Magnetic Resonance Imaging (MRI). But nowadays, and therefore modern “tailored” medicine, is changing, going towards Artificial Intelligence (AI), a technological evolution that brings with it the limits related to the training and updating of the healthcare personnel involved. For v vi Preface this reason, a section about the role of AI in the management of geriatric patients could not be missed at the end of this volume. Finally, the aim of this book is to simplify the approach and the diagnostic imag- ing process of geriatric diseases, bringing out the potential and limitations of each imaging technique. We recommend the reading of this book not only to radiologists for their daily clinical practice but also to all physicians who require a basic knowledge of imaging concerning the main geriatric pathologies, because of their complex clinical presentations. Foggia, Italy Giuseppe Guglielmi Amsterdam, The Netherlands Mario Maas Contents 1 Imaging Techniques in Geriatric Patients . . . . . . . . . . . . . . . . . . . . . . . 1 Caterina Bernetti, Carlo Augusto Mallio, Rosario Francesco Grasso, and Bruno Beomonte Zobel 2 Neurodegenerative Diseases in Geriatric Patients . . . . . . . . . . . . . . . . . 11 Camilla Russo, Rossana Senese, and Mario Muto 3 Neurovascular Emergencies in Geriatric Patients . . . . . . . . . . . . . . . . . 37 Giuseppe Maria Di Lella, Luca Ausili Cefaro, and Cesare Colosimo 4 Head and Neck in Geriatric Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 T. Popolizio, L. Cassano, A. Pennelli, R. Izzo, G. Fascia, M. Masciavè, and Giuseppe Guglielmi 5 Heart Diseases in Geriatric Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 Anna Palmisano, Raffaele Ascione, Francesco De Cobelli, and Antonio Esposito 6 Vascular Diseases in Geriatric Patients. . . . . . . . . . . . . . . . . . . . . . . . . . 137 Gloria Caredda, Giuseppe Guglielmi, and Luca Saba 7 Airway Diseases in Geriatric Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . 151 Maurizio Balbi, Roberta Eufrasia Ledda, Silvia Pamparino, Gianluca Milanese, Mario Silva, and Nicola Sverzellati 8 Neoplastic Diseases of the Respiratory System in Geriatric Patients . 171 Zeno Falaschi, Francesco Filippone, Sergio Pansini, Stefano Tricca, Paola Basile, Sara Cesano, and Alessandro Carriero 9 The Gastrointestinal System in Geriatric Patients . . . . . . . . . . . . . . . . 217 Damiano Caruso, Domenico De Santis, Francesco Pucciarelli, and Andrea Laghi 10 The Male Urogenital System in Geriatric Patients . . . . . . . . . . . . . . . . 235 Emilio Quaia and Filippo Crimí vii viii Contents 11 The Female Urogenital System in Geriatric Patients . . . . . . . . . . . . . . 271 Maria Assunta Cova, Lorella Bottaro, Cristina Marrocchio, and Alessandro Marco Bozzato 12 Osteoarthritis in Axial Skeleton in Geriatric Patients . . . . . . . . . . . . . . 319 Francesca Serpi, Salvatore Gitto, and Luca Maria Sconfienza 13 Osteoarthritis in Appendicular Skeleton in Geriatric Patients . . . . . . 345 Antonio Barile, Riccardo Monti, Federico Bruno, Julia Daffinà, Francesco Arrigoni, and Carlo Masciocchi 14 Metabolic Bone Disease in Geriatric Patients . . . . . . . . . . . . . . . . . . . . 367 Maria Pilar Aparisi Gómez, Francisco Aparisi, Giuseppe Guglielmi, and Alberto Bazzocchi 15 Body Composition in Geriatric Patients . . . . . . . . . . . . . . . . . . . . . . . . . 397 Maria Pilar Aparisi Gómez, Francisco Aparisi, Giuseppe Guglielmi, and Alberto Bazzocchi 16 Myeloid and Lymphoid Disorders in Geriatric Patients . . . . . . . . . . . . 427 Patrizia Toia, Massimo Galia, Giuseppe Filorizzo, Ludovico La Grutta, Federico Midiri, Pierpaolo Alongi, Emanuele Grassedonio, and Massimo Midiri 17 The Role of Artificial Intelligence (AI) in the Management of Geriatric Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 445 Salvatore Claudio Fanni, Sherif Mohsen Shalaby, and Emanuele Neri Imaging Techniques in Geriatric Patients 1 Caterina Bernetti, Carlo Augusto Mallio, Rosario Francesco Grasso, and Bruno Beomonte Zobel 1.1 I ntroduction: The Delicate Balance of Imaging in the Elderly In the last decades, there has been a rising trend toward global population aging, especially in developed nations. This longevity revolution is happening faster than historical precedents and a further increase of median age is expected in subsequent years [1]. The improvement of living conditions and the advent of modern medicine carry- ing innovations in treatment and prevention are some of the main reasons of increased life expectancy. This demographic change is determining a profound impact on society, in par- ticular with regard to the healthcare system, that now has to face more age-related diseases [2, 3]. In particular, people over 65 years, defined by convention as elderly, are more prone to develop multiple chronic conditions, such as cardiovascular diseases, dementia, cancer, and also osteoporosis that could lead to fragility fractures after minor traumas [4]. In this population, there is an intrinsic difficulty in distinguishing the boundary between para-physiologic modifications determined by aging and real pathologic conditions. Furthermore, given the possibility of an incomplete medical history, the complexity of symptoms and signs determined by the coexistence of multiple comorbidities, and the reduced sensitivity of laboratory tests, the diagnosis is often difficult to achieve. In this context, radiological imaging plays an important role in the diagnostic workup of elderly patients [2, 5]. C. Bernetti · C. A. Mallio · R. F. Grasso · B. B. Zobel (*) Imaging Center, Diagnostic Imaging and Interventional Radiology Department, University Hospital “Campus Bio-Medico”, Rome, Italy e-mail: [email protected]; [email protected]; [email protected]; [email protected] © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023 1 G. Guglielmi, M. Maas (eds.), Imaging in Geriatrics, Practical Issues in Geriatrics, https://doi.org/10.1007/978-3-031-14877-4_1