Imaging in alcohol research : proceedings of a workshop on imaging in alcohol research, May 9-11, 1991, Wild Dunes, South Carolina

426 Pages·1992·30 MB·English

by  Zakhari, Samir

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National Institute on Alcohol Abuse and Alcoholism
RESEARCH
Monograph
-
21
Imaging
in
Alcohol Research
DEPARTMENT OF HEALTH AND HUMAN SERVICES
U.S.
Public Health Service
Alcohol Drug Abuse, and Mental Health Administration

Research Monograph No.
21
CENTER
Proceedings of a Workshop on Imaging in Alcohol Research
May
9-11, 1991
Wild Dunes, South Carolina
Sponsored
by:
National Institute on Alcohol Abuse and Alcoholism
Edited by:
^tfju^'Sam Zakhari, Ph.D.
Ellen Witt, Ph.D.
DEPARTMENT OF HEALTH AND HUMAN SERVICES
U.S.
Public Health Service
Alcohol, Drug Abuse, and Mental Health Administration
National Institute on Alcohol Abuse and Alcoholism
5600 Fishers Lane
MD
Rockville, 20857
The Editors: Sam Zakhari, Ph.D., is currently Chief of the
Biomedical Research Branch in the Division of Basic Re-
search at the National Institute on Alcohol Abuse and
Alcoholism (NIAAA). Prior to his appointment in the Divi-
sion of Basic Research, Dr. Zakhari was Executive Secretary
of the Neuroscience and Behavior Subcommittee at NIAAA.
Ellen D. Witt Ph.D., is a Health Scientist Administrator in the
Division of Basic Research, NIAAA, and is responsible for
administering the Behavioral Sciences Program in the Neu-
roscience and Behavioral Research Branch.
NIAAA has obtained permission from the copyright holders
to reproduce figures and tables on pages 19, 20, 66-70, 180,
289, 309, and 314-322. Further reproduction of these mate-
rials is prohibited without specific permission of the copy-
right holders. All other material contained in the monograph,
except quoted passages from copyrighted sources, is in the
public domain and may be reproduced without permission
from the Institute or the authors. Citation of the source is
appreciated.
The U.S. Government does not endorse or favor any specific
commercial product (or commodity, service, or company).
Trade or proprietary names (or company names) appearing
in this publication are used only because they are consid-
ered essential in the context of the studies reported herein.
The opinions expressed herein are the views of the authors
and do not necessarily reflect the official position of NIAAA
or any other part of the U.S. Department of Health and
Human
Services.
DHHS Publication No. (ADM)92-1890
Printed 1992
OF CONTENTS
TABLE
Foreword v
Preface
vii
Participants xi
Event-Related Potentials and
Magnetoencephalogram Section
MEG
Can Imaging Be Useful in Alcoholism Research?
1.
David Cofien 3
The Use of Magnetic Field Tomography
2.
in the Study of Acute Alcohol Intoxication
R. Llinas and U. Rif^ary 13
Use of Animal Models for
3.
Electrophysiological Neural Imaging in Alcohol Research
L
Cindy Efilers 27
4. Brain Electrical Activity:
The Promise of New Technologies
George Fein, jonatfian Raz, and Bruce Turetsky 49
The Topographic Analysis of
5.
Model-Referenced Evoked Potential Components
jofin Odencrantz, Sean O’Connor, Henri Begleiter, and Guowang Zfiang. 79
.
Nuclear Magnetic Resonance Imaging Section
6. Structural Imaging of the Brain in Chronic Alcoholism ....
Adolf Rfefferbaum, Kelvin O. Lim, and Margaret Rosenbloom 99
7. Studies of Brain Structure in Chronic
Alcoholism Using Magnetic Resonance Imaging
Terry L. jernigan. Nelson Butters, and Laird S. Cermak 121
1
Magnetic Resonance Imaging and Contrast
8.
Agents in the Evaluation of EthanoEDamaged Livers ....
S.W. Young, M. Sidfiu, A. ]ones, H.H. Muller, and Aggeler 135
).
9. ^'P NMR As a Tool To Investigate
the Testicular Toxicity of Ethanol In Vivo
D.H. Van Thiel, H. Farghali, fS. Gavaler, and C. Ho 153
Nuclear Magnetic
Resonance Spectroscopy Section
10. Overview of Noninvasive Approaches
to Metabolic and Addictive Disease
Britton Chance 169
Magnetic Resonance Spectroscopy and
11.
Spectroscopic Imaging of Human Liver, Heart Kidney, and Brain
Dieter Meyerhoff, Hohy P. Hetherington, James W. Hugg,
j.
Gerald B. Matson, George Fein, Andrew Maudsley, and Michael W. Weiner 177
.
NMR
Studies of Cerebral Metabolism
12.
15. Robert G. Shulman, Kevin L. Behar,
Douglas L. Rothman, and Graeme E. Mason 195
13. Alterations in Membrane Metabolism and
Physiology in Alzheimer’s Disease Implications for Etio.log.y ..
jay W. Pettegrew, William E. Klunk, and Richard McClure 201
].
14. Molecular Insights into Schizophrenia
Jay W. Pettegrew and Nancy Minshew 215
J.
Influence of Mg^^ on Distribution of Ionized Ca^^
in Vascular Muscle and on Cellular Bioenergetics
and Intracellular Eree Mg ^ and pH in Perfused
Hearts Probed by Digital Imaging Microscopy,
11