Imaging Coronary Atherosclerosis

229 Pages·2014·9.958 MB·English

by  Stephen J. Nicholls, Tim Crowe (eds.)

Contemporary Cardiology
Series Editor: Christopher P. Cannon
Stephen J. Nicholls
Tim Crowe Editors
Imaging Coronary
Atherosclerosis
C C
ONTEMPORARY ARDIOLOGY
C P. C , MD
HRISTOPHER ANNON
SERIES EDITOR
For further volumes:
http://www.springer.com/series/7677

Stephen J. Nicholls (cid:129) Tim Crowe
Editors
Imaging Coronary
Atherosclerosis
Editors
Stephen J. Nicholls, MBBS, PhD, Tim Crowe, BS
FRACP, FACC, FESC, FAHA, C5Research
FCSANZ Cleveland Clinic
South Australian Health Cleveland , OH , USA
and Medical Research Institute
Royal Adelaide Hospital
University of Adelaide
Adelaide , SA , Australia
ISSN 2196-8969 ISSN 2196-8977 (electronic)
ISBN 978-1-4939-0571-3 ISBN 978-1-4939-0572-0 (eBook)
DOI 10.1007/978-1-4939-0572-0
Springer New York Heidelberg Dordrecht London
Library of Congress Control Number: 2014926606
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To Kathy, Emily, Oliver, and Angus
&
Connie, Justin, and Sean

Pref ace
For more than 50 years, we have used coronary angiography to diagnose and
quantify the extent of obstructive disease due to atherosclerosis. This has
provided an important tool for the cardiologist in the evaluation and manage-
ment of the patient with coronary artery disease. In more recent years, major
technological advances in arterial wall imaging enable more precise visual-
ization of the atherosclerotic plaque. These developments have expanded
beyond traditional angiographic techniques, which simply visualize the arte-
rial narrowings that develop as a complication of vascular disease. Rather, the
ability to use a range of intravascular and noninvasive imaging techniques
permits direct visualization of the full thickness of the artery wall and the
whole burden of disease within. As a result, we now have the opportunity to
image the amount of plaque, distinguish its individual components, and
potentially evaluate the functionality of the disease. The latter will be further
enhanced by a dvances in molecular imaging, which in combination with the
invasive and noninvasive approaches described in this book, have the ability
to translate the vascular biological insights from the experimental setting to
the daily management of patients. This has important implications for the risk
prediction, management, and evaluation of novel anti-atherosclerotic thera-
pies. In this book, we focus on each of the major approaches to imaging of the
coronary arteries. In particular, our authors have highlighted how each of
these modalities has enhanced our understanding of the disease process and
propose challenges that need to be overcome for their increasing integration
into clinical practice.
Adelaide, SA, Australia Stephen J. Nicholls
Cleveland, OH, USA Tim Crowe
vii

Contents
1 Residual Risk and Biology of the Disease:
Implications for Plaque Imaging ................................................. 1
Yu Kataoka and Stephen J. Nicholls
2 Advanced Coronary Imaging ....................................................... 23
Femi Philip and Samir R. Kapadia
3 Evaluation of Medical Therapies and Intravascular
Devices with Quantitative Coronary Angiography .................... 41
Sorin J. Brener
4 Use of Intravascular Ultrasound
in Interventional Cardiology ........................................................ 51
Samuel L. Sidharta, Matthew Worthley,
and Stephen Worthley
5 Monitoring the Progression and Regression of Coronary
Atherosclerosis with Intravascular Ultrasound ......................... 67
Rishi Puri and Stephen J. Nicholls
6 Evaluation of Cardiac Allograft Vasculopathy:
From Angiography to Intravascular
Ultrasound and Beyond ................................................................ 81
Olcay Aksoy and E. Murat Tuzcu
7 Assessment of Plaque Composition
by Intravascular Ultrasound ........................................................ 89
Salvatore Brugaletta and Hector M. Garcia-Garcia
8 Optical Coherence Tomography
of Coronary Atherosclerosis ......................................................... 105
Manabu Kashiwagi, Hironori Kitabata,
Takashi Akasaka, and Guillermo J. Tearney
9 Finding the Hot Plaque: Intravascular Thermography ............ 119
Konstantinos Toutouzas, Archontoula Michelongona,
Maria Drakopoulou, and Christodoulos Stefanadis
ix