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I Designed for the Internal Medicine Clerkship IM Essentials §2 A Medical KnowledgQ Self-Assessment Program® (MKSAP®) rot Students V', . i Philip A. Masters, MD, FACP Senior Physician Educator American College of Physicians Editor-in-Chief BACP CDIM American College of Physicians Clerkship Directors in Internal Medicine Contents Foreword ...........................................................................................ill 3 Gastroenterology and Hepatology Contributing Authors ...................................................................vi High Value Care Recommendations........................................72 16 Approach to Abdominal Pain ...........................................73 I Cardiovascular Medicine Seth Politano, DO and Eric Hsieh, MD 17 Dyspepsia ................................................................................78 High Value Care Recommendations............................................2 Chad S. Miller, MD 1 Approach to Chest Pain .........................................................3 18 Gastroesophageal Reflux Disease......................................81 Eric Goren, MD Corina Ungureanu, MD 2 Chronic Stable Angina...........................................................6 19 Peptic Ulcer Disease..............................................................84 John Varras, MD Karen Szauter, MD 3 Acute Coronary Syndrome...................................................11 20 Approach to Liver Chemistry Tests .................................86 Michael Picchioni, MD Jonathan S. Appelbaum, MD 4 Conduction Blocks and Bradyarrhythmias....................15 21 Hepatitis ...................................................................................89 Robert Trowbridge, MD Carlos Palacio, MD 5 Supraventricular Arrhythmias .........................................18 22 Cirrhosis...................................................................................93 ChadS. Miller, MD MarkJ. Fagan, MD 6 Ventricular Arrhythmias......................................................23 23 Diseases of the Gallbladder and Bile Ducts ..................98 Robert Trowbridge, MD Nora L. Porter, MD 7 Heart Failure ...........................................................................27 24 Acute Pancreatitis................................................................101 Alpesh N. Amin, MD Nora L. Porter, MD 8 Valvular Heart Disease.........................................................32 25 Approach to Diarrhea........................................................104 H. Douglas Walden, MD Lynda Misra, DO 9 Vascular Disease......................................................................37 26 Inflammatory Bowel Disease...........................................109 Leigh Simmons, MD and Robert Trowbridge, MD Susan T. Hingle, MD 27 Approach to Gastrointestinal Bleeding.........................113 2 Endocrinology and Metabolism Gauri Agarwal, MD High Value Care Recommendations.........................................44 10 Hypothalamic and Pituitary Disorders .........................45 4 General Internal Medicine Eric Goren, MD High Value Care Recommendations......................................118 11 Thyroid Disease......................................................................48 28 Diagnostic Decision Making ............................................119 Nona Kwong, MD and Erik K. Alexander, MD D. Michael Elnicki, MD 12 Adrenal Disease......................................................................54 29 Therapeutic Decision Making .........................................123 Cynthia A. Bums, MD Brian Heist, MD and D. Michael Elnicki, MD 13 Diabetes Mellitus...................................................................60 30 Health Promotion, Screening, and Prevention .........127 Nona Kwong, MD and ErikK. Alexander, MD L. James Nixon, MD and Briar Duffy, MD 14 Diabetic Ketoacidosis and Hyperglycemic 31 Hypertension........................................................................132 Hyperosmolar Syndrome....................................................65 Thomas M. DeFer, MD Nona Kwong, MD and Erik K Alexander, MD 32 Dyslipidemia ........................................................................136 15 Osteoporosis ...........................................................................67 Gary Tabas, MD and D. Michael Elnicki, MD Mark D. Corriere, MD 33 Obesity....................................................................................141 L. James Nixon, MD and Briar Duffy, MD 34 Approach to Low Back Pain..............................................144 Sarita Worrier, MD 35 Approach to Cough.............................................................148 58 Tuberculosis......................................................................245 Kendall Novoa-Takara, MD Bipin Thapa, MD 36 Smoking Cessation.............................................................152 59 Infective Endocarditis............................................................249 Nadia Ismail, MD Fred A. Lopez, MD 37 Depression..............................................................................156 60 Urinary Tract Infection......................................................252 Karen E. Kirkham, MD Irene Alexandraki, MD 38 Substance Abuse...................................................................160 61 Sexually Transmitted Diseases .......................................256 Bipin Thapa, MD Sara B. Fazio, MD 39 Disorders of Menstruation and Menopause ...............163 62 HIV Infection.........................................................................260 Sara B. Fazio, MD Juan Reyes, MD 40 Approach to Syncope .........................................................168 63 Osteomyelitis.........................................................................264 Gretchen Diemer, MD David C. Tompkins, MD 41 Approach to Lymphadenopathy......................................172 64 Sepsis Syndrome .................................................................267 Heather Harrell, MD Isaac O. Opole, MD 42 Approach to Involuntary Weight Loss............................174 65 Health Care-Associated Infections.................................271 Danelle Cayea, MD, MS Gonzalo Bearman, MD 43 Comprehensive Geriatric Assessment .........................177 Jenny Wright, MD and Anne Eacker, MD 7 Nephrology 44 Palliative Care........................................................................181 Susan Glod, MD High Value Care Recommendations......................................276 45 Genetics and Genetic Testing............................................185 66 Approach to Kidney Disease ...........................................277 Robert Robinson, MD and Madhusree Singh, MD John A. Walker, MD 46 Common Dermatologic Disorders.................................188 61 Fluid and Electrolyte Disorders......................................282 Matthew Burday, DO Mary Jane Barchman, MD 68 Calcium and Phosphorus Metabolism.........................288 Mary Jane Barchman, MD 5 Hematology 69 Acid-Base Disorders...........................................................291 High Value Care Recommendations......................................198 Joseph Charles, MD 47 Anemia ...................................................................................197 70 Acute Kidney Injury...........................................................295 Reed E. Drews, MD Harold M. Szerlip, MD 48 Sickle Cell Disease ..............................................................205 71 Chronic Kidney Disease....................................................300 Reed E. Drews, MD Matthew J Diamond, DO 49 Thrombocytopenia..............................................................208 72 Nephrolithiasis......................................................................307 Richard S. Eisenstaedt, MD Scott Herrle, MD 50 Hematopoietic Stem Cell Disorders ...............................211 Richard S. Eisenstaedt, MD 8 Neurology 51 Multiple Myeloma.................................................................216 Richard S. Eisenstaedt, MD High Value Care Recommendations......................................212 52 Bleeding Disorders..............................................................220 73 Headache................................................................................313 Joel Appel, DO Jonathan S. Appelbaum, MD 53 Thrombophilia......................................................................224 74 Approach to Meningitis and Encephalitis....................316 Amy Hayton, MD and Lawrence Loo, MD Fred A. Lopez, MD 54 Transfusion Medicine.........................................................228 75 Stroke and Transient Ischemic Attack .........................321 Dennis Chang, MD Jane P. Gagliardi, MD 76 Altered Mental Status, Dementia, and Delirium..........327 Jennifer S. Bequette, MD and Valerie J. Lang, MD 6 Infectious Disease Medicine 77 Peripheral Neuropathy......................................................333 High Value Care Recommendations......................................234 Christopher A. Klipstein, MD 55 Approach to Fever.................................................................235 78 Approach to Selected Movement Disorders...............336 Joseph T. Wayne, MD Bryan Ho, MD and Lianne Marks, MD, PhD 56 Common Upper Respiratory Infections.......................238 79 Seizures and Epilepsy.........................................................339 Jennifer Bierman, MD Martha Hlafka, MD 57 Community-Acquired Pneumonia.................................241 80 Other Neurologic Diseases ..............................................344 Irene Alexandraki, MD Amalia Landa Galindez, MD 9 Oncology 11 R heum atology High Value Care Recommendations......................................,150 High Value Care Recommendations......................................416 81 Lung Cancer...........................................................................351 97 Approach to Joint Pain ......................................................417 AlyssaC. McMunuinun. MD Thomas M. DeFer, MD 82 Breast Cancer........................................................................354 98 Approach to Knee and Shoulder Pain .........................422 Kathleen F. Ryan, MD Joseph Rencic, MD 83 Colorectal Cancer................................................................358 99 Osteoarthritis........................................................................425 Kathleen F. Ryan, MD Robert Pargamcnt, MD 84 Cervical Cancer ...................................................................361 100 Crystal Induced Arthritis.................................................429 Asra R. Khan. MD Sean Whelton, MD 85 Prostate Cancer ...................................................................366 101 Infectious Arthritis..............................................................432 Eric H. Green, MD Thomas M. De Fer, MD 86 Skin Cancer...........................................................................369 102 Rheumatoid Arthritis.........................................................435 Monica Ann Shaw, MD Alda Maria Gortzaga, MD 87 Lymphoid Malignancies ...................................................373 103 Systemic Lupus Erythematosus......................................440 Merry Jennifer Markham. MD Kimberly Tartaglia, MD 88 Oncologic Urgencies and Emergencies .......................379 104 Spondyloarthritis.................................................................444 Maria Dungo, MD and Liana Nikolaenko, MD Thomas M. De Fer, MD 105 Other Rheumatologic Conditions.................................448 Kevin M. McKown, MD 10 Pulmonary Medicine 106 Systemic Vasculitis..............................................................453 High Value Care Recommendations........................................384 Ernie L. Esquivel, MD 89 Interpretation of Pulmonary Function Tests .............385 Mysti D. W. Schott, MD Index ................................................................................................457 90 Approach to Dyspnea..........;...............................................388 Nina Mingioni, MD Color Plates ................................................................Back of Book 91 Pleural Effusion ......................................................................391 Roderick Go, DO Errata......................................https://ime.acponline.org/errata 92 Asthma .......................................................................................395 Patricia Short, MD 93 Chronic Obstructive Pulmonary Disease.....................400 Carlos Palacio, MD 94 Obstructive Sleep Apnea......................................................404 David V. Gugliotti, MD 95 Diffuse Parenchymal Lung Diseases .............................407 Feroza Daroowalla, MD 96 Pulmonary Vascular Disease ..............................................411 Aipesh N. Amin, MD Previous Author Acknowledgments ACP would like to thank the following people who contributed to earlier versions of the chapters listed below. Cardiovascular Medicine Chapter 2: Dr. Anna C. Maio Chapter 5: Dr. Charin L. Hanlon Chapter 6: Dr. Steven J. Durning, Dr. Mark C. Haigney, and Dr. Suma Pokala Chapter 7: Dr. James L. Sebastian Endocrinology and Metabolism Chapter 15: Dr. Melissa A. McNeil and Dr. Janine M. Frank Gastroenterology and Hepatology Chapter 16: Dr. Priya Radhakrishnan Chapter 17: Dr. Brown J. McCallum Chapter 18: Dr. Brown J. McCallum and Dr. Shalini Reddy Chapter 19: Dr. Brown J. McCallum Chapter 26: Dr. Brown J. McCallum General Internal Medicine Chapter 34: Dr. Lawrence I. Kaplan and Dr. Rosa Lee Chapter 37: Dr. Hugo A. Alvarez Chapter 40: Dr. Lawrence I. Kaplan Chapter 43: Dr. Ivonne Z. Jimenez-Velazquez Chapter 46: Dr. Hanah Polotsky and Dr. Robert Jablonover Hematology Chapter 50: Dr. Mark M. Udden Chapter 51: Dr. Mark M. Udden Chapter 52: Dr. Diane C. Sliwka Infectious Disease Chapter 56: Dr. Robert W. Nelson, Jr. Chapter 64: Dr. Charin L. Hanlon Nephrology Chapter 69: Dr. Tomoko Tanabe Pulmonary Medicine Chapter 89: Dr. Kevin D. Whittle Rheumatology Chapter 102: Dr. Kathryn A. Naus, Dr. Kyla Lokitz, and Dr. Seth Mark Bemy Chapter 103: Dr. Saba Khan and Dr. Seth Bemey XIV High Value Care Recommendations The High Value Care initiative of the American College of Physicians is an effort to improve health care outcomes by encouraging physi­ cians to provide care with proven benefit and to reduce harms and costs by avoiding unnecessary interventions. The initiative integrates the important concept of health care value (balancing clinical ben­ efit with costs and harms) for a given intervention into various edu­ cational materials to address the needs of medical students, trainees, practicing physicians, and patients. To incorporate high value care principles into IM Essentials, we have highlighted high value care recommendations throughout this book (in bold) that meet the definition below. In addition, we have aggregated each section’s recommendations at the beginning of the section so that they can be reviewed in one location. High Value Care Recommendation: A recommendation to choose diagnostic and management strategies for patients in specific clinical situations that balance clinical benefit with cost and harms with the goal of improving patient outcomes. XV

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