(ict) for the assessment of patients with alzheimer's disease and relate

380 Pages·2015·16.06 MB·English

THE USE OF INFORMATION AND
COMMUNICATION TECHNOLOGIES (ICT)
FOR THE ASSESSMENT OF PATIENTS WITH
ALZHEIMER’S DISEASE AND RELATED
DISORDERS
Cover design: Andrea Grigolli, Mona Lisa by Manfred Beumers,
reprinted with the permission of Carla and Galerie Beumers in
Monschau, Germany

Layout and printing: Proefschriftmaken.nl II Uitgeverij BOXPress

© Copyright Alexandra König, Maastricht 2015

All rights reserved. No part of this thesis may be reproduced or
transmitted in any form or by any means without prior written
permission of the author.
THE USE OF INFORMATION AND
COMMUNICATION TECHNOLOGIES (ICT)
FOR THE ASSESSMENT OF PATIENTS WITH
ALZHEIMER’S DISEASE AND RELATED
DISORDERS

PROEFSCHRIFT

Ter verkrijging van de graad van doctor
aan de Universiteit Maastricht, op gezag van Rector Magnificius,
Prof. Dr. L.L.G. Soete, volgens het besluit van het College van
Decanen, in het openbaar te verdedigen op
donderdag, 22 october 2015 om 10:00 uur

door

Alexandra Veronika König

Geboren op 26 April 1983 in Aachen, Duitsland
Supervisors: Prof. Frans Verhey
Prof. Philippe Robert

Co-supervisors: Dr. Pauline Aalten
Dr. Renaud David

Assessment committee: Prof. Rudolf Ponds, chair
Prof. Luc de Witte
Prof. Magda Tsolaki
Dr. Martin van Boxtel
Dr. Franka Meiland

The research described in this thesis was performed at the Memory
Clinic in the Geriatric Hospital in Nice, France, the research unit
CoBTeK (Cognition-Behavior-Technology), University of Nice
Sophia Antipolis, France and School for Mental Health and
Neuroscience, Alzheimer Center Limburg, Maastricht University
Medical Center, Maastricht, The Netherlands.

This research was performed within the framework of the European
FP7 project ”Dem@care” (http://www.demcare.eu/ - grant number
288199).

Printing of this thesis was kindly supported by: Maastricht University,
Lundbeck, Internationale Stichting Alzheimer Onderzoek, Alzheimer
Nederland, Novartis, Johson & Johnson, Pfizer, Scienceplus, Stichting
Alkemade-Keuls, Roche, Servier, AstraZeneca!!
!!!!!!!!!!!!!!
For my mother
A computer would deserve to be called intelligent if it
could deceive a human into believing that it was human

- Alan Turing –
CONTENTS

CHAPTER 1 General Introduction, aims and outline of thesis 10

PART I: Review and Recommendations for ICT use for assessment

CHAPTER 2 A review of current information and communication
technologies: can they be used to assess apathy?
International Journal of Geriatric Psychiatry, 2013 32

CHAPTER 3 Recommendations for ICT use in Alzheimer’s
disease assessment: Monaco CTAD Expert Meeting.
Journal of Nutrition, Health & Aging, 2013 70

PART II: Sensor-based studies

CHAPTER 4 Actigraphic motor activities in mild cognitive
impairment patients carrying out short functional
activity tasks: comparison between mild cognitive
impairment with and without depressive symptoms.
Journal of Alzheimer’s Disease, 2014 100

CHAPTER 5 Validation of an automatic video monitoring system
for the detection of instrumental activities of daily living
in dementia patients.
Journal of Alzheimer’s Disease, 2014 120

CHAPTER 6 Ecological assessment of autonomy in instrumental
activities of daily living in dementia patients by the
means of an automatic video monitoring system.
Frontiers in Aging Neuroscience, 2015 148

CHAPTER 7 Automatic speech analysis for the assessment of
pre-demented and Alzheimer patients.
Alzheimer’s & Dementia :
Diagnosis, Assessment & Disease Monitoring, 2015 183
PART III: Conclusion and future implications

CHAPTER 8 The role of information and communication technologies
in clinical trials with patients with Alzheimer’s disease
and related disorders.
Frontiers in Aging Neuroscience, 2015 225

CHAPTER 9 Recommendations for the use of
serious games in people with Alzheimer’s disease,
related disorders and frailty.
Frontiers in Aging in Neuroscience, 2014 241

CHAPTER 10 General discussion 283
Summary 307
Knowledge valorization 313
Author affiliations 321
Publications 326
Author information 333
Acknowledgements 335
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CHAPTER 1

GENERAL INTRODUCTION

AIMS AND RESEARCH QUESTIONS

OUTLINE OF THESIS

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