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Urol Int 97 | 2 | 16 print online www.karger.com/uin 97(2) 125–248 (2016) ISSN 0042–1138 e-ISSN 1423–0399 Risk Ratio M-H, Fixed, 95% CI 0.01 0.1 1 10 100 Surgical Conservative S. Karger Medical and Scientific Publishers Basel . Freiburg . Paris . Official Scientific Journal London . New York . Chennai . Deutsche Gesellschaft für Urologie New Delhi . Bangkok . Beijing . Shanghai . Tokyo . Kuala Lumpur . Singapore . Sydney Medical Statistics has never been easier! David E. Matthews D.E. Matthews . V.T. Farewell Vernon T. Farewell Using and Using and Understanding Understanding Medical Statistics Medical Statistics 5th, revised and extended edition ∑> CT> dp tor(cid:191)a- unestv FbtahaaAierte:llsromr uihtcle.eveuu nt=er3blte0 '8eo s.Ds 5rst0e 11ci(0aE4 ust8dx4lu9aob9cse3tir scTuelsots ifso)r Count Data 5th, revised and extended edition Pr(Y=1|X=x)=1+exepx(pa(+a+bxb)x) T=(O1−E1E1)2+(O2−E2E2)2 Matthews, D.E. (Waterloo, Ont.); The fifth revised edition of this highly successful book Contents Farewell, V.T. (Cambridge) presents the most extensive enhancement since Using and Understanding Medical Statistics Preface to the Fifth Edition 5th, revised and extended edition Using and Understanding Medical Statistics was first Prefaces to the Previous Editions XX + 338 p., 48 fig., 103 tab., 2015 published 30 years ago. Without question, the single CHF 49.00 / EUR 46.00 / USD 54.00 greatest change has been the inclusion of source • Basic Concepts (hard cover + online supplementary material) Online version for institutional purchase code, together with selected output, for the award- • Tests of Significance Prices subject to change, VAT not included winning, open-source, statistical package known as • Fisher’s Test for 2 × 2 Contingency Tables EUR price for eurozone countries, USD price for R. This innovation has enabled the authors to de- USA and Latin America only • Approximate Significance Tests for ISBN 978–3–318–05458–3 emphasize formulae and calculations, and let soft- (hard cover + online supplementary material) ware do all of the ‘heavy lifting’. Contingency Tables e-ISBN 978–3–318–05459–0 This edition also introduces readers to several graph- • Some Warnings concerning 2 × 2 Tables ical statistical tools, such as Q-Q plots to check nor- • Kaplan-Meier or ‘Actuarial’ Survival Curves eBook available on: mality, residual plots for multiple regression models, • The Log-Rank or Mantel-Haenszel Test for funnel plots to detect publication bias in a meta- Comparing Survival Curves analysis and Bland-Altman plots for assessing agree- • An Introduction to the Normal Distribution ment in clinical measurements. New examples that better serve the expository goals have been added • Analyzing Normally Distributed Data to a half-dozen chapters. In addition, there are new • Linear Regression Models for Medical Data sections describing exact confidence bands for the • Binary Logistic Regression Kaplan-Meier estimator, as well as negative binomial • Regression Models for Count Data and zero-inflated Poisson regression models for over- • Proportional Hazards Regression dispersed count data. The end result is not only an excellent introduction • The Analysis of Longitudinal Data to medical statistics, but also an invaluable reference • Analysis of Variance for every discerning reader of medical research lit- • Data Analysis erature. • The Question of Sample Size • The Design of Clinical Trials • Further Comments regarding Clinical Trials Dear Librarian • Meta-Analysis I have reviewed this publication and • Epidemiological Applications would like to recommend it for our library. • Diagnostic Tests Recommended by: • Agreement and Reliability References Subject Index Department: Date: The easiest way to order: www.karger.com/medical_statistics Signature: C 4 Karger – Medical and Scientific Publishers 6_ Orders may be placed with any bookshop, CH–4009 Basel, Switzerland 540 subscription agency, directly with the publisher [email protected], f: +41 61 306 12 34 KI1 www.karger.com or through a Karger distributor. GzD 2016 EB GL GI Official Scientific Journal of the Deutsche Gesellschaft für Urologie/ German Society of Urology Founded 1955 by Peter A. Narath and Heinrich Heusser Successors: G. Mayor (1968–1987); D. Hauri (1988–2005) Editors Board of Reviewing Editors M.P. Wirth, Dresden W. Artibani, Verona V.R. Marshall, Mintaro O.W. Hakenberg, Rostock M. Babjuk, Prague M. Mas, La Laguna, Tenerife D. Castro-Diaz, G. Baretton, Dresden M. May, Straubing Santa Cruz de Tenerife P. Bassi, Rome L. Mearini, Perugia B. Wullich, Erlangen N.N.P. Buchholz, Ilford S. Minhas, London M. Burger, Regensburg E. Montanari, Milan E. Costantini, Perugia G. Morgia, Catania Editorial Committee A.K. Ebert, Ulm G. Nicita, Florence M. Fisch, Hamburg R.T.D. Oliver, London A. Briganti, Milan P. Fornara, Halle S. Propping, Dresden S. Egawa, Tokyo B. Frea, Udine C. Protzel, Rostock S. Madersbacher, Vienna M. Froehner, Dresden P. Radziszewski, Warsaw M.S. Michel, Mannheim S. Füssel, Dresden P.N. Schlegel, New York V. 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In this book Gottfried Schatz, the world-renowned biochemist and co-discoverer of mitochondrial DNA, gives lucid – albeit often surprising – answers to universal questions and takes the reader on a fasci- nating journey of discovery across the boundaries of scientific disciplines. GG. SScchhaattzz ((BBaasseell)) With passion and a keen sense of wonder he draws on philosophy, A Matter of Wonder cultural history and art to formulate his reflections on the mysteries of life. What Biology Reveals about Us, Our World, and Our Dreams These essays on key issues in the natural sciences will appeal not only to Translated by A. Shields scientists but to all inquisitive minds, regardless of educational and XII + 190 p., 2 color fig., hard cover, 2011 professional background. CHF 29.00 / EUR 27.00 / USD 29.00 ISBN 978–3–8055–9744–9 S. Karger AG, P.O. Box Fax +41 61 306 12 34 More information and sample essays at CH–4009 Basel E-Mail [email protected] (Switzerland) www.karger.com www.karger.com/schatz KI11274 © 2016 S. Karger AG, Basel E-Mail [email protected] The Guidelines for Authors are available at: www.karger.com www.karger.com/uin_Guidelines 7 1 0 2 A International Congress of Andrology C6 - 9 May 2017 Copenhagen, Denmark I TOPICS Oncofertility  The aging male  Epididymis  Genetics of male infertility  Lifestyle and the male epigenome  New roles of androgens  Sexual health  Semen quality as a health marker   Molecular basis of sperm function www.ICA2017.dk F17018 General Information Urologia Internationalis ISSN Print Edition: 0042–1138 Subscription Rates: Subscriptions run for Back Volumes and Single Issues: Information on ISSN Online Edition: 1423–0399 a full calendar year. 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V;C Zaogulptisnohais,lc VEo.s;p tGyraodswioaml ini, D. This journal covers the most active and promising areas of current re- Selected contributions search in gynecology and obstetrics. Invited, well-referenced reviews • External Validation of the Endometriosis Fertility Index (EFI) for Predicting by noted experts keep readers in touch with the general framework and Spontaneous Pregnancy after Surgery: Further Considerations on Its direction of international study. Original papers report selected experi- Validity: Garavaglia, E.; Pagliardini, L.; Tandoi, I.; Sigismondi, C.; Viganò, P.; mental and clinical investigations in all fields related to gynecology, Ferrari, S.; Candiani, M. (Milano) • Knowledge and Attitude towards Menopause and Hormone obstetrics and reproduction. Short communications are published to Replacement Therapy in Chinese Women: Jin, F.; Tao, M.; Teng, Y.; Shao, H.; allow immediate discussion of new data. The international and interdis- Li, C. (Shanghai); Mills, E. (Ottawa, Ont./Stanford, Calif.) ciplinary character of this periodical provides an avenue to less acces- • Prognostic Significance of Pretreatment Plasma Fibrinogen and Platelet sible sources and to worldwide research for investigators and practitio- Levels in Patients with Early-Stage Cervical Cancer: Zhao, K.; Deng, H.; ners. Qin, Y.; Liao, W.; Liang, W. (Guangzhou) • In vitro Fertilization Outcome following Embryo Transfer with or without Preinstillation of Human Chorionic Gonadotropin into the Uterine Cavity: A Randomized Controlled Trial: Aaleyasin, A.; Aghahosseini, M.; Rashidi, M.; Safdarian, L.; Sarvi, F.; Najmi, Z.; Mobasseri, A.; Amoozgar, B. (Tehran) • Laparoendoscopic Single-Site Surgery for Benign Ovarian Cystectomies: Bedaiwy, M.A. (Cleveland, Ohio/Vancouver, B.C.); Sheyn, D. (Cleveland, Ohio); Gynecologic and Obstetric Investigation Eghdami, L. (Vancouver, B.C.); Abdelhafez, F.F. (Cleveland, Ohio); Volsky, J.G. Founded: 1895 (Chicago, Ill.); Nickles-Fader, A. (Baltmore, Md); Escobar, P.F. (Cleveland, Ohio) Category: Clinical and Basic Research • Metastatic Choriocarcinoma Presenting in a Gravid Woman: Fields of Interest: Gynecology, Obstetrics Byrd, K. (Bethesda, Md.); Seay, R. (Washington, D.C.); Bechert, C.J.; Maxwell, G.L.; Bicher, A. (Falls Church, Va.) Listed in bibliographic services, including: • Outcomes of Follicle-Stimulating Hormone Priming and Nonpriming in PubMed/MEDLINE, Web of Science, in vitro Maturation of Oocytes in Infertile Women with Polycystic Ovarian Google Scholar, Scopus, Embase Syndrome: A Single-Blinded Randomized Study: Choavaratana, R.; Thanaboonyawat, I.; Laokirkkiat, P.; Prechapanich, J.; Suksompong, S.; 2017: Volumes 82 Mekemaharn, O.; Petyim, S. (Bangkok) 4 issues per volume • Effectiveness of Combining Plasma Exchange with Plasma Perfusion Language: English in Acute Fatty Liver of Pregnancy: A Retrospective Analysis: Ding, J.; ISSN 0378–7346 Han, L.-P.; Lou, X.-P.; Geng, L.-N.; Liu, D.; Yang, Q.; Gao, S. (Zhengzhou) e-ISSN 1423–002X 6 4 Impact Factor: 1.672 More information at www.karger.com/goi KF170 The world of nephrology united in one publication Editor-in-Chief Section Editors A. Benigni, Clinical Practice Bergamo D. Warnock, Birmingham, Ala. Experimental Nephrology and Genetics F. Terzi, Paris N.V.V.A.M. Knoers, Utrecht Physiology F. Lang, Tübingen Nephron comprises three sections, which are each under the editorship Selected contributions of internationally recognized leaders and served by specialized Associ- • The Gut as a Source of Inflammation in Chronic Kidney Disease: Lau, W.L.; ate Editors. Apart from high-quality original research, Nephron pub- Kalantar-Zadeh, K.; Vaziri, N.D. (Orange, Calif.) lishes invited reviews/minireviews on up-to-date topics. Papers un- • Quality of Life in Dialysis Patients: A Retrospective Cohort Study: dergo an innovative and transparent peer review process encompassing Broers, N.J.H. (Maastricht); Usvyat, L.A. (Waltham, Mass.); Kooman, J.P.; van der Sande, F.M. (Maastricht); Lacson, Jr., E. (Waltham, Mass.); Kotanko, P. a Presentation Report which assesses and summarizes the presentation (New York, N.Y.); Maddux, F.W. (Waltham, Mass.) of the paper in an unbiased and standardized way. • Assessment of the HNF1B Score as a Tool to Select Patients for HNF1B The open access journal Nephron Extra provides additional contents Genetic Testing: Clissold, R.; Shields, B.; Ellard, S.; Hattersley, A.; Bingham, C. based on reviewed and accepted submissions to the main journal Neph- (Exeter) ron on www.karger.com/nne. • Urine Osmolarity Predicts the Body Weight-Reduction Response to Tolvaptan in Chronic Kidney Disease Patients: A Retrospective, Observational Study: Iwatani, H.; Kawabata, H.; Sakaguchi, Y.; Yamamoto, R.; Hamano, T.; Rakugi, H.; Isaka, Y. (Suita) • The Low AGE Diet: A Neglected Aspect of Clinical Nephrology Practice?: Uribarri, J.; He, J.C. (New York, N.Y.) • HPSE2 Mutations in Urofacial Syndrome, Non-Neurogenic Neurogenic Bladder and Lower Urinary Tract Dysfunction: Bulum, B.; Özçakar, Z.B.; Duman, D.; Cengiz, F.B.; Kavaz, A.; Burgu, B.; Baskın, E.; Çakar, N.; Soygür, T.; Ekim, M. (Ankara); Tekin, M. (Miami, Fla.); Yalçınkaya, F. (Ankara) • Kidney Volume Estimations with Ellipsoid Equations by Magnetic Nephron Resonance Imaging in Autosomal Dominant Polycystic Kidney Disease: Founded: 1964 Higashihara, E.; Nutahara, K.; Okegawa, T.; Tanbo, M.; Hara, H.; Miyazaki, I.; Category: Clinical and Basic Research Kobayasi, K.; Nitatori, T. (Tokyo) Field of Interest: Nephrology • Determination of the Renal Threshold for Glucose Excretion in Familial Renal Glucosuria: Aires, I. (Lisbon); Fila, M. (Paris); Polidori, D. (San Diego, Calif.); Listed in bibliographic services, including Santos, A.R.; Costa, A.B.; Calado, J. (Lisbon) Journal Citation Reports, PubMed/MEDLINE, Biological Abstracts, Embase, Amedeo 2016: Volumes 132, 133, 134 4 issues per volume Language: English ISSN 1660–8151 074 e-ISSN 2235–3186 More information at www.karger.com/nef KF16 A unique forum for research on sexual development Genetics, Molecular Biology, Evolution, Endocrinology, Embryology and Pathology of Sex Determination and Differentiation Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation NPuobwM liesdte/Md iend line Editors-in-Chief Section Editors Endocrinology Michael Schmid, Olaf Hiort, Lübeck Genetics Würzburg Ken-ichirou Morohashi, Richard Behringer, Peter Koopman, Fukuoka Houston, Tex. Brisbane, Qld. Development Biology Manfred Schartl, Molecular Biology Marilyn B. Renfree, David Zarkower, Würzburg Melbourne, Vic. Minneapolis, Minn. Blanche Capel, Robin Lovell-Badge, Durham, N.C. London Pathology Evolution Eric Vilain, David Crews, Austin, Tex. Los Angeles, Calif. Horacio Merchant-Larios, Ken McElreavey, Paris Mexico City Recent discoveries in experimental and clinical research have led to im- Selected contributions pressive advances in our knowledge of the genetic and environmental • The Genetics of Disorders of Sex Development in Humans: Ohnesorg, T. mechanisms governing sex determination and differentiation, their evo- (Melbourne, Vic.); Vilain, E. (Los Angeles, Calif.); Sinclair, A.H. (Melbourne, Vic.) lution as well as the mutations or endocrine and metabolic abnormalities • Characteristic Features of Reproductive Hormone Profiles in Late that interfere with normal gonadal development. Sexual Development Adolescent and Adult Females with Complete Androgen Insensitivity provides a unique forum for this rapidly expanding field. Its broad scope Syndrome: Doehnert, U. (Lübeck); Bertelloni, S. (Pisa); Werner, R. (Lübeck); covers all a spects of genetics, molecular biology, embryology, endocrinol- Dati, E. (Pisa); Hiort, O. (Lübeck) • Promoter-Dependent Activity on Androgen Receptor N-Terminal ogy, evolution and path ology of sex determination and differentiation in Domain Mutations in Androgen Insensitivity Syndrome: humans and animals. It publishes high-quality original research manu- Tadokoro-Cuccaro, R.; Davies, J. (Cambridge); Mongan, N.P. (Nottingham); scripts, review articles, short reports, case reports and commentaries. An Bunch, T. (Cambridge); Brown, R.S. (Boston, Mass.); Audi, L. (Barcelona); Watt, K.; internationally renowned and multidisciplinary editorial team of three McEwan, I.J. (Aberdeen); Hughes, I.A. (Cambridge) chief editors, ten prominent scientists serving as section editors, and a • Characterising Novel Pathways in Testis Determination Using Mouse distinguished panel of editorial board members ensures fast and author- Genetics: Carré, G.-A.; Greenfield, A. (Harwell) friendly editorial processing and peer reviewing. • Building an Ovary: Insights into Establishment of Somatic Cell Lineages in the Mouse: Nicol, B.; Yao, H.H.-C. (Research Triangle Park, N.C.) • Temperature-Dependent Sex Determination Ruled Out in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis) via Molecular Cytogenetics and Sexual Development Incubation Experiments across Populations: Mu, Y. (Beijing); Zhao, B. Founded: 2007 (Hangzhou); Tang, W.-Q.; Sun, B.-J.; Zeng, Z.-G. (Beijing); Valenzuela, N. Category: Basic and Clinical Research (Ames, Iowa); Du, W.-G. (Beijing) Field of Interest: Genetics • Development of Avian External Genitalia: Interspecific Differences and Sexual Differentiation of the Male and Female Phallus: Herrera, A.M. Listed in bibliographic services, including (Gainesville, Fla.); Brennan, P.L.R. (Amherst, Mass.); Cohn, M.J. (Gainesville, Fla.) Journal Citation Reports, PubMed/MEDLINE, • Anatomical and Molecular Analyses of XY Ovaries from the African Biological Abstracts, Embase Pygmy Mouse Mus minutoides: Rahmoun, M.; Perez, J.; Saunders, P.A.; Boizet-Bonhoure, B. (Montpellier); Wilhelm, D. (Clayton, Vic.); Poulat, F.; 2016: Volume 10 Veyrunes, F. (Montpellier) 6 issues per volume Language: English ISSN 1661–5425 e-ISSN 1661–5433 9 9 Impact Factor: 2.288 More information at www.karger.com/sxd KF160

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The Log-Rank or Mantel-Haenszel Test for. Comparing . complete mailing address, e-mail address, as well as (for detailed instructions, see http://www.karger.com/uin). Case Reports should include the most important clinical .. Anatomical and Molecular Analyses of XY Ovaries from the African.
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