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Hutchison’s Clinical Methods For Elsevier Commissioning Editor: Laurence Hunter Development Editor: Sheila Black Project Manager: Joannah Duncan/Louisa Talbott Designer: Stewart Larking Illustration Manager: Merlyn Harvey Illustrator: Amanda Williams Twenty-third Edition Hutchison’s Clinical Methods An integrated approach to clinical practice Edited by Michael Glynn MA MD FRCP FHEA Consultant Physician and Gastroenterologist, Barts and the London NHS Trust; Honorary Senior Lecturer, Barts and the London School of Medicine and Dentistry; Director, North East Thames Foundation School, London, UK William M. Drake DM FRCP Consultant Physician, Barts and the London NHS Trust; Professor of Clinical Endocrinology, Barts and the London School of Medicine and Dentistry, London, UK Edinburgh London New York Oxford Philadelphia St Louis Sydney Toronto 2012 © 2012 Elsevier Ltd. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the Publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). First edition 1897 Twenty-third edition 2012 ISBN 978-0-7020-4091-7 International ISBN 978-0-7020-4092-4 British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Cataloging in Publication Data A catalog record for this book is available from the Library of Congress Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. The Working together to grow publisher’s libraries in developing countries policy is to use paper manufactured from sustainable forests www.elsevier.com | www.bookaid.org | www.sabre.org Printed in China SECTION  v  Prefacetothetwenty-thirdedition With each new edition of Hutchison, the ques- essentials of practice, the clinical teacher and the tion arises as to its relevance to the contemporary clinical student must work as hard as ever to ensure study and practice of medicine. Although updated that core clinical skills are taught, learned and prac- with new clinical knowledge, and new priorities and tised skilfully and appropriately. methods of investigation, the fundamentals of the Hutchison’s Clinical Methods emphasizes this book have remained unchanged for many years. By approach to clinical medicine, being split into four following the same basic pattern, past and current sections. The first describes overall patient assess- editors hope to emphasize the overriding impor- ment, and the second assessment in particular situ- tance of a thorough and systematic approach to ations. The third includes chapters on the core body taking a history, examining a patient and formulating systems and the fourth covers clinical methods as a differential diagnosis, which remains as essential as seen by the key clinical specialties. Overall this ever to providing good patient care. forms a logical sequence if read straight through, The complexity and fragmentation of many but also allows study of each section separately. modern health systems, and the expectation of some The organization of the book still follows the patients that ‘there is a test for every disease’, work aims set out by Hutchison with his colleague, Rainy, counter to the application of a basic clinical method, in the first edition, published in 1897. and also tend to lead clinicians towards incomplete The plan of this new edition continues to empha- diagnosis and therefore the wrong management plan size that teaching the medical history and examina- for their patients. In turn, this can lead to over- tion in isolation from the process of diagnosis and investigation, inappropriate treatment and increased planning management is illogical and likely to lead suffering for patients. For many patients, diagnosis to error. Therefore, each chapter describes both the by history and examination alone is far preferable to process of history taking and examination, and how the application of complex tests. This saves both the the information gained is integrated into the process patient and doctor time, reduces the cost of tests, of diagnosis and planning of care, making the book helps avoid the potential adverse consequences of an essential adjunct to a standard textbook of medi- these tests and is universally applicable, both in cine, surgery or a specialty. developed and less-developed areas of the world. As in all past editions of Hutchison, all the authors Complex or expensive tests clearly have an increas- have existing or past links with ‘Barts and the ing role in modern medical and surgical practice. London’, now consisting of The Royal London Hos- They will often reveal new subtleties to old- pital, St Bartholomew’s Hospital and The London established clinical methods, and their role must be Chest Hospital. The editors gratefully acknowledge absorbed into clinical methodology. Every clinical the work of all the current authors, as well as previ- test and investigation has its own relevance, and ous authors who have not contributed to this new any test, whether simple and old-established, or a edition. complex modern investigation, should be applied only when it is likely to yield trustworthy informa- Michael Glynn and Will Drake tion, and not in other circumstances. To learn these Royal London Hospital This page intentionally left blank Sir Robert Hutchison MD FRCP (1871-1960) Clinical Methods began in 1897, three years after Robert Hutchison was appointed Assistant Physician to The London Hospital (named the Royal London Hospital since its 250th anniversary in 1990). He was appointed full physician to The London and to the Hospital for Sick Children, Great Ormond Street in 1900. He steered Clinical Methods through no less than 13 editions, at first with the assistance of Dr H. Rainy and then, from the 9th edition, pub- lished in 1929, with the help of Dr Donald Hunter. Although Hutchison retired from hospital practice in 1934, he continued to direct new editions of the book with Donald Hunter, and from 1949 with the assistance also of Dr Richard Bomford. The 13th edition, the first produced without Hutchison’s guiding hand, was published in 1956 under the direction of Donald Hunter and Richard Bomford. Dr A. Stuart Mason and Dr Michael Swash joined Richard Bomford on Donald Hunter’s retirement to produce the 16th edition, published in 1975, and following Richard Bomford’s retirement prepared the 17th, 18th and 19th editions. Dr Swash edited the 20th and 21st editions himself, and was joined by Dr Michael Glynn for the 22nd edition. Each of these editions was revised with the help of col- leagues at The Royal London Hospital, in keeping with the tradition that lies behind the book. Sir Robert Hutchison died in 1960 in his 90th year. It is evident from the memoirs of his contem- poraries that he had a remarkable personality. Many of his clinical sayings became, in their day, aphorisms to be remembered and passed on to future genera- tions of students. Of these, the best known is his petition, written in 1953, his 82nd year: ‘From inability to let well alone; from too much zeal for the new and contempt for what is old; from putting knowledge before wisdom, science before art, and cleverness before common sense; from treating patients as cases; and from making the cure of the disease more grievous than the endurance of the same, Good Lord, deliver us.’ Michael Glynn and Will Drake Royal London Hospital This page intentionally left blank Contributors F. Runa Ali BSc MBBS PhD FRCP Adam Feather FRCP(UK) Consultant Physician in Respiratory Medicine Senior Lecturer in Medical Education and and Allergy Honorary Consultant Geriatrician Barts and the London NHS Trust Barts and the London School of Medicine London, UK and Dentistry and Newham University Hospital NHS Trust Andrew Archbold MBBS MD FRCP London, UK Consultant Cardiologist Barts and the London NHS Trust Jayne Gallagher MBBS FRCA FFPMRCA London, UK Consultant in Pain Medicine Department of Anaesthesia and Pain Medicine Rino Cerio BSc FRCP(Lon) FRCP(Edin) FRCPath Barts and the London NHS Trust DipRCPath ICDPath London, UK Director, Clinical Academic Unit Cutaneous Medicine and Surgery Michael Glynn MA MD FRCP FHEA Barts and the London NHS Trust Consultant Physician and Gastroenterologist London, UK Barts and the London NHS Trust; Honorary Senior Lecturer Tahseen A. Chowdhury MD FRCP Barts and the London School of Medicine Consultant Physician and Dentistry; Department of Diabetes and Metabolism Director Barts and the London NHS Trust North East Thames Foundation School London, UK London, UK Andrew Coombes BSc MBBS FRCOphth Robert Ghosh MBChB FRCP FFICM Consultant Eye Surgeon and Lead Clinician Consultant Physician for Ophthalmology Director of Intensive Care Barts and the London NHS Trust; Director of Acute Medicine Honorary Senior Lecturer Clinical Director of Critical and Urgent Care Barts and the London School of Medicine Homerton University Hospital NHS Trust and Dentistry London, UK London, UK Beng T. Goh MBBS FRCP FRCPI DipDerm DipVen David P. D’Cruz MD FRCP Consultant Genitourinary Physician Consultant Rheumatologist Department of Genitourinary Medicine George Koukis Reader in Vascular Rheumatology Barts and the London NHS Trust The Louise Coote Lupus Unit London, UK Guy’s and St Thomas’ NHS Trust London, UK John P. Monson MD FRCP FRCPI Emeritus Professor of Clinical Endocrinology William M. Drake DM FRCP Barts and the London School of Medicine; Consultant Physician, Barts and the London Consultant Physician and Endocrinologist NHS Trust; London Clinic Centre for Endocrinology Professor of Clinical Endocrinology London, UK Barts and the London School of Medicine and Dentistry London, UK

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