Humoral Factors in Host Defense PDF
Preview Humoral Factors in Host Defense
PROCEEDINGS OF THE FIRST TAKEDA SYMPOSIUM Members of the Symposium Committee Setsuro Ebashi The University of Tokyo Tokyo, japan Osamu Hayaishi Kyoto University Kyoto, japan Tomoji Suzuki Kyoto University Kyoto, japan Hamao Umezawa Institute of Microbial Chemistry Tokyo, japan Yuichi Yamamura Osaka University Osaka, japan HUMORAL FACTORS IN HOST DEFENSE Edited by Yuichi Yamamura Tadamitsu Kishimoto Osaka University Osaka University Osaka, Japan Osaka, japan Hideo Hayashi Masami Muramatsu Kumamoto University The University of Tokyo Kumamoto, Japan Tokyo, japan Tasuku Honjo Toshiaki Osawa Osaka University The University of Tokyo Osaka, japan Tokyo, japan 1983 ACADEMIC PRESS Λ Subsidiary of Harcourt Brace jovanovich, Publishers Tokyo New York London Paris San Diego San Francisco Säo Paulo Sydney Toronto ACADEMIC PRESS RAPID MANUSCRIPT REPRODUCTION Proceedings of the First Takeda Science Foundation Symposium on Bioscience, Held in Kyoto, Japan October 28-30, 1982 COPYRIGHT © 1983, BY THE TAKEDA SCIENCE FOUNDATION ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS JAPAN, INC. Hokoku Bldg. 3-1 1-13, Iidabashi, Chiyoda-ku, Tokyo 102 United States Edition published by ACADEMIC PRESS, INC. 11 1 Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS, INC. (LONDON) LTD. 24/28 Oval Road, London NW1 7DX Takeda Science Foundation Symposium on Bioscience (1st : 1982 : Kyoto, Japan) Humoral factors in host defense. Proceedings of the First Takeda Science Foundation Symposium on Bioscience, held Oct. 28-30, 1982 in Kyoto. Japan. Includes index. 1. Immune response—Regulation—Congresses. 2. Inter- feron—Congresses. 3. Τ cells—Congresses. 4. Immunoglobulins—Congresses. 5. Antigens—Congresses. 1. Yamamura, Yuichi. II. Takeda Kagaku Shinko Zaidan. III. Title. [DNLM: 1. Antibody formation—Congresses. 2. Interferons—Congresses. 3. Immunity, Cellular— Congresses. W3 TA163M 1st 1982h / QW 575 T136 1982h] QR186.T34 1982 559'.0295 83-12317 ISBN 0-12-768220-1 (alk. paper) PRI NTtDi IN THE UNITDE STATSE Of AMERIAC 83 84 85 86 9 8 7 6 5 4 3 2 1 CONTRIBUTORS Numbers in parentheses indicate the pages on which the authors' contributions begin. Jan Andersson (45), Biomedium, University of Uppsala, Uppsala, Sweden D. W. Andrews (343), Department of Biochemistry and Molecular Biology, Har- vard University, Cambridge, Massachusetts 02138 Benjamin Αφ (307), Department of Microbiology and immunology SC-42, Uni- versity of Washington, Seattle, Washington 98J95 Makoto Asada (291), Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan C. A. Auffray (343), Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138 Peter E. Barker (323), Department of Biology, Yale University, New Haven, Con- necticut 06511 David I. Beller (257), Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 M. R. Bono (343), Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138 Joseph L. Butler (81), Laboratory of Immunoregulation, National Institute of Aller- gy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205 H. Cantor (61), Laboratory of lmmunopathology, Färber Cancer Institute, Boston, Massachusetts 02115 Stanley Cohen (245), Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032 Catherine Corbel (45), Basel Institute for Immunology, 4005 Basel, Switzerland John R. David (279), The Departments of Medicine, Harvard Medical School and Robert B. Brigham Hospital, A Division of Brigham and Women s Hospital, Boston, Massachusetts 02115 Mitchell Dukovich (269), Microbiology Program, Department of Microbiology, Cell Biology, Biochemistry, and Biophysics, The Pennsylvania State Univer- sity, University Park, Pennsylvania 16802 IX χ CONTRIBUTORS Anthony S. Fauci (81), Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205 Georgia Floyd-Smith (157), Department of Molecular Biophysics and Biochemis- try, Yale University, New Haven Connecticut 065 JI Walter Gerhard (45), The Wistar institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104 Judith Giri (269), Microbiology Program, Department of Microbiology, Cell Biol- ogy, Biochemistry, and Biophysics, The Pennsylvania State University, Uni- versity Park, Pennsylvania 16802 Mark I. Greene (269), Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 Toshiyuki Hamaoka (1), Department of Oncogenesis, Institute for Cancer Re- search, Osaka University Medical School, Osaka 553, Japan Yoshinobu Hara (1), Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, Osaka 553, Japan Noboru Hashimoto (1), Department of Oncogenesis, institute for Cancer Research, Osaka University Medical School, Osaka 553, Japan Shin-ichi Hayashi (1), Department of Oncogenesis, institute for Cancer Research, Osaka University Medical School, Osaka 553, Japan Joel Haynes (111), Connaught Research Institute, Willowdale, Ontario M2R 3T4, Canada Masahiro Higuchi (291), Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan Cindy Hill (269), Microbiology Program, Department of Microbiology, Cell Biol- ogy, Biochemistry, and Biophysics, The Pennsylvania State University, Uni- versity Park, Pennsylvania 16802 Hiroshi Hisajima (323), Department of Genetics, Osaka University Medical School, Osaka 553, Japan Tasuku Honjo (323), Department of Genetics, Osaka University Medical School, Osaka 553, Japan Leroy Hood (337), Division of Biology, California Institute of Technology, Pasadena, California 91125 Maureen Howard (269), Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205 Norio Ishii (1), Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, Osaka 553, Japan S. Itoh (131), Kyowa Hakko Kogyo Co., Ltd., Machida-Shi, Tokyo 194, Japan Bettadapura M. Jayaram (157), Department of Molecular Biophysics and Biochem- istry, Yale University, New Haven, Connecticut 06511 Masamoto Kanno (71), Department of Immunology, School of Medicine, Chiba University, Chiba 280, Japan CONTRIBUTORS xi J. F. Kaufman 1(343), Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138 Yoshimi Kawade (175), institute for Virus Research, Kyoto University, Kyoto 606, Japan Ian M. Kerr (141), Imperial Cancer Research Fund Laboratories, Lincoln s Inn Fields, London WC2A 3PX, United Kingdom Tadamitsu Kishimoto (93), Department of Pathology and Medicine, Osaka Uni- versity Medical School, Osaka 553, Japan P. J. Knudsen (343), Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138 Yoshiro Kobayashi (291), Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan A. J. Korman (343), Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138 Peter Lengyel (157), Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511 Maria Leptin (45), Basel Institute for Immunology, 4005 Basel, Switzerland Waldemar Lernhardt (45), Basel Institute for Immunology, 4005 Basel, Switzerland Christopher Y. Lu (257), Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 Shuichiro Maeda (191), Roche Institute of Molecular Biology, Nutley, New Jersey 07110 Michael D. McMullen (307), Department of Microbiology and Immunology SC-42, University of Washington, Seattle, Washington 98195 Fritz Melchers (45), Basel Institute for Immunology, 4005 Basel, Switzerland Jim Miller (307), Department of Microbiology and Immunology SC-42, University of Washington, Seattle, Washington 98195 Steven B. Mizel (269), Microbiology Program, Department of Microbiology, Cell Biology, Biochemistry, and Biophysics, The Pennsylvania State University, University Park, Pennsylvania 16802 Atsushi Muraguchi (81), Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205 Sumiko Nakai (323), Department of Genetics, Osaka University Medical School, Osaka 553, Japan T. Nishi (131), Department of Biochemistry, Cancer Institute, Japanese Founda- tion for Cancer Research, Toshima-ku, Tokyo 170, Japan Yasuyoshi Nishida (323), Department of Genetics, Osaka University Medical School, Osaka 553, Japan Sharon Ogden (307), Department of Microbiology and Immunology SC-42, Uni- versity of Washington, Seattle, Washington 98195 S. Ohno (131), Department of Biochemistry, Cancer Institute, Japanese Founda- tion for Cancer Research, Toshima-ku, Tokyo 170, Japan Xll CONTRIBUTORS Kumeo Ono (71), Department of Immunology, School of Medicine, Chiba Uni- versity, Chiba 280, Japan Toshiaki Osawa (291), Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113, Japan William E. Paul (269), Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205 Sidney Pestka (191), Roche Institute of Molecular Biology, Nutley, New Jersey 07110 Heinz G. Remold (279), The Departments of Medicine, Harvard Medical School and Robert B. Brigham Hospital, A Division of Brigham and Women s Hos- pital, Boston, Massachusetts 02115 Jay Rothstein (269), Microbiology Program, Department of Microbiology, Cell Biology, Biochemistry, and Biophysics, The Pennsylvania State University, University Park, Pennsylvania 16802 M. Roux-Dosseto (343), Department of Biochemistry and Molecular Biology, Har- vard University, Cambridge, Massachusetts 02138 Frank H. Ruddle (323), Department of Biology, Yale University, New Haven, Connecticut 06511 Himadri Samanta (157), Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511 Yoshimi Sano (1), Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, Osaka 553, Japan A. Schamboeck (343), Department of Biochemistry and Molecular Biology, Har- vard University, Cambridge, Massachusetts 02138 Helmuth Schmidt (157), Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511 Erik Seising (307), Department of Microbiology and Immunology SC-42, Univer- sity of Washington, Seattle, Washington, 98195 D. Shackelford (343), Department of Biochemistry and Molecular Biology, Har- vard University, Cambridge, Massachusetts 02138 Kazuhiro Shigemoto (71), Department of Immunology, School of Medicine, Chiba University, Chiba 280, Japan Kendall A. Smith (17), Immunology Program, Dartmouth Medical School, Han- over, New Hampshire 03756 Michael Steinmetz (337), Division of Biology, California Institute of Technology, Pasadena, California 91125 Ursula Storb (307), Department of Microbiology and Immunology SC-42, Univer- sity of Washington, Seattle, Washington 98195 J. L. Strominger (343), Department of Biochemistry and Molecular Biology, Har- vard University, Cambridge, Massachusetts 02138 Takayuki Sumida (71), Department of immunology, School of Medicine, Chiba University, Chiba 280, Japan CONTRIBUTORS xiii Masatoshi Tagawa (71), Department of Immunology, School of Medicine, Chiba University, Chiba 280, Japan Naoki Takahashi (323), Department of Genetics, Osaka University Medical School, Osaka 553, Japan C. Takaoka (131), Department of Biochemistry, Cancer Institute, Japanese Foun- dation for Cancer Research, J-37-1 Kami-Ikebukuro, Japan Kiyoshi Takatsu (1), Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, Osaka 553, Japan Izumi Takei (71), Department of Immunology, School of Medicine, Chiba Univer- sity, Chiba 280, Japan Masaru Taniguchi (71), Department of Immunology, School of Medicine, Chiba University, Chiba 280, Japan T. Taniguchi (131), Department of Biochemistry, Cancer Institute, Japanese Foundation for Cancer Research, Toshima-ku, Tokyo 170, Japan Takeshi Tokuhisa (71), Department of Immunology, School of Medicine, Chiba University, Chiba 280, Japan Akira Tominaga (1, 269), Department of Oncogenesis, Institute for Cancer Re- search, Osaka University Medical School, Osaka 553, Japan, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 Shohken Tomita (1), Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, Osaka 553, Japan Shintaro Ueda (323), Department of Genetics, Osaka University Medical School, Osaka 553, Japan Emil R. Unanue (257), Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115 Weishui Y. Weiser (279), The Departments of Medicine, Harvard Medical School and Robert B. Brigham Hospital, A Division of Brigham and Women s Hos- pital, Boston, Massachusetts 02115 Charles Weissmann (111), Institutfür Molekularbiologie I, Universität Zürich, 8093 Zürich, Switzerland Ron Wilson (307), Department of Microbiology and Immunology SC-42, University of Washington, Seattle, Washington 98195 Takeshi Yoshida (245), Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032 Osamu Yoshie (157), Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511 Jesper Zeuthen (45), Basel Institute for Immunology, 4005 Basel, Switzerland FOREWORD The aims of the Takeda Science Foundation, established in 1963 through a donation from Takeda Chemical Industries, Ltd., have been to promote and support scientific studies and technology, thus contributing to scientific progress throughout the world. During the last two or three decades, the health and welfare of mankind have been extensively improved as a consequence of new scientific and technological knowledge. Nevertheless, in the biosciences, there are still many problems to be solved. Solutions will come with continued research, leading to new findings in many branches of science. This task will not be easy, but we must persevere in our efforts to enhance the well-being of man. One way of achieving this goal is by encouraging scientists working in different countries and disciplines to communicate with one another and to exchange ideas and information. Promotion of international cooperation will assist in making this possible, and, for this purpose, the Takeda Science Foundation will hold an annual Takeda Science Foundation Symposium on Bioscience under the supervision of a Symposium Committee. The members of the committee are: Setsuro Ebashi, M.D. (University of Tokyo); Osamu Hayaishi, M.D. (Kyoto University); Tomoji Suzuki, Ph.D. (Kyoto University); Hamao Umezawa, M.D. (Institute of Microbial Chem- istry); and Yuichi Yamamura, M.D. (Osaka University). The Foundation held its first symposium on bioscience in 1982: "Humoral Fac- tors in Host Defense." This work includes the proceedings of the symposium edited by the Organizing Committee headed by Dr. Y. Yamamura. I would like to express our gratitude to the members of the Symposium Commit- tee for supervising this first symposium. I am also very grateful to the members of the Organizing Committee for arranging the symposium and ensuring its success. SUEO TATSUOKA, PH.D. Chairman, the Board of Trustees Takeda Science Foundation xv PREFACE This volume contains the proceedings of the Takeda Science Foundation Sympo- sium on Bioscience, held in October 1982 in Kyoto on "Humoral Factors in Host Defense." The meeting was attended by 217 scientists from the United States, the United Kingdom, Switzerland, and Japan. Since the discovery of Τ and Β lymphocytes in the 1960s, the humoral factors regulating immune responses have been one of the central and most extensively studied problems in immunology. Introduction of hybridoma technology by G. Köhler and C. Milstein in 1975 launched a new era in this field. This technology has made it possible to study functional Τ cells and to obtain monoclonal im- munoregulatory molecules. Discovery of the growth factor specific for Τ cells, Τ cell growth factor (TCGF), or interleukin 2 (IL-2), has also made it possible to clone functional Τ cells. The regulatory mechanism of the immune system can now be analyzed at a molecular basis as a result of the development of such new technology. Application of recombinant DNA technology to lymphocytes has resulted in revolutionary developments in this field. Molecular mechanisms in the generation of antibody diversity have been revealed, and differentiation of lymphocytes can be discussed on the basis of immunoglobulin gene structure. Cloning of MHC genes has provided a powerful strategy for the study of the mechanism of self and not-self recognition and of Ir gene control of the immune response. This technology has also provided a powerful tool for the preparation of interferons and will be employed for the isolation and characterization of several immunoregulatory molecules. The enormous progress that has occurred in this discipline is reflected in the four sessions of this symposium: (1) Τ cell-derived immunoregulatory molecules; (2) interferon; (3) factors involved in differentiation and activation of immunocytes; and (4) molecular genetic approach to host defense factors. These advances make it possible to probe new and more effective forms of treatment for diseases, including immunodeficiencies, allergies, autoimmune diseases, and malignancies. Of course, no conference is possible without the help and dedication of the many individuals who assist in the planning and funding of the meeting. I owe a special debt of gratitude to the members of the organizing committee and the secretarial staff who made this symposium possible. I am also indebted to the Takeda Science Foundation for providing the funding for the symposium. XVll
The list of books you might like
